DK0677109T3 - Ekspressionssystem til fremstilling af apolipoprotein AI-M - Google Patents

Ekspressionssystem til fremstilling af apolipoprotein AI-M

Info

Publication number
DK0677109T3
DK0677109T3 DK94902173T DK94902173T DK0677109T3 DK 0677109 T3 DK0677109 T3 DK 0677109T3 DK 94902173 T DK94902173 T DK 94902173T DK 94902173 T DK94902173 T DK 94902173T DK 0677109 T3 DK0677109 T3 DK 0677109T3
Authority
DK
Denmark
Prior art keywords
apolipoprotein
pct
expression system
sec
dna sequence
Prior art date
Application number
DK94902173T
Other languages
Danish (da)
English (en)
Inventor
Lars Abrahmsen
Erik Holmgren
Christina Kaldeden
Mats Lake
Asa Mikaelsson
Torsten Sejlitz
Original Assignee
Esperion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esperion Therapeutics Inc filed Critical Esperion Therapeutics Inc
Application granted granted Critical
Publication of DK0677109T3 publication Critical patent/DK0677109T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
DK94902173T 1992-12-11 1993-12-09 Ekspressionssystem til fremstilling af apolipoprotein AI-M DK0677109T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9203753A SE9203753D0 (sv) 1992-12-11 1992-12-11 Expression system for producing apolipoprotein ai-m
PCT/SE1993/001061 WO1994013819A1 (en) 1992-12-11 1993-12-09 Expression system for producing apolipoprotein ai-m

Publications (1)

Publication Number Publication Date
DK0677109T3 true DK0677109T3 (da) 2000-07-17

Family

ID=20388112

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94902173T DK0677109T3 (da) 1992-12-11 1993-12-09 Ekspressionssystem til fremstilling af apolipoprotein AI-M

Country Status (22)

Country Link
US (1) US5721114A (cs)
EP (1) EP0677109B1 (cs)
JP (1) JP3899121B2 (cs)
AT (1) ATE191930T1 (cs)
AU (1) AU5663794A (cs)
CA (1) CA2150928C (cs)
CZ (1) CZ290865B6 (cs)
DE (1) DE69328442T2 (cs)
DK (1) DK0677109T3 (cs)
ES (1) ES2146646T3 (cs)
FI (1) FI952847A (cs)
GR (1) GR3033966T3 (cs)
HU (1) HU220193B (cs)
IL (1) IL107896A (cs)
MX (1) MX9307855A (cs)
NO (1) NO319497B1 (cs)
PL (1) PL175955B1 (cs)
PT (1) PT677109E (cs)
SE (1) SE9203753D0 (cs)
SK (1) SK76695A3 (cs)
WO (1) WO1994013819A1 (cs)
ZA (1) ZA939266B (cs)

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US6037323A (en) 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
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US20020064820A1 (en) * 2000-03-13 2002-05-30 Jean-Michel Dayer Apo-A-I regulation of T-cell signaling
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US7217785B2 (en) * 2001-05-09 2007-05-15 The Regents Of The University Of California Cysteine-containing peptides having antioxidant properties
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US20030229062A1 (en) * 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
US7470659B2 (en) * 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US7223726B2 (en) * 2002-01-14 2007-05-29 The Regents Of The University Of California Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same
US7691965B2 (en) * 2002-05-08 2010-04-06 The Regents Of The University Of California Helical synthetic peptides that stimulate cellular cholesterol efflux
US20100204103A1 (en) * 2002-05-08 2010-08-12 The Regents Of The University Of California Helical synthetic peptides that stimulate cellular cholesterol efflux
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Also Published As

Publication number Publication date
JPH08506723A (ja) 1996-07-23
HUT71697A (en) 1996-01-29
GR3033966T3 (en) 2000-11-30
NO952297L (no) 1995-06-09
ES2146646T3 (es) 2000-08-16
HU9501680D0 (en) 1995-08-28
NO952297D0 (no) 1995-06-09
EP0677109B1 (en) 2000-04-19
HU220193B (hu) 2001-11-28
MX9307855A (es) 1994-06-30
AU5663794A (en) 1994-07-04
WO1994013819A1 (en) 1994-06-23
CZ148795A3 (en) 1996-01-17
PL309292A1 (en) 1995-10-02
ATE191930T1 (de) 2000-05-15
DE69328442T2 (de) 2000-09-07
FI952847A0 (fi) 1995-06-09
JP3899121B2 (ja) 2007-03-28
PT677109E (pt) 2000-07-31
US5721114A (en) 1998-02-24
CA2150928A1 (en) 1994-06-23
CZ290865B6 (cs) 2002-11-13
PL175955B1 (pl) 1999-03-31
CA2150928C (en) 2005-02-08
FI952847A (fi) 1995-06-09
DE69328442D1 (de) 2000-05-25
ZA939266B (en) 1994-08-08
SE9203753D0 (sv) 1992-12-11
SK76695A3 (en) 1996-02-07
EP0677109A1 (en) 1995-10-18
IL107896A (en) 2004-06-01
NO319497B1 (no) 2005-08-22
IL107896A0 (en) 1994-04-12

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