DK0651825T3 - Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp - Google Patents

Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp

Info

Publication number
DK0651825T3
DK0651825T3 DK93917113T DK93917113T DK0651825T3 DK 0651825 T3 DK0651825 T3 DK 0651825T3 DK 93917113 T DK93917113 T DK 93917113T DK 93917113 T DK93917113 T DK 93917113T DK 0651825 T3 DK0651825 T3 DK 0651825T3
Authority
DK
Denmark
Prior art keywords
stress
methods
toxicity
compound
diagnostic kits
Prior art date
Application number
DK93917113T
Other languages
English (en)
Inventor
Spencer B Farr
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DK0651825T3 publication Critical patent/DK0651825T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
DK93917113T 1992-07-06 1993-07-06 Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp DK0651825T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91079392A 1992-07-06 1992-07-06
PCT/US1993/006537 WO1994001584A1 (en) 1992-07-06 1993-07-06 Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes

Publications (1)

Publication Number Publication Date
DK0651825T3 true DK0651825T3 (da) 1998-09-14

Family

ID=25429335

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93917113T DK0651825T3 (da) 1992-07-06 1993-07-06 Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp

Country Status (15)

Country Link
US (2) US5589337A (da)
EP (1) EP0651825B1 (da)
JP (1) JP3456703B2 (da)
KR (1) KR100300932B1 (da)
AT (1) ATE162225T1 (da)
AU (1) AU687353B2 (da)
CA (1) CA2139667C (da)
DE (1) DE69316368T2 (da)
DK (1) DK0651825T3 (da)
ES (1) ES2113546T3 (da)
GR (1) GR3026639T3 (da)
HK (1) HK1008433A1 (da)
NO (1) NO319372B1 (da)
SG (1) SG77101A1 (da)
WO (1) WO1994001584A1 (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107815A (en) * 1992-12-04 2003-12-10 Du Pont Genetic constructs comprising a stress-responsive promoter linked to a lux reporter operon and methods of use in environmental testing
ATE160178T1 (de) * 1993-01-21 1997-11-15 Harvard College Verfahren und diagnostische kits unter verwendung von säuger-stresspromotoren zur bestimmung der toxizität einer verbindung
GB9420735D0 (en) * 1994-10-14 1994-11-30 Karobio Ab Reporter cell line
JPH10509049A (ja) * 1994-11-23 1998-09-08 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 毒物検出のための凍結乾燥生物発光細菌試薬
US6387651B1 (en) 1995-04-12 2002-05-14 Biolog, Inc. Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device
ATE217971T1 (de) 1996-01-26 2002-06-15 Virco Nv Verfahren zur überwachung der chemotherapie von hiv-positiven patienten basierend auf der phenotypischen medikamentempfindlichkeit vom hiv stamm des patienten
WO1998021347A1 (en) * 1996-11-15 1998-05-22 E.I. Du Pont De Nemours And Company A small volume, highly sensitive method for detecting environmental insults
JP2001516573A (ja) * 1997-09-18 2001-10-02 スミスクライン・ビーチャム・コーポレイション 抗微生物化合物のスクリーニング方法
EP0950717A1 (en) * 1998-04-14 1999-10-20 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Diagnostic system and method for determining the presence of a genotoxic compound in a sample
US6953666B1 (en) 1998-11-06 2005-10-11 Emory University Biomarkers for oxidative stress
CA2348685A1 (en) * 1998-11-06 2000-05-18 Emory University Biomarkers for oxidative stress
AU4546300A (en) * 1999-04-10 2000-11-14 Merlin Gesellschaft Fur Mikrobiologische Diagnostika Mbh Genotypic classification method
US6410255B1 (en) * 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
US6931396B1 (en) 1999-06-29 2005-08-16 Gene Logic Inc. Biological data processing
US20030232056A1 (en) * 1999-09-10 2003-12-18 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
WO2001062919A1 (en) * 2000-02-23 2001-08-30 Aurora Biosciences Corporation Modified fluorescent proteins
US6696239B1 (en) 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US20030171876A1 (en) * 2002-03-05 2003-09-11 Victor Markowitz System and method for managing gene expression data
US7020561B1 (en) 2000-05-23 2006-03-28 Gene Logic, Inc. Methods and systems for efficient comparison, identification, processing, and importing of gene expression data
US6667153B1 (en) 2000-06-26 2003-12-23 Susan Margaret Thomas Composition and method for detecting mutagens
EP1409718A2 (en) * 2000-07-21 2004-04-21 Phase-1 Molecular Toxicology Canine toxicity genes
US20030119094A1 (en) * 2001-09-24 2003-06-26 Irm Llc Solubility reporter gene constructs
JP2004535772A (ja) * 2000-11-21 2004-12-02 アイアールエム エルエルシー 溶解性レポーター遺伝子構造
US20020192671A1 (en) * 2001-01-23 2002-12-19 Castle Arthur L. Method and system for predicting the biological activity, including toxicology and toxicity, of substances
US7054758B2 (en) * 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
US7405081B2 (en) * 2001-02-05 2008-07-29 Pan Shen Q Methods and kits for identifying scavengers of reactive oxygen species (ROS)
WO2002073504A1 (en) * 2001-03-14 2002-09-19 Gene Logic, Inc. A system and method for retrieving and using gene expression data from multiple sources
US20020146698A1 (en) * 2001-04-05 2002-10-10 Genelink, Inc. Kits and methods for assessing oxidative stress
US7211383B2 (en) * 2001-04-05 2007-05-01 Genelink, Inc. Kits and methods for assessing skin health
US7251642B1 (en) 2001-08-06 2007-07-31 Gene Logic Inc. Analysis engine and work space manager for use with gene expression data
DE20116898U1 (de) * 2001-10-15 2002-01-17 Festo Ag & Co Mikroventil
KR20030040923A (ko) * 2001-11-17 2003-05-23 광주과학기술원 산화적 손상과 관련된 유해성 탐지를 위한 재조합발광박테리아 대장균DH5@/pSodaLux(EBHJ1)[KCTC10098BP]
KR100461757B1 (ko) * 2002-06-20 2004-12-14 광주과학기술원 화학물질의 독성과 그 유해성을 탐지할 수 있는 재조합발광 박테리아
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
WO2005045426A2 (en) * 2003-11-10 2005-05-19 Aic Gene expression profiling of hazardous compounds and corresponding database clustering algorithm
GB0415963D0 (en) * 2004-07-16 2004-08-18 Cxr Biosciences Ltd Detection of cellular stress
CA2475456A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
WO2006096063A1 (en) * 2005-03-11 2006-09-14 Stichting Voor De Technische Wetenschappen Construct and method for screening, selection and identification of stress factors
US7646450B2 (en) * 2005-12-29 2010-01-12 Lg Display Co., Ltd. Light emitting diode array, method of manufacturing the same, backlight assembly having the same, and LCD having the same
ES2307395B2 (es) * 2006-09-04 2009-07-09 Universidad De Oviedo Metodo rapido de deteccion y evaluacion de agentes genotoxicos.
EP2067104A1 (en) 2006-09-28 2009-06-10 Xeround Systems Ltd. Apparatus and method for a distributed storage global database
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
AU2018366213A1 (en) 2017-11-08 2020-05-14 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
RU2020130024A (ru) * 2018-02-13 2022-03-14 Твинстранд Биосайенсис, Инк. Способы и реагенты для обнаружения и оценки генотоксичности
US20210269873A1 (en) 2018-07-12 2021-09-02 Twinstrand Biosciences, Inc. Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063522B1 (en) * 1981-04-14 1989-07-19 Institut Pasteur An inducible dna replication-cell division coupling mechanism in escherichia coli
FR2533584B1 (fr) * 1982-09-28 1986-03-21 Pasteur Institut Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos
US4569916A (en) * 1984-05-21 1986-02-11 Massachusetts Institute Of Technology Assay for tumor promoting agents
EP0370813A3 (en) * 1988-11-25 1991-06-19 Exemplar Corporation Rapid screening mutagenesis and teratogenesis assay
KR920701453A (ko) * 1989-03-17 1992-08-11 미리엄 디. 멕코나헤이 유전자발현의 외부조절

Also Published As

Publication number Publication date
JP3456703B2 (ja) 2003-10-14
CA2139667C (en) 2005-03-29
JPH08501930A (ja) 1996-03-05
WO1994001584A1 (en) 1994-01-20
US5585232A (en) 1996-12-17
SG77101A1 (en) 2000-12-19
EP0651825B1 (en) 1998-01-14
CA2139667A1 (en) 1994-01-20
HK1008433A1 (en) 1999-05-07
DE69316368T2 (de) 1998-06-25
NO950040D0 (no) 1995-01-05
US5589337A (en) 1996-12-31
GR3026639T3 (en) 1998-07-31
AU4588493A (en) 1994-01-31
ES2113546T3 (es) 1998-05-01
DE69316368D1 (de) 1998-02-19
AU687353B2 (en) 1998-02-26
EP0651825A1 (en) 1995-05-10
NO319372B1 (no) 2005-07-25
NO950040L (no) 1995-03-06
ATE162225T1 (de) 1998-01-15
KR100300932B1 (ko) 2001-10-22
KR950702639A (ko) 1995-07-29

Similar Documents

Publication Publication Date Title
DK0651825T3 (da) Fremgangsmåder og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse af en bakterielle stressp
DK0680517T4 (da) Fremgangsmåde og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse afstress-promotorer fra pattedyr
Hausmann et al. Toward a standardized quantitative and qualitative insect monitoring scheme
BRPI0210771B8 (pt) construção de dna recombinante, método para a produção de um produto de gene em uma célula, e, uso de uma sequência de dna
Bailey et al. Turning research on microbial bioherbicides into commercial products–a Phoma story
ATE340870T1 (de) Adressierbare protein arrays
EA199900483A1 (ru) δ-ЭНДОТОКСИНЫ ШИРОКОГО СПЕКТРА ДЕЙСТВИЯ
EP1925677A3 (en) Marker genes for determining renal toxicity
Reullier et al. Diversity, distribution and exchange of blood parasites meeting at an avian moving contact zone
EA200300243A1 (ru) Антитела против tnf, композиции, способы и применения
EA199700087A1 (ru) Способ ингибирования катепсина к
FI883708A (fi) Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
ATE473292T1 (de) Sicherheitssystem
Leary et al. Method development for metaproteomic analyses of marine biofilms
BR9809516A (pt) Proteìnas com atividades inseticidas e método de uso
ATE188507T1 (de) Polyphenol oxidase gene
DK0948604T3 (da) Screeningsmetoder for forbindelser som binder til PYK2-polypeptidet
DK0981631T3 (da) Polypeptider, som har aminopeptidase-aktivitet, og nukleinsyrer, som koder for samme
Kundu et al. The first complete mitochondrial genome of the Indian Tent Turtle, Pangshura tentoria (Testudines: Geoemydidae): Characterization and comparative analysis
McCauley et al. Comparison of ELISA and CFT assays for Chlamydophila abortus antibodies in ovine sera
EA199901001A1 (ru) Бетаины, используемые в качестве адъювантов для проверки чувствительности и антимикробной терапии
Palva et al. Gene fusions to the ptsM/pel locus of Escherichia coli
MAcDERMOT et al. beta-Bungarotoxin. Separation of two discrete proteins with different synaptic actions
PT1123396E (pt) Promotores minimos e seus usos