DK0750747T3 - Identifikation af aminosyrer ved massespektrometri - Google Patents

Identifikation af aminosyrer ved massespektrometri

Info

Publication number
DK0750747T3
DK0750747T3 DK95914051T DK95914051T DK0750747T3 DK 0750747 T3 DK0750747 T3 DK 0750747T3 DK 95914051 T DK95914051 T DK 95914051T DK 95914051 T DK95914051 T DK 95914051T DK 0750747 T3 DK0750747 T3 DK 0750747T3
Authority
DK
Denmark
Prior art keywords
mass
peptide
fragment
predicted
spectrum
Prior art date
Application number
DK95914051T
Other languages
English (en)
Inventor
John R Yates Iii
James K Eng
Andrew J Link
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK0750747T3 publication Critical patent/DK0750747T3/da

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818—Sequencing of polypeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Evolutionary Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Databases & Information Systems (AREA)
  • Diabetes (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Computer Vision & Pattern Recognition (AREA)
DK95914051T 1994-03-14 1995-03-14 Identifikation af aminosyrer ved massespektrometri DK0750747T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/212,433 US5538897A (en) 1994-03-14 1994-03-14 Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
PCT/US1995/003239 WO1995025281A1 (en) 1994-03-14 1995-03-14 Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry

Publications (1)

Publication Number Publication Date
DK0750747T3 true DK0750747T3 (da) 2003-09-29

Family

ID=22790986

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95914051T DK0750747T3 (da) 1994-03-14 1995-03-14 Identifikation af aminosyrer ved massespektrometri

Country Status (9)

Country Link
US (2) US6017693A (da)
EP (2) EP0750747B1 (da)
JP (1) JP3195358B2 (da)
AT (1) ATE241809T1 (da)
CA (1) CA2185574C (da)
DE (1) DE69530915T2 (da)
DK (1) DK0750747T3 (da)
ES (1) ES2199986T3 (da)
WO (1) WO1995025281A1 (da)

Families Citing this family (281)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US20030027216A1 (en) * 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
WO1996037777A1 (en) 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
US20020164818A1 (en) * 1995-05-23 2002-11-07 Gruber Karl F. Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids
US5701256A (en) * 1995-05-31 1997-12-23 Cold Spring Harbor Laboratory Method and apparatus for biological sequence comparison
EP0886681A1 (en) * 1996-03-04 1998-12-30 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
DE19624802A1 (de) 1996-06-21 1998-01-02 Forssmann Wolf Georg Verfahren zum direkten diagnostischen Nachweis von pathogenen, genetisch bedingten Punktmutationen in Proteinen bei Herzerkrankungen durch chemische und physikalische Methoden, besonders der direkten und indirekten Kopplung der Hochdruck-Flüssigkeitschromatographie und der Massenspektrometrie
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US20030129589A1 (en) * 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
AU5794498A (en) 1996-12-10 1998-07-03 Genetrace Systems, Inc. Releasable nonvolatile mass-label molecules
GB9710582D0 (en) * 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
US5824556A (en) * 1997-06-11 1998-10-20 Tarr; George E. Peptide mass ladders generated using carbon disulfide
NZ516848A (en) 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
EP0991930B1 (en) * 1997-06-26 2004-06-16 Perseptive Biosystems, Inc. High density sample holder for analysis of biological samples
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6492491B1 (en) 1997-10-31 2002-12-10 University Of Florida Research Foundation Method of making hypusine peptides
EP1032586A4 (en) * 1997-11-21 2000-11-15 Univ Florida PEPTIDES CONTAINING HYPUSINE
GB9800378D0 (en) * 1998-01-08 1998-03-04 Univ Liverpool Proteome analysis
EP2189791A3 (en) * 1998-02-04 2011-03-09 Life Technologies Corporation Microarrays and uses therefor
US6379971B1 (en) * 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6191418B1 (en) 1998-03-27 2001-02-20 Synsorb Biotech, Inc. Device for delivery of multiple liquid sample streams to a mass spectrometer
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
ATE536422T1 (de) 1998-08-25 2011-12-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
WO2000013025A1 (en) * 1998-08-31 2000-03-09 University Of Washington Stable isotope metabolic labeling for analysis of biopolymers
US20120244594A9 (en) 1998-09-04 2012-09-27 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
GB9821393D0 (en) * 1998-10-01 1998-11-25 Brax Genomics Ltd Protein profiling 2
US6593084B2 (en) * 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
GB9824444D0 (en) * 1998-11-06 1999-01-06 Univ Manchester Metropolitan Micro-Organism identification
US7020559B1 (en) * 1998-11-17 2006-03-28 University Of Maryland Methods for identifying and classifying organisms by mass spectrometry and database searching
WO2000029987A1 (en) * 1998-11-17 2000-05-25 University Of Maryland Methods for identifying and classifying organisms by mass spectrometry and database searching
AU2710700A (en) * 1998-12-16 2000-07-03 Sequel Genetics, Incorporated Methods and products for peptide-based dna sequence characterization and analysis
US7297545B2 (en) * 1999-01-30 2007-11-20 Pediatrix Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry and internal standards therefor
US7238531B2 (en) 1999-01-30 2007-07-03 Pediatrix Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US6258605B1 (en) 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6629040B1 (en) 1999-03-19 2003-09-30 University Of Washington Isotope distribution encoded tags for protein identification
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6489121B1 (en) 1999-04-06 2002-12-03 Micromass Limited Methods of identifying peptides and proteins by mass spectrometry
DE60026452T2 (de) 1999-04-06 2006-08-10 Micromass Uk Ltd. Verfahren zur Identifizierung von Peptidensequenzen und Proteinensequenzen mittels Massenspektromterie
US6764817B1 (en) * 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6716636B1 (en) * 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
AU774662B2 (en) * 1999-04-20 2004-07-01 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
WO2000073787A1 (en) * 1999-05-27 2000-12-07 Rockefeller University An expert system for protein identification using mass spectrometric information combined with database searching
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7668658B2 (en) * 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US6528784B1 (en) 1999-12-03 2003-03-04 Thermo Finnigan Llc Mass spectrometer system including a double ion guide interface and method of operation
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
WO2001056955A1 (en) * 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Nonredundant split/pool synthesis of combinatorial libraries
JP2003532117A (ja) * 2000-04-13 2003-10-28 サーモ フィニガン リミテッド ライアビリティ カンパニー 並列質量分析によるプロテオミクス解析
US8399383B2 (en) * 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
EP1303760A2 (en) * 2000-05-09 2003-04-23 DGI BioTechnologies, Inc. Methods of identifying the activity of gene products
US7158862B2 (en) * 2000-06-12 2007-01-02 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method and system for mining mass spectral data
JP2004503780A (ja) 2000-06-12 2004-02-05 ユニバーシティ　オブ　ワシントン リンペプチドの選択的標識および単離ならびにプロテオーム分析への適用
AU2001268468A1 (en) 2000-06-13 2001-12-24 The Trustees Of Boston University Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
GB0014342D0 (en) * 2000-06-13 2000-08-02 Scient Analysis Instr Limited Method of analysis
SE517259C2 (sv) * 2000-06-14 2002-05-14 Jan Eriksson System för molekylidentifiering
WO2002004628A2 (en) * 2000-07-06 2002-01-17 Genvec, Inc. Method of identifying a binding partner of a gene product
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
DE10038694C2 (de) * 2000-07-28 2003-09-25 Anagnostec Ges Fuer Analytisch Verfahren zur Identifizierung von Mikroorganismen mittels MALDI-TOF-MS
US6539102B1 (en) 2000-09-01 2003-03-25 Large Scale Proteomics Reference database
US6980674B2 (en) * 2000-09-01 2005-12-27 Large Scale Proteomics Corp. Reference database
AU2001288501A1 (en) * 2000-09-01 2002-03-22 Large Scale Proteomics Corporation Reference database
US6963807B2 (en) 2000-09-08 2005-11-08 Oxford Glycosciences (Uk) Ltd. Automated identification of peptides
WO2002025265A1 (fr) * 2000-09-20 2002-03-28 Hitachi, Ltd. Procede de sondage faisant intervenir un spectrometre de masse a piege ionique et dispositif de sondage
US6902938B1 (en) * 2000-10-10 2005-06-07 Jeol Usa, Inc. Chemical analysis method for multiplexed samples
IL138946A0 (en) * 2000-10-11 2001-11-25 Compugen Ltd Method for the identification of peptides and proteins
WO2002031484A2 (en) * 2000-10-11 2002-04-18 Ciphergen Biosystems, Inc. Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry
AU2002246744B2 (en) * 2000-10-19 2008-04-10 Target Discovery, Inc. Methods for determining protein and peptide terminal sequences
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
CA2429824A1 (en) * 2000-11-28 2002-06-06 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
US20020120404A1 (en) * 2000-12-21 2002-08-29 Parker Kenneth C. Methods and apparatus for mass fingerprinting of biomolecules
US20020090652A1 (en) * 2000-12-22 2002-07-11 Fu Emil Wei-Ming Inverse labeling method for the rapid identification of marker/target proteins
US20020119490A1 (en) * 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US20030009293A1 (en) * 2001-01-09 2003-01-09 Anderson Norman G. Reference database
US7166436B2 (en) * 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US6969757B2 (en) * 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
WO2002061047A2 (en) * 2001-02-01 2002-08-08 Ciphergen Biosystems, Inc. Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) * 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
CA2440582A1 (en) * 2001-03-09 2002-10-03 Dyax Corp. Serum albumin binding moieties
US20030031350A1 (en) * 2001-03-09 2003-02-13 Pe Corporation (Ny) Methods for large scale protein matching
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US7314717B2 (en) 2001-04-30 2008-01-01 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1562 daltons
US20040224423A1 (en) * 2001-04-30 2004-11-11 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 2056 daltons
US6602855B2 (en) * 2001-04-30 2003-08-05 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1449 daltons
US6627608B2 (en) 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1206 daltons
US6617308B2 (en) 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
US20020160532A1 (en) * 2001-04-30 2002-10-31 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1998 daltons
US20020160417A1 (en) * 2001-04-30 2002-10-31 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1424 daltons
US20040198950A1 (en) * 2001-04-30 2004-10-07 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1518 daltons
US6593298B2 (en) * 2001-04-30 2003-07-15 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1690 daltons
US6620786B2 (en) 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having molecular weight of 2937 daltons
US20020160418A1 (en) * 2001-04-30 2002-10-31 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1949 daltons
US20020160434A1 (en) * 2001-04-30 2002-10-31 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1777 daltons
US6627607B2 (en) 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1845 daltons
US6620787B2 (en) 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2267 daltons
US6693080B2 (en) 2001-04-30 2004-02-17 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1521 daltons
US6627606B2 (en) 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1465 daltons
US20020160533A1 (en) * 2001-04-30 2002-10-31 George Jackowski Biopolymer marker indicative of disease state having a molecular of weight of 1525 daltons
US6998243B2 (en) 2001-04-30 2006-02-14 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1793 daltons
US7049397B2 (en) * 2001-04-30 2006-05-23 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1211 daltons
US6890763B2 (en) * 2001-04-30 2005-05-10 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1350 daltons
US6703366B2 (en) * 2001-04-30 2004-03-09 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1,896 daltons
US6599877B2 (en) * 2001-04-30 2003-07-29 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1020 daltons
US7294688B2 (en) 2001-04-30 2007-11-13 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
US20030040602A1 (en) * 2001-04-30 2003-02-27 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1406 daltons
US7008800B2 (en) * 2001-04-30 2006-03-07 Artemis Proteomics, Ltd. Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons
US20020160423A1 (en) * 2001-04-30 2002-10-31 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1536 daltons
US6677303B2 (en) 2001-04-30 2004-01-13 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1097 daltons
US7087435B2 (en) * 2001-04-30 2006-08-08 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2753 daltons
US6756476B2 (en) * 2001-04-30 2004-06-29 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2021 daltons
US7045296B2 (en) * 2001-05-08 2006-05-16 Applera Corporation Process for analyzing protein samples
GB0112428D0 (en) * 2001-05-22 2001-07-11 Secr Defence Brit Identifying micro-organisms
US20050130222A1 (en) * 2001-05-25 2005-06-16 Lee Peter J.J. Sample concentration maldi plates for maldi mass spectrometry
CA2349265A1 (en) * 2001-05-30 2002-11-30 Andrew Emili Protein expression profile database
US20020194201A1 (en) * 2001-06-05 2002-12-19 Wilbanks John Thompson Systems, methods and computer program products for integrating biological/chemical databases to create an ontology network
US20020194154A1 (en) * 2001-06-05 2002-12-19 Levy Joshua Lerner Systems, methods and computer program products for integrating biological/chemical databases using aliases
AU2002312446A1 (en) * 2001-06-12 2002-12-23 Mds Proteomics, Inc. Improved proteomic analysis
US20110111424A1 (en) 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
WO2004094996A2 (en) * 2001-07-12 2004-11-04 Duke University System and method for determining differential protein expression, diagnostic biomarker discovery system and method of using the same, and protein biomarkers and therapeutic and diagnostic uses thereof
CA2453725A1 (en) * 2001-07-13 2003-01-23 Syngenta Participations Ag System and method of determining proteomic differences
US20030036207A1 (en) * 2001-07-13 2003-02-20 Washburn Michael P. System and method for storing mass spectrometry data
US6800449B1 (en) * 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
US7133864B2 (en) 2001-08-23 2006-11-07 Syngenta Participations Ag System and method for accessing biological data
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
AT410983B (de) * 2001-09-14 2003-09-25 Huber Christian G Dr Verfahren zur ermittlung der sequenz von nukleinsäuren
DE10145904A1 (de) * 2001-09-18 2003-04-10 Bruker Daltonik Gmbh Verfahren zur Aufklärung des Metabolismus
CA2460568A1 (en) * 2001-09-21 2003-03-27 Caprion Pharmaceuticals Inc. Preparation of highly-purified plasma membranes
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
AU2002347462A1 (en) * 2001-11-01 2003-05-12 Biobridge Computing Ab A computer system and method using mass spectrometry data and a protein database for identifying unknown proteins
US20030139885A1 (en) * 2001-11-05 2003-07-24 Irm, Llc Methods and devices for proteomics data complexity reduction
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US7179605B2 (en) 2001-11-23 2007-02-20 Nanogen Inc. Fibronectin precursor biopolymer markers indicative of alzheimer's disease
US6946653B2 (en) 2001-11-27 2005-09-20 Ciphergen Biosystems, Inc. Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
GB2385918B (en) * 2001-12-08 2004-05-26 Micromass Ltd Method of mass spectrometry
GB2396914B (en) * 2001-12-08 2005-06-22 Micromass Ltd Method of mass spectrometry
ATE427495T1 (de) * 2001-12-11 2009-04-15 Univ New Jersey Med Diagnoseverfahren fur proteinprofilierung
US6998608B2 (en) * 2002-02-08 2006-02-14 Ionalytics Corporation FAIMS with non-destructive detection of selectively transmitted ions
AU2002323683A1 (en) * 2002-03-01 2003-09-16 Applera Corporation Method for protein identification using mass spectrometry data
CA2476412C (en) 2002-03-22 2008-02-19 Phenomenome Discoveries Inc. Method of visualizing non-targeted metabolomic data generated from fourier transform ion cyclotron resonance mass spectrometers
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
WO2003093296A2 (en) * 2002-05-03 2003-11-13 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
AU2003299466A1 (en) * 2002-05-03 2004-06-07 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
CA2484625A1 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
US8116981B2 (en) * 2002-05-28 2012-02-14 California Institute Of Technology Detector using mass spectroscopy for characterization of biological community
US20040044481A1 (en) * 2002-05-31 2004-03-04 Halpern Benjamin R. Method for protein identification using mass spectrometry data
WO2003106493A1 (en) * 2002-06-14 2003-12-24 Dyax Corporation Protein analysis
JP3743717B2 (ja) * 2002-06-25 2006-02-08 株式会社日立製作所 質量分析データの解析方法および質量分析データの解析装置および質量分析データの解析プログラムならびにソリューション提供システム
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US7409296B2 (en) * 2002-07-29 2008-08-05 Geneva Bioinformatics (Genebio), S.A. System and method for scoring peptide matches
WO2004019003A2 (en) * 2002-08-23 2004-03-04 Efeckta Technologies Corporation Image processing of mass spectrometry data for using at multiple resolutions
US6891154B2 (en) * 2002-08-30 2005-05-10 Syn X Pharma, Inc. Amino acid sequence pattern matching
FR2844357A1 (fr) * 2002-09-10 2004-03-12 Centre Nat Rech Scient Procede de determination de molecules branchees a partir de donnees de masse
CA2502246A1 (en) * 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
US6944549B2 (en) * 2002-10-25 2005-09-13 Syngenta Participations Ag Method and apparatus for automated detection of peaks in spectroscopic data
US20040096982A1 (en) * 2002-11-19 2004-05-20 International Business Machines Corporation Methods and apparatus for analysis of mass spectra
EP1578399A4 (en) 2002-12-06 2007-11-28 Isis Pharmaceuticals Inc METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND BEETS
GB2414287B (en) * 2002-12-09 2007-08-15 Waters Investments Ltd Peltier based freeze-thaw valves and method of use
JP3885020B2 (ja) * 2002-12-09 2007-02-21 株式会社日立製作所 化合物構造解析システム，質量分析データ解析方法，質量分析データ解析装置及び質量分析データ解析プログラム
US20040121477A1 (en) * 2002-12-20 2004-06-24 Thompson Dean R. Method for improving data dependent ion selection in tandem mass spectroscopy of protein digests
US20040234952A1 (en) * 2003-01-07 2004-11-25 Wibke Kallow Process for identifying microoraganisms by means of mass spectrometry
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
AU2003290773A1 (en) * 2003-02-05 2004-09-06 Ciphergen Biosystems, Inc. Non-invasive assessment of intra-amniotic environment
JP3817523B2 (ja) * 2003-02-14 2006-09-06 株式会社日立製作所 質量分析データ解析システム
KR100496886B1 (ko) * 2003-02-28 2005-06-23 삼성전자주식회사 확장된 플레이트 전극을 갖는 강유전체 기억소자 및 그제조방법
US20070141570A1 (en) * 2003-03-07 2007-06-21 Sequenom, Inc. Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
US7457708B2 (en) * 2003-03-13 2008-11-25 Agilent Technologies Inc Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components
US8507285B2 (en) * 2003-03-13 2013-08-13 Agilent Technologies, Inc. Methods and devices for identifying biopolymers using mass spectroscopy
EP1606757A1 (en) * 2003-03-25 2005-12-21 Institut Suisse de Bioinformatique Method for comparing proteomes
US7529629B2 (en) * 2003-04-28 2009-05-05 Cerno Bioscience Llc Computational methods and systems for multidimensional analysis
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
WO2004109449A2 (en) * 2003-05-30 2004-12-16 Novatia, Llc Analysis of data from a mass spectrometer
WO2004108948A2 (en) * 2003-06-04 2004-12-16 President And Fellows Of Harvard College Systems, methods and kits for characterizing phosphoproteomes
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
EP1648911A1 (en) * 2003-06-11 2006-04-26 Proteome Systems Intellectual Property Pty Ltd. Method of identifying glycan structures using mass spectrometer data
US7072772B2 (en) * 2003-06-12 2006-07-04 Predicant Bioscience, Inc. Method and apparatus for modeling mass spectrometer lineshapes
US20050255606A1 (en) * 2004-05-13 2005-11-17 Biospect, Inc., A California Corporation Methods for accurate component intensity extraction from separations-mass spectrometry data
US7691643B2 (en) 2003-06-23 2010-04-06 Hitachi High-Technologies Corporation Mass analysis method and mass analysis apparatus
US20050074816A1 (en) * 2003-07-07 2005-04-07 Duncan Mark W. Method for protein identification from tandem mass spectral employing both spectrum comparison and de novo sequencing for biomedical applications
US20050060652A1 (en) * 2003-07-07 2005-03-17 David Chazin Interactive system for performing automated protein identification from mass spectrometry data
US20050267689A1 (en) * 2003-07-07 2005-12-01 Maxim Tsypin Method to automatically identify peak and monoisotopic peaks in mass spectral data for biomolecular applications
WO2005011576A2 (en) * 2003-07-25 2005-02-10 Beyond Genomics, Inc. Digital chromatography
GB2404981A (en) * 2003-08-15 2005-02-16 Univ Geneve Diagnostic method for stroke
CN1864068B (zh) * 2003-08-18 2010-10-13 特提斯生物科学公司 用小表位抗体降低样品复杂度的方法
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US20050133712A1 (en) * 2003-12-18 2005-06-23 Predicant Biosciences, Inc. Scan pipelining for sensitivity improvement of orthogonal time-of-flight mass spectrometers
US20070148720A1 (en) * 2003-12-19 2007-06-28 Hiroaki Torii Method of identifying protein with the use of mass spectometry
US20060030053A1 (en) * 2003-12-19 2006-02-09 Applera Corporation Methods and systems for protein and peptide evidence assembly
EP1700129B1 (en) * 2003-12-23 2007-11-28 Roche Diagnostics GmbH Method of assessing rheumatoid arthritis by measuring anti-ccp and interleukin 6
WO2005069934A2 (en) * 2004-01-20 2005-08-04 Mcw Research Foundation, Inc. Peptide identification
US20050192755A1 (en) * 2004-02-27 2005-09-01 Srinivasa Nagalla Methods and systems for identification of macromolecules
US20050196809A1 (en) * 2004-03-05 2005-09-08 Kelleher Neil L. Identification and characterization of proteins using new database search modes
US6958473B2 (en) * 2004-03-25 2005-10-25 Predicant Biosciences, Inc. A-priori biomarker knowledge based mass filtering for enhanced biomarker detection
AU2005230936B2 (en) 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
DE112005001166B4 (de) * 2004-05-20 2014-10-09 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren und Vorrichtung zum Identifizieren von Proteinen in Gemischen
US7962489B1 (en) 2004-07-08 2011-06-14 Sage-N Research, Inc. Indexing using contiguous, non-overlapping ranges
EP1778874B1 (en) 2004-07-30 2011-11-23 Adeza Biomedical Corporation Oncofetal fibronectin as a marker for cervical cancer
DE102004051016A1 (de) * 2004-10-20 2006-05-04 Protagen Ag Verfahren und System zur Aufklärung der Primärstruktur von Biopolymeren
JP4541122B2 (ja) * 2004-12-10 2010-09-08 株式会社メディカル・プロテオスコープ 質量分析法を用いたアミノ酸配列同定方法
EP2290369B1 (en) 2004-12-22 2013-08-14 California Institute Of Technology Methods for proteomic profiling using non-natural amino acids
JP4620446B2 (ja) * 2004-12-24 2011-01-26 株式会社日立ハイテクノロジーズ 質量分析方法、質量分析システム、診断システム、検査システム及び質量分析プログラム
US7765068B2 (en) * 2005-01-31 2010-07-27 The Board Of Trustees Of The University Of Illinois Identification and characterization of protein fragments
GB0503411D0 (en) * 2005-02-18 2005-03-30 Shimadzu Res Lab Europe Ltd Mass spectrometry precursor ion selection
JP4505589B2 (ja) * 2005-03-15 2010-07-21 独立行政法人産業技術総合研究所 周期判定装置、周期判定方法および周期判定プログラム
US9097723B2 (en) * 2005-04-01 2015-08-04 Caliper Life Sciences, Inc. Method and apparatus for performing peptide digestion on a microfluidic device
TW200720653A (en) * 2005-04-13 2007-06-01 Nat Inst Of Advanced Ind Scien Method of forecasting sugar chain structure
US7801684B2 (en) * 2005-04-22 2010-09-21 Syngenta Participations Ag Methods, systems, and computer program products for producing theoretical mass spectral fragmentation patterns of chemical structures
US7297940B2 (en) * 2005-05-03 2007-11-20 Palo Alto Research Center Incorporated Method, apparatus, and program product for classifying ionized molecular fragments
US20060249668A1 (en) * 2005-05-05 2006-11-09 Palo Alto Research Center Incorporated Automatic detection of quality spectra
US7230235B2 (en) * 2005-05-05 2007-06-12 Palo Alto Research Center Incorporated Automatic detection of quality spectra
JP4522910B2 (ja) 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ 質量分析方法及び質量分析装置
WO2006133191A2 (en) * 2005-06-03 2006-12-14 Waters Investments Limited Methods and apparatus for performing retention-time matching
JP5011283B2 (ja) * 2005-06-03 2012-08-29 ウオーターズ・テクノロジーズ・コーポレイシヨン 化学分析のためのポリペプチド関連情報のカタログの発生および使用
KR100805775B1 (ko) * 2005-08-08 2008-02-21 한국기초과학지원연구원 변형된 폴리펩티드(Ｍｏｄｉｆｉｅｄｐｏｌｙｐｅｐｔｉｄｅ)의 서열 및 변형 정보를 분석하는방법
JP4644560B2 (ja) * 2005-08-09 2011-03-02 株式会社日立ハイテクノロジーズ 質量分析システム
SG182169A1 (en) 2005-09-12 2012-07-30 Phenomenome Discoveries Inc Method for the diagnosis of colorectal cancer and ovarian cancer by the measurement of vitamin e-related metabolites
EP1762629B1 (en) 2005-09-12 2009-11-11 Roche Diagnostics GmbH Detection of biological DNA
US7662400B2 (en) * 2005-10-14 2010-02-16 Mayo Foundation For Medical Education And Research Fungus-induced inflammation and eosinophil degranulation
DE102005050114A1 (de) * 2005-10-18 2007-04-19 Studiengesellschaft Kohle Mbh Analyse von Stoffgemischen
US7781729B2 (en) * 2006-05-26 2010-08-24 Cerno Bioscience Llc Analyzing mass spectral data
US7429727B2 (en) * 2005-12-13 2008-09-30 Palo Alto Research Center Incorporated Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
US8108153B2 (en) * 2005-12-13 2012-01-31 Palo Alto Research Center Incorporated Method, apparatus, and program product for creating an index into a database of complex molecules
FR2895834B1 (fr) * 2006-01-03 2012-11-02 Physikron Procede et systeme de spectrometrie de masse en tandem sans selection de masse primaire et a temps de vol,pour des ions multicharges
JP4782579B2 (ja) * 2006-02-15 2011-09-28 株式会社日立ハイテクノロジーズ タンデム型質量分析システム及び方法
WO2008076139A1 (en) * 2006-03-10 2008-06-26 Tethys Bioscience, Inc. Multiplex protein fractionation
US7736905B2 (en) 2006-03-31 2010-06-15 Biodesix, Inc. Method and system for determining whether a drug will be effective on a patient with a disease
US8758991B2 (en) * 2006-04-26 2014-06-24 University Of Louisville Research Foundation, Inc. Isolation of membrane vesicles from biological fluids and methods of using same
US20070282537A1 (en) * 2006-05-26 2007-12-06 The Ohio State University Rapid characterization of post-translationally modified proteins from tandem mass spectra
SG137718A1 (en) * 2006-05-26 2007-12-28 Nanyang Polytechnic System and method for mass spectrometry data search using adapted quantum grover algorithm
CA2656481C (en) * 2006-07-03 2016-04-05 Physikron Method and system of tandem mass spectrometry without primary mass selection for multicharged ions
JP5535622B2 (ja) * 2006-07-03 2014-07-02 フィジクロン 多帯電イオンのための一次質量選択を行わないタンデム質量分光測定の方法および装置
US20150232540A1 (en) 2006-07-11 2015-08-20 Cell Signaling Technology, Inc. Analysis of ubiquitnated polypeptides
US20080073499A1 (en) * 2006-07-25 2008-03-27 George Yefchak Peak finding in low-resolution mass spectrometry by use of chromatographic integration routines
US20080097183A1 (en) * 2006-09-06 2008-04-24 Donald Martin Monro Passive in vivo substance spectroscopy
JP4811466B2 (ja) * 2006-11-15 2011-11-09 株式会社島津製作所 質量分析方法及び質量分析装置
US20110224104A1 (en) * 2007-04-13 2011-09-15 Science & Engineering Services, Inc. Method and system for indentification of microorganisms
WO2008142170A1 (en) * 2007-05-24 2008-11-27 Physikron Method and system of tandem mass spectrometry without primary mass selection with secondary ionization of dissociated neutral fragments.
US7555393B2 (en) * 2007-06-01 2009-06-30 Thermo Finnigan Llc Evaluating the probability that MS/MS spectral data matches candidate sequence data
WO2009080833A2 (en) * 2007-12-26 2009-07-02 Physikron Method and system of tandem mass spectrometry without primary mass selection for monocharged ions
US7698098B2 (en) * 2008-02-18 2010-04-13 Thermo Electron Scientific Instruments Llc Efficient spectral matching, particularly for multicomponent spectra
US9671408B2 (en) * 2008-11-18 2017-06-06 Protein Metrics Inc. Wild-card-modification search technique for peptide identification
US20100173791A1 (en) * 2009-01-05 2010-07-08 Bio-Rad Laboratories, Inc. Process design using mass spectrometry
JP5782021B2 (ja) 2009-04-02 2015-09-24 ノボザイムス アクティーゼルスカブ 乳由来タンパク質加水分解物の製法
US8395113B2 (en) 2009-05-08 2013-03-12 Thermo Finnigan Llc Methods and systems for matching product ions to precursor in tandem mass spectrometry
KR101114228B1 (ko) * 2009-06-01 2012-03-05 한국기초과학지원연구원 데이터 비의존성 분석법과 데이터 의존성 분석법을 복합화한 단백질 분석방법
WO2011106084A1 (en) * 2010-02-24 2011-09-01 Biodesix, Inc. Cancer patient selection for administration of therapeutic agents using mass spectral analysis
US8486707B2 (en) 2010-04-26 2013-07-16 Agilent Technologies, Inc. Method of oligonucleotide sequencing by mass spectrometry
US9530633B2 (en) * 2010-05-25 2016-12-27 Agilent Technologies, Inc. Method for isomer discrimination by tandem mass spectrometry
JP5768983B2 (ja) * 2010-06-09 2015-08-26 日本電気株式会社 契約違反予測システム、契約違反予測方法および契約違反予測プログラム
WO2012095948A1 (ja) * 2011-01-11 2012-07-19 株式会社島津製作所 質量分析データ解析方法、質量分析データ解析装置、及び質量分析データ解析用プログラム
DE102012102875B4 (de) 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
US8536524B2 (en) * 2011-10-06 2013-09-17 Schlumberger Technology Corporation Fast mud gas logging using tandem mass spectroscopy
DE102012100781B4 (de) * 2012-01-31 2013-08-14 Eberhard-Karls-Universität Tübingen Universitätsklinikum Forensisches Verfahren
RU2673551C2 (ru) * 2012-11-12 2018-11-28 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича" Российской академии медицинских наук (ФГБУ "ИБМХ" РАМН) Протеотипический пептид q9y4w6-02 и способ масс-спектрометрического анализа содержания afg3-подобного белка человека на его основе
EP2929339A4 (en) * 2012-11-15 2016-06-01 Dh Technologies Dev Pte Ltd SYSTEMS AND METHOD FOR IDENTIFYING CONNECTIONS FROM MS / MS DATA WITHOUT PRIORITIES INFORMATION
US10141169B2 (en) 2012-11-15 2018-11-27 Dh Technologies Development Pte. Ltd. Systems and methods for identifying compounds from MS/MS data without precursor ion information
JP6065652B2 (ja) * 2013-03-01 2017-01-25 株式会社島津製作所 糖鎖構造解析方法及び装置
CN103245714B (zh) * 2013-03-25 2015-04-29 暨南大学 基于候选肽段区分度标记图谱的蛋白质二级质谱鉴定方法
JP6079439B2 (ja) 2013-05-29 2017-02-15 株式会社島津製作所 タンパク質又はペプチドの分析方法及び分析装置
CN104182658B (zh) * 2014-08-06 2017-05-03 中国科学院计算技术研究所 一种串联质谱谱图鉴定方法
GB201417387D0 (en) 2014-10-01 2014-11-12 Micromass Ltd Haemoglobin variant analysis using pseudo MS/MS/MS via atmospheric pressures elctron capture dissociation ("AP-ECD") and collision induced dissociation("CID")
DK3082056T4 (da) * 2015-04-14 2022-05-02 Peaccel Fremgangsmåde og elektronisk system til forudsigelse af mindst en fitnessværdi af et protein, relateret computerprogramprodukt
CN105758928B (zh) * 2016-02-26 2019-04-30 中国科学院计算技术研究所 一种糖结构鉴定方法及糖结构鉴定装置
CN107271575B (zh) * 2016-04-08 2020-01-14 株式会社岛津制作所 离子迁移谱和质谱并行分析的方法及装置
JP6710407B2 (ja) 2016-04-20 2020-06-17 広州吉嗣利嬰児用品有限公司 多用途の折り畳み式家具
WO2018067772A1 (en) * 2016-10-07 2018-04-12 Thermo Finnigan Llc System and method for real-time isotope identification
WO2019173687A1 (en) * 2018-03-08 2019-09-12 The Trustees Of Indiana University Constrained de novo sequencing of neo-epitope peptides using tandem mass spectrometry
GB2572319A (en) * 2018-03-12 2019-10-02 Imperial College Sci Tech & Medicine Methods and systems for analysis
US10878944B2 (en) 2018-03-23 2020-12-29 Thermo Finnigan Llc Methods for combining predicted and observed mass spectral fragmentation data
CN108572214B (zh) * 2018-05-18 2020-06-05 西南大学 一种基于家蚕组织样品进行大规模蛋白质组学鉴定的方法
WO2020128538A1 (en) 2018-12-19 2020-06-25 Rudjer Boskovic Institute Novel method for identification of viruses and diagnostic kit using the same
IL303893A (en) 2019-08-05 2023-08-01 Seer Inc Systems and methods for sample preparation, data generation and corona protein analysis
CN116825198B (zh) * 2023-07-14 2024-05-10 湖南工商大学 基于图注意机制的肽序列标签鉴定方法

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US5240859A (en) * 1991-02-22 1993-08-31 B.R. Centre Limited Methods for amino acid sequencing of a polypeptide
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