DE69901658D1 - Omega-Zykloalkyl-Prostaglandin E1 Derivate - Google Patents

Omega-Zykloalkyl-Prostaglandin E1 Derivate

Info

Publication number
DE69901658D1
DE69901658D1 DE69901658T DE69901658T DE69901658D1 DE 69901658 D1 DE69901658 D1 DE 69901658D1 DE 69901658 T DE69901658 T DE 69901658T DE 69901658 T DE69901658 T DE 69901658T DE 69901658 D1 DE69901658 D1 DE 69901658D1
Authority
DE
Germany
Prior art keywords
omega
derivatives
prostaglandin
cycloalkyl
hepatopathy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69901658T
Other languages
English (en)
Other versions
DE69901658T2 (de
Inventor
Shuichi Ohuchida
Kousuke Tani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of DE69901658D1 publication Critical patent/DE69901658D1/de
Application granted granted Critical
Publication of DE69901658T2 publication Critical patent/DE69901658T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69901658T 1998-07-21 1999-07-20 Omega-Zykloalkyl-Prostaglandin E1 Derivate Expired - Fee Related DE69901658T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22105498 1998-07-21

Publications (2)

Publication Number Publication Date
DE69901658D1 true DE69901658D1 (de) 2002-07-11
DE69901658T2 DE69901658T2 (de) 2002-11-21

Family

ID=16760781

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69901658T Expired - Fee Related DE69901658T2 (de) 1998-07-21 1999-07-20 Omega-Zykloalkyl-Prostaglandin E1 Derivate

Country Status (8)

Country Link
US (1) US6235780B1 (de)
EP (1) EP0974580B1 (de)
KR (1) KR100349964B1 (de)
AT (1) ATE218544T1 (de)
DE (1) DE69901658T2 (de)
DK (1) DK0974580T3 (de)
ES (1) ES2178352T3 (de)
PT (1) PT974580E (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006021998A (ja) * 2002-07-18 2006-01-26 Ono Pharmaceut Co Ltd Ｅｐ２アゴニストを有効成分とする月経困難症治療剤
ES2584606T3 (es) 2002-10-10 2016-09-28 Ono Pharmaceutical Co., Ltd. Microesferas que comprenden ONO-1301
CA2513652A1 (en) * 2003-03-03 2004-09-16 Applied Research Systems Ars Holding N.V. G-lactam derivatives as prostaglandin agonists
JP2006528154A (ja) * 2003-07-18 2006-12-14 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ プロスタグランジン受容体のモジュレータとしてのヒドラジド誘導体
EP1661580B1 (de) * 2003-07-25 2014-01-08 Ono Pharmaceutical Co., Ltd. Mittel zur behandlung von knorpelbedingten erkrankungen
JP4893999B2 (ja) 2004-10-22 2012-03-07 小野薬品工業株式会社 吸入用医薬組成物
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
TWI404529B (zh) 2005-06-03 2013-08-11 Ono Pharmaceutical Co 神經再生及／或保護劑
EP3205644A1 (de) 2005-12-29 2017-08-16 Celtaxsys Inc. Diaminderivate als inhibitoren der leukotrien-a4 hydrolase
EP2073806B1 (de) 2006-10-12 2012-02-15 Xenon Pharmaceuticals Inc. Verwendung von spiro-oxindol-verbindungen als therapeutika
US20110294842A9 (en) * 2006-10-12 2011-12-01 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
JP5271272B2 (ja) 2006-11-16 2013-08-21 ジェンムス ファーマ インコーポレイティド Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬
CN106928247A (zh) 2008-10-17 2017-07-07 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
EP2350091B1 (de) * 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Spiro-oxindol verbindungen und ihre verwendung als therapeutische wirkstoffe
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20170202A1 (es) * 2009-10-14 2017-03-24 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
MA34083B1 (fr) 2010-02-26 2013-03-05 Xenon Pharmaceuticals Inc Compositions pharmaceutques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques
US9487535B2 (en) 2012-04-12 2016-11-08 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
US20150272874A1 (en) 2012-10-29 2015-10-01 Cardio Incorporated Pulmonary disease-specific therapeutic agent
MX2015011677A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
WO2015056504A1 (ja) 2013-10-15 2015-04-23 小野薬品工業株式会社 薬剤溶出性ステントグラフト
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
WO2017218920A1 (en) 2016-06-16 2017-12-21 Teva Pharmaceuticals International Gmbh Asymmetric synthesis of funapide
WO2018107158A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
CA3045887A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
RU2019119652A (ru) 2016-12-09 2021-01-11 Селтакссис, Инк. Ингибиторы лейкотриен-а4-гидролазы
US12042503B2 (en) 2020-02-12 2024-07-23 Cytoagents, Inc. Compositions and methods for treating coronavirus infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132738A (en) 1978-02-23 1979-01-02 Miles Laboratories, Inc. Preparation of 15-deoxy-16-hydroxyprostaglandins
US5204371A (en) 1979-12-10 1993-04-20 Schering Aktiengesellschaft Pharmaceutically active 9-chloroprostaglandins
DE2950027A1 (de) 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3126924A1 (de) 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
JPS5883670A (ja) * 1981-11-13 1983-05-19 Teijin Ltd プロスタグランデインｅ↓１類の製造法
JP3502952B2 (ja) * 1992-10-20 2004-03-02 大正製薬株式会社 プロスタグランジン誘導体
AU669226B2 (en) * 1992-10-20 1996-05-30 Fumie Sato Prostaglandine derivative
DE4330177A1 (de) * 1993-08-31 1995-03-02 Schering Ag Neue 9-Chlor-prostaglandin-derivate
JP3579448B2 (ja) * 1993-12-29 2004-10-20 大正製薬株式会社 プロスタグランジン誘導体、その塩およびその使用
JP3506485B2 (ja) * 1994-04-19 2004-03-15 大正製薬株式会社 プロスタグランジン誘導体
JP3162668B2 (ja) * 1997-02-04 2001-05-08 小野薬品工業株式会社 ω−シクロアルキル−プロスタグランジンＥ２誘導体
NO317155B1 (no) * 1997-02-04 2004-08-30 Ono Pharmaceutical Co <omega>-cykloalkyl-prostagladin-E<N>2</N>-derivater
DE69821987T2 (de) * 1997-12-25 2004-12-16 Ono Pharmaceutical Co. Ltd. Omega-cycloalkyl-prostaglandin e2 derivate

Also Published As

Publication number Publication date
US6235780B1 (en) 2001-05-22
KR20000011866A (ko) 2000-02-25
DE69901658T2 (de) 2002-11-21
KR100349964B1 (ko) 2002-08-22
ES2178352T3 (es) 2002-12-16
EP0974580A1 (de) 2000-01-26
EP0974580B1 (de) 2002-06-05
PT974580E (pt) 2002-10-31
DK0974580T3 (da) 2002-09-30
ATE218544T1 (de) 2002-06-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee