DK0819135T3 - Carbohydrate modified cytostatics - Google Patents

Carbohydrate modified cytostatics

Info

Publication number
DK0819135T3
DK0819135T3 DK96910926T DK96910926T DK0819135T3 DK 0819135 T3 DK0819135 T3 DK 0819135T3 DK 96910926 T DK96910926 T DK 96910926T DK 96910926 T DK96910926 T DK 96910926T DK 0819135 T3 DK0819135 T3 DK 0819135T3
Authority
DK
Denmark
Prior art keywords
cytostatics
carbohydrate modified
modified cytostatics
carbohydrate
tumor
Prior art date
Application number
DK96910926T
Other languages
Danish (da)
Inventor
Uwe Petersen
Norbert Piel
Hans-Georg Lerchen
Dem Bruch Karsten Von
Joerg Baumgarten
Horst-Peter Antonicek
Walter Weichel
Michael Sperzel
Klaus Dieter Bremm
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK0819135T3 publication Critical patent/DK0819135T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to cytostatics which, by modification with sugar, are tumor-specific. Suitable spacers ensure serum stability and at the same time an intracellular action.
DK96910926T 1995-04-04 1996-03-22 Carbohydrate modified cytostatics DK0819135T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19512484A DE19512484A1 (en) 1995-04-04 1995-04-04 Carbohydrate modified cytostatics
PCT/EP1996/001279 WO1996031532A1 (en) 1995-04-04 1996-03-22 Sugar-modified cytostatics

Publications (1)

Publication Number Publication Date
DK0819135T3 true DK0819135T3 (en) 2000-05-08

Family

ID=7758679

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96910926T DK0819135T3 (en) 1995-04-04 1996-03-22 Carbohydrate modified cytostatics

Country Status (27)

Country Link
US (1) US6271342B1 (en)
EP (1) EP0819135B1 (en)
JP (1) JPH11502860A (en)
KR (1) KR19980703591A (en)
CN (1) CN1185786A (en)
AT (1) ATE186738T1 (en)
AU (1) AU713466B2 (en)
BG (1) BG63048B1 (en)
BR (1) BR9604825A (en)
CA (1) CA2217164A1 (en)
CZ (1) CZ291098B6 (en)
DE (2) DE19512484A1 (en)
DK (1) DK0819135T3 (en)
EE (1) EE03619B1 (en)
ES (1) ES2140078T3 (en)
GR (1) GR3032605T3 (en)
HU (1) HUP9800513A3 (en)
IS (1) IS1822B (en)
MX (1) MX9707613A (en)
NO (1) NO974564L (en)
NZ (1) NZ305855A (en)
PL (1) PL183574B1 (en)
RU (1) RU2170234C2 (en)
SK (1) SK281785B6 (en)
TW (1) TW384290B (en)
UA (1) UA61054C2 (en)
WO (1) WO1996031532A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT934329E (en) * 1996-09-30 2002-05-31 Bayer Ag GLYCOCONYGATES OF MODIFIED CAMPTOTECIN DERIVATIVES (LIGACAO 20-O)
DE19640970A1 (en) * 1996-10-04 1998-04-16 Bayer Ag Modified cytostatics
ID23424A (en) * 1997-05-14 2000-04-20 Bayer Ag GLIKOKONJUGUS OF 20 (S) -CAMPTOTESIN
MY138335A (en) 1997-09-15 2009-05-29 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
US6613879B1 (en) * 1999-05-14 2003-09-02 Boehringer Ingelheim Pharma Kg FAP-activated anti-tumour compounds
DE10005275A1 (en) * 2000-02-07 2001-08-09 Bayer Ag Novel glycoconjugates
US7220824B1 (en) * 2000-08-28 2007-05-22 Bayer Aktiengesellschaft Integrin-mediated drug targeting
EP1219634A1 (en) * 2000-12-27 2002-07-03 Bayer Aktiengesellschaft Cytostatic-glycoconjugates having specifically cleavable peptidic linking units
EP1238678A1 (en) * 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
US20050037423A1 (en) * 2001-11-09 2005-02-17 Bayer Healthcare Ag Isotopycally coded affinity marker 2
US7199149B2 (en) * 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors
AU2004309347B2 (en) 2003-12-19 2010-03-04 Genentech, Inc. Monovalent antibody fragments useful as therapeutics
MY148393A (en) 2006-03-28 2013-04-15 Taigen Biotechnology Co Ltd Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
KR101030202B1 (en) 2006-03-28 2011-04-22 워너 칠콧 컴퍼니 엘엘씨 A hydride reduction process for preparing quinolone intermediates
WO2007110835A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
WO2016109880A1 (en) 2015-01-06 2016-07-14 Immunovaccine Technologies Inc. Lipid a mimics, methods of preparation, and uses thereof
DK3380124T3 (en) 2015-11-25 2024-06-24 Ligachem Biosciences Inc Conjugates comprising self-immolative groups and methods related thereto
CN107847605B (en) * 2015-11-25 2021-12-24 乐高化学生物科学股份有限公司 Antibody-drug conjugates comprising branched linkers and methods related thereto
BR112019020136A2 (en) 2017-03-29 2020-04-22 Legochem Biosciences Inc prodrug of pyrrolobenzodiazepine dimer and compound of ligand-ligand conjugate of the same
BR112020022299A2 (en) 2018-05-09 2021-02-23 Legochem Biosciences, Inc. compositions and methods related to anti-cd19 antibody-drug conjugates
KR20210028544A (en) 2019-09-04 2021-03-12 주식회사 레고켐 바이오사이언스 Antibody-drug conjugate comprising antibody binding to antibody against human ROR1 and its use

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5977356A (en) * 1982-06-30 1984-05-02 Fuji Photo Film Co Ltd Multilayer analysis element for fluorescent assay and fluorescent assay using the same
DE3611194A1 (en) 1986-04-04 1987-10-08 Bayer Ag CANCEROSTATIC AGENT
EP0284071B1 (en) * 1987-03-26 1994-06-08 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
DE3837825A1 (en) 1988-11-08 1990-05-10 Hoechst Ag NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
US6075121A (en) 1990-05-15 2000-06-13 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
US5420297A (en) 1990-10-24 1995-05-30 Fujisawa Pharmaceutical Co., Ltd. Peptides having substance P antagonistic activity
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
DE4106101A1 (en) * 1991-02-27 1992-09-03 Bayer Ag FUCOSE-MARKED CYTOSTATICS
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
FR2676058B1 (en) 1991-04-30 1994-02-25 Hoechst Lab GLYCOSYLATED PRODUCTS, THEIR PREPARATION PROCESS AND THEIR USE IN THE TREATMENT OF CANCERS.
DE4120646A1 (en) * 1991-06-22 1992-12-24 Bayer Ag 7-ISOINDOLINYL-CHINOLONE AND NAPHTHYRIDONE CARBONIC ACID DERIVATIVES
ES2137937T3 (en) 1991-11-29 2000-01-01 Hoechst Ag PEPTIDES WITH EFFECT OF THE TYPE OF INSULIN.
SE9103612D0 (en) 1991-12-04 1991-12-04 Astra Ab NEW PEPTIDE DERIVATIVES
AU662434B2 (en) 1992-08-07 1995-08-31 Sankyo Company Limited Peptides capable of inhibiting the activity of HIV protease, their preparation and their use
US5872207A (en) 1992-09-04 1999-02-16 Sanofi Pharmaceuticals, Inc. N-terminal-marked peptides immobilized on glass beads and method of preparation and method of use thereof
IL106998A0 (en) 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
DE4236237A1 (en) * 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, their preparation and use as medicines
US5576298A (en) 1992-11-30 1996-11-19 Research And Development Institute, Inc. At Montana State University Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity
SE9300012D0 (en) 1993-01-05 1993-01-05 Astra Ab NEW PEPTIDES
US5750648A (en) 1993-08-20 1998-05-12 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
GB9320781D0 (en) 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
CA2173990A1 (en) * 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
US5610145A (en) 1994-04-15 1997-03-11 Warner-Lambert Company Tachykinin antagonists
US5780589A (en) 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
FR2729668A1 (en) 1995-01-23 1996-07-26 Adir NOVEL MERCAPTOALCANOYLDIPEPTIDES DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5677286A (en) * 1995-04-27 1997-10-14 The University Of Michigan Glycosylated analogs of camptothecin
US6143931A (en) 1997-04-16 2000-11-07 Arqule, Inc. Synthesis and use of α-ketoamide derivatives and arrays

Also Published As

Publication number Publication date
KR19980703591A (en) 1998-11-05
CN1185786A (en) 1998-06-24
PL322681A1 (en) 1998-02-16
GR3032605T3 (en) 2000-05-31
NO974564L (en) 1997-11-25
HUP9800513A3 (en) 1998-09-28
AU713466B2 (en) 1999-12-02
PL183574B1 (en) 2002-06-28
US6271342B1 (en) 2001-08-07
DE59603678D1 (en) 1999-12-23
CZ291098B6 (en) 2002-12-11
EP0819135A1 (en) 1998-01-21
MX9707613A (en) 1997-12-31
IS1822B (en) 2002-10-01
HUP9800513A2 (en) 1998-06-29
AU5397696A (en) 1996-10-23
NZ305855A (en) 1999-11-29
ES2140078T3 (en) 2000-02-16
IS4562A (en) 1997-09-18
NO974564D0 (en) 1997-10-02
UA61054C2 (en) 2003-11-17
CA2217164A1 (en) 1996-10-10
ATE186738T1 (en) 1999-12-15
BG63048B1 (en) 2001-02-28
BR9604825A (en) 1999-01-05
DE19512484A1 (en) 1996-10-17
EE03619B1 (en) 2002-02-15
TW384290B (en) 2000-03-11
CZ314397A3 (en) 1998-01-14
SK134597A3 (en) 1998-05-06
EP0819135B1 (en) 1999-11-17
JPH11502860A (en) 1999-03-09
WO1996031532A1 (en) 1996-10-10
SK281785B6 (en) 2001-07-10
RU2170234C2 (en) 2001-07-10
EE9700258A (en) 1998-04-15
BG101892A (en) 1998-05-29

Similar Documents

Publication Publication Date Title
DK0819135T3 (en) Carbohydrate modified cytostatics
PL336580A1 (en) Fine-molecular compounds useful in treating inflammatory diseases
DK108288D0 (en) HYDROPHOBIC MODIFIED, NON-IONIC POLYGALACTOMANNAN ETHERS
ID23374A (en) HALOGENOPIRIMIDIN
FI890225A0 (en) DATAOEVERFOERINGSSYSTEM, SOM BAER FJAERRSTYRNINGAR.
IT1214906B (en) HINGE, IN PARTICULAR FOR FURNITURE.
FI83346B (en) CALENDAR, SAERSKILT EN SUPERKALANDER.
FI880159A (en) FOERFARANDE FOER VAERMEKRACKNING AV KOLVAETEN, VID VILKET PARTIKELFORMIGT FAST MATERIAL ANVAENDS SOM VAERMEOEVERFOERINGSMEDEL.
ATE285474T1 (en) HAEMOPHILUS ADHESION PROTEINS
DE69023430T2 (en) Enzyme electrode.
FI885070A (en) FOTOHAERDBAR ELEKTROSTATISK TRYCKSKIVA, SOM INNEHAOLLER ELEKTRONACCEPTOR ELLER -DONATOR.
FI891364A (en) FAST, VATTENFRI RANEY CATALYSATORD DISPERSION.
DE69840673D1 (en) MODIFIED POLYSACCHARIDES WITH CHANGED BIOLOGICAL DETECTION
YU31697A (en) Aprotinin variants having improved properties
FR2733500B1 (en) NOVEL ANTISENS DIRECTED AGAINST RAS, PREPARATION AND USES
IT9048066A0 (en) 2- 6, 7-SUSTITUTED AMINOTETRALINES ACTIVE AS IMMUNOMODULANTS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
FI881241A (en) LAETTKONSTRUKTIONSKAERNA, SAERSKILT SOM STOEDKAERNA I SKIDA.
FI884154A0 (en) ELMASKIN, SOM INNEFATTAR SLITSKILAR.
YU53596A (en) Carbonydrate-modified cytostatics
FR2705964B1 (en) Polyalkoxylated imidazo-oxazoles, their preparations and their uses.
FR2656141B1 (en) PUBLIC ADVERTISER.
FI881259A0 (en) ANORDNING FOER ATT BLANDA VISST AEMNE, T.EX. TVAOL, I VATTEN.
ES1032202Y (en) COMETA Glider.
TR26599A (en) MUSIC WEAR KILLER (HERBISID), SUBSTITUTED ARIL- HALOALKILPIRAZOLES.
FI870273A0 (en) ANORDNING FOER PRESENTATION AV FOEREMAOL, SPECIELLT MATTOR.