DK0678097T3 - Hidtil ukendte colon- eller ileumspecifikke steroidderivater - Google Patents

Hidtil ukendte colon- eller ileumspecifikke steroidderivater

Info

Publication number
DK0678097T3
DK0678097T3 DK94904364T DK94904364T DK0678097T3 DK 0678097 T3 DK0678097 T3 DK 0678097T3 DK 94904364 T DK94904364 T DK 94904364T DK 94904364 T DK94904364 T DK 94904364T DK 0678097 T3 DK0678097 T3 DK 0678097T3
Authority
DK
Denmark
Prior art keywords
ileum
steroid derivatives
specific steroid
compounds
newly known
Prior art date
Application number
DK94904364T
Other languages
Danish (da)
English (en)
Inventor
Ralph Lennart Brattsand
Peter Edman
Stinabritt Nilsson
Bror Arne Thalen
Jan Erik Ulmius
Thomas Higberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300030A external-priority patent/SE9300030D0/xx
Priority claimed from SE9300082A external-priority patent/SE9300082D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Application granted granted Critical
Publication of DK0678097T3 publication Critical patent/DK0678097T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK94904364T 1993-01-08 1993-12-17 Hidtil ukendte colon- eller ileumspecifikke steroidderivater DK0678097T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300030A SE9300030D0 (sv) 1993-01-08 1993-01-08 Novel colon- or ileum-specific steroid derivatives
SE9300082A SE9300082D0 (sv) 1993-01-14 1993-01-14 Novel colon- or ileum-specific steroid derivatives
PCT/SE1993/001081 WO1994015947A1 (en) 1993-01-08 1993-12-17 Novel colon- or ileum-specific steroid derivatives

Publications (1)

Publication Number Publication Date
DK0678097T3 true DK0678097T3 (da) 2000-02-07

Family

ID=26661623

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94904364T DK0678097T3 (da) 1993-01-08 1993-12-17 Hidtil ukendte colon- eller ileumspecifikke steroidderivater

Country Status (22)

Country Link
US (2) US5908833A (cs)
EP (1) EP0678097B1 (cs)
JP (1) JP3366640B2 (cs)
KR (1) KR960700266A (cs)
AT (1) ATE183192T1 (cs)
BR (1) BR9307746A (cs)
CA (1) CA2152374A1 (cs)
CZ (1) CZ171095A3 (cs)
DK (1) DK0678097T3 (cs)
ES (1) ES2137353T3 (cs)
FI (1) FI953358L (cs)
GR (1) GR3031789T3 (cs)
HU (1) HU221584B (cs)
IS (1) IS4111A (cs)
LV (1) LV10961B (cs)
NO (1) NO305367B1 (cs)
NZ (1) NZ259596A (cs)
PL (1) PL178307B1 (cs)
RU (1) RU95115547A (cs)
SK (1) SK87295A3 (cs)
TW (1) TW261615B (cs)
WO (1) WO1994015947A1 (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo
WO1995009177A1 (en) * 1993-09-29 1995-04-06 Nissin Shokuhin Kabushiki Kaisha 21-substituted steroid compound
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
JP4610734B2 (ja) * 1998-03-19 2011-01-12 三笠製薬株式会社 ２１−置換グリコシルステロイド化合物
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
CN1250563C (zh) 1999-05-04 2006-04-12 斯特拉坎有限公司 雄激素糖苷及其产生雄性征的活性
PT1183014E (pt) 1999-06-14 2003-12-31 Cosmo Spa Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor
US8895064B2 (en) 1999-06-14 2014-11-25 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
WO2001051057A2 (en) * 2000-01-14 2001-07-19 Strakan Limited Glycosides and orthoester glycosides of glucocorticoids and uses thereof
SE0101220D0 (sv) * 2001-04-04 2001-04-04 Astrazeneca Ab New use
EP1625854B1 (en) * 2004-08-09 2008-10-15 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Albumin conjugates containing a glucuronic linker
WO2008100560A2 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators, associated pharmaceutical compositions and methods of use
US10154964B2 (en) 2011-09-07 2018-12-18 Cosmo Technologies Limited Controlled release and taste masking oral pharmaceutical composition
CN110291097A (zh) 2016-11-08 2019-09-27 里珍纳龙药品有限公司 类固醇类化合物及其蛋白质-偶联物
US11491232B2 (en) 2017-03-30 2022-11-08 Fruithy Holdings Limited Lactuloside compounds and preparation and use thereof
WO2018213077A1 (en) 2017-05-18 2018-11-22 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
CA3080857A1 (en) 2017-11-07 2019-05-16 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
KR102786381B1 (ko) 2018-01-08 2025-03-26 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 항체-접합체
WO2019217591A1 (en) 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378109B (cs) * 1972-05-19 1975-08-18 Bofors Ab
SE378110B (cs) * 1972-05-19 1975-08-18 Bofors Ab
US3938233A (en) * 1974-08-12 1976-02-17 Cannon Robert B Heat transfer apparatus
DE2803660A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte steroide der pregnanreihe, ihre herstellung und verwendung
BG33738A3 (bg) * 1978-01-25 1983-04-15 Schering Aktiengesellschaft Метод за получаване на заместени в 17-а позиция стероиди на прегнановия ред
US4221787A (en) * 1978-03-28 1980-09-09 Interx Research Corporation Esteramide prodrugs of anti-inflammatory corticosteroids
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4472392A (en) * 1983-01-21 1984-09-18 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
US4469689A (en) * 1983-03-30 1984-09-04 The Upjohn Company Sulfonate containing ester prodrugs of corticosteroids
WO1984004041A1 (en) * 1983-04-14 1984-10-25 Univ California Colon-specific drug delivery system
US4548922A (en) * 1983-06-06 1985-10-22 Beth Israel Hospital Drug administration
US4959358A (en) * 1983-06-06 1990-09-25 Beth Israel Hospital Assn. Drug administration
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
GB8600491D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid derivatives
GB8600489D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
GB8600490D0 (en) * 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
DE3787437T2 (de) * 1986-05-12 1994-01-20 Kanto Ishi Pharma Co Ltd Sialosylcholesterol, verfahren zu dessen herstellung und arzneimittel zur behandlung von krankheiten des nervensystems.
CA1299653C (en) * 1988-07-07 1992-04-28 Markwell Medical Institute, Inc. Biological fluid measuring device
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
WO1993022334A1 (en) * 1992-05-04 1993-11-11 Sri International Pharmaceutical compositions and methods for colonic delivery of corticosteroids
BR9307746A (pt) * 1993-01-08 1995-11-14 Astra Ab Derivados de esteróides especificos para otratamento de cólon e ileo

Also Published As

Publication number Publication date
HU9502087D0 (en) 1995-09-28
LV10961A (lv) 1995-12-20
NO305367B1 (no) 1999-05-18
FI953358A7 (fi) 1995-07-07
JP3366640B2 (ja) 2003-01-14
LV10961B (en) 1996-08-20
WO1994015947A1 (en) 1994-07-21
PL309777A1 (en) 1995-11-13
ES2137353T3 (es) 1999-12-16
FI953358A0 (fi) 1995-07-07
FI953358L (fi) 1995-07-07
RU95115547A (ru) 1997-06-10
NO952683D0 (no) 1995-07-06
SK87295A3 (en) 1996-04-03
CZ171095A3 (en) 1996-01-17
EP0678097A1 (en) 1995-10-25
GR3031789T3 (en) 2000-02-29
JPH08505616A (ja) 1996-06-18
HU221584B (hu) 2002-11-28
TW261615B (cs) 1995-11-01
NO952683L (no) 1995-07-06
ATE183192T1 (de) 1999-08-15
AU5844794A (en) 1994-08-15
HUT73227A (en) 1996-07-29
PL178307B1 (pl) 2000-04-28
BR9307746A (pt) 1995-11-14
EP0678097B1 (en) 1999-08-11
IS4111A (is) 1994-07-09
NZ259596A (en) 1997-04-24
US5908833A (en) 1999-06-01
AU678803B2 (en) 1997-06-12
US6140308A (en) 2000-10-31
CA2152374A1 (en) 1994-07-21
KR960700266A (ko) 1996-01-19

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