DK0758644T3 - Sulfonyl- eller sulfinyl-benzoyl-guanidin-derivater - Google Patents

Sulfonyl- eller sulfinyl-benzoyl-guanidin-derivater

Info

Publication number
DK0758644T3
DK0758644T3 DK96112498T DK96112498T DK0758644T3 DK 0758644 T3 DK0758644 T3 DK 0758644T3 DK 96112498 T DK96112498 T DK 96112498T DK 96112498 T DK96112498 T DK 96112498T DK 0758644 T3 DK0758644 T3 DK 0758644T3
Authority
DK
Denmark
Prior art keywords
halo
benzoyl
sulfinyl
sulfonyl
ch2f
Prior art date
Application number
DK96112498T
Other languages
Danish (da)
English (en)
Inventor
Norbert Dr Beier
Manfred Dr Baumgarth
Klaus-Otto Dr Minck
Rolf Dr Gericke
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7769293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0758644(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0758644T3 publication Critical patent/DK0758644T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Leads Or Probes (AREA)
DK96112498T 1995-08-11 1996-08-02 Sulfonyl- eller sulfinyl-benzoyl-guanidin-derivater DK0758644T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19529612A DE19529612A1 (de) 1995-08-11 1995-08-11 Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Publications (1)

Publication Number Publication Date
DK0758644T3 true DK0758644T3 (da) 2003-12-22

Family

ID=7769293

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96112498T DK0758644T3 (da) 1995-08-11 1996-08-02 Sulfonyl- eller sulfinyl-benzoyl-guanidin-derivater

Country Status (25)

Country Link
US (1) US5744641A (pt)
EP (1) EP0758644B1 (pt)
JP (1) JP3901766B2 (pt)
KR (1) KR100447111B1 (pt)
CN (1) CN1071743C (pt)
AR (1) AR004677A1 (pt)
AT (1) ATE252075T1 (pt)
AU (1) AU709800B2 (pt)
BR (1) BR9603377B1 (pt)
CA (1) CA2183050C (pt)
CZ (1) CZ292974B6 (pt)
DE (2) DE19529612A1 (pt)
DK (1) DK0758644T3 (pt)
ES (1) ES2206534T3 (pt)
HU (1) HU226134B1 (pt)
MX (1) MX9603300A (pt)
NO (1) NO306858B1 (pt)
PL (1) PL184320B1 (pt)
PT (1) PT758644E (pt)
RU (1) RU2159232C2 (pt)
SI (1) SI0758644T1 (pt)
SK (1) SK281661B6 (pt)
TW (1) TW432039B (pt)
UA (1) UA45965C2 (pt)
ZA (1) ZA966773B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19833118C2 (de) 1998-07-23 2000-07-27 Merck Patent Gmbh Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
DE19951418A1 (de) * 1999-10-26 2001-05-03 Merck Patent Gmbh Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
DE10001879A1 (de) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
KR100643561B1 (ko) * 2000-12-08 2006-11-10 엘지.필립스 엘시디 주식회사 액정표시장치용 어레이기판과 어레이기판의 제조방법
DE10305070A1 (de) * 2003-02-07 2004-08-26 Merck Patent Gmbh Verwendung von N-(4,5-Methansulfonyl-2-methyl-benzoyl)-guanidin
US7629493B2 (en) * 2003-05-06 2009-12-08 Merck Patent Gmbh Process for the crystallisation of guandinium salts
DE102004045825A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisat enthaltend N-Diaminomethylen-2-methyl-4,5-di-(methylsulfonyl)-benzamid
AU2009243749B2 (en) * 2008-05-09 2013-11-21 Merck Patent Gmbh Pharmaceutical composition comprising rimeporide for treating diseases associated with insulin resistance and beta-cell dysfunction
MX2011001821A (es) * 2008-09-02 2011-03-25 Sanofi Aventis Aminoindanos sustituidos y sus analogos, y el uso farmaceutico de los mismos.
FR2948028B1 (fr) 2009-07-17 2011-12-02 Merck Sante Sas Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine
EP3414225B1 (en) * 2016-02-08 2023-10-25 Merck Patent GmbH Crystalline modifications of n-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride and n-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine salts
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
ES2097409T3 (es) * 1992-09-22 1997-04-01 Hoechst Ag Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos.
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
RU2159232C2 (ru) 2000-11-20
KR100447111B1 (ko) 2004-12-08
KR970010740A (ko) 1997-03-27
US5744641A (en) 1998-04-28
CZ231296A3 (en) 1997-02-12
ES2206534T3 (es) 2004-05-16
MX9603300A (es) 1997-03-29
HU226134B1 (en) 2008-05-28
ZA966773B (en) 1997-02-19
UA45965C2 (uk) 2002-05-15
AR004677A1 (es) 1999-03-10
HUP9602196A2 (en) 1997-05-28
CZ292974B6 (cs) 2004-01-14
CN1148590A (zh) 1997-04-30
PL315611A1 (en) 1997-02-17
HUP9602196A3 (en) 1998-07-28
CA2183050A1 (en) 1997-02-12
JPH0952876A (ja) 1997-02-25
EP0758644A1 (de) 1997-02-19
ATE252075T1 (de) 2003-11-15
PT758644E (pt) 2004-02-27
DE19529612A1 (de) 1997-02-13
DE59610773D1 (de) 2003-11-20
CA2183050C (en) 2008-09-30
AU709800B2 (en) 1999-09-09
NO963340D0 (no) 1996-08-09
CN1071743C (zh) 2001-09-26
SK103396A3 (en) 1997-03-05
SI0758644T1 (en) 2004-04-30
JP3901766B2 (ja) 2007-04-04
HU9602196D0 (en) 1996-10-28
NO306858B1 (no) 2000-01-03
NO963340L (no) 1997-02-12
BR9603377B1 (pt) 2009-01-13
EP0758644B1 (de) 2003-10-15
SK281661B6 (sk) 2001-06-11
PL184320B1 (pl) 2002-10-31
BR9603377A (pt) 1998-05-12
TW432039B (en) 2001-05-01
AU6191796A (en) 1997-02-13

Similar Documents

Publication Publication Date Title
DK0758644T3 (da) Sulfonyl- eller sulfinyl-benzoyl-guanidin-derivater
DK0667341T3 (da) 4-Amino-1-piperidylbenzoylguanidiner som Na+/H+-antiporter-inhibitorer
DE3881489T2 (de) Peptide mit collagenase hemmender wirkung.
DE3776433D1 (de) Antimikrobielle mittel.
GR3029894T3 (en) Heterocyclic substituted benzoylguanidine
RU93004979A (ru) Производное пиколиновой кислоты и гербицидная композиция
FR2431531A1 (fr) Solutions aqueuses concentrees stables au stockage d'azurants optiques contenant des groupes acide sulfonique
ATE172716T1 (de) Arylbenzoylguanidine
HU9602331D0 (en) Alkenyl-benzoyl-guanidine derivatives
ATE178052T1 (de) Alkyl-5-methylsulfonyl-benzoyl-guanidin-derivat
DK0694537T3 (da) Heterocyclyloxy-benzoylguanidinderivater, fremstilling deraf og anvendelse deraf som inhibitorer for den cellulære Na+/H+-antiporter
BR9600151A (pt) Processo para a preparação de 2-cloro piridinas 5-substituídas
NO960112D0 (no) 3-Alkoksykarbonyltiadiazinoner
GR3035097T3 (en) Acyl substituted aminopyrans with a modulating effect on calcium channels
ECSP961641A (es) Derivados de la 4-amino-benzoilguanidina