DK0743319T3 - Benzokondenserede azepinon- og piperidinonforbindelser, der er nyttige som ACE- og NEP-inhibitorer - Google Patents

Benzokondenserede azepinon- og piperidinonforbindelser, der er nyttige som ACE- og NEP-inhibitorer

Info

Publication number
DK0743319T3
DK0743319T3 DK96107787T DK96107787T DK0743319T3 DK 0743319 T3 DK0743319 T3 DK 0743319T3 DK 96107787 T DK96107787 T DK 96107787T DK 96107787 T DK96107787 T DK 96107787T DK 0743319 T3 DK0743319 T3 DK 0743319T3
Authority
DK
Denmark
Prior art keywords
ace
azepinone
benzo
condensed
compounds useful
Prior art date
Application number
DK96107787T
Other languages
English (en)
Inventor
Jeffrey A Robl
Chong-Qing Sun
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK0743319T3 publication Critical patent/DK0743319T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK96107787T 1995-05-17 1996-05-15 Benzokondenserede azepinon- og piperidinonforbindelser, der er nyttige som ACE- og NEP-inhibitorer DK0743319T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/443,278 US5877313A (en) 1995-05-17 1995-05-17 Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP

Publications (1)

Publication Number Publication Date
DK0743319T3 true DK0743319T3 (da) 2001-01-02

Family

ID=23760151

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96107787T DK0743319T3 (da) 1995-05-17 1996-05-15 Benzokondenserede azepinon- og piperidinonforbindelser, der er nyttige som ACE- og NEP-inhibitorer

Country Status (11)

Country Link
US (2) US5877313A (da)
EP (1) EP0743319B1 (da)
JP (1) JPH08325152A (da)
AT (1) ATE196149T1 (da)
AU (1) AU695929B2 (da)
CA (1) CA2176415A1 (da)
DE (1) DE69610145T2 (da)
DK (1) DK0743319T3 (da)
ES (1) ES2150613T3 (da)
GR (1) GR3034834T3 (da)
PT (1) PT743319E (da)

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US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6340752B1 (en) 1998-01-06 2002-01-22 Bristol-Myers Squibb Co. Deprotection and recrystallization processes
CA2319766A1 (en) * 1998-02-12 1999-08-19 Molecumetics Ltd. .beta.-sheet mimetics and methods relating to the use thereof
JP2005526722A (ja) 2002-02-14 2005-09-08 ミリアド・ジェネティックス・インコーポレイテッド β−シートミメティックならびにそれに関連する組成物および方法
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
JP5968426B2 (ja) 2011-04-26 2016-08-10 スリーエム イノベイティブ プロパティズ カンパニー 混合光架橋系を含む感圧性接着剤
JP6275284B2 (ja) 2014-05-29 2018-02-07 スリーエム イノベイティブ プロパティズ カンパニー 分子量が制御されたアクリル系接着剤組成物
US10093753B2 (en) 2014-12-05 2018-10-09 3M Innovative Properties Company Syrup polymer compositions and adhesives therefrom
JP6359199B2 (ja) 2015-02-18 2018-07-18 スリーエム イノベイティブ プロパティズ カンパニー 保護された光架橋剤由来のアクリル系接着剤組成物
US10975221B2 (en) 2016-10-27 2021-04-13 3M Innovative Properties Company Crosslinkable composition including a (meth)acrylic polymer and methods of making a crosslinked composition

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Also Published As

Publication number Publication date
ATE196149T1 (de) 2000-09-15
JPH08325152A (ja) 1996-12-10
GR3034834T3 (en) 2001-02-28
DE69610145D1 (de) 2000-10-12
AU5230296A (en) 1996-11-28
US5877313A (en) 1999-03-02
AU695929B2 (en) 1998-08-27
DE69610145T2 (de) 2001-06-07
US6235922B1 (en) 2001-05-22
PT743319E (pt) 2000-12-29
EP0743319B1 (en) 2000-09-06
EP0743319A1 (en) 1996-11-20
ES2150613T3 (es) 2000-12-01
CA2176415A1 (en) 1996-11-18

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