DK0583578T3 - 17-(3-furyl)- og 17-(4-pyridazinyl)-5beta,14beta-androstanderivater med aktivitet på det cardiovaskulære system, fremgangsmåder til deres fremstilling og farmaceutiske præparater indeholdende disse - Google Patents
17-(3-furyl)- og 17-(4-pyridazinyl)-5beta,14beta-androstanderivater med aktivitet på det cardiovaskulære system, fremgangsmåder til deres fremstilling og farmaceutiske præparater indeholdende disseInfo
- Publication number
- DK0583578T3 DK0583578T3 DK93110187.7T DK93110187T DK0583578T3 DK 0583578 T3 DK0583578 T3 DK 0583578T3 DK 93110187 T DK93110187 T DK 93110187T DK 0583578 T3 DK0583578 T3 DK 0583578T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridazinyl
- furyl
- pharmaceutical compositions
- compositions containing
- 14beta
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 title 1
- ZJPDCQUXBTYIRX-KNGLENPESA-N 4-[(5s,8r,9s,10s,13s,14r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pyridazine Chemical class C([C@@H]1[C@H]2[C@@H]([C@]3(CCCC[C@H]3CC2)C)CC[C@@]11C)CC1C1=CC=NN=C1 ZJPDCQUXBTYIRX-KNGLENPESA-N 0.000 title 1
- 210000000748 cardiovascular system Anatomy 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0021—Oxiranes at position 14(15)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4227616A DE4227616C2 (de) | 1992-08-20 | 1992-08-20 | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0583578T3 true DK0583578T3 (da) | 1997-07-21 |
Family
ID=6465993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93110187.7T DK0583578T3 (da) | 1992-08-20 | 1993-06-25 | 17-(3-furyl)- og 17-(4-pyridazinyl)-5beta,14beta-androstanderivater med aktivitet på det cardiovaskulære system, fremgangsmåder til deres fremstilling og farmaceutiske præparater indeholdende disse |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5591734A (da) |
| EP (1) | EP0583578B1 (da) |
| JP (2) | JP3357427B2 (da) |
| KR (1) | KR100276528B1 (da) |
| AT (1) | ATE152118T1 (da) |
| CA (1) | CA2103826C (da) |
| DE (2) | DE4227616C2 (da) |
| DK (1) | DK0583578T3 (da) |
| ES (1) | ES2100396T3 (da) |
| GR (1) | GR3023311T3 (da) |
| HK (1) | HK1005876A1 (da) |
| ZA (1) | ZA935865B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2329826A1 (en) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of multiple sclerosis |
| EP1951738B1 (en) | 2005-11-25 | 2012-01-18 | Rostaquo S.p.A. | Further crystalline forms of rostafuroxin |
| EP2431469A3 (en) | 2006-05-15 | 2012-05-30 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| HUE025599T2 (en) * | 2007-06-07 | 2016-05-30 | Sigma Tau Ind Farmaceuti | 5ß, 14β-androstane derivatives for treating diseases caused by organ fibrosis |
| KR101656797B1 (ko) * | 2009-03-23 | 2016-09-12 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | 단백뇨, 사구체경화증 및 신부전의 치료에 유용한 5-β, 14-β-안드로스탄 유도체 |
| WO2010149666A1 (en) | 2009-06-22 | 2010-12-29 | Medexis S.A. | Methods for treating neoplasia |
| WO2011029639A2 (en) | 2009-09-08 | 2011-03-17 | Medexis S.A. | Compounds and methods for treating neoplasia |
| ME02347B (me) | 2009-10-19 | 2016-06-20 | Rostaquo S P A | Rostafuroksin za farmakogenomsko lečenje kardiovaskularnih stanja |
| CN108152432B (zh) * | 2017-12-29 | 2020-11-20 | 兆科药业（合肥）有限公司 | 一种罗他夫辛片高效液相检测方法 |
| US11337988B2 (en) | 2018-09-27 | 2022-05-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of ouabain antagonists to inhibit viral infection |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH621803A5 (da) * | 1974-08-08 | 1981-02-27 | Siphar Sa | |
| HU171166B (hu) * | 1975-07-15 | 1977-11-28 | Richter Gedeon Vegyeszet | Sposob poluchenija novykh ehpoksi-androstanov |
| DE2614046C2 (de) * | 1976-04-01 | 1984-08-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| US4380624A (en) * | 1981-07-31 | 1983-04-19 | Advance Biofactures Corp. | Novel isomers of bufalin and resibufogenin and their preparation |
| DE4221636C1 (de) * | 1992-07-01 | 1994-03-31 | Sigma Tau Ind Farmaceuti | Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate |
-
1992
- 1992-08-20 DE DE4227616A patent/DE4227616C2/de not_active Expired - Fee Related
-
1993
- 1993-06-25 DK DK93110187.7T patent/DK0583578T3/da active
- 1993-06-25 EP EP93110187A patent/EP0583578B1/en not_active Expired - Lifetime
- 1993-06-25 AT AT93110187T patent/ATE152118T1/de active
- 1993-06-25 DE DE69310052T patent/DE69310052T2/de not_active Expired - Lifetime
- 1993-06-25 ES ES93110187T patent/ES2100396T3/es not_active Expired - Lifetime
- 1993-08-11 CA CA002103826A patent/CA2103826C/en not_active Expired - Lifetime
- 1993-08-12 ZA ZA935865A patent/ZA935865B/xx unknown
- 1993-08-16 US US08/106,893 patent/US5591734A/en not_active Expired - Lifetime
- 1993-08-19 JP JP20494793A patent/JP3357427B2/ja not_active Expired - Lifetime
- 1993-08-20 KR KR1019930016226A patent/KR100276528B1/ko not_active IP Right Cessation
- 1993-11-18 JP JP5289181A patent/JPH06219951A/ja active Pending
-
1995
- 1995-06-02 US US08/458,822 patent/US5567697A/en not_active Expired - Lifetime
-
1997
- 1997-05-02 GR GR970400967T patent/GR3023311T3/el unknown
-
1998
- 1998-06-05 HK HK98104942A patent/HK1005876A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0583578B1 (en) | 1997-04-23 |
| EP0583578A2 (en) | 1994-02-23 |
| ES2100396T3 (es) | 1997-06-16 |
| JP3357427B2 (ja) | 2002-12-16 |
| DE69310052T2 (de) | 1997-09-18 |
| ATE152118T1 (de) | 1997-05-15 |
| CA2103826A1 (en) | 1994-02-21 |
| US5591734A (en) | 1997-01-07 |
| JPH06219951A (ja) | 1994-08-09 |
| EP0583578A3 (en) | 1994-07-06 |
| KR100276528B1 (ko) | 2001-02-01 |
| DE4227616A1 (de) | 1994-03-10 |
| ZA935865B (en) | 1994-03-10 |
| DE69310052D1 (de) | 1997-05-28 |
| HK1005876A1 (en) | 1999-01-29 |
| DE4227616C2 (de) | 1995-04-13 |
| JPH06157586A (ja) | 1994-06-03 |
| KR940003964A (ko) | 1994-03-14 |
| CA2103826C (en) | 1998-12-22 |
| US5567697A (en) | 1996-10-22 |
| GR3023311T3 (en) | 1997-08-29 |
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