ES2140078T3 - Citostaticos modificados con hidratos de carbono. - Google Patents
Citostaticos modificados con hidratos de carbono.Info
- Publication number
- ES2140078T3 ES2140078T3 ES96910926T ES96910926T ES2140078T3 ES 2140078 T3 ES2140078 T3 ES 2140078T3 ES 96910926 T ES96910926 T ES 96910926T ES 96910926 T ES96910926 T ES 96910926T ES 2140078 T3 ES2140078 T3 ES 2140078T3
- Authority
- ES
- Spain
- Prior art keywords
- modified
- cytostatics
- carbon hydrates
- hydrates
- carbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000824 cytostatic agent Substances 0.000 title abstract 2
- -1 CARBON HYDRATES Chemical group 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000000405 serological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/02—Halogenated hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Steroid Compounds (AREA)
Abstract
LA INVENCION TRATA DE CITOESTATICOS ESPECIFICOS PARA TUMORES AL HABER SIDO MODIFICADOS CON AZUCAR. UNOS SPACERS APROPIADOS GARANTIZAN LA ESTABILIDAD SEROLOGICA ADEMAS DE UN EFECTO INTRACELULAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19512484A DE19512484A1 (de) | 1995-04-04 | 1995-04-04 | Kohlenhydratmodifizierte Cytostatika |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2140078T3 true ES2140078T3 (es) | 2000-02-16 |
Family
ID=7758679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96910926T Expired - Lifetime ES2140078T3 (es) | 1995-04-04 | 1996-03-22 | Citostaticos modificados con hidratos de carbono. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6271342B1 (es) |
EP (1) | EP0819135B1 (es) |
JP (1) | JPH11502860A (es) |
KR (1) | KR19980703591A (es) |
CN (1) | CN1185786A (es) |
AT (1) | ATE186738T1 (es) |
AU (1) | AU713466B2 (es) |
BG (1) | BG63048B1 (es) |
BR (1) | BR9604825A (es) |
CA (1) | CA2217164A1 (es) |
CZ (1) | CZ291098B6 (es) |
DE (2) | DE19512484A1 (es) |
DK (1) | DK0819135T3 (es) |
EE (1) | EE03619B1 (es) |
ES (1) | ES2140078T3 (es) |
GR (1) | GR3032605T3 (es) |
HU (1) | HUP9800513A3 (es) |
IS (1) | IS1822B (es) |
MX (1) | MX9707613A (es) |
NO (1) | NO974564L (es) |
NZ (1) | NZ305855A (es) |
PL (1) | PL183574B1 (es) |
RU (1) | RU2170234C2 (es) |
SK (1) | SK281785B6 (es) |
TW (1) | TW384290B (es) |
UA (1) | UA61054C2 (es) |
WO (1) | WO1996031532A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0934329B1 (de) * | 1996-09-30 | 2001-12-12 | Bayer Ag | Glycokonjugate von modifizierten camptothecin-derivaten (20-o-verknüpfung) |
DE19640970A1 (de) * | 1996-10-04 | 1998-04-16 | Bayer Ag | Modifizierte Cytostatika |
ID23424A (id) * | 1997-05-14 | 2000-04-20 | Bayer Ag | Glikokonjugat dari 20(s)-kamptotesin |
US6387928B1 (en) | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
AU735186B2 (en) | 1997-09-15 | 2001-07-05 | Warner Chilcott Company, Llc | Antimicrobial quinolones, their compositions and uses |
US6613879B1 (en) * | 1999-05-14 | 2003-09-02 | Boehringer Ingelheim Pharma Kg | FAP-activated anti-tumour compounds |
DE10005275A1 (de) * | 2000-02-07 | 2001-08-09 | Bayer Ag | Neuartige Glycokonjugate |
US7220824B1 (en) * | 2000-08-28 | 2007-05-22 | Bayer Aktiengesellschaft | Integrin-mediated drug targeting |
EP1219634A1 (en) * | 2000-12-27 | 2002-07-03 | Bayer Aktiengesellschaft | Cytostatic-glycoconjugates having specifically cleavable peptidic linking units |
EP1238678A1 (en) | 2001-03-08 | 2002-09-11 | Bayer Aktiengesellschaft | Enzyme-activated cytostatic conjugates with integrin ligands |
AU2002350650A1 (en) * | 2001-11-09 | 2003-05-19 | Bayer Aktiengesellschaft | Isotopically coded affinity marker 2 |
US7199149B2 (en) * | 2003-10-01 | 2007-04-03 | Bristol Myers Squibb Company | Monocyclic and bicyclic lactams as factor Xa inhibitors |
PT1718677E (pt) | 2003-12-19 | 2012-07-18 | Genentech Inc | Fragmentos de anticorpo monovalentes úteis como agentes terapêuticos |
KR101084521B1 (ko) | 2006-03-28 | 2011-11-18 | 워너 칠콧 컴퍼니 엘엘씨 | 퀴놀론 중간체를 제조하기 위한 커플링 방법 |
BRPI0709209A2 (pt) | 2006-03-28 | 2011-06-28 | Procter & Gamble | processo de redução de hidreto para preparo de intermediários de quinolona |
MX2008012328A (es) | 2006-03-28 | 2008-10-09 | Procter & Gamble | Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico. |
WO2016109880A1 (en) | 2015-01-06 | 2016-07-14 | Immunovaccine Technologies Inc. | Lipid a mimics, methods of preparation, and uses thereof |
CN107847606A (zh) | 2015-11-25 | 2018-03-27 | 乐高化学生物科学股份有限公司 | 包含自降解基团的缀合物及其相关方法 |
KR20180078329A (ko) | 2015-11-25 | 2018-07-09 | 주식회사 레고켐 바이오사이언스 | 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법 |
BR112019020136A2 (pt) | 2017-03-29 | 2020-04-22 | Legochem Biosciences Inc | profármaco de dímero de pirrolobenzodiazepina e composto de conjugado ligando-ligante do mesmo |
BR112020022299A2 (pt) | 2018-05-09 | 2021-02-23 | Legochem Biosciences, Inc. | composições e métodos relacionados a conjugados de anticorpo-fármaco anti-cd19 |
KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5977356A (ja) * | 1982-06-30 | 1984-05-02 | Fuji Photo Film Co Ltd | 螢光アツセイ用多層分析要素およびそれを用いる螢光アツセイ法 |
DE3611194A1 (de) | 1986-04-04 | 1987-10-08 | Bayer Ag | Cancerostatisches mittel |
ATE106898T1 (de) * | 1987-03-26 | 1994-06-15 | Neorx Corp | Metall-radionuklid-markierte proteine und glykoproteine zur diagnose und therapie. |
US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US5965695A (en) | 1990-05-15 | 1999-10-12 | Chiron Corporation | Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such |
US5420297A (en) | 1990-10-24 | 1995-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Peptides having substance P antagonistic activity |
US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
DE4106101A1 (de) * | 1991-02-27 | 1992-09-03 | Bayer Ag | Fucose-markierte cytostatika |
US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
DE4120646A1 (de) | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
EP0545198B1 (de) | 1991-11-29 | 1999-09-15 | Hoechst Aktiengesellschaft | Peptide mit insulinartiger Wirkung |
SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
ZA935697B (en) | 1992-08-07 | 1994-03-10 | Sankyo Co | Peptides capable of inhibiting the activity of hiv protease their preparation and their therapeutic use |
US5872207A (en) | 1992-09-04 | 1999-02-16 | Sanofi Pharmaceuticals, Inc. | N-terminal-marked peptides immobilized on glass beads and method of preparation and method of use thereof |
IL106998A0 (en) | 1992-09-17 | 1993-12-28 | Univ Florida | Brain-enhanced delivery of neuroactive peptides by sequential metabolism |
DE4236237A1 (de) * | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
US5576298A (en) | 1992-11-30 | 1996-11-19 | Research And Development Institute, Inc. At Montana State University | Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity |
SE9300012D0 (sv) | 1993-01-05 | 1993-01-05 | Astra Ab | New peptides |
US5750648A (en) | 1993-08-20 | 1998-05-12 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
EP0647450A1 (en) | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
GB9320781D0 (en) | 1993-10-08 | 1993-12-01 | Erba Carlo Spa | Polymer-bound camptothecin derivatives |
CA2173990A1 (en) * | 1993-10-12 | 1995-04-20 | Narasinga Rao | A library of glyco-peptides useful for identification of cell adhesion inhibitors |
US5610145A (en) | 1994-04-15 | 1997-03-11 | Warner-Lambert Company | Tachykinin antagonists |
US5780589A (en) | 1994-11-30 | 1998-07-14 | The United States Of America As Represented By The Department Of Health And Human Services | Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof |
FR2729668A1 (fr) | 1995-01-23 | 1996-07-26 | Adir | Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5677286A (en) * | 1995-04-27 | 1997-10-14 | The University Of Michigan | Glycosylated analogs of camptothecin |
US6143931A (en) | 1997-04-16 | 2000-11-07 | Arqule, Inc. | Synthesis and use of α-ketoamide derivatives and arrays |
-
1995
- 1995-04-04 DE DE19512484A patent/DE19512484A1/de not_active Withdrawn
-
1996
- 1996-03-22 US US08/930,546 patent/US6271342B1/en not_active Expired - Fee Related
- 1996-03-22 MX MX9707613A patent/MX9707613A/es unknown
- 1996-03-22 PL PL96322681A patent/PL183574B1/pl unknown
- 1996-03-22 WO PCT/EP1996/001279 patent/WO1996031532A1/de active IP Right Grant
- 1996-03-22 SK SK1345-97A patent/SK281785B6/sk unknown
- 1996-03-22 AT AT96910926T patent/ATE186738T1/de not_active IP Right Cessation
- 1996-03-22 CZ CZ19973143A patent/CZ291098B6/cs not_active IP Right Cessation
- 1996-03-22 DK DK96910926T patent/DK0819135T3/da active
- 1996-03-22 KR KR1019970706996A patent/KR19980703591A/ko active IP Right Grant
- 1996-03-22 DE DE59603678T patent/DE59603678D1/de not_active Expired - Fee Related
- 1996-03-22 CN CN96194180A patent/CN1185786A/zh active Pending
- 1996-03-22 HU HU9800513A patent/HUP9800513A3/hu unknown
- 1996-03-22 UA UA97115364A patent/UA61054C2/uk unknown
- 1996-03-22 JP JP8529934A patent/JPH11502860A/ja not_active Ceased
- 1996-03-22 CA CA002217164A patent/CA2217164A1/en not_active Abandoned
- 1996-03-22 RU RU97118421/04A patent/RU2170234C2/ru not_active IP Right Cessation
- 1996-03-22 EP EP96910926A patent/EP0819135B1/de not_active Expired - Lifetime
- 1996-03-22 BR BR9604825A patent/BR9604825A/pt not_active IP Right Cessation
- 1996-03-22 ES ES96910926T patent/ES2140078T3/es not_active Expired - Lifetime
- 1996-03-22 EE EE9700258A patent/EE03619B1/xx not_active IP Right Cessation
- 1996-03-22 AU AU53976/96A patent/AU713466B2/en not_active Ceased
- 1996-03-22 NZ NZ305855A patent/NZ305855A/xx unknown
- 1996-10-01 TW TW085111956A patent/TW384290B/zh not_active IP Right Cessation
-
1997
- 1997-09-16 BG BG101892A patent/BG63048B1/bg unknown
- 1997-09-18 IS IS4562A patent/IS1822B/is unknown
- 1997-10-02 NO NO974564A patent/NO974564L/no not_active Application Discontinuation
-
2000
- 2000-02-09 GR GR20000400304T patent/GR3032605T3/el not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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