DK0651825T3 - Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp - Google Patents

Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp

Info

Publication number
DK0651825T3
DK0651825T3 DK93917113T DK93917113T DK0651825T3 DK 0651825 T3 DK0651825 T3 DK 0651825T3 DK 93917113 T DK93917113 T DK 93917113T DK 93917113 T DK93917113 T DK 93917113T DK 0651825 T3 DK0651825 T3 DK 0651825T3
Authority
DK
Denmark
Prior art keywords
stress
methods
toxicity
compound
diagnostic kits
Prior art date
Application number
DK93917113T
Other languages
Danish (da)
English (en)
Inventor
Spencer B Farr
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DK0651825T3 publication Critical patent/DK0651825T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
DK93917113T 1992-07-06 1993-07-06 Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp DK0651825T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91079392A 1992-07-06 1992-07-06
PCT/US1993/006537 WO1994001584A1 (en) 1992-07-06 1993-07-06 Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes

Publications (1)

Publication Number Publication Date
DK0651825T3 true DK0651825T3 (da) 1998-09-14

Family

ID=25429335

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93917113T DK0651825T3 (da) 1992-07-06 1993-07-06 Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp

Country Status (15)

Country Link
US (2) US5589337A (es)
EP (1) EP0651825B1 (es)
JP (1) JP3456703B2 (es)
KR (1) KR100300932B1 (es)
AT (1) ATE162225T1 (es)
AU (1) AU687353B2 (es)
CA (1) CA2139667C (es)
DE (1) DE69316368T2 (es)
DK (1) DK0651825T3 (es)
ES (1) ES2113546T3 (es)
GR (1) GR3026639T3 (es)
HK (1) HK1008433A1 (es)
NO (1) NO319372B1 (es)
SG (1) SG77101A1 (es)
WO (1) WO1994001584A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107815A (en) * 1992-12-04 2003-12-10 Du Pont Genetic constructs comprising a stress-responsive promoter linked to a lux reporter operon and methods of use in environmental testing
EP0680517B2 (en) * 1993-01-21 2005-01-19 President And Fellows Of Harvard College Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound
GB9420735D0 (en) * 1994-10-14 1994-11-30 Karobio Ab Reporter cell line
JPH10509049A (ja) * 1994-11-23 1998-09-08 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 毒物検出のための凍結乾燥生物発光細菌試薬
US6387651B1 (en) 1995-04-12 2002-05-14 Biolog, Inc. Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device
AU717755B2 (en) 1996-01-26 2000-03-30 Virco Bvba Method of managing the chemotherapy of patients who are HIV positive based on the phenotypic drug sensitivity of human HIV strains
CA2267999A1 (en) * 1996-11-15 1998-05-22 E.I. Du Pont De Nemours And Company A small volume, highly sensitive method for detecting environmental insults
WO1999014311A1 (en) * 1997-09-18 1999-03-25 Smithkline Beecham Corporation Method of screening for antimicrobial compounds
EP0950717A1 (en) 1998-04-14 1999-10-20 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Diagnostic system and method for determining the presence of a genotoxic compound in a sample
US6953666B1 (en) 1998-11-06 2005-10-11 Emory University Biomarkers for oxidative stress
AU1243500A (en) * 1998-11-06 2000-05-29 Emory University Biomarkers for oxidative stress
AU4546300A (en) * 1999-04-10 2000-11-14 Merlin Gesellschaft Fur Mikrobiologische Diagnostika Mbh Genotypic classification method
US6410255B1 (en) * 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
US6931396B1 (en) 1999-06-29 2005-08-16 Gene Logic Inc. Biological data processing
US20030232056A1 (en) * 1999-09-10 2003-12-18 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
EP1259608B1 (en) * 2000-02-23 2009-08-12 Life Technologies Corporation Modified fluorescent proteins
US6696239B1 (en) 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US20030171876A1 (en) * 2002-03-05 2003-09-11 Victor Markowitz System and method for managing gene expression data
US7020561B1 (en) 2000-05-23 2006-03-28 Gene Logic, Inc. Methods and systems for efficient comparison, identification, processing, and importing of gene expression data
US6667153B1 (en) 2000-06-26 2003-12-23 Susan Margaret Thomas Composition and method for detecting mutagens
AU2001280746A1 (en) * 2000-07-21 2002-02-05 Phase-1 Molecular Toxicology Canine toxicity genes
US20030119094A1 (en) * 2001-09-24 2003-06-26 Irm Llc Solubility reporter gene constructs
JP2004535772A (ja) * 2000-11-21 2004-12-02 アイアールエム エルエルシー 溶解性レポーター遺伝子構造
WO2002059560A2 (en) * 2001-01-23 2002-08-01 Gene Logic, Inc. A method and system for predicting the biological activity, including toxicology and toxicity, of substances
US7054758B2 (en) * 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
CN100406569C (zh) * 2001-02-05 2008-07-30 潘申权 用于鉴别活性氧类物质清除剂的方法和试剂盒
WO2002073504A1 (en) * 2001-03-14 2002-09-19 Gene Logic, Inc. A system and method for retrieving and using gene expression data from multiple sources
US20020146698A1 (en) * 2001-04-05 2002-10-10 Genelink, Inc. Kits and methods for assessing oxidative stress
US7211383B2 (en) * 2001-04-05 2007-05-01 Genelink, Inc. Kits and methods for assessing skin health
US7251642B1 (en) 2001-08-06 2007-07-31 Gene Logic Inc. Analysis engine and work space manager for use with gene expression data
DE20116898U1 (de) * 2001-10-15 2002-01-17 Festo Ag & Co Mikroventil
KR20030040923A (ko) * 2001-11-17 2003-05-23 광주과학기술원 산화적 손상과 관련된 유해성 탐지를 위한 재조합발광박테리아 대장균ＤＨ5@/ｐＳｏｄａＬｕｘ（ＥＢＨＪ1）［ＫＣＴＣ10098ＢＰ］
KR100461757B1 (ko) * 2002-06-20 2004-12-14 광주과학기술원 화학물질의 독성과 그 유해성을 탐지할 수 있는 재조합발광 박테리아
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
WO2005045426A2 (en) * 2003-11-10 2005-05-19 Aic Gene expression profiling of hazardous compounds and corresponding database clustering algorithm
GB0415963D0 (en) * 2004-07-16 2004-08-18 Cxr Biosciences Ltd Detection of cellular stress
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
CA2475456A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
WO2006096063A1 (en) * 2005-03-11 2006-09-14 Stichting Voor De Technische Wetenschappen Construct and method for screening, selection and identification of stress factors
US7646450B2 (en) * 2005-12-29 2010-01-12 Lg Display Co., Ltd. Light emitting diode array, method of manufacturing the same, backlight assembly having the same, and LCD having the same
ES2307395B2 (es) * 2006-09-04 2009-07-09 Universidad De Oviedo Metodo rapido de deteccion y evaluacion de agentes genotoxicos.
EP2067104A1 (en) 2006-09-28 2009-06-10 Xeround Systems Ltd. Apparatus and method for a distributed storage global database
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11739367B2 (en) 2017-11-08 2023-08-29 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
CA3091022A1 (en) * 2018-02-13 2019-08-22 Twinstrand Biosciences, Inc. Methods and reagents for detecting and assessing genotoxicity
AU2019300172A1 (en) 2018-07-12 2021-01-28 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3279823D1 (en) * 1981-04-14 1989-08-24 Pasteur Institut An inducible dna replication-cell division coupling mechanism in escherichia coli
FR2533584B1 (fr) * 1982-09-28 1986-03-21 Pasteur Institut Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos
US4569916A (en) * 1984-05-21 1986-02-11 Massachusetts Institute Of Technology Assay for tumor promoting agents
EP0370813A3 (en) * 1988-11-25 1991-06-19 Exemplar Corporation Rapid screening mutagenesis and teratogenesis assay
EP0463056A1 (en) * 1989-03-17 1992-01-02 E.I. Du Pont De Nemours And Company External regulation of gene expression

Also Published As

Publication number Publication date
DE69316368T2 (de) 1998-06-25
NO950040L (no) 1995-03-06
EP0651825B1 (en) 1998-01-14
ATE162225T1 (de) 1998-01-15
NO319372B1 (no) 2005-07-25
DE69316368D1 (de) 1998-02-19
KR950702639A (ko) 1995-07-29
GR3026639T3 (en) 1998-07-31
AU4588493A (en) 1994-01-31
EP0651825A1 (en) 1995-05-10
SG77101A1 (en) 2000-12-19
NO950040D0 (no) 1995-01-05
AU687353B2 (en) 1998-02-26
HK1008433A1 (en) 1999-05-07
US5585232A (en) 1996-12-17
ES2113546T3 (es) 1998-05-01
CA2139667C (en) 2005-03-29
US5589337A (en) 1996-12-31
JPH08501930A (ja) 1996-03-05
WO1994001584A1 (en) 1994-01-20
KR100300932B1 (ko) 2001-10-22
JP3456703B2 (ja) 2003-10-14
CA2139667A1 (en) 1994-01-20

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