ATE240348T1 - Verfahren zur herstellung eines proteins - Google Patents

Verfahren zur herstellung eines proteins

Info

Publication number
ATE240348T1
ATE240348T1 AT96906136T AT96906136T ATE240348T1 AT E240348 T1 ATE240348 T1 AT E240348T1 AT 96906136 T AT96906136 T AT 96906136T AT 96906136 T AT96906136 T AT 96906136T AT E240348 T1 ATE240348 T1 AT E240348T1
Authority
AT
Austria
Prior art keywords
apoe
apoa
matrix
endotoxins
aqueous solution
Prior art date
Application number
AT96906136T
Other languages
English (en)
Inventor
Hans Ageland
Lena Romander
Original Assignee
Esperion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esperion Therapeutics Inc filed Critical Esperion Therapeutics Inc
Application granted granted Critical
Publication of ATE240348T1 publication Critical patent/ATE240348T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT96906136T 1995-03-03 1996-03-01 Verfahren zur herstellung eines proteins ATE240348T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9500778A SE9500778D0 (sv) 1995-03-03 1995-03-03 Process for producing a protein
PCT/SE1996/000271 WO1996027608A1 (en) 1995-03-03 1996-03-01 Process for producing a protein

Publications (1)

Publication Number Publication Date
ATE240348T1 true ATE240348T1 (de) 2003-05-15

Family

ID=20397430

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96906136T ATE240348T1 (de) 1995-03-03 1996-03-01 Verfahren zur herstellung eines proteins

Country Status (15)

Country Link
US (3) US5834596A (de)
EP (1) EP0813541B1 (de)
JP (1) JPH11501046A (de)
AT (1) ATE240348T1 (de)
AU (1) AU694623B2 (de)
CA (1) CA2212125A1 (de)
DE (1) DE69628148T2 (de)
DK (1) DK0813541T3 (de)
ES (1) ES2199284T3 (de)
IL (1) IL117320A (de)
NZ (1) NZ303325A (de)
PT (1) PT813541E (de)
SE (1) SE9500778D0 (de)
WO (1) WO1996027608A1 (de)
ZA (1) ZA961679B (de)

Families Citing this family (56)

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SE9500778D0 (sv) 1995-03-03 1995-03-03 Pharmacia Ab Process for producing a protein
SE9603068D0 (sv) 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (sv) * 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
SE9603303D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
DE19859703B4 (de) * 1998-12-23 2009-10-29 Macherey, Nagel Gmbh & Co. Handelsgesellschaft Verfahren zur Aufreinigung von Nukleinsäuren sowie Anionenaustauscher zur Durchführung dieses Verfahrens
ATE384035T1 (de) * 1999-04-01 2008-02-15 Esperion Therapeutics Inc Ether-verbindungen, zusammensetzungen und ihre verwendung
US8568766B2 (en) * 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
CA2428114C (en) * 2000-11-10 2013-07-23 Proteopharma Aps Apolipoprotein analogues
CN1283313C (zh) * 2001-09-28 2006-11-08 埃斯佩里安医疗公司 α螺旋状载脂蛋白或HDL关联蛋白在制备局部给药预防和治疗再狭窄的药物中的用途
CA2468989A1 (en) * 2001-12-07 2003-06-19 Daniel M. Schwartz Treatment for age-related macular degeneration
US7470659B2 (en) 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US20030229062A1 (en) * 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
EP1556413A4 (de) * 2002-05-17 2009-07-08 Esperion Therapeutics Inc Verfahren und zusammensetzungen zur behandlung ischämischer reperfusion
US7335689B2 (en) * 2003-01-23 2008-02-26 Esperion Therapeutics, Inc. Dihydroxyl compounds and compositions for cholesterol management and related uses
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US20050176623A1 (en) * 2004-02-11 2005-08-11 Neil Wagle Non-invasive treatment of disease using amphipathic compounds
WO2005097206A2 (en) * 2004-04-06 2005-10-20 Cedars-Sinai Medical Center Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein a-i and apolipoprotein a-i milano
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JP2008539235A (ja) 2005-04-29 2008-11-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 炎症反応によって特徴付けられる病状を処置するためのペプチドおよびペプチド模倣物
EP2041174A2 (de) * 2006-06-16 2009-04-01 Lipid Sciences, Inc. Neue, den lipidausstrom fördernde peptide
US20080227686A1 (en) * 2006-06-16 2008-09-18 Lipid Sciences, Inc. Novel Peptides that Promote Lipid Efflux
US20080206142A1 (en) * 2006-06-16 2008-08-28 Lipid Sciences, Inc. Novel Peptides That Promote Lipid Efflux
US9375499B2 (en) 2006-07-14 2016-06-28 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
WO2008021088A2 (en) 2006-08-08 2008-02-21 The Regents Of The University Of Californina Salicylanilides enhance oral delivery of therapeutic peptides
US20080138284A1 (en) * 2006-09-26 2008-06-12 Lipid Sciences, Inc. Novel Peptides That Promote Lipid Efflux
CN100586958C (zh) * 2006-12-20 2010-02-03 上海莱士血液制品股份有限公司 高纯度载脂蛋白a-i的制备方法
US8013122B2 (en) * 2006-12-20 2011-09-06 Kieu Hoang Method of purifying apolipoprotein A-1
CA2704729C (en) 2007-08-28 2020-06-23 Uab Research Foundation Synthetic apolipoprotein e mimicking polypeptides and methods of use
CA2697957A1 (en) 2007-08-28 2009-03-12 Uab Research Foundation Synthetic apolipoprotein e mimicking polypeptides and methods of use
EP3757090B1 (de) 2008-11-10 2024-06-12 Arbutus Biopharma Corporation Neuartige lipide und zusammensetzungen zur verabreichung von therapeutika
CA2751342C (en) 2009-01-29 2019-05-07 Alnylam Pharmaceuticals, Inc. Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
CA2754043A1 (en) 2009-03-12 2010-09-16 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
KR102229618B1 (ko) 2009-05-05 2021-03-18 알닐람 파마슈티칼스 인코포레이티드 지질 조성물
SG10201912450XA (en) 2009-06-10 2020-03-30 Arbutus Biopharma Corp Improved lipid formulation
EP2464336A4 (de) 2009-08-14 2013-11-20 Alnylam Pharmaceuticals Inc Zusammensetzungen aus lipidformulierungen und verfahren zur hemmung der expression eines gens aus dem ebolavirus
AU2010328336B2 (en) 2009-12-07 2017-03-02 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
CA2784568A1 (en) 2009-12-18 2011-06-23 Martin A. Maier Lipid particles for delivery of nucleic acids
US20130156845A1 (en) 2010-04-29 2013-06-20 Alnylam Pharmaceuticals, Inc. Lipid formulated single stranded rna
US20130137628A1 (en) 2010-05-11 2013-05-30 Esperion Therapeutics, Inc. Dimeric Oxidation-Resistant Apolipoprotein A1 Variants
US9012498B2 (en) 2010-06-03 2015-04-21 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
US20130323269A1 (en) 2010-07-30 2013-12-05 Muthiah Manoharan Methods and compositions for delivery of active agents
US20130202652A1 (en) 2010-07-30 2013-08-08 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
CN110123830A (zh) 2010-11-09 2019-08-16 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
US9999673B2 (en) 2011-01-11 2018-06-19 Alnylam Pharmaceuticals, Inc. PEGylated lipids and their use for drug delivery
ES2717455T3 (es) 2011-02-07 2019-06-21 Cerenis Therapeutics Holding Sa Complejos de lipoproteínas y fabricación y usos de los mismos
WO2013049328A1 (en) 2011-09-27 2013-04-04 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
CA2859156C (en) 2011-12-12 2020-10-06 Melior Pharmaceuticals I, Inc. Treatment of type i and type ii diabetes
JP2015519361A (ja) * 2012-05-31 2015-07-09 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 正電荷有機添加剤での処理によるタンパク質製剤におけるタンパク質−不純物複合体及び凝集体のレベルを低下させるための方法
US9610324B2 (en) 2012-07-11 2017-04-04 Esperion Therapeutics, Inc. Apolipoprotein mixtures
AU2015260929A1 (en) 2014-05-02 2016-12-15 Cerenis Therapeutics Holding Sa HDL therapy markers
BR112017001860A2 (pt) 2014-07-31 2018-02-27 Uab Research Foundation peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal
SG11201707497UA (en) 2015-03-13 2017-10-30 Esperion Therapeutics Inc Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
CN107033237B (zh) * 2017-05-11 2021-07-20 深圳市卫光生物制品股份有限公司 一种人血浆载脂蛋白a-i的分离纯化方法
EP3986860A1 (de) 2019-06-21 2022-04-27 Esperion Therapeutics, Inc. Salzformen von bempedoinsäure und verfahren zu deren verwendung
WO2022035784A1 (en) * 2020-08-10 2022-02-17 Gel4Med, Inc. Antifungal matrix formed from peptide hydrogels

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SE9500778D0 (sv) * 1995-03-03 1995-03-03 Pharmacia Ab Process for producing a protein
US5672685A (en) * 1995-10-04 1997-09-30 Duke University Source of apolipoprotein E and method of isolating apolipoprotein E
SE9603068D0 (sv) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein

Also Published As

Publication number Publication date
JPH11501046A (ja) 1999-01-26
DE69628148T2 (de) 2004-01-08
ES2199284T3 (es) 2004-02-16
AU694623B2 (en) 1998-07-23
US5834596A (en) 1998-11-10
WO1996027608A1 (en) 1996-09-12
IL117320A0 (en) 1996-06-18
EP0813541A1 (de) 1997-12-29
CA2212125A1 (en) 1996-09-12
DK0813541T3 (da) 2003-09-15
AU4960796A (en) 1996-09-23
ZA961679B (en) 1996-10-07
US6506879B1 (en) 2003-01-14
NZ303325A (en) 1998-12-23
IL117320A (en) 2001-06-14
PT813541E (pt) 2003-09-30
SE9500778D0 (sv) 1995-03-03
DE69628148D1 (de) 2003-06-18
EP0813541B1 (de) 2003-05-14
US5990081A (en) 1999-11-23

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