DK0702721T3 - Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp - Google Patents
Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvampInfo
- Publication number
- DK0702721T3 DK0702721T3 DK94920443T DK94920443T DK0702721T3 DK 0702721 T3 DK0702721 T3 DK 0702721T3 DK 94920443 T DK94920443 T DK 94920443T DK 94920443 T DK94920443 T DK 94920443T DK 0702721 T3 DK0702721 T3 DK 0702721T3
- Authority
- DK
- Denmark
- Prior art keywords
- gene
- aspergillus
- present
- scfv
- mould
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93201660 | 1993-06-09 | ||
EP93201661 | 1993-06-09 | ||
EP93201706 | 1993-06-14 | ||
PCT/EP1994/001906 WO1994029457A2 (fr) | 1993-06-09 | 1994-06-09 | Procede de production de proteines de fusion comprenant des fragments de scfv a l'aide d'un moule transforme |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0702721T3 true DK0702721T3 (da) | 2001-05-21 |
Family
ID=27235312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94920443T DK0702721T3 (da) | 1993-06-09 | 1994-06-09 | Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0702721B1 (fr) |
JP (1) | JPH08511160A (fr) |
AT (1) | ATE198490T1 (fr) |
AU (1) | AU7123494A (fr) |
CA (1) | CA2162878A1 (fr) |
DE (1) | DE69426527T2 (fr) |
DK (1) | DK0702721T3 (fr) |
ES (1) | ES2155854T3 (fr) |
FI (1) | FI114870B (fr) |
WO (1) | WO1994029457A2 (fr) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9504344D0 (en) * | 1995-03-03 | 1995-04-19 | Unilever Plc | Antibody fragment production |
DK0826054T3 (da) * | 1995-05-18 | 2004-04-19 | Genencor Int | Ekspression af glycosyltransferase i Aspergillus |
AU8437398A (en) | 1997-06-13 | 1998-12-30 | Unilever Plc | Bleaching enzymes |
EP0954978B1 (fr) | 1998-03-12 | 2011-11-30 | VHsquared Limited | Produits contenant des levures ou des moisissures inactivées, ayant sur leur surface externe des anticorps actifs |
ATE535154T1 (de) | 1998-03-12 | 2011-12-15 | Vhsquared Ltd | Produkten die inaktivierte hefen oder schimmel enthalten, die auf ihrer aussenoberfläche aktive antikörper haben |
AU6153100A (en) | 1999-07-27 | 2001-02-13 | Davis, Paul James | Bleaching detergent compositions |
EP1368380B1 (fr) | 2000-12-19 | 2009-09-02 | Unilever N.V. | Stabilisation d'anticorps à chaine lourde de chameau par des sels de potassium |
BR0307216A (pt) * | 2002-01-28 | 2005-12-20 | Medarex Inc | Anticorpos monoclonais humanos para antìgeno de membrana especìfica de próstata (psma) |
WO2006122787A1 (fr) | 2005-05-18 | 2006-11-23 | Ablynx Nv | Proteines de liaison a l'albumine serique |
KR101414438B1 (ko) | 2005-05-20 | 2014-07-10 | 아블린쓰 엔.브이. | 폰 빌레브란트 인자에 대한 단일 도메인 vhh 항체 |
EP2557090A3 (fr) | 2006-12-19 | 2013-05-29 | Ablynx N.V. | Séquences d'acides aminés dirigées contre les GPCR et polypeptides les comprenant pour le traitement de maladies et de troubles liés au GPCR |
WO2008074840A2 (fr) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Séquences d'acides aminés dirigées contre une métalloprotéinase de la famille adam et polypeptides les comprenant à des fins de traitement de maladies et troubles liés à adam |
WO2008081031A2 (fr) * | 2007-01-05 | 2008-07-10 | Novozymes A/S | Surexpression de la chaperonne bip dans un hétérocaryon |
EP2260058A2 (fr) | 2008-04-07 | 2010-12-15 | Ablynx N.V. | Séquences d acides aminés dirigées contre les voies notch et leurs utilisations |
CN102388069B (zh) | 2009-04-10 | 2016-01-20 | 埃博灵克斯股份有限公司 | 用于治疗il-6r相关疾病和病症的改进的针对il-6r的氨基酸序列和包含其的多肽 |
US9403898B2 (en) | 2009-05-07 | 2016-08-02 | Novozymes Biopharma Dk A/S | Method for purifying albumin |
RU2016103067A (ru) | 2009-06-05 | 2018-11-20 | Аблинкс Нв | Улучшенные аминокислотные последовательности, направленные против респираторно-синцитиального вируса человека (hrsv), и полипептиды, включающие такие последовательности, для профилактики и/или лечения инфекций дыхательных путей |
US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
US8962807B2 (en) | 2009-12-14 | 2015-02-24 | Ablynx N.V. | Single variable domain antibodies against OX40L, constructs and therapeutic use |
WO2011083141A2 (fr) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Procédé de production de séquences d'immunoglobulines par utilisation de particules de lipoprotéines |
US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
WO2011117423A1 (fr) | 2010-03-26 | 2011-09-29 | Ablynx N.V. | Domaines variables uniques de l'immunoglobuline dirigés contre cxcr7 |
CN102906118B (zh) | 2010-05-20 | 2017-07-28 | 埃博灵克斯股份有限公司 | 与her3相关的生物材料 |
EP2621953B1 (fr) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Matières biologiques associées à c-met |
WO2012062713A1 (fr) | 2010-11-08 | 2012-05-18 | Novartis Ag | Polypeptides se liant aux récepteurs de chimiokines |
US20150158948A9 (en) | 2011-03-28 | 2015-06-11 | Francis Descamps | Bispecific anti-cxcr7 immunoglobulin single variable domains |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
CN104271598A (zh) | 2011-06-23 | 2015-01-07 | 埃博灵克斯股份有限公司 | 针对IgE的免疫球蛋白单可变结构域 |
CA2850261C (fr) | 2011-09-30 | 2021-04-20 | Ablynx Nv | Domaines de variable simple d'immunoglobuline c-met |
US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
WO2014087010A1 (fr) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | Polypeptides améliorés dirigés contre ige |
DK3071598T3 (da) | 2013-05-29 | 2021-09-13 | Vybion Inc | Enkeltkædede intrabodies, der ændrer nedbrydning af huntingtin-mutant |
NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
WO2016097313A1 (fr) | 2014-12-19 | 2016-06-23 | Ablynx N.V. | Dimères de nano-anticorps liés à de la cystéine |
CN114920848A (zh) | 2015-05-13 | 2022-08-19 | 埃博灵克斯股份有限公司 | 基于cd3反应性的t细胞募集多肽 |
HUE045437T2 (hu) | 2015-05-13 | 2019-12-30 | Ablynx Nv | TCR-alfa-béta reaktivitásán alapulva T-sejtet toborzó polipeptidek |
WO2017013270A1 (fr) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Utilisation d'un inhibiteur de la signalisation de la leptine pour la protection des reins de patients atteints de ciliopathie |
IL261188B (en) | 2016-03-04 | 2022-08-01 | Jn Biosciences Llc | An anti-tigit antibody that binds to the tigit polypeptide on one or more amino acid residues |
EP3526253A1 (fr) | 2016-10-14 | 2019-08-21 | Institut Curie | Nouvel anticorps anti-lsp1 |
WO2018091606A1 (fr) | 2016-11-16 | 2018-05-24 | Ablynx Nv | Polypeptides de recrutement de lymphocytes t capables de se lier à cd123 et tcr alpha/bêta |
EP3624854A1 (fr) | 2017-05-16 | 2020-03-25 | Université de Strasbourg | Conjugués protéine-médicament et leur utilisation dans le traitement de cancers |
BR112019025097A2 (pt) | 2017-06-02 | 2020-07-28 | Merck Patent Gmbh | imunoglobulinas de ligação a mmp13 |
KR20200013247A (ko) | 2017-06-02 | 2020-02-06 | 아블린쓰 엔.브이. | 아그레칸 결합 면역글로불린 |
JP7249961B2 (ja) | 2017-06-02 | 2023-03-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Adamts5、mmp13およびアグリカンに結合するポリペプチド |
EP3630847A1 (fr) | 2017-06-02 | 2020-04-08 | Merck Patent GmbH | Immunoglobulines liant les adamts |
EP3658915A1 (fr) | 2017-07-28 | 2020-06-03 | Institut Curie | Nouvelles sous-populations de fibroblastes associés au cancer comme marqueurs pronostiques pour traitements d'immunothérapie |
AR114269A1 (es) | 2018-02-26 | 2020-08-12 | Ablynx Nv | Secuencias nucleotídicas mejoradas que codifican para péptidos de unión |
KR101875564B1 (ko) * | 2018-05-24 | 2018-07-09 | 국민대학교산학협력단 | 포도당 및 글리세롤을 이용한 유가식 배양을 통한 리시놀레산으로 오메가-하이드록시운덱-9-에논산의 생물전환공정 |
EP3636657A1 (fr) | 2018-10-08 | 2020-04-15 | Ablynx N.V. | Procédé de purification d'anticorps sans chromatographie |
WO2020245663A1 (fr) | 2019-06-01 | 2020-12-10 | Institut Pasteur | Dosage ns1 à base de nanocorps pour le diagnostic spécifique d'une infection aiguë par le virus zika |
MX2022015157A (es) | 2020-06-02 | 2023-01-16 | Arcus Biosciences Inc | Anticuerpos para tigit. |
EP4263610A1 (fr) | 2020-12-18 | 2023-10-25 | Ablynx N.V. | Polypeptides de recrutement de lymphocytes t basés sur la réactivité tcr alpha/bêta |
EP4337691A1 (fr) | 2021-05-12 | 2024-03-20 | Université de Strasbourg | Anticorps à domaine unique spécifique de h2ax phosphorylé et ses utilisations |
WO2023151894A1 (fr) | 2022-02-11 | 2023-08-17 | Henkel Ag & Co. Kgaa | Méthode de synthèse d'alpha-méthylène-gamma-butyrolactone |
US20240132624A1 (en) | 2022-07-27 | 2024-04-25 | Ablynx N.V. | Polypeptides binding to a specific epitope of the neonatal fc receptor |
WO2024083843A1 (fr) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Séquences d'acides aminés dirigées contre le récepteur de la mélanocortine 4 et polypeptides les comprenant pour le traitement de maladies et de troubles liés à mc4r |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0539395A1 (fr) * | 1990-07-16 | 1993-05-05 | Alko Group Ltd. | PRODUCTION D'IMMUNOGLOBULINES PAR LES $i(TRICHODERMAS) |
WO1993008300A1 (fr) * | 1991-10-18 | 1993-04-29 | The University Of Calgary | Vecteurs d'expression/secretion destines a la production de fragments de fv biologiquement actifs |
IT1270866B (it) * | 1993-03-10 | 1997-05-13 | Eniricerche Spa | Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis |
-
1994
- 1994-06-09 DK DK94920443T patent/DK0702721T3/da active
- 1994-06-09 DE DE69426527T patent/DE69426527T2/de not_active Expired - Fee Related
- 1994-06-09 AT AT94920443T patent/ATE198490T1/de not_active IP Right Cessation
- 1994-06-09 JP JP7501340A patent/JPH08511160A/ja active Pending
- 1994-06-09 EP EP94920443A patent/EP0702721B1/fr not_active Expired - Lifetime
- 1994-06-09 CA CA002162878A patent/CA2162878A1/fr not_active Abandoned
- 1994-06-09 AU AU71234/94A patent/AU7123494A/en not_active Abandoned
- 1994-06-09 WO PCT/EP1994/001906 patent/WO1994029457A2/fr active IP Right Grant
- 1994-06-09 ES ES94920443T patent/ES2155854T3/es not_active Expired - Lifetime
-
1995
- 1995-11-13 FI FI955446A patent/FI114870B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69426527D1 (de) | 2001-02-08 |
AU7123494A (en) | 1995-01-03 |
WO1994029457A2 (fr) | 1994-12-22 |
EP0702721A1 (fr) | 1996-03-27 |
DE69426527T2 (de) | 2001-08-30 |
FI114870B (fi) | 2005-01-14 |
JPH08511160A (ja) | 1996-11-26 |
ES2155854T3 (es) | 2001-06-01 |
CA2162878A1 (fr) | 1994-12-22 |
FI955446A0 (fi) | 1995-11-13 |
FI955446A (fi) | 1995-12-11 |
EP0702721B1 (fr) | 2001-01-03 |
ATE198490T1 (de) | 2001-01-15 |
WO1994029457A3 (fr) | 1995-03-09 |
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