DK0996444T3 - Behandling af diabetes med thiazolidindion og metformin - Google Patents

Behandling af diabetes med thiazolidindion og metformin

Info

Publication number
DK0996444T3
DK0996444T3 DK98936364T DK98936364T DK0996444T3 DK 0996444 T3 DK0996444 T3 DK 0996444T3 DK 98936364 T DK98936364 T DK 98936364T DK 98936364 T DK98936364 T DK 98936364T DK 0996444 T3 DK0996444 T3 DK 0996444T3
Authority
DK
Denmark
Prior art keywords
thiazolidinedione
metformin
diabetes
treatment
Prior art date
Application number
DK98936364T
Other languages
English (en)
Inventor
Stephen Smith
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26311745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0996444(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9712857.3A external-priority patent/GB9712857D0/en
Priority claimed from GBGB9806706.9A external-priority patent/GB9806706D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0996444T3 publication Critical patent/DK0996444T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98936364T 1997-06-18 1998-06-15 Behandling af diabetes med thiazolidindion og metformin DK0996444T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9712857.3A GB9712857D0 (en) 1997-06-18 1997-06-18 Novel method of treatment
GBGB9806706.9A GB9806706D0 (en) 1998-03-27 1998-03-27 Novel method
PCT/EP1998/003690 WO1998057634A1 (en) 1997-06-18 1998-06-15 Treatment of diabetes with thiazolidinedione and metformin

Publications (1)

Publication Number Publication Date
DK0996444T3 true DK0996444T3 (da) 2007-07-02

Family

ID=26311745

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98936364T DK0996444T3 (da) 1997-06-18 1998-06-15 Behandling af diabetes med thiazolidindion og metformin

Country Status (39)

Country Link
US (3) US20060100247A1 (da)
EP (2) EP1787646A3 (da)
JP (1) JP2002504137A (da)
KR (2) KR100666591B1 (da)
CN (2) CN1230171C (da)
AP (1) AP1279A (da)
AR (2) AR012995A1 (da)
AT (1) ATE355840T1 (da)
AU (1) AU8539398A (da)
BG (2) BG64818B1 (da)
BR (1) BR9810172A (da)
CA (1) CA2294582C (da)
CY (2) CY1107643T1 (da)
CZ (1) CZ298469B6 (da)
DE (2) DE122007000054I1 (da)
DK (1) DK0996444T3 (da)
DZ (1) DZ2520A1 (da)
EA (1) EA003144B1 (da)
ES (1) ES2284212T3 (da)
HK (1) HK1028193A1 (da)
ID (1) ID23372A (da)
IL (3) IL133142A0 (da)
IN (1) IN189722B (da)
LU (1) LU91356I2 (da)
MA (1) MA26512A1 (da)
MY (1) MY129897A (da)
NL (1) NL300288I2 (da)
NO (4) NO324993B1 (da)
NZ (1) NZ501260A (da)
OA (1) OA11516A (da)
PE (1) PE83199A1 (da)
PL (2) PL195140B1 (da)
PT (1) PT996444E (da)
SI (1) SI0996444T1 (da)
SK (1) SK286029B6 (da)
TR (1) TR199903057T2 (da)
TW (1) TW565449B (da)
UY (1) UY25049A1 (da)
WO (1) WO1998057634A1 (da)

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GB9712857D0 (en) * 1997-06-18 1997-08-20 Smithkline Beecham Plc Novel method of treatment
PT974356E (pt) 1998-07-15 2004-02-27 Merck Sante Sas Comprimidos compreendendo uma combinacao de metformina e de glibenclamida
AU3960400A (en) * 1999-03-05 2000-09-28 Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv
TWI249401B (en) * 1999-04-14 2006-02-21 Takeda Chemical Industries Ltd Agent for improving ketosis
DZ3155A1 (fr) 1999-04-23 2000-11-02 Smithkline Beecham Plc Nouvelle composition pharmaceutique.
US6586438B2 (en) 1999-11-03 2003-07-01 Bristol-Myers Squibb Co. Antidiabetic formulation and method
BR0015294A (pt) 1999-11-03 2003-07-15 Bristol Myers Squibb Co Método para tratamento da diabetes
MY125516A (en) * 1999-11-16 2006-08-30 Smithkline Beecham Plc Novel composition based on thiazolidinedione and metformin and use
JP2003514011A (ja) * 1999-11-16 2003-04-15 スミスクライン ビーチャム パブリック リミテッド カンパニー チアゾリジンジオン−塩酸メトホルミンを含む医薬組成物
US20010036479A1 (en) 2000-01-14 2001-11-01 Gillian Cave Glyburide composition
GB0006133D0 (en) 2000-03-14 2000-05-03 Smithkline Beecham Plc Novel pharmaceutical
EP1278513B1 (en) * 2000-05-01 2007-07-18 Aeropharm Technology, LLC A core formulation
FR2812547B1 (fr) * 2000-08-04 2002-10-31 Lipha Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
US7964216B2 (en) 2001-01-12 2011-06-21 Sun Pharma Advanced Research Company Limited Spaced drug delivery system
FR2838968A1 (fr) * 2002-04-30 2003-10-31 Lipha Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
WO2003105809A1 (en) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
EP2604266A1 (en) * 2002-09-20 2013-06-19 Andrx Labs Llc Novel pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
UA80991C2 (en) * 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
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CA2562391A1 (en) 2004-04-14 2005-10-27 Takeda Pharmaceutical Company Limited Solid pharmaceutical preparation
CN1327840C (zh) * 2004-06-08 2007-07-25 天津药物研究院 一种药物组合物及其在制备用于治疗糖尿病中的应用
JPWO2006011397A1 (ja) * 2004-07-27 2008-05-01 興和株式会社 糖尿病の予防または治療のための薬剤
US20070032420A1 (en) * 2005-02-09 2007-02-08 Entelos, Inc. Treating diabetes with glucagon-like peptide-1 secretagogues
KR20080028415A (ko) * 2005-07-12 2008-03-31 다이이찌 산쿄 가부시키가이샤 ＰＰＡＲγ 애고니스트를 함유하는 의약 조성물
US7435741B2 (en) 2006-05-09 2008-10-14 Teva Pharmaceutical Industries, Ltd. 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
DE06252444T8 (de) * 2006-05-09 2009-03-19 Teva Pharmaceutical Industries Ltd. 2-N-{5-[[4-[2-(Methyl-2-pyridinylamino)-ethoxy]-phenyl]-methyl]-2,4-thiazolidindion}-bernsteinsäure, Verfahren zur Herstellung und Zusammensetzungen mit Rosiglitazonmaleat
CN101069745B (zh) * 2006-05-12 2010-07-21 北京华安佛医药研究中心有限公司 治疗2型糖尿病的药物组合物
US7919410B2 (en) * 2007-03-14 2011-04-05 Aptina Imaging Corporation Packaging methods for imager devices
JP2012503595A (ja) * 2008-07-28 2012-02-09 シダンスク ユニバーシティ 代謝病の治療用の化合物
DE102009053562A1 (de) 2009-11-18 2011-05-19 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Rosiglitazonsuccinat enthaltende pharmazeutische Zusammensetzung
US8796338B2 (en) 2011-01-07 2014-08-05 Elcelyx Therapeutics, Inc Biguanide compositions and methods of treating metabolic disorders
US9211263B2 (en) 2012-01-06 2015-12-15 Elcelyx Therapeutics, Inc. Compositions and methods of treating metabolic disorders
US9480663B2 (en) 2011-01-07 2016-11-01 Elcelyx Therapeutics, Inc. Biguanide compositions and methods of treating metabolic disorders
US11759441B2 (en) 2011-01-07 2023-09-19 Anji Pharmaceuticals Inc. Biguanide compositions and methods of treating metabolic disorders
SI2661266T1 (sl) 2011-01-07 2021-01-29 Anji Pharma (Us) Llc Terapije, na osnovi kemosenzoričnih receptorskih ligandov
US9572784B2 (en) 2011-01-07 2017-02-21 Elcelyx Therapeutics, Inc. Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
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MX2014008190A (es) 2012-01-06 2015-02-04 Elcelyx Therapeutics Inc Composiciones de biguanida y métodos para tratar transtornos metabólicos.
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Also Published As

Publication number Publication date
PE83199A1 (es) 1999-10-22
EP0996444A1 (en) 2000-05-03
NO326958B1 (no) 2009-03-23
IN189722B (da) 2003-04-19
MY129897A (en) 2007-05-31
SK179299A3 (en) 2000-11-07
CA2294582A1 (en) 1998-12-23
CZ298469B6 (cs) 2007-10-10
AR012998A1 (es) 2000-11-22
CZ9904578A3 (en) 2001-06-13
TR199903057T2 (xx) 2000-04-21
EA200000041A1 (ru) 2000-08-28
EP1787646A3 (en) 2007-10-03
BG64818B1 (bg) 2006-05-31
BG109398A (bg) 2006-05-31
AP9901719A0 (en) 1999-12-31
NO324993B1 (no) 2008-01-14
NO20090846L (no) 1999-12-17
CY1107643T1 (el) 2012-01-25
IL133142A0 (en) 2001-03-19
CN1260716A (zh) 2000-07-19
NO20063000L (no) 1999-12-17
PL337362A1 (en) 2000-08-14
AR012995A1 (es) 2000-11-22
NO2008003I2 (no) 2010-06-28
NZ501260A (en) 2002-09-27
ATE355840T1 (de) 2007-03-15
PL195136B1 (pl) 2007-08-31
EP0996444B1 (en) 2007-03-07
CY2007018I1 (el) 2012-01-25
CN1230171C (zh) 2005-12-07
DE69837261T2 (de) 2007-11-08
IL133142A (en) 2006-06-11
DZ2520A1 (fr) 2003-02-01
ID23372A (id) 2000-04-20
NO2008003I1 (no) 2008-04-21
BG104060A (en) 2000-10-31
SK286029B6 (sk) 2008-01-07
SI0996444T1 (sl) 2007-08-31
PL195140B1 (pl) 2007-08-31
US20060100247A1 (en) 2006-05-11
KR100666591B1 (ko) 2007-01-11
CA2294582C (en) 2008-02-12
TW565449B (en) 2003-12-11
CN1114404C (zh) 2003-07-16
CN1429551A (zh) 2003-07-16
HK1028193A1 (en) 2001-02-09
AP1279A (en) 2004-05-20
NO996266L (no) 1999-12-17
BR9810172A (pt) 2000-08-08
ES2284212T3 (es) 2007-11-01
PT996444E (pt) 2007-06-08
UY25049A1 (es) 2000-09-29
NO996266D0 (no) 1999-12-17
US20070004780A1 (en) 2007-01-04
NL300288I1 (nl) 2007-11-01
DE122007000054I1 (de) 2007-12-13
NL300288I2 (nl) 2009-06-02
DE69837261D1 (de) 2007-04-19
JP2002504137A (ja) 2002-02-05
IL173650A0 (en) 2006-07-05
AU8539398A (en) 1999-01-04
LU91356I2 (fr) 2008-01-29
EP1787646A2 (en) 2007-05-23
OA11516A (en) 2004-02-04
EA003144B1 (ru) 2003-02-27
US20080090881A1 (en) 2008-04-17
MA26512A1 (fr) 2004-12-20
KR20060105005A (ko) 2006-10-09
WO1998057634A1 (en) 1998-12-23
KR20010013844A (ko) 2001-02-26

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