DK0737207T3 - Inhibitorer for humant plasmin afledt af Kunitz-domæner - Google Patents
Inhibitorer for humant plasmin afledt af Kunitz-domænerInfo
- Publication number
- DK0737207T3 DK0737207T3 DK95908460T DK95908460T DK0737207T3 DK 0737207 T3 DK0737207 T3 DK 0737207T3 DK 95908460 T DK95908460 T DK 95908460T DK 95908460 T DK95908460 T DK 95908460T DK 0737207 T3 DK0737207 T3 DK 0737207T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- kunitz domains
- human plasmin
- plasmin derived
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/515—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics
- C04B35/58—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides
- C04B35/584—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride
- C04B35/593—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride obtained by pressure sintering
- C04B35/5935—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride obtained by pressure sintering obtained by gas pressure sintering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ceramic Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Structural Engineering (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Manufacturing & Machinery (AREA)
- Genetics & Genomics (AREA)
- Materials Engineering (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17965894A | 1994-01-11 | 1994-01-11 | |
US20826594A | 1994-03-10 | 1994-03-10 | |
PCT/US1995/000298 WO1995018830A2 (en) | 1994-01-11 | 1995-01-11 | Inhibitors of human plasmin derived from the kunitz domains |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0737207T3 true DK0737207T3 (da) | 2005-01-31 |
Family
ID=26875521
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04022346.3T DK1489097T3 (da) | 1994-01-11 | 1995-01-11 | Hæmmere af humant plasmin, der er afledt af kunitz-domæner, og nukleinsyrer, der koder for samme |
DK95908460T DK0737207T3 (da) | 1994-01-11 | 1995-01-11 | Inhibitorer for humant plasmin afledt af Kunitz-domæner |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04022346.3T DK1489097T3 (da) | 1994-01-11 | 1995-01-11 | Hæmmere af humant plasmin, der er afledt af kunitz-domæner, og nukleinsyrer, der koder for samme |
Country Status (10)
Country | Link |
---|---|
US (11) | US6010880A (pt) |
EP (2) | EP0737207B1 (pt) |
JP (5) | JP4137997B2 (pt) |
AT (2) | ATE529444T1 (pt) |
CA (1) | CA2180954C (pt) |
DE (1) | DE69533544T2 (pt) |
DK (2) | DK1489097T3 (pt) |
ES (2) | ES2229236T3 (pt) |
PT (2) | PT737207E (pt) |
WO (1) | WO1995018830A2 (pt) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
CA2180954C (en) | 1994-01-11 | 2007-03-20 | William Markland | Inhibitors of human plasmin derived from the kunitz domains |
US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
EP0831893B1 (en) * | 1995-06-07 | 2003-05-07 | Chiron Corporation | Regulation of neutrophil elastase synthesis and release |
US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
CA2247888A1 (en) | 1996-03-11 | 1997-09-18 | Bayer Corporation | Human bikunin |
EP0963435B1 (en) * | 1997-01-08 | 2008-05-28 | Invitrogen Corporation | Methods for production of proteins |
US20060025329A1 (en) * | 1997-02-06 | 2006-02-02 | Todd Hembrough | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
US6946439B2 (en) | 1997-02-06 | 2005-09-20 | Entre Med, Inc. | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
US5981471A (en) | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
US20020076728A1 (en) * | 1997-03-21 | 2002-06-20 | Maclennan John Moore | Engineering affinity ligands for macromolecules |
US6087473A (en) * | 1999-05-26 | 2000-07-11 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
US6380354B1 (en) | 1998-09-03 | 2002-04-30 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun6 |
CA2342072C (en) * | 1998-09-03 | 2005-01-11 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun6 |
US5994310A (en) * | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
US20030032146A1 (en) * | 2001-07-10 | 2003-02-13 | Dwulet Francis Edward | Enzyme/tag binding and detection system |
KR20110014661A (ko) * | 2002-02-07 | 2011-02-11 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민-융합 쿠니츠 도메인 펩타이드 |
US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
SI2386310T1 (sl) * | 2002-08-28 | 2019-03-29 | Dyax Corp. | Metode za ohranjanje organov in tkiv |
US20040209243A1 (en) * | 2003-01-07 | 2004-10-21 | Andrew Nixon | Kunitz domain library |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
WO2005021557A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
CA2537113A1 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
US7740973B2 (en) * | 2004-08-05 | 2010-06-22 | General Motors Corporation | Modular electrochemical power system |
US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
JP2008520729A (ja) * | 2004-11-22 | 2008-06-19 | ダイアックス コーポレーション | プラスミン阻害療法 |
EP2500031A3 (en) | 2005-02-24 | 2012-12-26 | Joslin Diabetes Center, Inc. | Compositions and Methods for Treating Vascular Permeability |
GB0521404D0 (en) * | 2005-10-20 | 2005-11-30 | Ares Trading Sa | Kunitz domain containing protein |
WO2007070372A2 (en) * | 2005-12-09 | 2007-06-21 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
AU2013202021B2 (en) * | 2005-12-29 | 2016-03-10 | The Regents Of The University Of California | Methods and compositions related to mutant Kunitz domain of TFPI-2 |
PT1981519T (pt) | 2005-12-29 | 2018-02-23 | Dyax Corp | Inibição de protéases |
US8993719B2 (en) * | 2005-12-29 | 2015-03-31 | The Regents Of The University Of California | Methods and compositions related to mutant Kunitz domain I of TFPI-2 |
EP1981538B1 (en) | 2005-12-30 | 2014-09-17 | Dyax Corporation | Metalloproteinase binding proteins |
CA2644255A1 (en) * | 2006-03-08 | 2007-09-13 | Bayer Healthcare Ag | Chimeric kunitz domains and their use |
CA2643693A1 (en) * | 2006-03-10 | 2007-09-20 | Dyax Corp. | Formulations for ecallantide |
HUE031701T2 (en) * | 2006-03-16 | 2017-07-28 | Dyax Corp | Plasma kallikrein inhibiting peptides for use in treating eye diseases |
PL2374472T3 (pl) | 2006-03-16 | 2018-11-30 | Dyax Corp. | Kompozycje i sposoby leczenia zaburzeń okulistycznych |
US20100119512A1 (en) * | 2007-01-25 | 2010-05-13 | Joslin Diabetes Center | Methods of diagnosing, treating, and preventing increased vascular permeability |
WO2009026334A2 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
WO2009030464A2 (de) * | 2007-09-08 | 2009-03-12 | Bayer Schering Pharma Aktiengesellschaft | HERSTELLUNG UND VERWENDUNG VON VARIANTEN HUMANER KUNITZ-TYP PROTEASE-INHIBITOREN (hKTPI) |
DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
KR20170091801A (ko) | 2008-10-02 | 2017-08-09 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Cd86 길항제 다중-표적 결합 단백질 |
EA032828B1 (ru) * | 2008-10-10 | 2019-07-31 | Аптево Рисёрч Энд Девелопмент Ллс | Иммунотерапевтические средства против комплекса tcr |
ES2773766T3 (es) | 2008-12-19 | 2020-07-14 | Baxalta GmbH | Inhibidores de TFPI y métodos de uso |
CN102307594A (zh) * | 2009-01-06 | 2012-01-04 | 戴埃克斯有限公司 | 用激肽释放酶抑制剂治疗粘膜炎 |
EP2516467A2 (en) | 2009-12-23 | 2012-10-31 | Emergent Product Development Seattle, LLC | Compositions comprising tnf-alpha and il-6 antagonists and methods of use thereof |
JP5856073B2 (ja) | 2009-12-29 | 2016-02-09 | エマージェント プロダクト デベロップメント シアトル, エルエルシー | Ron結合構築体およびその使用方法 |
HUE039605T2 (hu) | 2010-01-06 | 2019-01-28 | Dyax Corp | Plazma kallikreint kötõ proteinek |
AU2011227714B2 (en) | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
WO2012158818A2 (en) | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
AU2013235741C1 (en) | 2012-03-21 | 2017-12-21 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
JP6509724B2 (ja) | 2012-04-20 | 2019-05-08 | アプティーボ リサーチ アンド デベロップメント エルエルシー | Cd3結合ポリペプチド |
WO2014024914A1 (ja) * | 2012-08-08 | 2014-02-13 | 第一三共株式会社 | ペプチド・ライブラリー及びその利用 |
DK2971039T3 (da) | 2013-03-14 | 2020-04-06 | Immusoft Corp | Fremgangsmåder til in vitro-differentiering af hukommelses-b-celler og transduktion med vsv-g-pseudotypeomdannede virusvektorer |
WO2014144658A1 (en) * | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Dual reactivity potent kunitz inhibitor of fibrinolysis |
US10196444B2 (en) | 2013-07-29 | 2019-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
SG10201803533YA (en) | 2013-10-31 | 2018-06-28 | Hutchinson Fred Cancer Res | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
KR20230007559A (ko) | 2013-12-20 | 2023-01-12 | 프레드 허친슨 캔서 센터 | 태그된 키메라 이펙터 분자 및 그의 리셉터 |
WO2015148790A1 (en) | 2014-03-27 | 2015-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
CA2971430A1 (en) | 2014-12-19 | 2016-06-23 | Immusoft Corporation | B cells for in vivo delivery of therapeutic agents |
KR20170120701A (ko) | 2015-03-05 | 2017-10-31 | 프레드 헛친슨 켄서 리서치 센터 | 면역조절 융합 단백질 및 그 용도 |
JP6985934B2 (ja) | 2015-04-29 | 2021-12-22 | フレッド ハッチンソン キャンサー リサーチ センター | 操作された造血幹細胞/前駆細胞及び非tエフェクター細胞、ならびにその使用 |
WO2016176652A2 (en) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
KR20180053322A (ko) | 2015-09-21 | 2018-05-21 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Cd3 결합 폴리펩타이드 |
NZ744233A (en) | 2015-12-11 | 2023-11-24 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
EP3430058A4 (en) | 2016-03-15 | 2019-10-23 | Generon (Shanghai) Corporation Ltd. | MULTISPECIFIC FAB FUSION PROTEINS AND USES THEREOF |
CA3020857A1 (en) | 2016-04-14 | 2017-10-19 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
KR20240063204A (ko) | 2017-02-17 | 2024-05-10 | 프레드 허친슨 캔서 센터 | Bcma 관련 암 및 자가면역 장애의 치료를 위한 조합 요법 |
MX2019010812A (es) | 2017-03-17 | 2019-12-11 | Hutchinson Fred Cancer Res | Proteinas de fusion inmunomoduladoras y sus usos. |
CA3084551A1 (en) | 2017-12-14 | 2019-06-20 | Bluebird Bio, Inc. | Daric interleukin receptors |
EP3849565A4 (en) | 2018-09-12 | 2022-12-28 | Fred Hutchinson Cancer Research Center | REDUCING CD33 EXPRESSION FOR SELECTIVE PROTECTION OF THERAPEUTIC CELLS |
AU2020267349A1 (en) | 2019-05-04 | 2021-11-11 | Inhibrx Biosciences, Inc. | CLEC12a-binding polypeptides and uses thereof |
EP3994270A1 (en) | 2019-07-02 | 2022-05-11 | Fred Hutchinson Cancer Research Center | Recombinant ad35 vectors and related gene therapy improvements |
WO2021198534A1 (en) | 2020-04-04 | 2021-10-07 | Oxurion NV | Plasma kallikrein inhibitors for use in the treatment of coronaviral disease |
CN116096754A (zh) | 2020-05-04 | 2023-05-09 | 免疫里森公司 | 前体三特异性抗体构建体及其使用方法 |
WO2023144030A1 (en) | 2022-01-31 | 2023-08-03 | Oxurion NV | Plasma kallikrein inhibitor therapy for anti-vegf sensitization |
WO2023148016A1 (en) | 2022-02-04 | 2023-08-10 | Oxurion NV | Biomarker for plasma kallikrein inhibitor therapy response |
WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
DE2619246A1 (de) * | 1976-04-30 | 1977-11-10 | Bayer Ag | Desamino-derivate des kallikrein- trypsin-inhibitors, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2654124A1 (de) * | 1976-11-29 | 1978-06-01 | Bayer Ag | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
US4657893A (en) * | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
US4845242A (en) * | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
GB2208511A (en) | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
DK225488D0 (da) | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
ES2066033T3 (es) * | 1989-05-13 | 1995-03-01 | Bayer Ag | Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. |
US7413537B2 (en) * | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
US5278285A (en) | 1990-02-01 | 1994-01-11 | Bayer Aktiengesellschaft | Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology |
US5278144A (en) | 1990-09-04 | 1994-01-11 | Cor Therapeutics, Inc. | Antithrombosis agents |
US5583107A (en) | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
US5409895A (en) * | 1990-11-13 | 1995-04-25 | Mochida Pharmaceutical Co., Ltd. | Protease inhibitory polypeptides derived from urinary trypsin inhibitor and compositions thereof |
US5166133A (en) | 1991-04-17 | 1992-11-24 | Cetus Corporation | Method for inhibing adhesion of white blood cells to endothelial cells |
EP0523872B1 (en) * | 1991-06-28 | 1996-03-27 | Wecotec Limited | Sheet corner transfer |
IL104325A (en) * | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
IL104326A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
IL104324A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
AU5684594A (en) * | 1992-12-02 | 1994-06-22 | Novo Nordisk A/S | Novel human amyloid protein precursor homologue and kunitz-type inhibitors |
WO1995007986A1 (en) | 1993-09-14 | 1995-03-23 | Genentech, Inc. | Pharmaceutical compositions containing ecotin and homologs thereof |
CA2180954C (en) * | 1994-01-11 | 2007-03-20 | William Markland | Inhibitors of human plasmin derived from the kunitz domains |
JP3805785B2 (ja) | 1994-01-11 | 2006-08-09 | ダイアックス コープ. | カリクレイン阻害クニッツドメイン蛋白質およびその相同体 |
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5589359A (en) | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
US5780265A (en) | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
US5786328A (en) | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US6004579A (en) | 1995-09-14 | 1999-12-21 | Lxr Biotechnology, Inc. | Compositions which inhibit apoptosis, methods of making the compositions and uses thereof |
US5736364A (en) | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
AU1210797A (en) | 1996-01-08 | 1997-08-01 | Nissin Food Products Co., Ltd. | Cancerous metastasis inhibitor |
JP3357807B2 (ja) * | 1997-01-13 | 2002-12-16 | 株式会社東芝 | 受信装置および移相器 |
US7383135B1 (en) * | 1998-05-04 | 2008-06-03 | Vertex Pharmaceuticals Incorporated | Methods of designing inhibitors for JNK kinases |
JP2000106882A (ja) * | 1998-10-02 | 2000-04-18 | Chemo Sero Therapeut Res Inst | 癌転移増殖抑制作用を有する血漿蛋白断片産生酵素および当該酵素により断片化された血漿蛋白断片 |
EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
IL159015A0 (en) | 2001-05-25 | 2004-05-12 | Genset Sa | Polypeptides, their preparation and use |
KR20110014661A (ko) | 2002-02-07 | 2011-02-11 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민-융합 쿠니츠 도메인 펩타이드 |
US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
WO2003103475A2 (en) | 2002-06-07 | 2003-12-18 | Dyax Corp. | Prevention and reduction of blood loss |
SI2386310T1 (sl) | 2002-08-28 | 2019-03-29 | Dyax Corp. | Metode za ohranjanje organov in tkiv |
AU2003265866A1 (en) * | 2002-09-03 | 2004-03-29 | Vit Lauermann | Targeted release |
US20040209243A1 (en) * | 2003-01-07 | 2004-10-21 | Andrew Nixon | Kunitz domain library |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
WO2005021557A2 (en) * | 2003-08-29 | 2005-03-10 | Dyax Corp. | Poly-pegylated protease inhibitors |
-
1995
- 1995-01-11 CA CA002180954A patent/CA2180954C/en not_active Expired - Fee Related
- 1995-01-11 DK DK04022346.3T patent/DK1489097T3/da active
- 1995-01-11 AT AT04022346T patent/ATE529444T1/de active
- 1995-01-11 JP JP51866795A patent/JP4137997B2/ja not_active Expired - Fee Related
- 1995-01-11 EP EP95908460A patent/EP0737207B1/en not_active Expired - Lifetime
- 1995-01-11 WO PCT/US1995/000298 patent/WO1995018830A2/en active IP Right Grant
- 1995-01-11 EP EP04022346A patent/EP1489097B1/en not_active Expired - Lifetime
- 1995-01-11 DE DE69533544T patent/DE69533544T2/de not_active Expired - Lifetime
- 1995-01-11 ES ES95908460T patent/ES2229236T3/es not_active Expired - Lifetime
- 1995-01-11 PT PT95908460T patent/PT737207E/pt unknown
- 1995-01-11 PT PT04022346T patent/PT1489097E/pt unknown
- 1995-01-11 DK DK95908460T patent/DK0737207T3/da active
- 1995-01-11 US US08/676,124 patent/US6010880A/en not_active Expired - Lifetime
- 1995-01-11 ES ES04022346T patent/ES2375561T3/es not_active Expired - Lifetime
- 1995-01-11 AT AT95908460T patent/ATE277081T1/de active
-
1999
- 1999-01-29 US US09/240,136 patent/US6103499A/en not_active Expired - Lifetime
- 1999-10-08 US US09/414,878 patent/US6071723A/en not_active Expired - Lifetime
-
2000
- 2000-08-15 US US09/638,770 patent/US6423498B1/en not_active Expired - Fee Related
-
2002
- 2002-06-11 US US10/167,351 patent/US6953674B2/en not_active Expired - Fee Related
-
2005
- 2005-03-18 US US11/083,742 patent/US8431359B2/en not_active Expired - Fee Related
-
2007
- 2007-10-24 JP JP2007276165A patent/JP2008113657A/ja active Pending
- 2007-10-30 US US11/928,497 patent/US20080182283A1/en not_active Abandoned
- 2007-10-30 US US11/928,351 patent/US20090036365A1/en not_active Abandoned
- 2007-10-30 US US11/928,448 patent/US7919462B2/en not_active Expired - Fee Related
- 2007-10-31 US US11/932,411 patent/US20090023651A1/en not_active Abandoned
-
2008
- 2008-11-19 JP JP2008295610A patent/JP2009183281A/ja active Pending
-
2011
- 2011-02-25 US US13/034,967 patent/US20110152193A1/en not_active Abandoned
-
2012
- 2012-02-29 JP JP2012044051A patent/JP2012111779A/ja active Pending
-
2013
- 2013-06-19 JP JP2013128491A patent/JP2013249302A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0737207T3 (da) | Inhibitorer for humant plasmin afledt af Kunitz-domæner | |
ES2194852T3 (es) | Inhibidor de metaloproteinasa de tejido de tipo tres (timp-3). | |
ATE226634T1 (de) | Fibronektin bindendes protein | |
DE69922958D1 (de) | Hcv hüllproteine partikel : verwendung für therapeutische impfung | |
EP1484339A3 (en) | Kallikrein-inhibiting "Kunitz Domain" proteins and nucleic acids encoding the same | |
MY120693A (en) | Human bikunin | |
DK1175909T3 (da) | Terapeutiske sammensætninger af antistoffer og antisense-nukleinsyrer mod Serrate | |
ATE184052T1 (de) | Gdf-1 und uog1 proteine | |
NL300272I1 (nl) | DNA dat humaan papillomavirus type 18 codeert. | |
DE3587875D1 (de) | Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu. | |
DK0610260T3 (da) | Vacciner mod Actinobacillus pleuropneumoniae | |
DK0901526T3 (da) | Cortistatin: neuropeptider, sammensætninger og metoder | |
NO882380D0 (no) | Fibfonektin-bindende protein, samt fremstilling derav. | |
SE9003374D0 (sv) | A collagen binding protein as well as its preparation | |
SE9602822D0 (sv) | New receptor | |
PT816504E (pt) | Acetil-hidrolase para o factor activador das plaquetas, e seu gene | |
DE68924464D1 (de) | Interferon-gamma bindende Proteine. | |
AU2001238064A1 (en) | 18477, a human protein kinase and uses therefor | |
BR9811690A (pt) | Proteìnas de armazenamento de café. | |
SE9604439D0 (sv) | New receptor | |
ATE404576T1 (de) | Neuartiges polypeptid und dessen kodierende nukleinsäuren |