DK0795326T3 - Okulærtensionssænkende middel - Google Patents
Okulærtensionssænkende middelInfo
- Publication number
- DK0795326T3 DK0795326T3 DK95912428T DK95912428T DK0795326T3 DK 0795326 T3 DK0795326 T3 DK 0795326T3 DK 95912428 T DK95912428 T DK 95912428T DK 95912428 T DK95912428 T DK 95912428T DK 0795326 T3 DK0795326 T3 DK 0795326T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- alkyl
- formula
- alkenyl
- carboxyl
- Prior art date
Links
- 230000014759 maintenance of location Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010030043 Ocular hypertension Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 229940097320 beta blocking agent Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000003431 oxalo group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4540494 | 1994-03-16 | ||
| PCT/JP1995/000444 WO1995024902A1 (en) | 1994-03-16 | 1995-03-16 | Ocular tension depressant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0795326T3 true DK0795326T3 (da) | 2001-11-26 |
Family
ID=12718322
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95912428T DK0795326T3 (da) | 1994-03-16 | 1995-03-16 | Okulærtensionssænkende middel |
| DK01102527T DK1110551T3 (da) | 1994-03-16 | 1995-03-16 | Okulærtensionssænkende middel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01102527T DK1110551T3 (da) | 1994-03-16 | 1995-03-16 | Okulærtensionssænkende middel |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5925664A (cg-RX-API-DMAC7.html) |
| EP (2) | EP1110551B1 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100211446B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN1104898C (cg-RX-API-DMAC7.html) |
| AT (2) | ATE266402T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU684916B2 (cg-RX-API-DMAC7.html) |
| CZ (1) | CZ284395B6 (cg-RX-API-DMAC7.html) |
| DE (2) | DE69533045T2 (cg-RX-API-DMAC7.html) |
| DK (2) | DK0795326T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2163501T3 (cg-RX-API-DMAC7.html) |
| FI (2) | FI114897B (cg-RX-API-DMAC7.html) |
| GR (1) | GR3036989T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HUT74734A (cg-RX-API-DMAC7.html) |
| MX (1) | MX9604109A (cg-RX-API-DMAC7.html) |
| NO (1) | NO311068B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ282485A (cg-RX-API-DMAC7.html) |
| PT (2) | PT1110551E (cg-RX-API-DMAC7.html) |
| RU (1) | RU2123847C1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1995024902A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1186302B1 (en) * | 1999-06-11 | 2005-05-18 | Sankyo Company, Limited | Ocular tension lowering composition for topical adminstration |
| JP4000505B2 (ja) * | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
| GR20000100281A (el) * | 2000-08-17 | 2002-05-24 | Ιωαννης Ματσουκας | Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων |
| AU2002218527A1 (en) * | 2000-12-05 | 2002-06-18 | Sankyo Company Limited | Ocular tension-lowering compositions for topical administration |
| EP2517728B1 (en) * | 2003-04-15 | 2015-01-28 | Daiichi Sankyo Company, Limited | Olmesartan medoxomil for preventing or treating angiogenic eye diseases |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2549049B1 (fr) * | 1983-07-13 | 1986-06-20 | Chauvin Blache Lab | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| ZA875052B (en) * | 1986-07-11 | 1989-03-29 | Du Pont | Angiotensin ii receptor blocking imidazoles |
| US5138069A (en) * | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
| DK0479903T3 (da) * | 1989-06-30 | 1996-03-18 | Du Pont | Substituerede imidazoler og deres anvendelse som angiotensin II hæmmere |
| WO1991015206A1 (en) * | 1990-04-05 | 1991-10-17 | E.I. Du Pont De Nemours And Company | Treatment of glaucoma and ocular hypertension with imidazole angiotensin-ii receptor antagonists |
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5126342A (en) * | 1990-10-01 | 1992-06-30 | Merck & Co., Inc. | Imidazole angiotensin ii antagonists incorporating acidic functional groups |
| CA2061607C (en) * | 1991-02-21 | 1999-01-19 | Hiroaki Yanagisawa | 1-biphenylimidazole derivatives, their preparation and their therapeutic use |
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| DE4132631A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Imidazolyl-propensaeurederivate |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| EP0573218B1 (en) * | 1992-06-02 | 2001-03-07 | Sankyo Company Limited | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use |
| US5310929A (en) * | 1992-08-06 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists |
| CA2111662C (en) * | 1992-12-17 | 2004-11-23 | Hiroaki Yanagisawa | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease |
| CZ154994A3 (en) * | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
| CN1140409A (zh) * | 1994-02-08 | 1997-01-15 | 希巴-盖吉股份公司 | 血管紧张素ii拮抗剂对正常眼压性青光眼的治疗 |
-
1995
- 1995-03-16 DE DE69533045T patent/DE69533045T2/de not_active Expired - Fee Related
- 1995-03-16 MX MX9604109A patent/MX9604109A/es not_active IP Right Cessation
- 1995-03-16 NZ NZ282485A patent/NZ282485A/en not_active IP Right Cessation
- 1995-03-16 CZ CZ962694A patent/CZ284395B6/cs not_active IP Right Cessation
- 1995-03-16 ES ES95912428T patent/ES2163501T3/es not_active Expired - Lifetime
- 1995-03-16 KR KR1019960705082A patent/KR100211446B1/ko not_active Expired - Fee Related
- 1995-03-16 DK DK95912428T patent/DK0795326T3/da active
- 1995-03-16 PT PT01102527T patent/PT1110551E/pt unknown
- 1995-03-16 ES ES01102527T patent/ES2221872T3/es not_active Expired - Lifetime
- 1995-03-16 EP EP01102527A patent/EP1110551B1/en not_active Expired - Lifetime
- 1995-03-16 RU RU96121253A patent/RU2123847C1/ru active
- 1995-03-16 WO PCT/JP1995/000444 patent/WO1995024902A1/ja not_active Ceased
- 1995-03-16 EP EP95912428A patent/EP0795326B1/en not_active Expired - Lifetime
- 1995-03-16 DK DK01102527T patent/DK1110551T3/da active
- 1995-03-16 DE DE69522955T patent/DE69522955T2/de not_active Expired - Fee Related
- 1995-03-16 AT AT01102527T patent/ATE266402T1/de not_active IP Right Cessation
- 1995-03-16 HU HU9602534A patent/HUT74734A/hu unknown
- 1995-03-16 AU AU19602/95A patent/AU684916B2/en not_active Ceased
- 1995-03-16 CN CN95193132A patent/CN1104898C/zh not_active Expired - Fee Related
- 1995-03-16 PT PT95912428T patent/PT795326E/pt unknown
- 1995-03-16 AT AT95912428T patent/ATE206050T1/de not_active IP Right Cessation
-
1996
- 1996-09-13 NO NO19963854A patent/NO311068B1/no not_active IP Right Cessation
- 1996-09-16 US US08/725,197 patent/US5925664A/en not_active Expired - Fee Related
- 1996-09-16 FI FI963645A patent/FI114897B/fi active IP Right Grant
-
2001
- 2001-10-24 GR GR20010401862T patent/GR3036989T3/el not_active IP Right Cessation
-
2002
- 2002-05-11 CN CNB021199396A patent/CN1202819C/zh not_active Expired - Fee Related
-
2004
- 2004-09-24 FI FI20041236A patent/FI115197B/fi active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0449216T3 (da) | 3,5-Di-tertiærbutyl-4-hydroxyphenylmethylenderivater af 2-substituerede thiazolidinoner, oxazolidinoner og imidazolidinoner som antiinflammatoriske midler | |
| ATE194335T1 (de) | 4,5-diaryloxazol-derivate | |
| DE69331843D1 (de) | Xanthine-Derivate als Antidepressiva | |
| ATE275134T1 (de) | 4-oxo-1,4-dihydro-3-chinolincarboxamide als antivirale mittel | |
| DE69111816D1 (de) | Indolederivate und ihre verwendung als serotonin-antagoniste. | |
| ATE227710T1 (de) | Oxazole derivate,ihre herstellung und verwendung | |
| DK0916651T3 (da) | Phenylalkylcarboxylsyrederivater | |
| ATE421524T1 (de) | 5-ring-heterocyclen, ihre herstellung, ihre verwendung als inhibitoren der leukozytenadhäsion und sie enthaltende pharmazeutische präparate | |
| DE69321609D1 (de) | Piperazinderivate | |
| DK0795326T3 (da) | Okulærtensionssænkende middel | |
| NO872874D0 (no) | Amid-derivater. | |
| NO893039L (no) | Bruk av imidazopyrazol-derivater som analgesiske og antiinflammatoriske midler. | |
| ATE144900T1 (de) | Verwendung von xanthinderivaten gegen magengeschwüre |