DK0819135T3 - Kulhydratmodificerede cytostatika - Google Patents

Kulhydratmodificerede cytostatika

Info

Publication number
DK0819135T3
DK0819135T3 DK96910926T DK96910926T DK0819135T3 DK 0819135 T3 DK0819135 T3 DK 0819135T3 DK 96910926 T DK96910926 T DK 96910926T DK 96910926 T DK96910926 T DK 96910926T DK 0819135 T3 DK0819135 T3 DK 0819135T3
Authority
DK
Denmark
Prior art keywords
cytostatics
carbohydrate modified
modified cytostatics
carbohydrate
tumor
Prior art date
Application number
DK96910926T
Other languages
Danish (da)
English (en)
Inventor
Uwe Petersen
Norbert Piel
Hans-Georg Lerchen
Dem Bruch Karsten Von
Joerg Baumgarten
Horst-Peter Antonicek
Walter Weichel
Michael Sperzel
Klaus Dieter Bremm
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0819135T3 publication Critical patent/DK0819135T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Steroid Compounds (AREA)
DK96910926T 1995-04-04 1996-03-22 Kulhydratmodificerede cytostatika DK0819135T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19512484A DE19512484A1 (de) 1995-04-04 1995-04-04 Kohlenhydratmodifizierte Cytostatika
PCT/EP1996/001279 WO1996031532A1 (de) 1995-04-04 1996-03-22 Kohlenhydratmodifizierte cytostatika

Publications (1)

Publication Number Publication Date
DK0819135T3 true DK0819135T3 (da) 2000-05-08

Family

ID=7758679

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96910926T DK0819135T3 (da) 1995-04-04 1996-03-22 Kulhydratmodificerede cytostatika

Country Status (27)

Country Link
US (1) US6271342B1 (es)
EP (1) EP0819135B1 (es)
JP (1) JPH11502860A (es)
KR (1) KR19980703591A (es)
CN (1) CN1185786A (es)
AT (1) ATE186738T1 (es)
AU (1) AU713466B2 (es)
BG (1) BG63048B1 (es)
BR (1) BR9604825A (es)
CA (1) CA2217164A1 (es)
CZ (1) CZ291098B6 (es)
DE (2) DE19512484A1 (es)
DK (1) DK0819135T3 (es)
EE (1) EE03619B1 (es)
ES (1) ES2140078T3 (es)
GR (1) GR3032605T3 (es)
HU (1) HUP9800513A3 (es)
IS (1) IS1822B (es)
MX (1) MX9707613A (es)
NO (1) NO974564L (es)
NZ (1) NZ305855A (es)
PL (1) PL183574B1 (es)
RU (1) RU2170234C2 (es)
SK (1) SK281785B6 (es)
TW (1) TW384290B (es)
UA (1) UA61054C2 (es)
WO (1) WO1996031532A1 (es)

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EP0934329B1 (de) * 1996-09-30 2001-12-12 Bayer Ag Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung)
DE19640970A1 (de) * 1996-10-04 1998-04-16 Bayer Ag Modifizierte Cytostatika
ID23424A (id) * 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
AU735186B2 (en) 1997-09-15 2001-07-05 Warner Chilcott Company, Llc Antimicrobial quinolones, their compositions and uses
US6613879B1 (en) * 1999-05-14 2003-09-02 Boehringer Ingelheim Pharma Kg FAP-activated anti-tumour compounds
DE10005275A1 (de) * 2000-02-07 2001-08-09 Bayer Ag Neuartige Glycokonjugate
US7220824B1 (en) * 2000-08-28 2007-05-22 Bayer Aktiengesellschaft Integrin-mediated drug targeting
EP1219634A1 (en) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
EP1238678A1 (en) 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
AU2002350650A1 (en) * 2001-11-09 2003-05-19 Bayer Aktiengesellschaft Isotopically coded affinity marker 2
US7199149B2 (en) * 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors
PT1718677E (pt) 2003-12-19 2012-07-18 Genentech Inc Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos
KR101084521B1 (ko) 2006-03-28 2011-11-18 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
BRPI0709209A2 (pt) 2006-03-28 2011-06-28 Procter & Gamble processo de redução de hidreto para preparo de intermediários de quinolona
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
WO2016109880A1 (en) 2015-01-06 2016-07-14 Immunovaccine Technologies Inc. Lipid a mimics, methods of preparation, and uses thereof
CN107847606A (zh) 2015-11-25 2018-03-27 乐高化学生物科学股份有限公司 包含自降解基团的缀合物及其相关方法
KR20180078329A (ko) 2015-11-25 2018-07-09 주식회사 레고켐 바이오사이언스 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법
BR112019020136A2 (pt) 2017-03-29 2020-04-22 Legochem Biosciences Inc profármaco de dímero de pirrolobenzodiazepina e composto de conjugado ligando-ligante do mesmo
BR112020022299A2 (pt) 2018-05-09 2021-02-23 Legochem Biosciences, Inc. composições e métodos relacionados a conjugados de anticorpo-fármaco anti-cd19
KR20210028544A (ko) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도

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JPS5977356A (ja) * 1982-06-30 1984-05-02 Fuji Photo Film Co Ltd 螢光アツセイ用多層分析要素およびそれを用いる螢光アツセイ法
DE3611194A1 (de) 1986-04-04 1987-10-08 Bayer Ag Cancerostatisches mittel
ATE106898T1 (de) * 1987-03-26 1994-06-15 Neorx Corp Metall-radionuklid-markierte proteine und glykoproteine zur diagnose und therapie.
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DE3837825A1 (de) 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5965695A (en) 1990-05-15 1999-10-12 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
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US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
DE4106101A1 (de) * 1991-02-27 1992-09-03 Bayer Ag Fucose-markierte cytostatika
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
FR2676058B1 (fr) 1991-04-30 1994-02-25 Hoechst Lab Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
DE4120646A1 (de) 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
EP0545198B1 (de) 1991-11-29 1999-09-15 Hoechst Aktiengesellschaft Peptide mit insulinartiger Wirkung
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
ZA935697B (en) 1992-08-07 1994-03-10 Sankyo Co Peptides capable of inhibiting the activity of hiv protease their preparation and their therapeutic use
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IL106998A0 (en) 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
DE4236237A1 (de) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
US5576298A (en) 1992-11-30 1996-11-19 Research And Development Institute, Inc. At Montana State University Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity
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Also Published As

Publication number Publication date
NO974564D0 (no) 1997-10-02
KR19980703591A (ko) 1998-11-05
JPH11502860A (ja) 1999-03-09
AU5397696A (en) 1996-10-23
WO1996031532A1 (de) 1996-10-10
TW384290B (en) 2000-03-11
EP0819135A1 (de) 1998-01-21
SK281785B6 (sk) 2001-07-10
CA2217164A1 (en) 1996-10-10
PL183574B1 (pl) 2002-06-28
GR3032605T3 (en) 2000-05-31
NO974564L (no) 1997-11-25
EP0819135B1 (de) 1999-11-17
EE9700258A (et) 1998-04-15
BG63048B1 (bg) 2001-02-28
ES2140078T3 (es) 2000-02-16
CZ314397A3 (cs) 1998-01-14
CZ291098B6 (cs) 2002-12-11
BG101892A (en) 1998-05-29
IS4562A (is) 1997-09-18
IS1822B (is) 2002-10-01
SK134597A3 (en) 1998-05-06
AU713466B2 (en) 1999-12-02
ATE186738T1 (de) 1999-12-15
HUP9800513A3 (en) 1998-09-28
US6271342B1 (en) 2001-08-07
DE19512484A1 (de) 1996-10-17
EE03619B1 (et) 2002-02-15
RU2170234C2 (ru) 2001-07-10
UA61054C2 (en) 2003-11-17
HUP9800513A2 (hu) 1998-06-29
CN1185786A (zh) 1998-06-24
NZ305855A (en) 1999-11-29
DE59603678D1 (de) 1999-12-23
PL322681A1 (en) 1998-02-16
MX9707613A (es) 1997-12-31
BR9604825A (pt) 1999-01-05

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