DE69310052D1 - Kardioaktive 17B-(3-Furyl) und 17B-(4-Pyridazinyl)-5beta, 14beta-Androstan Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon - Google Patents

Kardioaktive 17B-(3-Furyl) und 17B-(4-Pyridazinyl)-5beta, 14beta-Androstan Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon

Info

Publication number
DE69310052D1
DE69310052D1 DE69310052T DE69310052T DE69310052D1 DE 69310052 D1 DE69310052 D1 DE 69310052D1 DE 69310052 T DE69310052 T DE 69310052T DE 69310052 T DE69310052 T DE 69310052T DE 69310052 D1 DE69310052 D1 DE 69310052D1
Authority
DE
Germany
Prior art keywords
pyridazinyl
furyl
processes
14beta
5beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69310052T
Other languages
English (en)
Other versions
DE69310052T2 (de
Inventor
Luisa Quadri
Luigi Bernardi
Giuseppe Bianci
Patrizia Ferrari
Piero Melloni
Loredana Valentino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ROSTAQUO S.P.A., POMENZIA, IT
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to DE69310052T priority Critical patent/DE69310052T2/de
Application granted granted Critical
Publication of DE69310052D1 publication Critical patent/DE69310052D1/de
Publication of DE69310052T2 publication Critical patent/DE69310052T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0021—Oxiranes at position 14(15)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DE69310052T 1992-08-20 1993-06-25 Kardioaktive 17B-(3-Furyl) und 17B-(4-Pyridazinyl)-5beta, 14beta-Androstan Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon Expired - Lifetime DE69310052T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69310052T DE69310052T2 (de) 1992-08-20 1993-06-25 Kardioaktive 17B-(3-Furyl) und 17B-(4-Pyridazinyl)-5beta, 14beta-Androstan Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4227616A DE4227616C2 (de) 1992-08-20 1992-08-20 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
DE69310052T DE69310052T2 (de) 1992-08-20 1993-06-25 Kardioaktive 17B-(3-Furyl) und 17B-(4-Pyridazinyl)-5beta, 14beta-Androstan Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon

Publications (2)

Publication Number Publication Date
DE69310052D1 true DE69310052D1 (de) 1997-05-28
DE69310052T2 DE69310052T2 (de) 1997-09-18

Family

ID=6465993

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4227616A Expired - Fee Related DE4227616C2 (de) 1992-08-20 1992-08-20 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen
DE69310052T Expired - Lifetime DE69310052T2 (de) 1992-08-20 1993-06-25 Kardioaktive 17B-(3-Furyl) und 17B-(4-Pyridazinyl)-5beta, 14beta-Androstan Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate davon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4227616A Expired - Fee Related DE4227616C2 (de) 1992-08-20 1992-08-20 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen

Country Status (12)

Country Link
US (2) US5591734A (de)
EP (1) EP0583578B1 (de)
JP (2) JP3357427B2 (de)
KR (1) KR100276528B1 (de)
AT (1) ATE152118T1 (de)
CA (1) CA2103826C (de)
DE (2) DE4227616C2 (de)
DK (1) DK0583578T3 (de)
ES (1) ES2100396T3 (de)
GR (1) GR3023311T3 (de)
HK (1) HK1005876A1 (de)
ZA (1) ZA935865B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003005971A2 (en) 2001-07-13 2003-01-23 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
ATE541855T1 (de) 2005-11-25 2012-02-15 Rostaquo S P A Weitere kristalline formen von rostafuroxin
JP2009537139A (ja) 2006-05-15 2009-10-29 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法
BRPI0812775B8 (pt) * 2007-06-07 2021-05-25 Alfasigma Spa uso de 17 beta-(3-furil)-5 beta-androstano-3 beta, 14 beta, 17 alfa- triol na preparação de um medicamento para prevenção ou tratamento de doenças devidas à fibrose hepática
PL2411015T3 (pl) * 2009-03-23 2016-05-31 Cvie Therapeutics Ltd Pochodne 5-beta,14-beta-androstanu przydatne w leczeniu białkomoczu, stwardnienia kłębków nerkowych i niewydolności nerek
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
WO2011029639A2 (en) 2009-09-08 2011-03-17 Medexis S.A. Compounds and methods for treating neoplasia
ME02347B (me) 2009-10-19 2016-06-20 Rostaquo S P A Rostafuroksin za farmakogenomsko lečenje kardiovaskularnih stanja
CN108152432B (zh) * 2017-12-29 2020-11-20 兆科药业（合肥）有限公司 一种罗他夫辛片高效液相检测方法
US11337988B2 (en) 2018-09-27 2022-05-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of ouabain antagonists to inhibit viral infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621803A5 (de) * 1974-08-08 1981-02-27 Siphar Sa
HU171166B (hu) * 1975-07-15 1977-11-28 Richter Gedeon Vegyeszet Sposob poluchenija novykh ehpoksi-androstanov
DE2614046C2 (de) * 1976-04-01 1984-08-02 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
JPH06219951A (ja) 1994-08-09
CA2103826A1 (en) 1994-02-21
DE4227616C2 (de) 1995-04-13
DK0583578T3 (da) 1997-07-21
JP3357427B2 (ja) 2002-12-16
ZA935865B (en) 1994-03-10
US5567697A (en) 1996-10-22
EP0583578A2 (de) 1994-02-23
ATE152118T1 (de) 1997-05-15
CA2103826C (en) 1998-12-22
US5591734A (en) 1997-01-07
JPH06157586A (ja) 1994-06-03
DE69310052T2 (de) 1997-09-18
EP0583578B1 (de) 1997-04-23
DE4227616A1 (de) 1994-03-10
KR100276528B1 (ko) 2001-02-01
GR3023311T3 (en) 1997-08-29
ES2100396T3 (es) 1997-06-16
HK1005876A1 (en) 1999-01-29
EP0583578A3 (en) 1994-07-06
KR940003964A (ko) 1994-03-14

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Legal Events

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Owner name: ROSTAQUO S.P.A., POMENZIA, IT