DK0972020T3 - Agonistmolekyler rettet imod insulinlignende vækstfaktorer - Google Patents
Agonistmolekyler rettet imod insulinlignende vækstfaktorerInfo
- Publication number
- DK0972020T3 DK0972020T3 DK98915236T DK98915236T DK0972020T3 DK 0972020 T3 DK0972020 T3 DK 0972020T3 DK 98915236 T DK98915236 T DK 98915236T DK 98915236 T DK98915236 T DK 98915236T DK 0972020 T3 DK0972020 T3 DK 0972020T3
- Authority
- DK
- Denmark
- Prior art keywords
- growth factors
- directed against
- agonist molecules
- molecules directed
- against insulin
- Prior art date
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 2
- 102000013275 Somatomedins Human genes 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title abstract 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 2
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/825,852 US6121416A (en) | 1997-04-04 | 1997-04-04 | Insulin-like growth factor agonist molecules |
PCT/US1998/006514 WO1998045427A2 (en) | 1997-04-04 | 1998-03-31 | Insulin-like growth factor agonist peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0972020T3 true DK0972020T3 (da) | 2003-02-03 |
Family
ID=25245064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98915236T DK0972020T3 (da) | 1997-04-04 | 1998-03-31 | Agonistmolekyler rettet imod insulinlignende vækstfaktorer |
Country Status (13)
Country | Link |
---|---|
US (16) | US6121416A (de) |
EP (2) | EP1251137A3 (de) |
JP (1) | JP4562814B2 (de) |
AT (1) | ATE224951T1 (de) |
AU (1) | AU732989B2 (de) |
CA (1) | CA2286264A1 (de) |
DE (1) | DE69808258T2 (de) |
DK (1) | DK0972020T3 (de) |
ES (1) | ES2183344T3 (de) |
HK (1) | HK1047755A1 (de) |
IL (1) | IL131925A0 (de) |
PT (1) | PT972020E (de) |
WO (1) | WO1998045427A2 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
WO2000040612A1 (en) | 1999-01-06 | 2000-07-13 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
DK1141014T3 (da) | 1999-01-06 | 2005-04-11 | Genentech Inc | Insulinlignende vækstfaktor (IGF) i mutantvariant |
US20030224017A1 (en) * | 2002-03-06 | 2003-12-04 | Samal Siba K. | Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors |
ATE321885T1 (de) * | 1999-10-29 | 2006-04-15 | Univ Oregon Health Sciences | Modulation der neurokrinen differenzierung durch protein 25.1 |
EP1265630B1 (de) | 2000-03-24 | 2006-06-07 | Genentech, Inc. | Verwendung von insulin zur behandlung von knorpelkrankheiten |
AU2001263215A1 (en) | 2000-05-16 | 2001-11-26 | Genentech Inc. | Method for treating cartilage disorders |
FR2810675B1 (fr) * | 2000-06-22 | 2002-09-27 | Pf Medicament | Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes |
ATE495443T1 (de) * | 2000-11-28 | 2011-01-15 | Premacure Ab | Reduzierung des risikos für komplikationen bei frühgeburten |
US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
DK1358209T3 (da) | 2001-02-09 | 2007-05-07 | Genentech Inc | Krystallisering af IGF-1 |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
US6790672B2 (en) * | 2001-02-19 | 2004-09-14 | Board Of Regents The University Of Texas System | Encoded molecular sieve particle-based sensors |
EP1401476A4 (de) | 2001-03-14 | 2006-03-08 | Genentech Inc | Igf-antagonistenpeptide |
US6841386B2 (en) | 2001-04-10 | 2005-01-11 | Viacell, Inc. | Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein |
US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
WO2003041655A2 (en) * | 2001-11-13 | 2003-05-22 | Loi Tran | Therapeutic agent composition and method of use |
US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
NZ571508A (en) | 2002-05-24 | 2010-05-28 | Schering Corp | Neutralizing human anti-IGFR antibody |
CA2488497A1 (en) * | 2002-06-11 | 2003-12-18 | The Burnham Institute | Neuroprotective synergy of erythropoietin and insulin-like growth factor |
US7118877B2 (en) * | 2002-07-08 | 2006-10-10 | Wyeth | Caspase 9 activation and uses therefor |
JP4719465B2 (ja) * | 2002-09-04 | 2011-07-06 | ディーエスエム アイピー アセッツ ビー.ブイ. | インスリン感受性増強剤およびペプチド画分を含む栄養補給用および治療用組成物 |
EP1540815B1 (de) * | 2002-09-06 | 2006-12-27 | Telefonaktiebolaget LM Ericsson (publ) | Zusammengesetzter leistungsverstärker |
US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
JP2006504694A (ja) * | 2002-09-18 | 2006-02-09 | サントル・オスピタリエ・ドゥ・リュニヴェルシテ・ドゥ・モントリオール・(シー・エイチ・ユー・エム) | Ghrh類似体 |
US20040142359A1 (en) * | 2002-11-14 | 2004-07-22 | Wyeth | Methods and compositions for treating neurological disorders |
US7273788B2 (en) * | 2003-05-21 | 2007-09-25 | Micron Technology, Inc. | Ultra-thin semiconductors bonded on glass substrates |
PL1636593T3 (pl) | 2003-06-06 | 2009-08-31 | Genentech Inc | Modulowanie oddziaływania pomiędzy łańcuchem beta HGF i c-met. |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
ATE536186T1 (de) | 2003-09-12 | 2011-12-15 | Tercica Inc | Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel |
EP1670822A2 (de) * | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf-bindende proteine |
US7326567B2 (en) | 2003-11-12 | 2008-02-05 | Schering Corporation | Plasmid system for multigene expression |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
AR046639A1 (es) | 2003-11-21 | 2005-12-14 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti- igfr1 |
AU2004298483A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
KR101165867B1 (ko) * | 2004-03-19 | 2012-07-13 | 메르크 파텐트 게엠베하 | 변형 부가닌 단백질, 그 세포독소 및 이의 생산방법과 용도 |
US20060020192A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
WO2006060419A2 (en) | 2004-12-03 | 2006-06-08 | Schering Corporation | Biomarkers for pre-selection of patients for anti-igf1r therapy |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
BRPI0608777A2 (pt) * | 2005-04-15 | 2010-01-26 | Schering Corp | métodos para tratamento ou prevenção de cáncer, bem como uso de inibidores de igf1r na preparação de composições farmacêuticas |
AU2006259536A1 (en) * | 2005-06-15 | 2006-12-28 | Schering Corporation | Anti-IGF1R antibody formulations |
CN101467039B (zh) | 2006-04-10 | 2013-11-06 | 健泰科生物技术公司 | 散乱蛋白pdz调节剂 |
WO2008130315A1 (en) | 2007-04-18 | 2008-10-30 | Premacure Ab | Method and product for treatment and/or prevention of complications of prematurity |
US20090054473A1 (en) * | 2007-08-22 | 2009-02-26 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
EP2252196A4 (de) | 2008-02-21 | 2013-05-15 | Dexcom Inc | Systeme und verfahren zur verarbeitung, übertragung und anzeige von sensordaten |
US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
WO2011146902A1 (en) | 2010-05-21 | 2011-11-24 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
SG189271A1 (en) | 2010-10-20 | 2013-05-31 | Genentech Inc | Methods and compositions for modulating the wnt pathway |
EP2766028B1 (de) | 2011-10-14 | 2017-08-16 | F. Hoffmann-La Roche AG | Peptidinhibitoren von bace1 |
EP2766034B1 (de) | 2011-10-14 | 2018-06-13 | F. Hoffmann-La Roche AG | Zymogen-aktivatoren |
CN115960249A (zh) | 2015-10-02 | 2023-04-14 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
EA202090705A1 (ru) | 2017-09-11 | 2020-06-11 | Шайр Хьюман Дженетик Терапиз, Инк. | Способы и композиции, предназначенные для лечения хронических заболеваний легких |
CN112423774A (zh) | 2018-05-15 | 2021-02-26 | L·H·L·特兰 | 用于治疗轻度认知障碍、抑郁和心理障碍的治疗剂组成及使用方法 |
US20210008172A1 (en) | 2019-07-11 | 2021-01-14 | Opko Biologics Ltd. | Long-acting igf-1 or igf-1 variants and methods of producing same |
GB201913196D0 (en) | 2019-09-12 | 2019-10-30 | Univ Newcastle | Culture method |
CN117098547A (zh) | 2020-10-19 | 2023-11-21 | 奥克希尔生物有限公司 | 适用于新生儿的组合物 |
DE102021122096A1 (de) | 2021-08-26 | 2023-03-02 | Forschungsinstitut für Nutztierbiologie | IGF-1, IGFBP-2 und Insulin umfassende Zusammensetzungen und ihre Verwendung |
WO2023139115A1 (en) | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions and methods for reducing oxidation of igf‐1/igfbp |
CN117347626B (zh) * | 2023-12-06 | 2024-03-12 | 安徽惠邦生物工程有限公司 | 人胰岛素样生长因子结合蛋白-1化学发光免疫分析试剂盒及其制备方法 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US3721252A (en) * | 1971-04-01 | 1973-03-20 | Catheter And Instr Corp | Spring guide washer |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
PH23185A (en) | 1983-06-13 | 1989-05-29 | Scheindel Ass Inc | Pressure operated dispensing container |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
DE3463991D1 (en) | 1983-08-15 | 1987-07-02 | Amp Inc | An improved compliant section for circuit board contact elements |
WO1987001038A1 (en) * | 1985-08-22 | 1987-02-26 | Commonwealth Scientific And Industrial Research Or | Peptide analogues of mammalian insulin-like growth factor-1 |
SE8505922D0 (sv) * | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
ATE90690T1 (de) * | 1987-04-06 | 1993-07-15 | Celtrix Pharma | Menschliche somatomedin-traeger-proteinuntereinheiten und verfahren zu ihrer herstellung. |
EP0288451B1 (de) * | 1987-04-23 | 1994-08-10 | Monsanto Company | Sekretion eines dem Insulin ähnlichen Wachstumsfaktors in E. coli |
SE8703625D0 (sv) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
DE3852636T2 (de) * | 1987-12-24 | 1995-05-04 | Gropep Pty Ltd | Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2). |
US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
EP0327503B1 (de) * | 1988-02-05 | 1993-03-10 | Ciba-Geigy Ag | Verwendung von IGF I zur Herstellung eines Präparates für die Behandlung von Nierenkrankheiten |
US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
DK131988A (da) * | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
EP0418230B1 (de) * | 1988-04-12 | 1995-12-27 | Amgen Boulder Inc. | Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
GB8826451D0 (en) * | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
EP0379338A3 (de) * | 1989-01-17 | 1991-07-24 | Merck & Co. Inc. | Menschlicher insulinähnlicher Wachstumsfaktor und seine Herstellung in Hefe |
US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
GB8920381D0 (en) * | 1989-09-08 | 1989-10-25 | Greater Glasgow Health Board | Treatment of insulin-resistant diabetes |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
US5210017A (en) * | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
US5593844A (en) * | 1990-11-19 | 1997-01-14 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
SE9100099D0 (sv) * | 1991-01-11 | 1991-01-11 | Kabi Pharmacia Ab | Use of growth factor |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
JP4146512B2 (ja) * | 1991-03-01 | 2008-09-10 | ダイアックス コープ. | 小型タンパク質 |
US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
US5202119A (en) * | 1991-06-28 | 1993-04-13 | Genentech, Inc. | Method of stimulating immune response |
DK0597033T3 (da) * | 1991-08-01 | 1997-06-02 | Genentech Inc | IGF-1 til forbedring af den neurale tilstand |
US6310040B1 (en) * | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
SE9201573D0 (sv) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | Use of igf-1 |
CA2136969C (en) * | 1992-06-12 | 2009-03-24 | Michael E. Lewis | Prevention and treatment of peripheral neuropathy |
GB9217696D0 (en) * | 1992-08-20 | 1992-09-30 | Agricultural & Food Res | Use of specific binding molecules |
US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
EP0642350A4 (de) * | 1993-01-25 | 1995-06-28 | Beth Israel Hospital | Methode zur modifizierung, diagnose und dem aufspüren von igf-1 sensitiven zellbarriereeigenschaften. |
CA2154078A1 (en) * | 1993-01-29 | 1994-08-04 | George N. Cox | Wound healing composition |
US5478852C1 (en) * | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
US5767085A (en) * | 1993-12-23 | 1998-06-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
AU683121B2 (en) * | 1993-12-23 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
SE9402370D0 (sv) * | 1994-07-04 | 1994-07-04 | Pharmacia Ab | Use of IGF-I |
US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
SE9501472D0 (sv) * | 1995-04-21 | 1995-04-21 | Pharmacia Ab | Truncated IGF-I |
US5622932A (en) * | 1995-05-05 | 1997-04-22 | Eli Lilly And Company | IGF-1 superagonists |
AU697119B2 (en) * | 1995-05-26 | 1998-09-24 | Theratechnologies Inc. | Chimeric fatty body-pro-GRF analogs with increased biological potency |
WO1996040189A1 (en) * | 1995-06-07 | 1996-12-19 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
PL185040B1 (pl) * | 1995-06-07 | 2003-02-28 | Affymax Tech Nv | Peptyd wiążący się z receptorami erytropoetyny, kompozycja farmaceutyczna zawierająca ten peptyd i jego zastosowanie do wytwarzania środka leczniczego |
ES2303338T3 (es) * | 1995-06-07 | 2008-08-01 | Glaxo Group Limited | Peptidos y compuestos que se unen a un receptor de trombopoyetina. |
US5958872A (en) * | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
EP0854884A1 (de) * | 1996-04-17 | 1998-07-29 | Neurocrine Biosciences, Inc. | Inhibitoren von liganden der insulin-ähnlichen faktor bindenden proteine und methoden für ihre verwendung |
EP0895459B1 (de) | 1996-04-25 | 2001-11-14 | Karl Storz GmbH & Co. KG | Chirurgisches instrumentensystem |
CA2276049A1 (en) | 1996-12-27 | 1998-07-09 | Daiichi Pharmaceutical Co., Ltd. | Method for elevating the concentration of free insulin-like growth factor |
US6420518B1 (en) * | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
AU6515499A (en) | 1998-10-16 | 2000-05-08 | Musc Foundation For Research Development | Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof |
-
1997
- 1997-04-04 US US08/825,852 patent/US6121416A/en not_active Expired - Fee Related
-
1998
- 1998-03-31 DE DE69808258T patent/DE69808258T2/de not_active Expired - Lifetime
- 1998-03-31 PT PT98915236T patent/PT972020E/pt unknown
- 1998-03-31 EP EP02014880A patent/EP1251137A3/de not_active Withdrawn
- 1998-03-31 CA CA002286264A patent/CA2286264A1/en not_active Abandoned
- 1998-03-31 JP JP54289498A patent/JP4562814B2/ja not_active Expired - Fee Related
- 1998-03-31 AU AU69470/98A patent/AU732989B2/en not_active Ceased
- 1998-03-31 IL IL13192598A patent/IL131925A0/xx not_active IP Right Cessation
- 1998-03-31 US US09/052,888 patent/US6251865B1/en not_active Expired - Fee Related
- 1998-03-31 ES ES98915236T patent/ES2183344T3/es not_active Expired - Lifetime
- 1998-03-31 EP EP98915236A patent/EP0972020B1/de not_active Expired - Lifetime
- 1998-03-31 WO PCT/US1998/006514 patent/WO1998045427A2/en active IP Right Grant
- 1998-03-31 AT AT98915236T patent/ATE224951T1/de active
- 1998-03-31 DK DK98915236T patent/DK0972020T3/da active
-
2000
- 2000-11-28 US US09/723,901 patent/US6620789B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,913 patent/US6683053B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,481 patent/US6949349B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,157 patent/US6693079B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,912 patent/US6689751B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,873 patent/US6677305B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,547 patent/US6632794B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/724,062 patent/US6713451B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,931 patent/US6645775B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,095 patent/US6693078B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,114 patent/US6680298B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,890 patent/US6608031B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,127 patent/US6635619B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,065 patent/US6716586B1/en not_active Expired - Fee Related
-
2002
- 2002-12-30 HK HK02109420.9A patent/HK1047755A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ATE224951T1 (de) | 2002-10-15 |
US6677305B1 (en) | 2004-01-13 |
EP0972020B1 (de) | 2002-09-25 |
CA2286264A1 (en) | 1998-10-15 |
US6608031B1 (en) | 2003-08-19 |
US6689751B1 (en) | 2004-02-10 |
DE69808258T2 (de) | 2003-09-18 |
DE69808258D1 (de) | 2002-10-31 |
WO1998045427A3 (en) | 1999-01-07 |
PT972020E (pt) | 2003-02-28 |
EP0972020A1 (de) | 2000-01-19 |
IL131925A0 (en) | 2001-03-19 |
ES2183344T3 (es) | 2003-03-16 |
AU6947098A (en) | 1998-10-30 |
EP1251137A3 (de) | 2003-04-16 |
US6645775B1 (en) | 2003-11-11 |
WO1998045427A2 (en) | 1998-10-15 |
US6121416A (en) | 2000-09-19 |
AU732989B2 (en) | 2001-05-03 |
JP2002510194A (ja) | 2002-04-02 |
US6680298B1 (en) | 2004-01-20 |
JP4562814B2 (ja) | 2010-10-13 |
US6620789B1 (en) | 2003-09-16 |
US6251865B1 (en) | 2001-06-26 |
US6693078B1 (en) | 2004-02-17 |
US6632794B1 (en) | 2003-10-14 |
US6713451B1 (en) | 2004-03-30 |
US6949349B1 (en) | 2005-09-27 |
EP1251137A2 (de) | 2002-10-23 |
US6683053B1 (en) | 2004-01-27 |
US6635619B1 (en) | 2003-10-21 |
US6693079B1 (en) | 2004-02-17 |
HK1047755A1 (zh) | 2003-03-07 |
US6716586B1 (en) | 2004-04-06 |
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