ATE445227T1 - Methoden und apparat für die massenspektrometrie - Google Patents
Methoden und apparat für die massenspektrometrieInfo
- Publication number
- ATE445227T1 ATE445227T1 AT05025116T AT05025116T ATE445227T1 AT E445227 T1 ATE445227 T1 AT E445227T1 AT 05025116 T AT05025116 T AT 05025116T AT 05025116 T AT05025116 T AT 05025116T AT E445227 T1 ATE445227 T1 AT E445227T1
- Authority
- AT
- Austria
- Prior art keywords
- ions
- parent
- daughter
- mode
- mass spectra
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004949 mass spectrometry Methods 0.000 title 1
- 150000002500 ions Chemical class 0.000 abstract 12
- 238000001819 mass spectrum Methods 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
- H01J49/4215—Quadrupole mass filters
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0014062A GB0014062D0 (en) | 2000-06-09 | 2000-06-09 | Methods and apparatus for tandem mass spectrometry |
| GB0101048A GB0101048D0 (en) | 2001-01-15 | 2001-01-15 | Methods and apparatus for tandem mass spectrometry |
| GB0105227A GB2364168B (en) | 2000-06-09 | 2001-03-02 | Methods and apparatus for mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445227T1 true ATE445227T1 (de) | 2009-10-15 |
Family
ID=26244455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05025116T ATE445227T1 (de) | 2000-06-09 | 2001-06-11 | Methoden und apparat für die massenspektrometrie |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6586727B2 (de) |
| EP (2) | EP2299469B1 (de) |
| JP (1) | JP5154511B2 (de) |
| AT (1) | ATE445227T1 (de) |
| DE (2) | DE60140150D1 (de) |
| GB (1) | GB2364168B (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020115056A1 (en) | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US7038197B2 (en) * | 2001-04-03 | 2006-05-02 | Micromass Limited | Mass spectrometer and method of mass spectrometry |
| US6777671B2 (en) * | 2001-04-10 | 2004-08-17 | Science & Engineering Services, Inc. | Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same |
| JP2005526962A (ja) * | 2002-02-28 | 2005-09-08 | メタノミクス ゲーエムベーハー ウント ツェーオー.カーゲーアーアー | 物質の混合物を分析する質量分析方法 |
| JP4312708B2 (ja) * | 2002-04-29 | 2009-08-12 | エムディーエス インコーポレイテッド ドゥーイング ビジネス アズ エムディーエス サイエックス | 衝突エネルギーを変化させることによる質量分析における広いイオンフラグメント化範囲を得る方法 |
| US6770871B1 (en) * | 2002-05-31 | 2004-08-03 | Michrom Bioresources, Inc. | Two-dimensional tandem mass spectrometry |
| GB0305796D0 (en) * | 2002-07-24 | 2003-04-16 | Micromass Ltd | Method of mass spectrometry and a mass spectrometer |
| US20060076482A1 (en) * | 2002-12-13 | 2006-04-13 | Hobbs Steven E | High throughput systems and methods for parallel sample analysis |
| US6987263B2 (en) * | 2002-12-13 | 2006-01-17 | Nanostream, Inc. | High throughput systems and methods for parallel sample analysis |
| JP3816883B2 (ja) * | 2003-03-06 | 2006-08-30 | 株式会社日立ハイテクノロジーズ | 液体クロマトグラフ質量分析装置 |
| US7041968B2 (en) * | 2003-03-20 | 2006-05-09 | Science & Technology Corporation @ Unm | Distance of flight spectrometer for MS and simultaneous scanless MS/MS |
| US7009174B2 (en) * | 2003-04-09 | 2006-03-07 | Mds Inc. | Dynamic background signal exclusion in chromatography/mass spectrometry data-dependent, data acquisition |
| US20050227251A1 (en) | 2003-10-23 | 2005-10-13 | Robert Darnell | Method of purifying RNA binding protein-RNA complexes |
| US20060186028A1 (en) * | 2004-02-06 | 2006-08-24 | Micromass Uk Limited | Mass spectrometer |
| DE112005001385T5 (de) * | 2004-06-15 | 2007-05-10 | Griffin analytical Technologies Inc., West Lafayette | Analyseinstrumente, -baugruppen und -verfahren |
| GB0416288D0 (en) | 2004-07-21 | 2004-08-25 | Micromass Ltd | Mass spectrometer |
| US8680461B2 (en) | 2005-04-25 | 2014-03-25 | Griffin Analytical Technologies, L.L.C. | Analytical instrumentation, apparatuses, and methods |
| US7417223B2 (en) * | 2005-10-28 | 2008-08-26 | Mds Inc. | Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences |
| GB2432712B (en) * | 2005-11-23 | 2007-12-27 | Micromass Ltd | Mass spectrometer |
| EP1971998B1 (de) * | 2006-01-11 | 2019-05-08 | DH Technologies Development Pte. Ltd. | Fragmentierung von ionen in der massenspektrometrie |
| CA2639903C (en) | 2006-04-13 | 2012-01-03 | Thermo Fisher Scientific (Bremen) Gmbh | Ion energy spread reduction for mass spectrometer |
| GB0607542D0 (en) | 2006-04-13 | 2006-05-24 | Thermo Finnigan Llc | Mass spectrometer |
| GB0609253D0 (en) * | 2006-05-10 | 2006-06-21 | Micromass Ltd | Mass spectrometer |
| US8180576B2 (en) * | 2006-05-11 | 2012-05-15 | Shimadzu Corporation | Data processor for mass spectrometer |
| US7992424B1 (en) | 2006-09-14 | 2011-08-09 | Griffin Analytical Technologies, L.L.C. | Analytical instrumentation and sample analysis methods |
| US7511267B2 (en) * | 2006-11-10 | 2009-03-31 | Thermo Finnigan Llc | Data-dependent accurate mass neutral loss analysis |
| EP1933366B1 (de) * | 2006-12-14 | 2019-06-12 | Tofwerk AG | Vorrichtung zur Massenanalyse von Ionen |
| EP1933365A1 (de) * | 2006-12-14 | 2008-06-18 | Tofwerk AG | Vorrichtung zur Massenanalyse von Ionen |
| EP1968100B1 (de) * | 2007-03-08 | 2014-04-30 | Tofwerk AG | Ionenführungskammer |
| JP5579161B2 (ja) * | 2008-03-20 | 2014-08-27 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 質量分析計を用いて物質を分析するシステムおよび方法 |
| DE102008025972B4 (de) * | 2008-05-30 | 2018-11-29 | Bruker Daltonik Gmbh | Verfahren zur Messung der Mobilität massenspektrometrisch ausgewählter Ionensorten |
| WO2010032276A1 (ja) * | 2008-09-16 | 2010-03-25 | 株式会社島津製作所 | 飛行時間型質量分析装置 |
| WO2010135829A1 (en) * | 2009-05-27 | 2010-12-02 | Dh Technologies Development Pte. Ltd. | Method for high efficiency tandem mass spectrometry |
| GB0915474D0 (en) * | 2009-09-04 | 2009-10-07 | Micromass Ltd | Multiple reaction monitoring with a time-of-flight based mass spectrometer |
| GB0919870D0 (en) * | 2009-11-13 | 2009-12-30 | Micromass Ltd | A method to detect and quantitatively profile organic species using a mass spectrometer |
| JP5314603B2 (ja) * | 2010-01-15 | 2013-10-16 | 日本電子株式会社 | 飛行時間型質量分析装置 |
| US8455818B2 (en) | 2010-04-14 | 2013-06-04 | Wisconsin Alumni Research Foundation | Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation |
| US8809770B2 (en) * | 2010-09-15 | 2014-08-19 | Dh Technologies Development Pte. Ltd. | Data independent acquisition of product ion spectra and reference spectra library matching |
| US8742333B2 (en) | 2010-09-17 | 2014-06-03 | Wisconsin Alumni Research Foundation | Method to perform beam-type collision-activated dissociation in the pre-existing ion injection pathway of a mass spectrometer |
| CA2821669C (en) * | 2010-12-29 | 2018-11-27 | Dh Technologies Development Pte. Ltd. | Method for triggering dependent spectra for data acquisition |
| GB201104225D0 (en) * | 2011-03-14 | 2011-04-27 | Micromass Ltd | Pre scan for mass to charge ratio range |
| US8975575B2 (en) * | 2011-04-04 | 2015-03-10 | Shimadzu Corporation | Mass spectrometer and mass spectrometric method |
| US9040903B2 (en) | 2011-04-04 | 2015-05-26 | Wisconsin Alumni Research Foundation | Precursor selection using an artificial intelligence algorithm increases proteomic sample coverage and reproducibility |
| GB201106689D0 (en) * | 2011-04-20 | 2011-06-01 | Micromass Ltd | Function switching with fast asynchronous acquisition |
| JP5889403B2 (ja) * | 2011-06-03 | 2016-03-22 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | スキャン内ダイナミックレンジを改善するための可変窓バンドパスフィルタリングを使用する調査スキャンからのイオンの除去 |
| GB201116065D0 (en) | 2011-09-16 | 2011-11-02 | Micromass Ltd | Encoding of precursor ion beam to aid product ion assignment |
| US9177765B2 (en) * | 2011-11-29 | 2015-11-03 | Thermo Finnigan Llc | Method for automated checking and adjustment of mass spectrometer calibration |
| GB2497948A (en) | 2011-12-22 | 2013-07-03 | Thermo Fisher Scient Bremen | Collision cell for tandem mass spectrometry |
| GB201122178D0 (en) | 2011-12-22 | 2012-02-01 | Thermo Fisher Scient Bremen | Method of tandem mass spectrometry |
| US9048072B2 (en) * | 2012-03-12 | 2015-06-02 | Micromass Uk Limited | Method of mass spectrometry and a mass spectrometer |
| GB201205009D0 (en) * | 2012-03-22 | 2012-05-09 | Micromass Ltd | Multi-dimensional survey scans for improved data dependent acquisitions (DDA) |
| CA2868705A1 (en) * | 2012-04-05 | 2013-10-10 | Micromass Uk Limited | Ms/ms analysis using ecd or etd fragmentation |
| EP2741224A1 (de) * | 2012-11-20 | 2014-06-11 | Thermo Finnigan LLC | Verfahren zur Erzeugung von lokalen massenspektrometrischen Bibliotheken zur Interpretation überlagerter Massenspektren |
| EP3069374A1 (de) * | 2013-11-12 | 2016-09-21 | Micromass UK Limited | Datenabhängige ms/ms-analyse |
| EP3283877B1 (de) | 2015-04-14 | 2024-10-09 | Waters Technologies Corporation | Strukturaufklärung von isotopisch markierten analyten |
| WO2016196181A1 (en) * | 2015-05-29 | 2016-12-08 | Waters Technologies Corporation | Mass spectrometry with quadrupole and ion mobility separation capabilities |
| GB2544834A (en) | 2015-06-09 | 2017-05-31 | Waters Technologies Corp | Profile diagnositcs in personalized dermatology, dermatopathology and cosmetics |
| GB2565238A (en) | 2015-06-09 | 2019-02-06 | Waters Technologies Corp | Molecular diagnostics in personalized dermatology, dermatopathology and cosmetics |
| JP6455603B2 (ja) * | 2015-10-07 | 2019-01-23 | 株式会社島津製作所 | タンデム型質量分析装置 |
| EP3519831A1 (de) | 2016-09-27 | 2019-08-07 | Waters Technologies Corporation | Mehrfach-attribut-überwachungsverfahren für komplexe proben |
| GB2585372B (en) | 2019-07-04 | 2022-03-02 | Thermo Fisher Scient Bremen Gmbh | Methods and apparatus for mass spectrometry |
| CN110455907B (zh) * | 2019-07-04 | 2022-04-19 | 昆山禾信质谱技术有限公司 | 基于飞行时间质量分析器的串联质谱数据分析方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2120007B (en) * | 1982-04-16 | 1985-09-11 | Univ Sherbrooke | Isotope determination by mass spectrometry |
| US5073713A (en) * | 1990-05-29 | 1991-12-17 | Battelle Memorial Institute | Detection method for dissociation of multiple-charged ions |
| GB2250632B (en) * | 1990-10-18 | 1994-11-23 | Unisearch Ltd | Tandem mass spectrometry systems based on time-of-flight analyser |
| US5182451A (en) * | 1991-04-30 | 1993-01-26 | Finnigan Corporation | Method of operating an ion trap mass spectrometer in a high resolution mode |
| GB9510052D0 (en) * | 1995-05-18 | 1995-07-12 | Fisons Plc | Mass spectrometer |
| GB9518429D0 (en) * | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
| US6323482B1 (en) * | 1997-06-02 | 2001-11-27 | Advanced Research And Technology Institute, Inc. | Ion mobility and mass spectrometer |
| GB9717926D0 (en) * | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| CA2227806C (en) * | 1998-01-23 | 2006-07-18 | University Of Manitoba | Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use |
| AU2334199A (en) * | 1998-01-23 | 1999-08-09 | Analytica Of Branford, Inc. | Mass spectrometry with multipole ion guide |
| JP3405919B2 (ja) * | 1998-04-01 | 2003-05-12 | 株式会社日立製作所 | 大気圧イオン化質量分析計 |
| JP4540230B2 (ja) * | 1998-09-25 | 2010-09-08 | オレゴン州 | タンデム飛行時間質量分析計 |
| CA2255122C (en) | 1998-12-04 | 2007-10-09 | Mds Inc. | Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer |
| CA2340150C (en) * | 2000-06-09 | 2005-11-22 | Micromass Limited | Methods and apparatus for mass spectrometry |
-
2001
- 2001-03-02 GB GB0105227A patent/GB2364168B/en not_active Expired - Lifetime
- 2001-03-02 US US09/796,544 patent/US6586727B2/en not_active Expired - Lifetime
- 2001-06-11 AT AT05025116T patent/ATE445227T1/de not_active IP Right Cessation
- 2001-06-11 DE DE60140150T patent/DE60140150D1/de not_active Expired - Lifetime
- 2001-06-11 DE DE20122885U patent/DE20122885U1/de not_active Expired - Lifetime
- 2001-06-11 EP EP10182678.2A patent/EP2299469B1/de not_active Expired - Lifetime
- 2001-06-11 EP EP09002434.0A patent/EP2056334B1/de not_active Expired - Lifetime
-
2009
- 2009-06-12 JP JP2009141208A patent/JP5154511B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009258116A (ja) | 2009-11-05 |
| GB2364168B (en) | 2002-06-26 |
| EP2299469A1 (de) | 2011-03-23 |
| GB2364168A (en) | 2002-01-16 |
| EP2299469B1 (de) | 2016-01-06 |
| US20010052569A1 (en) | 2001-12-20 |
| DE60140150D1 (de) | 2009-11-19 |
| EP2056334B1 (de) | 2016-02-24 |
| DE20122885U1 (de) | 2008-12-24 |
| GB0105227D0 (en) | 2001-04-18 |
| EP2056334A3 (de) | 2009-12-02 |
| JP5154511B2 (ja) | 2013-02-27 |
| US6586727B2 (en) | 2003-07-01 |
| EP2056334A2 (de) | 2009-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |