DK0788356T3 - Fremgangsmåde og præparater til hæmning af proteinkinaser - Google Patents
Fremgangsmåde og præparater til hæmning af proteinkinaserInfo
- Publication number
- DK0788356T3 DK0788356T3 DK95941340T DK95941340T DK0788356T3 DK 0788356 T3 DK0788356 T3 DK 0788356T3 DK 95941340 T DK95941340 T DK 95941340T DK 95941340 T DK95941340 T DK 95941340T DK 0788356 T3 DK0788356 T3 DK 0788356T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparations
- inhibition
- methods
- independently represents
- protein kinases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/332,597 US5795910A (en) | 1994-10-28 | 1994-10-28 | Method and compositions for inhibiting protein kinases |
PCT/US1995/013882 WO1996013259A2 (en) | 1994-10-28 | 1995-10-26 | Method and compositions for inhibiting protein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0788356T3 true DK0788356T3 (da) | 2002-03-18 |
Family
ID=23298937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95941340T DK0788356T3 (da) | 1994-10-28 | 1995-10-26 | Fremgangsmåde og præparater til hæmning af proteinkinaser |
Country Status (14)
Country | Link |
---|---|
US (3) | US5795910A (zh) |
EP (1) | EP0788356B9 (zh) |
JP (1) | JPH10508024A (zh) |
KR (1) | KR970706812A (zh) |
CN (1) | CN1165481A (zh) |
AT (1) | ATE210439T1 (zh) |
AU (1) | AU706621B2 (zh) |
CA (1) | CA2203757A1 (zh) |
DE (1) | DE69524628T2 (zh) |
DK (1) | DK0788356T3 (zh) |
ES (1) | ES2170172T3 (zh) |
PT (1) | PT788356E (zh) |
TW (1) | TW467743B (zh) |
WO (1) | WO1996013259A2 (zh) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6699843B2 (en) * | 1995-06-07 | 2004-03-02 | Gilead Sciences, Inc. | Method for treatment of tumors using nucleic acid ligands to PDGF |
WO1998005999A1 (fr) * | 1996-08-06 | 1998-02-12 | Seiko Epson Corporation | Affichage a cristaux liquides et materiel electronique l'utilisant |
WO2000009113A1 (en) * | 1998-08-17 | 2000-02-24 | Trout William E | Use of zeranol to modulate reproductive cycles |
US20030219427A1 (en) * | 1998-08-18 | 2003-11-27 | Allen Hamish J. | TPL-2/COT kinase and methods of use |
ATE307601T1 (de) * | 1998-12-07 | 2005-11-15 | Ecosmart Technologies Inc | Brustkrebsbehandlung mittels natürlicher ätherischer öle |
EP1140069A1 (en) | 1998-12-24 | 2001-10-10 | Novation Pharmaceuticals Inc. | COMPOUNDS WHICH AFFECT mRNA STABILITY AND USES THEREFOR |
HUP0300923A3 (en) * | 1999-08-13 | 2005-12-28 | Scripps Research Inst | Methods and compositions useful for modulation of angiogenesis using protein kinase raf and ras |
GB9925958D0 (en) * | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
US7087608B2 (en) * | 2000-03-03 | 2006-08-08 | Robert Charles Atkins | Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy |
JP2004292314A (ja) * | 2000-12-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | ケラチノサイト増殖抑制剤 |
US6565864B2 (en) | 2000-12-28 | 2003-05-20 | Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. | Skin care product containing retinoids and phytoestrogens in a dual compartment package |
DE60218822T2 (de) * | 2001-02-09 | 2007-07-12 | Unilever N.V. | Nahrungsmittel enthaltend sojaprotein und statin |
WO2003041643A2 (en) * | 2001-11-09 | 2003-05-22 | Conforma Therapeutics Corporation | Hsp90-inhibiting zearalanol compounds and methods of producing and using same |
FR2835252B1 (fr) | 2002-01-25 | 2005-08-05 | Seppic Sa | Utilisation d'un compose inactivant la proteine kinase a dans une composition contenant un milieu cosmetiquement acceptable, pour eclaicir la peau |
US7915306B2 (en) * | 2002-03-08 | 2011-03-29 | Eisai Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
AU2003224672B2 (en) * | 2002-03-08 | 2010-02-04 | Eisai R&D Management Co., Ltd. | Macrocyclic compounds useful as pharmaceuticals |
CA2482940A1 (en) * | 2002-04-17 | 2003-10-23 | Taisho Pharmaceuticals Co., Ltd. | Hair growth tonic |
US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
EP1608338A1 (en) * | 2003-04-02 | 2005-12-28 | Celator Technologies Inc. | Pharmaceutical compositions containing active agents having a lactone group and transition metal ions |
EP3168304A1 (en) | 2003-08-27 | 2017-05-17 | Ophthotech Corporation | Combination therapy for the treatment of ocular neovascular disorders |
EP1794137A4 (en) * | 2004-09-27 | 2009-12-02 | Kosan Biosciences Inc | SPECIFIC KINASE INHIBITORS |
US20070149593A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
US7601852B2 (en) * | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
CN103539769B (zh) * | 2006-08-11 | 2016-03-16 | 斯特拉斯堡大学 | 用作激酶抑制剂和hsp90抑制剂的大环化合物 |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
JP5484327B2 (ja) | 2007-07-25 | 2014-05-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 癌の処置において使用するための多キナーゼインヒビター |
WO2009058908A2 (en) | 2007-10-29 | 2009-05-07 | Eisai R & D Management Co., Ltd. | Methods for prognosing the ability of a zearalenone analog compound to treat cancer |
CN101889005B (zh) | 2007-12-07 | 2015-06-03 | 卫材R&D管理株式会社 | 玉米赤霉烯酮大环内酯类似物合成过程中的中间物 |
US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
WO2010099139A2 (en) | 2009-02-25 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Combination anti-cancer therapy |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
JP2012519282A (ja) | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
CN101928700B (zh) * | 2009-07-28 | 2012-05-02 | 北京恒宇视野生物科技有限公司 | 蛋白激酶pftk1单克隆抗体及其制备方法 |
WO2012021974A1 (en) * | 2010-08-20 | 2012-02-23 | The Hospital For Sick Children | Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing |
US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US10434085B2 (en) | 2015-06-04 | 2019-10-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3196019A (en) * | 1964-04-06 | 1965-07-20 | Purdue Research Foundation | Anabolic and estrogenic compound and process of making |
JPS6239558A (ja) * | 1985-08-13 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | α−シアノアクリル酸アミド誘導体 |
JPS6239523A (ja) * | 1985-08-14 | 1987-02-20 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
JPS6242923A (ja) * | 1985-08-19 | 1987-02-24 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
JPS6242925A (ja) * | 1985-08-20 | 1987-02-24 | Kanegafuchi Chem Ind Co Ltd | 酵素阻害剤 |
US4842862A (en) * | 1986-07-03 | 1989-06-27 | International Minerals & Chemical Corp. | Immunostimulating agents |
GB9225396D0 (en) * | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
-
1994
- 1994-10-28 US US08/332,597 patent/US5795910A/en not_active Expired - Fee Related
-
1995
- 1995-06-05 US US08/462,475 patent/US5728726A/en not_active Expired - Fee Related
- 1995-06-05 US US08/463,773 patent/US5674892A/en not_active Expired - Lifetime
- 1995-10-26 EP EP95941340A patent/EP0788356B9/en not_active Expired - Lifetime
- 1995-10-26 DE DE69524628T patent/DE69524628T2/de not_active Expired - Fee Related
- 1995-10-26 JP JP8514745A patent/JPH10508024A/ja not_active Ceased
- 1995-10-26 CA CA002203757A patent/CA2203757A1/en not_active Abandoned
- 1995-10-26 CN CN95195945A patent/CN1165481A/zh active Pending
- 1995-10-26 ES ES95941340T patent/ES2170172T3/es not_active Expired - Lifetime
- 1995-10-26 KR KR1019970702786A patent/KR970706812A/ko not_active Application Discontinuation
- 1995-10-26 DK DK95941340T patent/DK0788356T3/da active
- 1995-10-26 PT PT95941340T patent/PT788356E/pt unknown
- 1995-10-26 AT AT95941340T patent/ATE210439T1/de not_active IP Right Cessation
- 1995-10-26 WO PCT/US1995/013882 patent/WO1996013259A2/en not_active Application Discontinuation
- 1995-10-26 AU AU42789/96A patent/AU706621B2/en not_active Ceased
- 1995-10-27 TW TW084111358A patent/TW467743B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0788356A2 (en) | 1997-08-13 |
PT788356E (pt) | 2002-06-28 |
US5795910A (en) | 1998-08-18 |
AU4278996A (en) | 1996-05-23 |
US5728726A (en) | 1998-03-17 |
EP0788356B1 (en) | 2001-12-12 |
TW467743B (en) | 2001-12-11 |
DE69524628T2 (de) | 2002-08-08 |
JPH10508024A (ja) | 1998-08-04 |
ES2170172T3 (es) | 2002-08-01 |
CA2203757A1 (en) | 1996-05-09 |
CN1165481A (zh) | 1997-11-19 |
EP0788356B9 (en) | 2002-10-02 |
US5674892A (en) | 1997-10-07 |
ATE210439T1 (de) | 2001-12-15 |
MX9703113A (es) | 1998-06-30 |
KR970706812A (ko) | 1997-12-01 |
AU706621B2 (en) | 1999-06-17 |
DE69524628D1 (de) | 2002-01-24 |
WO1996013259A2 (en) | 1996-05-09 |
WO1996013259A3 (en) | 1996-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0788356T3 (da) | Fremgangsmåde og præparater til hæmning af proteinkinaser | |
NO992492L (no) | Benzamidoaldehyder og deres anvendelse som cystein-protease-inhibitorer | |
NO941181D0 (no) | Heterocykliske inhibitorer for farnesyl-protein-transferase | |
YU31392A (sh) | Derivati heterocikličnih-cikličnih amina | |
DK0725790T3 (da) | Substituerede tetra- og pentapeptidinhibitorer af proteinfarnesyltransferase | |
DK0839133T3 (da) | Derivater af 4,9-ethano-benzo(f)isoindol, som er anvendelige som farnesyltransferase-inhibitorer | |
DE69516866T2 (de) | Stereochemische wortmanninderivate | |
NO951647D0 (no) | Inhibitorer for farnesylproteintransferase | |
FI950859A0 (fi) | Arylideeni- ja heteroarylideeni-oksindolijohdannaiset tyrosiinikinaasi-inhibiittoreina | |
NO973607D0 (no) | Nye farnesyltransferaseinhibitorer, deres fremstilling og preparater inneholdende inhibitorene | |
NO961814L (no) | Substituerte di- og tripetidinhibitorer for protein:farnesyl-transferase | |
NO983892L (no) | Inhibitorer for farnesyl-proteintransferase | |
DE69627179T2 (de) | Substituierte 2-anilino-pyrimidines verwendbar als protein kinase inhibitoren | |
NO991230L (no) | Trisykliske forbindelser for inhibering av G-proteinfunksjon og for behandling av proliferative sykdommer | |
DE69225023T2 (de) | Amin-Addukte als Korrosionsinhibitoren | |
IL127575A0 (en) | Prenyl transferase inhibitors | |
ATE262584T1 (de) | Verwendung eines inhibitors von tau/neurofilament-proteinkinase pk40 | |
PT950056E (pt) | N-(piridinilamino) isoindolinas e compostos relacionados | |
NO970350L (no) | Forbindelser anvendelige som anti-formeringsmidler og GARFT-inhibitorer | |
AR003529A1 (es) | Derivados de alfa-fenilpiperidin-1-propanol, procedimiento para su preparacion y su aplicacion terapeutica. | |
ATE227281T1 (de) | Verbindungen als farnesyl-protein transferase inhibitoren |