DK0860430T3 - Omega-cycloalkyl-prostaglandin E2-derivater - Google Patents
Omega-cycloalkyl-prostaglandin E2-derivaterInfo
- Publication number
- DK0860430T3 DK0860430T3 DK98300769T DK98300769T DK0860430T3 DK 0860430 T3 DK0860430 T3 DK 0860430T3 DK 98300769 T DK98300769 T DK 98300769T DK 98300769 T DK98300769 T DK 98300769T DK 0860430 T3 DK0860430 T3 DK 0860430T3
- Authority
- DK
- Denmark
- Prior art keywords
- cycloalkyl
- alkoxy
- alkyl
- halogen atom
- prostaglandin
- Prior art date
Links
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010067125 Liver injury Diseases 0.000 abstract 1
- 208000005107 Premature Birth Diseases 0.000 abstract 1
- 206010036590 Premature baby Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 206010000210 abortion Diseases 0.000 abstract 1
- 231100000176 abortion Toxicity 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 231100000234 hepatic damage Toxicity 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000008818 liver damage Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 230000016273 neuron death Effects 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 210000001525 retina Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3549997 | 1997-02-04 | ||
| JP31916997 | 1997-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0860430T3 true DK0860430T3 (da) | 2002-09-09 |
Family
ID=26374500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98300769T DK0860430T3 (da) | 1997-02-04 | 1998-02-03 | Omega-cycloalkyl-prostaglandin E2-derivater |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6110969A (pt) |
| EP (1) | EP0860430B1 (pt) |
| KR (1) | KR100573535B1 (pt) |
| AT (1) | ATE219054T1 (pt) |
| AU (1) | AU736271B2 (pt) |
| CA (1) | CA2228828A1 (pt) |
| DE (1) | DE69805874T2 (pt) |
| DK (1) | DK0860430T3 (pt) |
| ES (1) | ES2178808T3 (pt) |
| HU (1) | HUP9800208A3 (pt) |
| NO (1) | NO317155B1 (pt) |
| PT (1) | PT860430E (pt) |
| TW (1) | TW581756B (pt) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0951282T3 (da) | 1996-12-20 | 2008-07-14 | Pfizer | Forebyggelse og behandling af skeletlidelse med EP2-receptorsubtype-selektive prostaglandin E2-agonister |
| US6235780B1 (en) * | 1998-07-21 | 2001-05-22 | Ono Pharmaceutical Co., Ltd. | ω-cycloalkyl-prostaglandin E1 derivatives |
| ES2232434T3 (es) | 1999-03-05 | 2005-06-01 | Duke University | Analogos de prostaglandinas c-16 fp selectivas insaturadas. |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| WO2002009717A1 (fr) * | 2000-07-31 | 2002-02-07 | Ono Pharmaceutical Co., Ltd. | Remedes contre la dyserection contenant des derives de prostaglandine comme principe actif |
| US6410591B1 (en) * | 2001-05-08 | 2002-06-25 | Allergan Sales, Inc. | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US20030027853A1 (en) | 2001-06-14 | 2003-02-06 | Allergan Sales, Inc. | 3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| US7872045B2 (en) | 2001-06-14 | 2011-01-18 | Allergan, Inc. | Combination therapy for glaucoma treatment |
| JP2006021998A (ja) * | 2002-07-18 | 2006-01-26 | Ono Pharmaceut Co Ltd | Ｅｐ２アゴニストを有効成分とする月経困難症治療剤 |
| US7737182B2 (en) | 2002-08-09 | 2010-06-15 | Taisho Pharmaceutical Co., Ltd. | Pharmaceuticals for xerosis |
| AU2003254850B2 (en) * | 2002-08-09 | 2008-05-15 | Fumie Sato | Antipruritic agent |
| JP4497320B2 (ja) | 2002-10-10 | 2010-07-07 | 小野薬品工業株式会社 | 内因性修復因子産生促進剤 |
| AU2003301900A1 (en) * | 2002-11-13 | 2004-06-03 | Fumie Sato | Antipruritic drug |
| WO2004073591A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep2 (prostaglandin e2 ep2) |
| WO2004089411A1 (ja) * | 2003-04-03 | 2004-10-21 | Ono Pharmaceutical Co., Ltd. | 脊柱管狭窄症治療剤 |
| JP4666257B2 (ja) | 2003-07-25 | 2011-04-06 | 小野薬品工業株式会社 | 軟骨関連疾患治療剤 |
| WO2006043655A1 (ja) | 2004-10-22 | 2006-04-27 | Ono Pharmaceutical Co., Ltd. | 吸入用医薬組成物 |
| MY145694A (en) * | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| MY144968A (en) * | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| WO2006129788A1 (ja) | 2005-06-03 | 2006-12-07 | Ono Pharmaceutical Co., Ltd. | 神経再生および／または保護剤 |
| US7563924B2 (en) * | 2005-11-21 | 2009-07-21 | Schering Aktiengesellschaft | 9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments |
| WO2007079078A1 (en) | 2005-12-29 | 2007-07-12 | Bayer Schering Pharma Aktiengesellschaft | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| WO2008046049A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| WO2008058766A1 (en) | 2006-11-16 | 2008-05-22 | Bayer Schering Pharma Aktiengesellschaft | Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection |
| US7960378B2 (en) * | 2008-03-18 | 2011-06-14 | Allergan, Inc. | Therapeutic compounds |
| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| EP2149551A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors |
| EP2350091B1 (en) * | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| SG10201703086VA (en) | 2008-10-17 | 2017-05-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their use as therapeutic agents |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| AR077252A1 (es) * | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| RU2544852C2 (ru) * | 2009-10-14 | 2015-03-20 | Ксенон Фармасьютикалз Инк. | Способы синтеза спиро-оксиндольных соединений |
| WO2011047173A2 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| US9504671B2 (en) | 2010-02-26 | 2016-11-29 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| WO2013021935A1 (ja) | 2011-08-05 | 2013-02-14 | 小野薬品工業株式会社 | 軟骨障害治療用化合物 |
| KR20140059236A (ko) | 2011-08-19 | 2014-05-15 | 머크 샤프 앤드 돔 코포레이션 | Hcv 프로테아제 억제제의 결정 형태 |
| RU2474426C1 (ru) * | 2011-12-26 | 2013-02-10 | Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН | Простамиды и их аналоги, обладающие нейрозащитным действием |
| MX2014012266A (es) | 2012-04-12 | 2014-12-05 | Xenon Pharmaceuticals Inc | Sintesis asimetricas para compuestos espiro-oxindol utiles como agentes terapeuticos. |
| ES2733998T3 (es) | 2012-10-29 | 2019-12-03 | Cardio Incorporated | Agente terapéutico específico de enfermedad pulmonar |
| BR112015022226A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
| EP2818484A1 (en) | 2013-06-28 | 2014-12-31 | Universitat Autònoma de Barcelona | Synergistic combination of an anti-IgE antibody and an EP2 receptor agonist |
| WO2015056504A1 (ja) | 2013-10-15 | 2015-04-23 | 小野薬品工業株式会社 | 薬剤溶出性ステントグラフト |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| US10100060B2 (en) | 2016-06-16 | 2018-10-16 | Xenon Pharmaceuticals Inc. | Asymmetric synthesis of funapide |
| WO2018107158A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase |
| CA3045950A1 (en) | 2016-12-09 | 2018-06-14 | Celtaxsys, Inc. | Inhibitors of leukotriene a4 hydrolase |
| AU2017371362A1 (en) | 2016-12-09 | 2019-07-25 | Celltaxis, Llc | Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061670A (en) * | 1976-07-19 | 1977-12-06 | American Cyanamid Company | 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners |
| US4132738A (en) * | 1978-02-23 | 1979-01-02 | Miles Laboratories, Inc. | Preparation of 15-deoxy-16-hydroxyprostaglandins |
| US4336404A (en) * | 1979-05-14 | 1982-06-22 | Miles Laboratories, Inc. | 1-Acyloxy-15-deoxy-16-hydroxy-analogs of prostaglandin E1 |
| US4363817A (en) * | 1981-08-27 | 1982-12-14 | Miles Laboratories, Inc. | Enol acylate analogs of E1 and E2 prostaglandins |
| US5698598A (en) * | 1995-08-04 | 1997-12-16 | Allergan | EP2 -receptor agonists as agents for lowering intraocular pressure |
-
1998
- 1998-02-02 NO NO19980442A patent/NO317155B1/no unknown
- 1998-02-03 KR KR1019980002882A patent/KR100573535B1/ko not_active IP Right Cessation
- 1998-02-03 EP EP98300769A patent/EP0860430B1/en not_active Expired - Lifetime
- 1998-02-03 HU HU9800208A patent/HUP9800208A3/hu unknown
- 1998-02-03 ES ES98300769T patent/ES2178808T3/es not_active Expired - Lifetime
- 1998-02-03 AT AT98300769T patent/ATE219054T1/de not_active IP Right Cessation
- 1998-02-03 DK DK98300769T patent/DK0860430T3/da active
- 1998-02-03 PT PT98300769T patent/PT860430E/pt unknown
- 1998-02-03 DE DE69805874T patent/DE69805874T2/de not_active Expired - Lifetime
- 1998-02-03 TW TW087101279A patent/TW581756B/zh not_active IP Right Cessation
- 1998-02-04 US US09/018,565 patent/US6110969A/en not_active Expired - Lifetime
- 1998-02-04 AU AU52892/98A patent/AU736271B2/en not_active Ceased
- 1998-02-04 CA CA002228828A patent/CA2228828A1/en not_active Abandoned
-
2000
- 2000-05-12 US US09/570,728 patent/US6576785B1/en not_active Expired - Fee Related
-
2002
- 2002-09-11 US US10/238,623 patent/US20030186939A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0860430B1 (en) | 2002-06-12 |
| NO980442D0 (no) | 1998-02-02 |
| US6576785B1 (en) | 2003-06-10 |
| TW581756B (en) | 2004-04-01 |
| CA2228828A1 (en) | 1998-08-04 |
| DE69805874T2 (de) | 2002-12-19 |
| AU5289298A (en) | 1998-08-06 |
| NO317155B1 (no) | 2004-08-30 |
| HUP9800208A3 (en) | 2000-04-28 |
| KR100573535B1 (ko) | 2006-12-15 |
| EP0860430A2 (en) | 1998-08-26 |
| ES2178808T3 (es) | 2003-01-01 |
| ATE219054T1 (de) | 2002-06-15 |
| HU9800208D0 (en) | 1998-03-30 |
| AU736271B2 (en) | 2001-07-26 |
| US6110969A (en) | 2000-08-29 |
| EP0860430A3 (en) | 1999-06-23 |
| PT860430E (pt) | 2002-11-29 |
| KR19980071021A (ko) | 1998-10-26 |
| HUP9800208A2 (hu) | 1998-09-28 |
| NO980442L (no) | 1998-08-05 |
| DE69805874D1 (de) | 2002-07-18 |
| US20030186939A1 (en) | 2003-10-02 |
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