DK0813541T3 - Fremgangsmåde til fremstilling af et protein - Google Patents
Fremgangsmåde til fremstilling af et proteinInfo
- Publication number
- DK0813541T3 DK0813541T3 DK96906136T DK96906136T DK0813541T3 DK 0813541 T3 DK0813541 T3 DK 0813541T3 DK 96906136 T DK96906136 T DK 96906136T DK 96906136 T DK96906136 T DK 96906136T DK 0813541 T3 DK0813541 T3 DK 0813541T3
- Authority
- DK
- Denmark
- Prior art keywords
- apoe
- apoa
- matrix
- endotoxins
- aqueous solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500778A SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Process for producing a protein |
PCT/SE1996/000271 WO1996027608A1 (en) | 1995-03-03 | 1996-03-01 | Process for producing a protein |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0813541T3 true DK0813541T3 (da) | 2003-09-15 |
Family
ID=20397430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96906136T DK0813541T3 (da) | 1995-03-03 | 1996-03-01 | Fremgangsmåde til fremstilling af et protein |
Country Status (15)
Country | Link |
---|---|
US (3) | US5834596A (da) |
EP (1) | EP0813541B1 (da) |
JP (1) | JPH11501046A (da) |
AT (1) | ATE240348T1 (da) |
AU (1) | AU694623B2 (da) |
CA (1) | CA2212125A1 (da) |
DE (1) | DE69628148T2 (da) |
DK (1) | DK0813541T3 (da) |
ES (1) | ES2199284T3 (da) |
IL (1) | IL117320A (da) |
NZ (1) | NZ303325A (da) |
PT (1) | PT813541E (da) |
SE (1) | SE9500778D0 (da) |
WO (1) | WO1996027608A1 (da) |
ZA (1) | ZA961679B (da) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
SE9603068D0 (sv) | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
SE9603303D0 (sv) * | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
DE19859703B4 (de) * | 1998-12-23 | 2009-10-29 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Verfahren zur Aufreinigung von Nukleinsäuren sowie Anionenaustauscher zur Durchführung dieses Verfahrens |
MXPA01009893A (es) | 1999-04-01 | 2003-07-28 | Esperion Therapeutics Inc | Compuestos con eter, composiciones y usos de estos. |
US8568766B2 (en) * | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
JP4344136B2 (ja) | 2000-11-10 | 2009-10-14 | エフ・ホフマン−ラ・ロシュ・リミテッド | アポリポタンパク質類似体 |
PL372925A1 (en) * | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
JP2005511713A (ja) * | 2001-12-07 | 2005-04-28 | ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア | 加齢性黄斑変性についての処置 |
US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
IL165253A0 (en) * | 2002-05-17 | 2005-12-18 | Esperion Therapeutics Inc | Methods and compositions for the treatment of ischemic reperfusion |
EP1597223B1 (en) | 2003-01-23 | 2017-02-22 | Esperion Therapeutics Inc. | Hydroxyl compounds and compositions for cholesterol management and related uses |
TW200526778A (en) * | 2003-11-14 | 2005-08-16 | Sembiosys Genetics Inc | Methods for the production of apolipoproteins in transgenic plants |
US20050176623A1 (en) * | 2004-02-11 | 2005-08-11 | Neil Wagle | Non-invasive treatment of disease using amphipathic compounds |
US8926958B2 (en) * | 2004-04-06 | 2015-01-06 | Cedars-Sinai Medical Center | Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano |
KR100560102B1 (ko) * | 2004-06-25 | 2006-03-13 | 한국생명공학연구원 | 프로아포리포단백질 a-ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제 |
MX2007013430A (es) | 2005-04-29 | 2008-03-19 | Univ California | Peptidos y peptidos mimeticos para tratar patologias caracterizadas por una respuesta inflamatoria. |
US20080227686A1 (en) * | 2006-06-16 | 2008-09-18 | Lipid Sciences, Inc. | Novel Peptides that Promote Lipid Efflux |
EP2041174A2 (en) * | 2006-06-16 | 2009-04-01 | Lipid Sciences, Inc. | Novel peptides that promote lipid efflux |
US20080206142A1 (en) * | 2006-06-16 | 2008-08-28 | Lipid Sciences, Inc. | Novel Peptides That Promote Lipid Efflux |
AU2007272494B2 (en) | 2006-07-14 | 2011-07-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
AU2007284801A1 (en) | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
WO2008039843A2 (en) * | 2006-09-26 | 2008-04-03 | Lipid Sciences, Inc. | Novel peptides that promote lipid efflux |
US8013122B2 (en) * | 2006-12-20 | 2011-09-06 | Kieu Hoang | Method of purifying apolipoprotein A-1 |
CN100586958C (zh) * | 2006-12-20 | 2010-02-03 | 上海莱士血液制品股份有限公司 | 高纯度载脂蛋白a-i的制备方法 |
JP2010538005A (ja) | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法 |
US8557767B2 (en) | 2007-08-28 | 2013-10-15 | Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
KR102042721B1 (ko) | 2008-11-10 | 2019-11-11 | 알닐람 파마슈티칼스 인코포레이티드 | 치료제 운반용 신규 지질 및 조성물 |
EP2391343B1 (en) | 2009-01-29 | 2017-03-01 | Arbutus Biopharma Corporation | Improved lipid formulation for the delivery of nucleic acids |
CA2754043A1 (en) | 2009-03-12 | 2010-09-16 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes |
CA3042927C (en) | 2009-05-05 | 2022-05-17 | Arbutus Biopharma Corporation | Lipid compositions for the delivery of therapeutic agents |
KR20230098713A (ko) | 2009-06-10 | 2023-07-04 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
EP2810643A3 (en) | 2009-08-14 | 2015-03-11 | Alnylam Pharmaceuticals Inc. | Lipid formulated compositions and mehods for inhibiting expression of a gene from the ebola virus |
EP3296398A1 (en) | 2009-12-07 | 2018-03-21 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
WO2011075656A1 (en) | 2009-12-18 | 2011-06-23 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
US20130137628A1 (en) | 2010-05-11 | 2013-05-30 | Esperion Therapeutics, Inc. | Dimeric Oxidation-Resistant Apolipoprotein A1 Variants |
EP2575764B1 (en) | 2010-06-03 | 2017-04-19 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
US20130323269A1 (en) | 2010-07-30 | 2013-12-05 | Muthiah Manoharan | Methods and compositions for delivery of active agents |
US20130202652A1 (en) | 2010-07-30 | 2013-08-08 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
WO2012064824A1 (en) | 2010-11-09 | 2012-05-18 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes |
DK3202760T3 (da) | 2011-01-11 | 2019-11-25 | Alnylam Pharmaceuticals Inc | Pegylerede lipider og deres anvendelse til lægemiddelfremføring |
PL2767546T3 (pl) | 2011-02-07 | 2019-04-30 | Cerenis Therapeutics Holding Sa | Kompleksy lipoproteinowe i ich wytwarzanie oraz ich zastosowania |
JP6250543B2 (ja) | 2011-09-27 | 2017-12-20 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | ジ脂肪族置換peg化脂質 |
MX359171B (es) | 2011-12-12 | 2018-09-18 | Melior Pharmaceuticals I Inc | Tratamiento para diabetes tipo i y tipo ii. |
EP2855502B1 (en) * | 2012-05-31 | 2019-06-26 | Agency For Science, Technology And Research | Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives |
US9610324B2 (en) | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
US20150316566A1 (en) | 2014-05-02 | 2015-11-05 | Cerenis Therapeutics Holding Sa | Hdl therapy markers |
BR112017001860A2 (pt) | 2014-07-31 | 2018-02-27 | Uab Research Foundation | peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal |
CN107530307A (zh) | 2015-03-13 | 2018-01-02 | 艾斯柏伦治疗公司 | 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法 |
MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
CN107033237B (zh) * | 2017-05-11 | 2021-07-20 | 深圳市卫光生物制品股份有限公司 | 一种人血浆载脂蛋白a-i的分离纯化方法 |
JP2022536979A (ja) | 2019-06-21 | 2022-08-22 | エスペリオン・セラピューティクス・インコーポレイテッド | 塩形態のベンペド酸及びそれを使用する方法 |
WO2022035784A1 (en) * | 2020-08-10 | 2022-02-17 | Gel4Med, Inc. | Antifungal matrix formed from peptide hydrogels |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
JPS6196998A (ja) | 1984-10-16 | 1986-05-15 | Mitsubishi Chem Ind Ltd | ヒトアポリポプロテインa−i様蛋白の産生方法 |
SE462100B (sv) * | 1985-08-08 | 1990-05-07 | Perstorp Ab | Komposition och dess anvaendning i ett tvaa- eller flerfassystem |
EP0262651A3 (en) * | 1986-09-30 | 1990-06-20 | Union Carbide Corporation | Isolation of enzyme values from solution |
GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
US5128318A (en) * | 1987-05-20 | 1992-07-07 | The Rogosin Institute | Reconstituted HDL particles and uses thereof |
GB8712540D0 (en) * | 1987-05-28 | 1987-07-01 | Ucb Sa | Expression of human proapolipoprotein a-i |
JP2606228B2 (ja) * | 1987-09-18 | 1997-04-30 | 三菱化学株式会社 | ヒトプロアポリポプロテインa−i様蛋白の産生法 |
JP2561674B2 (ja) | 1987-10-06 | 1996-12-11 | 三菱化学株式会社 | 蛋白質の産生方法 |
CA1335077C (en) * | 1988-02-08 | 1995-04-04 | Henri Isliker | Process for the manufacture of apolipoproteins from human blood plasma or serum |
JPH01238534A (ja) * | 1988-03-17 | 1989-09-22 | Mitsui Toatsu Chem Inc | エンドトキシンの除去方法 |
EP0345155B1 (en) * | 1988-05-31 | 1994-08-10 | Mitsubishi Kasei Corporation | Process for producing natural human apolipoprotein e-like proteins |
DE3819463A1 (de) * | 1988-06-08 | 1989-12-14 | Behringwerke Ag | Expressionsvektoren zur herstellung unfusionierter proteine in mikroorganismen |
IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
AU651059B2 (en) * | 1989-10-31 | 1994-07-14 | Schering Corporation | E. coli secretory strains |
SE468881B (sv) * | 1991-01-09 | 1993-04-05 | Kabi Pharmacia Ab | Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar |
WO1993000443A1 (en) * | 1991-06-26 | 1993-01-07 | Bio-Technology General Corp. | Purification of recombinant apolipoprotein e from bacteria |
SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
DE69321118T2 (de) * | 1992-06-12 | 1999-06-02 | Innogenetics Nv | Peptide und Proteine, Verfahren zur Ihren Herstellung und die Verwendung als Cholesterol-Annehmer |
SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
JP3491917B2 (ja) * | 1993-02-05 | 2004-02-03 | メビオール株式会社 | 熱可逆性ハイドロゲル材料 |
US5643757A (en) * | 1994-03-21 | 1997-07-01 | American Cyanamid Company | High yield production of human apolipoprotein A1 in E. coli. |
JP3514514B2 (ja) * | 1994-06-14 | 2004-03-31 | 財団法人化学及血清療法研究所 | ヒト血漿からのアポリポ蛋白a−1の製造方法 |
SE9500724D0 (sv) * | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
WO1996004556A1 (en) * | 1994-08-01 | 1996-02-15 | Hsu James T | Lipoprotein cholesterol assays |
SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
US5672685A (en) * | 1995-10-04 | 1997-09-30 | Duke University | Source of apolipoprotein E and method of isolating apolipoprotein E |
SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
-
1995
- 1995-03-03 SE SE9500778A patent/SE9500778D0/xx unknown
-
1996
- 1996-02-29 IL IL11732096A patent/IL117320A/en not_active IP Right Cessation
- 1996-03-01 WO PCT/SE1996/000271 patent/WO1996027608A1/en active IP Right Grant
- 1996-03-01 US US08/875,125 patent/US5834596A/en not_active Expired - Lifetime
- 1996-03-01 DK DK96906136T patent/DK0813541T3/da active
- 1996-03-01 PT PT96906136T patent/PT813541E/pt unknown
- 1996-03-01 JP JP8526799A patent/JPH11501046A/ja active Pending
- 1996-03-01 AT AT96906136T patent/ATE240348T1/de not_active IP Right Cessation
- 1996-03-01 DE DE69628148T patent/DE69628148T2/de not_active Expired - Fee Related
- 1996-03-01 CA CA002212125A patent/CA2212125A1/en not_active Abandoned
- 1996-03-01 ES ES96906136T patent/ES2199284T3/es not_active Expired - Lifetime
- 1996-03-01 EP EP96906136A patent/EP0813541B1/en not_active Expired - Lifetime
- 1996-03-01 NZ NZ303325A patent/NZ303325A/xx unknown
- 1996-03-01 AU AU49607/96A patent/AU694623B2/en not_active Ceased
- 1996-03-01 ZA ZA961679A patent/ZA961679B/xx unknown
-
1998
- 1998-08-05 US US09/129,720 patent/US5990081A/en not_active Expired - Lifetime
-
1999
- 1999-11-22 US US09/444,816 patent/US6506879B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
SE9500778D0 (sv) | 1995-03-03 |
EP0813541B1 (en) | 2003-05-14 |
NZ303325A (en) | 1998-12-23 |
ATE240348T1 (de) | 2003-05-15 |
PT813541E (pt) | 2003-09-30 |
US5990081A (en) | 1999-11-23 |
JPH11501046A (ja) | 1999-01-26 |
IL117320A (en) | 2001-06-14 |
ZA961679B (en) | 1996-10-07 |
US6506879B1 (en) | 2003-01-14 |
ES2199284T3 (es) | 2004-02-16 |
AU694623B2 (en) | 1998-07-23 |
CA2212125A1 (en) | 1996-09-12 |
IL117320A0 (en) | 1996-06-18 |
US5834596A (en) | 1998-11-10 |
WO1996027608A1 (en) | 1996-09-12 |
DE69628148D1 (de) | 2003-06-18 |
AU4960796A (en) | 1996-09-23 |
DE69628148T2 (de) | 2004-01-08 |
EP0813541A1 (en) | 1997-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0813541T3 (da) | Fremgangsmåde til fremstilling af et protein | |
ES2155477T3 (es) | Purificacion cromatografica y procedimiento de separacion de acidos nucleicos. | |
DE69840678D1 (de) | Verfahren zur produktion von purinnukleosiden durch fermentation | |
SE9603068D0 (sv) | Process for purifying a protein | |
PT83205B (pt) | Metodo de purificacao e activacao de proteinas a partir de corpos de inclusao insoluveis | |
DK0550509T3 (da) | Fremgangsmåde til fremstilling af rensede glycolipider ved membranseparationsmetoden | |
MY128271A (en) | Purification method for (meth) acrylic acid | |
DE3576362D1 (de) | Verfahren zur reinigung einer physiologisch aktiven substanz, die durch rekombinante dna-technik hergestellt wurde. | |
ATE131490T1 (de) | Verfahren zur herstellung von gereinigten albuminlösungen | |
ATE428730T1 (de) | Verfahren zur herstellung einer alpha-1- antitrypsinlösung | |
FR2632302B1 (fr) | Procede de recuperation d'acide citrique a partir d'une liqueur en contenant | |
ATE222925T1 (de) | Verbessertes verfahren zur herstellung von faktor viii | |
DE69112415T2 (de) | Verfahren zur herstellung von glukose und fruktose aus sukrose. | |
DE69902816T2 (de) | Synthese von heteropolysäuren | |
ATE381577T1 (de) | Verfahren zur aufreinigung von apolipoprotein-a oder apolipoprotein-e aus menschlichem plasma | |
DE69024392D1 (de) | Verfahren zur Reinigung von Aussenmembran-Protein von Haemophilus influenza | |
DK0524143T3 (da) | Fremgangsmåde til fremstilling af aktiverede sialinsyrer | |
DK1001929T3 (da) | Fremgangsmåde til fremstilling af 3-cyano-2,4-dihalogen-5-flour-benzoesyrer | |
SE0203551D0 (sv) | Prothrombin purification | |
EP0446850A3 (en) | Process for purifying recombinant human beta-interferon | |
KR910015699A (ko) | 리포코틴의 정제방법 | |
FI916021A0 (fi) | Interferonin puhdistusmenetelmä | |
SE9301324D0 (sv) | New method of treatment | |
DE59105648D1 (de) | Verfahren zur Herstellung 2-Chlor-1,7-dihydropurin-6-on und Verfahren zu dessen Reinigung. | |
IT1261917B (it) | Proteine che catalizzano il processo di strutturazione funzionale di molecole proteiche, procedimento per la loro produzione e loro usi. |