DK0803576T3 - Fremgangsmåde til fremstilling af lipstatin og tetrahydrolipstatin - Google Patents

Fremgangsmåde til fremstilling af lipstatin og tetrahydrolipstatin

Info

Publication number
DK0803576T3
DK0803576T3 DK97106445T DK97106445T DK0803576T3 DK 0803576 T3 DK0803576 T3 DK 0803576T3 DK 97106445 T DK97106445 T DK 97106445T DK 97106445 T DK97106445 T DK 97106445T DK 0803576 T3 DK0803576 T3 DK 0803576T3
Authority
DK
Denmark
Prior art keywords
lipstatin
tetrahydrolipstatin
preparation
Prior art date
Application number
DK97106445T
Other languages
Danish (da)
English (en)
Inventor
Adelbert Bacher
Peter Stohler
Wolfgang Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0803576T3 publication Critical patent/DK0803576T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK97106445T 1996-04-26 1997-04-18 Fremgangsmåde til fremstilling af lipstatin og tetrahydrolipstatin DK0803576T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96106598 1996-04-26

Publications (1)

Publication Number Publication Date
DK0803576T3 true DK0803576T3 (da) 2003-03-24

Family

ID=8222717

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97106445T DK0803576T3 (da) 1996-04-26 1997-04-18 Fremgangsmåde til fremstilling af lipstatin og tetrahydrolipstatin

Country Status (15)

Country Link
US (1) US20020110873A1 (fr)
EP (1) EP0803576B1 (fr)
JP (1) JP4094698B2 (fr)
CN (1) CN1128224C (fr)
AR (1) AR006831A1 (fr)
AT (1) ATE229077T1 (fr)
BR (1) BR9701953A (fr)
CA (1) CA2202016C (fr)
DE (1) DE69717530T2 (fr)
DK (1) DK0803576T3 (fr)
ES (1) ES2186818T3 (fr)
ID (1) ID16410A (fr)
MY (1) MY116591A (fr)
PT (1) PT803576E (fr)
TR (1) TR199700289A3 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2185523T3 (es) * 1999-01-29 2003-05-01 Hoffmann La Roche Purificacion de lipstatina.
DE60218822T2 (de) * 2001-02-09 2007-07-12 Unilever N.V. Nahrungsmittel enthaltend sojaprotein und statin
AU2002362061A1 (en) * 2001-12-04 2003-06-17 Biogal Gyogyszergyar Rt Preparation of orlistat and orlistat crystalline forms
AU2002359601A1 (en) * 2001-12-04 2003-06-17 Biogal Gyogyszergyar Rt A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
WO2005007639A1 (fr) * 2003-07-17 2005-01-27 Biocon Limited Preparation de tetrahydrolipstatine par hydrogenation de lipstatine, extraction par solvant et purification
SK22006A3 (sk) * 2006-01-03 2007-08-02 Biotika, A. S. Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
EP1860194A1 (fr) * 2006-05-22 2007-11-28 KRKA, tovarna zdravil, d.d., Novo mesto Production par fermentation de lipstatine
WO2009040827A1 (fr) * 2007-09-24 2009-04-02 Biocon Limited Procédé d'obtention de tétrahydrolipstatine
ES2755736T3 (es) * 2008-03-26 2020-04-23 Biocon Ltd Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN103820510B (zh) * 2014-01-17 2016-01-20 浙江工业大学 一种微生物发酵生产利普司他汀的方法及培养基

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (fr) * 1983-06-22 1988-12-28 Paul Hadvary Derives de leucine
CH675966A5 (fr) 1987-02-20 1990-11-30 Firmenich & Cie
CA2098167C (fr) * 1992-06-24 2006-12-19 Dorothea Isler Aliments pour humains et animaux contenant un inhibiteur de la lipase

Also Published As

Publication number Publication date
JP4094698B2 (ja) 2008-06-04
EP0803576B1 (fr) 2002-12-04
CA2202016C (fr) 2009-12-08
CN1170761A (zh) 1998-01-21
JPH1066592A (ja) 1998-03-10
ES2186818T3 (es) 2003-05-16
MX9703057A (es) 1998-06-30
ATE229077T1 (de) 2002-12-15
AR006831A1 (es) 1999-09-29
CN1128224C (zh) 2003-11-19
TR199700289A2 (en) 1997-11-21
TR199700289A3 (tr) 1997-11-21
EP0803576A2 (fr) 1997-10-29
US20020110873A1 (en) 2002-08-15
DE69717530D1 (de) 2003-01-16
DE69717530T2 (de) 2003-11-06
BR9701953A (pt) 1998-09-15
MY116591A (en) 2004-02-28
PT803576E (pt) 2003-03-31
CA2202016A1 (fr) 1997-10-26
EP0803576A3 (fr) 1999-04-21
ID16410A (id) 1997-10-30

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