GR3026639T3 - Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes. - Google Patents

Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes.

Info

Publication number
GR3026639T3
GR3026639T3 GR980400840T GR980400840T GR3026639T3 GR 3026639 T3 GR3026639 T3 GR 3026639T3 GR 980400840 T GR980400840 T GR 980400840T GR 980400840 T GR980400840 T GR 980400840T GR 3026639 T3 GR3026639 T3 GR 3026639T3
Authority
GR
Greece
Prior art keywords
stress
methods
diagnostic kits
toxicity
compound
Prior art date
Application number
GR980400840T
Other languages
English (en)
Inventor
Spencer B Farr
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of GR3026639T3 publication Critical patent/GR3026639T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
GR980400840T 1992-07-06 1998-04-14 Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes. GR3026639T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91079392A 1992-07-06 1992-07-06
PCT/US1993/006537 WO1994001584A1 (en) 1992-07-06 1993-07-06 Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes

Publications (1)

Publication Number Publication Date
GR3026639T3 true GR3026639T3 (en) 1998-07-31

Family

ID=25429335

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400840T GR3026639T3 (en) 1992-07-06 1998-04-14 Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes.

Country Status (15)

Country Link
US (2) US5589337A (el)
EP (1) EP0651825B1 (el)
JP (1) JP3456703B2 (el)
KR (1) KR100300932B1 (el)
AT (1) ATE162225T1 (el)
AU (1) AU687353B2 (el)
CA (1) CA2139667C (el)
DE (1) DE69316368T2 (el)
DK (1) DK0651825T3 (el)
ES (1) ES2113546T3 (el)
GR (1) GR3026639T3 (el)
HK (1) HK1008433A1 (el)
NO (1) NO319372B1 (el)
SG (1) SG77101A1 (el)
WO (1) WO1994001584A1 (el)

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US6696239B1 (en) 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US7020561B1 (en) 2000-05-23 2006-03-28 Gene Logic, Inc. Methods and systems for efficient comparison, identification, processing, and importing of gene expression data
US20030171876A1 (en) * 2002-03-05 2003-09-11 Victor Markowitz System and method for managing gene expression data
US6667153B1 (en) 2000-06-26 2003-12-23 Susan Margaret Thomas Composition and method for detecting mutagens
WO2002008453A2 (en) * 2000-07-21 2002-01-31 Phase-1 Molecular Toxicology Canine toxicity genes
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US20030119094A1 (en) * 2001-09-24 2003-06-26 Irm Llc Solubility reporter gene constructs
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US20020146698A1 (en) * 2001-04-05 2002-10-10 Genelink, Inc. Kits and methods for assessing oxidative stress
US7211383B2 (en) * 2001-04-05 2007-05-01 Genelink, Inc. Kits and methods for assessing skin health
US7251642B1 (en) 2001-08-06 2007-07-31 Gene Logic Inc. Analysis engine and work space manager for use with gene expression data
DE20116898U1 (de) * 2001-10-15 2002-01-17 Festo Ag & Co Mikroventil
KR20030040923A (ko) * 2001-11-17 2003-05-23 광주과학기술원 산화적 손상과 관련된 유해성 탐지를 위한 재조합발광박테리아 대장균ＤＨ5@/ｐＳｏｄａＬｕｘ（ＥＢＨＪ1）［ＫＣＴＣ10098ＢＰ］
KR100461757B1 (ko) * 2002-06-20 2004-12-14 광주과학기술원 화학물질의 독성과 그 유해성을 탐지할 수 있는 재조합발광 박테리아
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WO2005045426A2 (en) * 2003-11-10 2005-05-19 Aic Gene expression profiling of hazardous compounds and corresponding database clustering algorithm
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CA2475456A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
WO2006096063A1 (en) * 2005-03-11 2006-09-14 Stichting Voor De Technische Wetenschappen Construct and method for screening, selection and identification of stress factors
US7646450B2 (en) * 2005-12-29 2010-01-12 Lg Display Co., Ltd. Light emitting diode array, method of manufacturing the same, backlight assembly having the same, and LCD having the same
ES2307395B2 (es) * 2006-09-04 2009-07-09 Universidad De Oviedo Metodo rapido de deteccion y evaluacion de agentes genotoxicos.
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US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
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JP7420388B2 (ja) * 2018-02-13 2024-01-23 ツインストランド・バイオサイエンシズ・インコーポレイテッド 遺伝毒性を検出し、評価するための方法および試薬
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EP0063522B1 (en) * 1981-04-14 1989-07-19 Institut Pasteur An inducible dna replication-cell division coupling mechanism in escherichia coli
FR2533584B1 (fr) * 1982-09-28 1986-03-21 Pasteur Institut Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos
US4569916A (en) * 1984-05-21 1986-02-11 Massachusetts Institute Of Technology Assay for tumor promoting agents
EP0370813A3 (en) * 1988-11-25 1991-06-19 Exemplar Corporation Rapid screening mutagenesis and teratogenesis assay
KR920701453A (ko) * 1989-03-17 1992-08-11 미리엄 디. 멕코나헤이 유전자발현의 외부조절

Also Published As

Publication number Publication date
SG77101A1 (en) 2000-12-19
HK1008433A1 (en) 1999-05-07
EP0651825B1 (en) 1998-01-14
NO950040L (no) 1995-03-06
US5585232A (en) 1996-12-17
DE69316368T2 (de) 1998-06-25
NO950040D0 (no) 1995-01-05
NO319372B1 (no) 2005-07-25
DE69316368D1 (de) 1998-02-19
CA2139667A1 (en) 1994-01-20
JP3456703B2 (ja) 2003-10-14
AU687353B2 (en) 1998-02-26
CA2139667C (en) 2005-03-29
KR100300932B1 (ko) 2001-10-22
ATE162225T1 (de) 1998-01-15
AU4588493A (en) 1994-01-31
KR950702639A (ko) 1995-07-29
DK0651825T3 (da) 1998-09-14
ES2113546T3 (es) 1998-05-01
US5589337A (en) 1996-12-31
WO1994001584A1 (en) 1994-01-20
JPH08501930A (ja) 1996-03-05
EP0651825A1 (en) 1995-05-10

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