DK0906426T3 - Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser - Google Patents
Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelserInfo
- Publication number
- DK0906426T3 DK0906426T3 DK97923243T DK97923243T DK0906426T3 DK 0906426 T3 DK0906426 T3 DK 0906426T3 DK 97923243 T DK97923243 T DK 97923243T DK 97923243 T DK97923243 T DK 97923243T DK 0906426 T3 DK0906426 T3 DK 0906426T3
- Authority
- DK
- Denmark
- Prior art keywords
- fibronectin
- domain
- antibodies
- construction
- specific
- Prior art date
Links
- 102000016359 Fibronectins Human genes 0.000 title abstract 3
- 108010067306 Fibronectins Proteins 0.000 title abstract 3
- 238000010276 construction Methods 0.000 title 1
- 230000027455 binding Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9610967A GB9610967D0 (en) | 1996-05-24 | 1996-05-24 | Specific binding members,materials and methods |
| PCT/GB1997/001412 WO1997045544A1 (fr) | 1996-05-24 | 1997-05-23 | Anticorps contre le domaine ed-b de la fibronectine, leur construction et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0906426T3 true DK0906426T3 (da) | 2007-09-10 |
Family
ID=10794298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97923243T DK0906426T3 (da) | 1996-05-24 | 1997-05-23 | Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US7273924B1 (fr) |
| EP (1) | EP0906426B1 (fr) |
| JP (2) | JP4750912B2 (fr) |
| KR (2) | KR20050010081A (fr) |
| CN (1) | CN100447159C (fr) |
| AT (1) | ATE361364T1 (fr) |
| AU (1) | AU729081B2 (fr) |
| BG (1) | BG65138B1 (fr) |
| BR (1) | BR9709350B1 (fr) |
| CA (1) | CA2256308C (fr) |
| CZ (1) | CZ295531B6 (fr) |
| DE (1) | DE69737683T2 (fr) |
| DK (1) | DK0906426T3 (fr) |
| EA (1) | EA004329B1 (fr) |
| ES (1) | ES2286831T3 (fr) |
| GB (1) | GB9610967D0 (fr) |
| HK (1) | HK1020990A1 (fr) |
| HU (1) | HUP0200546A2 (fr) |
| IL (2) | IL127216A0 (fr) |
| IS (1) | IS2508B (fr) |
| NO (1) | NO324904B1 (fr) |
| NZ (1) | NZ333083A (fr) |
| PL (1) | PL188557B1 (fr) |
| PT (1) | PT906426E (fr) |
| SI (1) | SI0906426T1 (fr) |
| SK (1) | SK285916B6 (fr) |
| TR (1) | TR199802416T2 (fr) |
| UA (1) | UA74129C2 (fr) |
| WO (1) | WO1997045544A1 (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
| US7244826B1 (en) * | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
| TWI259837B (en) * | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| US20030176663A1 (en) * | 1998-05-11 | 2003-09-18 | Eidgenossische Technische Hochscule | Specific binding molecules for scintigraphy |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| ES2373966T3 (es) * | 2000-02-24 | 2012-02-10 | Philogen S.P.A. | Composiciones y procedimientos para el tratamiento de la angiogénesis en lesiones patológicas. |
| CA2400622A1 (fr) * | 2000-02-24 | 2001-08-30 | Eidgenossische Technische Hochschule Zurich | Anticorps specifique au domaine ed-b de la fibronectine, conjugues contenant cet anticorps, et utilisation pour la detection et le traitement de l'angiogenese |
| US7094750B2 (en) | 2000-05-09 | 2006-08-22 | Greenville Hospital System | Therapeutic pore-forming peptides |
| AU2001281824A1 (en) * | 2000-06-15 | 2001-12-24 | Patrizia Castellani | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| EE200300092A (et) * | 2000-09-07 | 2005-06-15 | Schering Aktiengesellschaft | EDb-fibronektiinidomeeni retseptor |
| IT1317108B1 (it) * | 2000-12-06 | 2003-05-26 | Philogen Srl | Processo per la selezione di frammenti anticorporali anti-angiogenesi,frammenti anticorpali anti-angiogenesi cosi' ottenuti e loro uso. |
| US7456146B2 (en) * | 2001-05-09 | 2008-11-25 | Ghc Research Development Corporation | Lytic peptide prodrugs |
| IL162201A0 (en) | 2002-01-03 | 2005-11-20 | Schering Ag | New methods for diagnosis and treatment of tumours |
| WO2003076469A2 (fr) * | 2002-03-11 | 2003-09-18 | Philogen S.P.A. | Ciblage selectif d'un systeme vasculaire tumoral au moyen de molecules d'anticorps |
| MX337052B (es) | 2002-07-15 | 2016-02-11 | Univ Texas | Peptidos que se enlazan a fosfatidiletanolamina y sus usos en el tratamiento de infecciones virales y del cancer. |
| EP1603949B9 (fr) | 2003-03-14 | 2011-02-02 | Wyeth LLC | Anticorps diriges contre le recepteur humain de l'il-21 et utilisations correspondantes |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| CA2552590A1 (fr) | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Composes de ciblage |
| US20060024724A1 (en) | 2004-07-30 | 2006-02-02 | Robert Hussa | Oncofetal fibronectin as a marker for health and disease |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| EP1803814A1 (fr) | 2005-12-27 | 2007-07-04 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Procédé d'amélioration la capacité de sélection d'anticorps dans une bibliothèque d'affichage de phages |
| EP1925664A1 (fr) | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Protéines de liaison artificielles basées sur une région modifiée de type hélice alpha de l'ubiquitine |
| US8253725B2 (en) * | 2007-12-28 | 2012-08-28 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Method and system for generating surface models of geometric structures |
| ATE548052T1 (de) | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
| EP2100621A1 (fr) | 2008-03-10 | 2009-09-16 | mivenion GmbH | Conjugués de dendrimère de polyol de polyéther dotés de molécules effectrices pour le ciblage biologique |
| EP2116555A1 (fr) | 2008-05-08 | 2009-11-11 | Bayer Schering Pharma Aktiengesellschaft | Utilisation d'une molécule radiomarquée se liant spécifiquement à la fibronectine ED-B dans un procédé de traitement du lymphome Hodgkin |
| IT1392027B1 (it) * | 2008-12-12 | 2012-02-09 | Castellani | Anticorpo monoclonale e suo uso per la identificazione della isoforma oncofetale della fibronettina (b-fn) a scopo diagnostico o terapeutico. |
| CA2778871C (fr) | 2009-12-14 | 2017-08-01 | Scil Proteins Gmbh | Proteines d'ubiquitine modifiee possedant une activite de liaison specifique pour l'extradomaine b de la fibronectine |
| WO2011110490A1 (fr) | 2010-03-09 | 2011-09-15 | Bayer Pharma Aktiengesellschaft | Procédé pour la production de fragments d'anticorps scfv marqués radioactivement, kits et compositions |
| WO2012171541A1 (fr) | 2011-06-15 | 2012-12-20 | Scil Proteins Gmbh | Protéines hybrides humaines comportant des interférons et des protéines hétérodimériques modifiées par ubiquitine |
| US9492572B2 (en) | 2011-06-15 | 2016-11-15 | Scil Proteins Gmbh | Dimeric binding proteins based on modified ubiquitins |
| US20150183846A1 (en) | 2012-06-13 | 2015-07-02 | Scil Proteins Gmbh | Human fusion proteins comprising single chain tnfalpha and targeting domains |
| WO2014094799A1 (fr) | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Fragments d'ubiquitine en tant que moyens pour prolonger la demi-vie sérique |
| CN104395342B (zh) * | 2013-06-06 | 2017-07-04 | 合肥立方制药股份有限公司 | 人源抗纤连蛋白ed‑b结构域的抗体及其用途 |
| US10858405B2 (en) | 2015-02-06 | 2020-12-08 | Navigo Proteins Gmbh | EGFR binding proteins |
| CN107922483B (zh) | 2015-07-16 | 2021-07-30 | 纳维格蛋白质有限公司 | 新型免疫球蛋白结合蛋白及其在亲和纯化中的用途 |
| US10584152B2 (en) | 2015-07-20 | 2020-03-10 | Navigo Proteins Gmbh | Binding proteins based on di-ubiquitin muteins and methods for generation |
| EP3378947B1 (fr) * | 2015-11-16 | 2024-01-24 | Hefei Lifeon Pharmaceutical Co. Ltd. | Utilisation de protéine ed-b dans le diagnostic d'une hyperplasie tissulaire |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| WO2018029157A1 (fr) | 2016-08-11 | 2018-02-15 | Navigo Proteins Gmbh | Nouvelles protéines de liaison aux immunoglobulines stables alcalines |
| IL266112B2 (en) | 2016-10-17 | 2024-07-01 | Pfizer | Antibodies against EDB and antibody-drug conjugates |
| US11390666B2 (en) | 2017-06-07 | 2022-07-19 | Philogen S.P.A. | Vascular endothelial growth factor/anti-fibronectin antibody fusion proteins |
| CN111148759B (zh) | 2017-09-30 | 2023-09-19 | 合肥立方制药股份有限公司 | 结合至纤维连接蛋白b结构域的蛋白 |
| EP3706804B1 (fr) | 2017-11-07 | 2022-02-23 | Navigo Proteins GmbH | Protéines de fusion ayant une spécificité pour ed-b et une demi-vie sérique longue pour le diagnostic ou le traitement du cancer |
| WO2020070150A1 (fr) | 2018-10-02 | 2020-04-09 | Philogen S.P.A | Immunoconjugués d'il2 |
| EP3660039A1 (fr) | 2018-11-30 | 2020-06-03 | Philogen S.p.A. | Immunoconjugués d'il2 |
| JOP20220035A1 (ar) | 2019-08-15 | 2023-01-30 | Janssen Biotech Inc | مواد وطرق لتحسين أجزاء المتغير أحادي السلسلة |
| CA3164226A1 (fr) | 2019-12-11 | 2021-06-17 | Cilag Gmbh International | Molecules de liaison multispecifiques comprenant des domaines de liaison ltbr et edb et leurs utilisations |
| CN111171149B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的人源化单链抗体及其应用 |
| CN111234016B (zh) * | 2020-02-23 | 2021-09-07 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c5分子的全人源单克隆抗体及应用 |
| KR102614063B1 (ko) | 2020-12-24 | 2023-12-19 | 대화제약 주식회사 | 엑스트라도메인 b 피브로넥틴에 특이적으로 결합하는 신규한 항체 |
| WO2023131611A1 (fr) | 2022-01-04 | 2023-07-13 | Philogen S.P.A. | Combinaison d'une immunocytokine comprenant l'il-12 et un inhibiteur de kinase |
| WO2024028258A1 (fr) | 2022-08-01 | 2024-02-08 | Philochem Ag | Conjugués de fractions de liaison au psma avec des agents cytotoxiques |
| WO2024052333A1 (fr) | 2022-09-06 | 2024-03-14 | Philochem Ag | Ligands multivalents de protéine d'activation des fibroblastes pour applications d'administration ciblée |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPH082308B2 (ja) | 1985-01-28 | 1996-01-17 | インタ−ナショナル・ジェネティック・エンジニアリング，インコ−ポレイテッド | ａｒａＢプロモーターを含有する複製可能な発現ビヒクル |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4894326A (en) | 1986-04-09 | 1990-01-16 | Fred Hutchinson Cancer Research Center | Monoclonal antibody defining oncofetal structure of fibronectin |
| US5243029A (en) | 1986-04-09 | 1993-09-07 | Fred Hutchinson Cancer Research Center | Oncofetal structure of fibronectin |
| CA1341235C (fr) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Assemblage modulaire de genes d'anticorps, anticorps prepares de cette facon, ainsi que leur usage |
| JPH02598A (ja) * | 1987-10-09 | 1990-01-05 | De La Rue Co Plc:The | 集積回路カード |
| WO1989006283A1 (fr) | 1988-01-11 | 1989-07-13 | Ingene (International Genetic Engineering, Inc.) | Nouveau vecteur de plasmide avec sequence a fonction de signal pour pectate lyase |
| IT1217724B (it) | 1988-05-26 | 1990-03-30 | Ist Naz Ric Sul Cancro | Anticorpo monoclonale specifico per una sequenza di fibronettina espressa in cellule trasformate ibridoma secernente tale anticorpo e impiego dell'anticorpo monoclonale per la diagnosi di tumori |
| US5177015A (en) | 1988-08-12 | 1993-01-05 | Fred Hutchinson Cancer Research Centre | Onco-developmentally regulated α-N-acetylgalactosaminyltransferase |
| US5843156A (en) | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| JPH0276598A (ja) * | 1988-09-14 | 1990-03-15 | Fujita Gakuen | 抗ｅｄ−ｂ抗体 |
| JPH04169195A (ja) * | 1990-10-31 | 1992-06-17 | Fujita Gakuen | 抗ｅｄ―ｂモノクローナル抗体 |
| ES2165851T3 (es) | 1991-11-25 | 2002-04-01 | Enzon Inc | Proteinas multivalentes que se unen a antigenos. |
| US5629291A (en) | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| US5561114A (en) | 1992-09-25 | 1996-10-01 | Otsuka Pharmaceutical Factory Inc. | Adsorbent for cellular fibronectin, a method for fractional purification of fibronectin and a method of hemocatharisis |
| US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
| US5837242A (en) | 1992-12-04 | 1998-11-17 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| US6015897A (en) | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
| US5523229A (en) | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
| DE4417865A1 (de) | 1994-05-20 | 1995-11-23 | Behringwerke Ag | Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie |
| ITFI940095A1 (it) | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| WO1996023816A1 (fr) | 1995-02-01 | 1996-08-08 | British Technology Group Limited | Proteines radiomarquees |
| US6140470A (en) | 1995-06-30 | 2000-10-31 | Yale University | Human monoclonal anti-tumor antibodies |
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US5913884A (en) | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| US6267722B1 (en) | 1998-02-03 | 2001-07-31 | Adeza Biomedical Corporation | Point of care diagnostic systems |
| TWI259837B (en) | 1998-05-11 | 2006-08-11 | Eidgenossische Tech Hochscule | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| ES2373966T3 (es) | 2000-02-24 | 2012-02-10 | Philogen S.P.A. | Composiciones y procedimientos para el tratamiento de la angiogénesis en lesiones patológicas. |
| CA2400622A1 (fr) | 2000-02-24 | 2001-08-30 | Eidgenossische Technische Hochschule Zurich | Anticorps specifique au domaine ed-b de la fibronectine, conjugues contenant cet anticorps, et utilisation pour la detection et le traitement de l'angiogenese |
| IL162201A0 (en) | 2002-01-03 | 2005-11-20 | Schering Ag | New methods for diagnosis and treatment of tumours |
| JP4169195B2 (ja) * | 2003-06-24 | 2008-10-22 | 株式会社河合楽器製作所 | 電子楽音発生装置の記録制御装置 |
-
1996
- 1996-05-24 GB GB9610967A patent/GB9610967D0/en active Pending
-
1997
- 1997-05-23 KR KR10-2005-7000518A patent/KR20050010081A/ko not_active Application Discontinuation
- 1997-05-23 WO PCT/GB1997/001412 patent/WO1997045544A1/fr active IP Right Grant
- 1997-05-23 BR BRPI9709350-5A patent/BR9709350B1/pt not_active IP Right Cessation
- 1997-05-23 KR KR1020067006008A patent/KR100741452B1/ko not_active IP Right Cessation
- 1997-05-23 CZ CZ19983815A patent/CZ295531B6/cs not_active IP Right Cessation
- 1997-05-23 CA CA 2256308 patent/CA2256308C/fr not_active Expired - Lifetime
- 1997-05-23 PT PT97923243T patent/PT906426E/pt unknown
- 1997-05-23 TR TR1998/02416T patent/TR199802416T2/xx unknown
- 1997-05-23 IL IL12721697A patent/IL127216A0/xx active IP Right Grant
- 1997-05-23 CN CNB971949026A patent/CN100447159C/zh not_active Expired - Lifetime
- 1997-05-23 US US09/194,356 patent/US7273924B1/en not_active Expired - Fee Related
- 1997-05-23 SK SK1612-98A patent/SK285916B6/sk not_active IP Right Cessation
- 1997-05-23 NZ NZ33308397A patent/NZ333083A/xx not_active IP Right Cessation
- 1997-05-23 EA EA199801043A patent/EA004329B1/ru not_active IP Right Cessation
- 1997-05-23 DE DE1997637683 patent/DE69737683T2/de not_active Expired - Lifetime
- 1997-05-23 AU AU29101/97A patent/AU729081B2/en not_active Expired
- 1997-05-23 SI SI9730765T patent/SI0906426T1/sl unknown
- 1997-05-23 PL PL97330075A patent/PL188557B1/pl not_active IP Right Cessation
- 1997-05-23 DK DK97923243T patent/DK0906426T3/da active
- 1997-05-23 AT AT97923243T patent/ATE361364T1/de active
- 1997-05-23 UA UA98126836A patent/UA74129C2/uk unknown
- 1997-05-23 EP EP19970923243 patent/EP0906426B1/fr not_active Expired - Lifetime
- 1997-05-23 HU HU0200546A patent/HUP0200546A2/hu unknown
- 1997-05-23 JP JP54182897A patent/JP4750912B2/ja not_active Expired - Lifetime
- 1997-05-23 ES ES97923243T patent/ES2286831T3/es not_active Expired - Lifetime
-
1998
- 1998-10-29 IS IS4883A patent/IS2508B/is unknown
- 1998-11-23 NO NO19985459A patent/NO324904B1/no not_active IP Right Cessation
- 1998-11-23 IL IL127216A patent/IL127216A/en not_active IP Right Cessation
- 1998-11-24 BG BG102950A patent/BG65138B1/bg unknown
-
1999
- 1999-12-14 HK HK99105868A patent/HK1020990A1/xx not_active IP Right Cessation
-
2007
- 2007-08-21 US US11/842,774 patent/US8703143B2/en not_active Expired - Fee Related
-
2008
- 2008-08-07 JP JP2008204682A patent/JP2009050261A/ja active Pending
-
2013
- 2013-10-04 US US14/046,224 patent/US9096670B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0906426T3 (da) | Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser | |
| DK0488470T3 (da) | Fremgangsmåde til fremstilling af antistoffer | |
| DK0724456T3 (da) | CD40-Antistoffer | |
| ATE366816T1 (de) | Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine | |
| ES2177632T3 (es) | Purificacion de anticuerpos. | |
| DE69429095D1 (de) | Humanisierte antikoerper | |
| DK1255826T3 (da) | Automatisering af proteindesign for proteinbiblioteker | |
| DE69934597D1 (de) | Formstabile bindemittelsysteme | |
| ATE324381T1 (de) | Mutiertes scfv-fragment des okt-3 antikörpers | |
| PT973550E (pt) | Anticorpos antagonistas anti-integrina avb3 | |
| ES2173130T3 (es) | Metodo de fijacion de material al peptido beta-amiloide. | |
| DE69942668D1 (de) | Humanisierter monoklonaler antikörper gegen von-willebrand faktor | |
| DE50114321D1 (de) | REZEPTOR DER EDb-FIBRONEKTIN-DOMÄNE (II) | |
| DK0975601T3 (da) | Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor | |
| DE69434087D1 (de) | ENTEROTOXINE VON SHIGELLA FLEXNERI 2a | |
| DK1208213T3 (da) | Fremgangsmåde til fremstilling af proteiner i værtsceller under anvendelse af chaperoniner | |
| DK1161522T3 (da) | Fremgangsmåde til isolering af CD8+-celler og beslægtede hybridomaceller, antistoffer og polypeptider |