DK0632809T3 - Quinuclidinderivater som substans P-antagonister - Google Patents
Quinuclidinderivater som substans P-antagonisterInfo
- Publication number
- DK0632809T3 DK0632809T3 DK93907099T DK93907099T DK0632809T3 DK 0632809 T3 DK0632809 T3 DK 0632809T3 DK 93907099 T DK93907099 T DK 93907099T DK 93907099 T DK93907099 T DK 93907099T DK 0632809 T3 DK0632809 T3 DK 0632809T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- substituted
- alkoxy
- hydrogen
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6533792 | 1992-03-23 | ||
PCT/US1993/001810 WO1993019064A1 (en) | 1992-03-23 | 1993-03-05 | Quinuclidine derivatives as substance p antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0632809T3 true DK0632809T3 (da) | 2001-11-12 |
Family
ID=13284021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93907099T DK0632809T3 (da) | 1992-03-23 | 1993-03-05 | Quinuclidinderivater som substans P-antagonister |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0632809B1 (xx) |
JP (1) | JP2656702B2 (xx) |
KR (1) | KR950700908A (xx) |
AT (1) | ATE205207T1 (xx) |
AU (1) | AU3782493A (xx) |
CA (1) | CA2132541C (xx) |
DE (1) | DE69330714T2 (xx) |
DK (1) | DK0632809T3 (xx) |
ES (1) | ES2160596T3 (xx) |
FI (1) | FI944394A0 (xx) |
GR (1) | GR3037025T3 (xx) |
HU (1) | HU9402745D0 (xx) |
IL (1) | IL105098A0 (xx) |
MX (1) | MX9301634A (xx) |
NO (1) | NO943526L (xx) |
PT (1) | PT632809E (xx) |
WO (1) | WO1993019064A1 (xx) |
ZA (1) | ZA932016B (xx) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2700472B1 (fr) | 1993-01-19 | 1995-02-17 | Rhone Poulenc Rorer Sa | Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2. |
IL109646A0 (en) * | 1993-05-19 | 1994-08-26 | Pfizer | Heteroatom substituted alkyl benzylamino-quinuclidines |
US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
DK0708771T3 (da) * | 1993-07-15 | 1999-06-21 | Pfizer | Benzyloxyquinuclidiner som substans P antagonister |
DK0719253T3 (da) * | 1993-09-17 | 2004-07-26 | Pfizer | 3-amino-5-carboxy-substituerede piperidiner og 3-amino-4-carboxy-substituerede pyrrolidiner som tachykininantagonister |
US6083943A (en) * | 1993-09-17 | 2000-07-04 | Pfizer Inc | Substituted azaheterocyclecarboxylic acid |
EP0653208A3 (en) * | 1993-11-17 | 1995-10-11 | Pfizer | Substance P antagonists for the treatment or prevention of sunburn. |
EP0659409A3 (en) * | 1993-11-23 | 1995-08-09 | Pfizer | Substance P antagonists for the inhibition of angiogenesis. |
EP0655246A1 (en) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria |
IL116249A (en) * | 1994-12-12 | 2003-07-06 | Pfizer | Nk-1 receptor antagonists for the treatment of neuronal damage and stroke |
TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
MX9706944A (es) * | 1996-09-12 | 1998-08-30 | Pfizer | Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p. |
ATE387429T1 (de) | 1999-11-03 | 2008-03-15 | Amr Technology Inc | Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
US20040001895A1 (en) * | 2002-06-17 | 2004-01-01 | Pfizer Inc. | Combination treatment for depression and anxiety |
ZA200701232B (en) | 2004-07-15 | 2008-08-27 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
US7956050B2 (en) | 2005-07-15 | 2011-06-07 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP2109608B1 (en) | 2007-01-10 | 2011-03-23 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
CN102014631A (zh) | 2008-03-03 | 2011-04-13 | 泰格尔医药科技公司 | 酪氨酸激酶抑制剂 |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
EP2413932A4 (en) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | INHIBITORS OF AKT ACTIVITY |
JP5739415B2 (ja) | 2009-05-12 | 2015-06-24 | ブリストル−マイヤーズ スクウィブ カンパニー | (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用 |
CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
EP2488028B1 (en) | 2009-10-14 | 2020-08-19 | Merck Sharp & Dohme Corp. | Substituted piperidines that increase p53 activity and the uses thereof |
WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CN103068980B (zh) | 2010-08-02 | 2017-04-05 | 瑟纳治疗公司 | 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制 |
KR102072631B1 (ko) | 2010-08-17 | 2020-02-03 | 시르나 쎄러퓨틱스 인코퍼레이티드 | 짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제 |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
EP3766975A1 (en) | 2010-10-29 | 2021-01-20 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US20140046059A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Process for the preparation of morpholino sulfonyl indole derivatives |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
ES2651347T3 (es) | 2012-11-28 | 2018-01-25 | Merck Sharp & Dohme Corp. | Composiciones y métodos para el tratamiento del cáncer |
CA2895504A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005525A1 (en) * | 1988-11-23 | 1990-05-31 | Pfizer Inc. | Quinuclidine derivatives as substance p antagonists |
DE9290057U1 (de) * | 1991-05-22 | 1994-01-05 | Pfizer | Substituierte 3-Aminochinuclidine |
-
1992
- 1992-11-17 JP JP4307179A patent/JP2656702B2/ja not_active Expired - Fee Related
-
1993
- 1993-03-05 AT AT93907099T patent/ATE205207T1/de not_active IP Right Cessation
- 1993-03-05 DK DK93907099T patent/DK0632809T3/da active
- 1993-03-05 WO PCT/US1993/001810 patent/WO1993019064A1/en active IP Right Grant
- 1993-03-05 DE DE69330714T patent/DE69330714T2/de not_active Expired - Fee Related
- 1993-03-05 ES ES93907099T patent/ES2160596T3/es not_active Expired - Lifetime
- 1993-03-05 EP EP93907099A patent/EP0632809B1/en not_active Expired - Lifetime
- 1993-03-05 PT PT93907099T patent/PT632809E/pt unknown
- 1993-03-05 AU AU37824/93A patent/AU3782493A/en not_active Abandoned
- 1993-03-05 CA CA002132541A patent/CA2132541C/en not_active Expired - Fee Related
- 1993-03-05 HU HU9402745A patent/HU9402745D0/hu unknown
- 1993-03-18 IL IL105098A patent/IL105098A0/xx unknown
- 1993-03-22 ZA ZA932016A patent/ZA932016B/xx unknown
- 1993-03-23 MX MX9301634A patent/MX9301634A/es unknown
-
1994
- 1994-09-22 NO NO943526A patent/NO943526L/no unknown
- 1994-09-22 KR KR1019940703285A patent/KR950700908A/ko not_active Application Discontinuation
- 1994-09-22 FI FI944394A patent/FI944394A0/fi not_active Application Discontinuation
-
2001
- 2001-10-25 GR GR20010401896T patent/GR3037025T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0632809B1 (en) | 2001-09-05 |
AU3782493A (en) | 1993-10-21 |
CA2132541C (en) | 1997-11-25 |
FI944394A (fi) | 1994-09-22 |
DE69330714T2 (de) | 2002-02-07 |
DE69330714D1 (de) | 2001-10-11 |
HU9402745D0 (en) | 1994-12-28 |
ATE205207T1 (de) | 2001-09-15 |
EP0632809A1 (en) | 1995-01-11 |
NO943526D0 (no) | 1994-09-22 |
NO943526L (no) | 1994-09-22 |
ZA932016B (en) | 1994-09-22 |
JPH05320162A (ja) | 1993-12-03 |
IL105098A0 (en) | 1993-07-08 |
FI944394A0 (fi) | 1994-09-22 |
PT632809E (pt) | 2001-12-28 |
MX9301634A (es) | 1994-07-29 |
KR950700908A (ko) | 1995-02-20 |
CA2132541A1 (en) | 1993-09-30 |
ES2160596T3 (es) | 2001-11-16 |
JP2656702B2 (ja) | 1997-09-24 |
GR3037025T3 (en) | 2002-01-31 |
WO1993019064A1 (en) | 1993-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0632809T3 (da) | Quinuclidinderivater som substans P-antagonister | |
DK0665843T3 (da) | Substituerede quinuclidiner som substans P-antagonister | |
NO854941L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive, sure indol-derivater. | |
NO851054L (no) | Fremgangsmaate for fremstilling av terapeutisk aktive 3-substituerte 2-oksindol-1-karbokamider | |
HN1998000074A (es) | Derivados de macrolidos c-4 sustituidos | |
ATE268337T1 (de) | C11-carbamate von antibakteriellen makroliden | |
UY24499A1 (es) | Nuevos derivados de 2-(3h)-oxazolona | |
DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
DK174389A (da) | Anvendelse af 3-substituerede 2-oxindol-1-carboxamid-forbindelser til fremstilling af farmaceutiske praeparater til inhibering af interleukin-1-biosyntese | |
AR020294A1 (es) | COMPUESTOS DERIVADOS DE 1-TRIFLUOROMETIL-4-HIDROXI-7-PIPERIDINIL-AMINOMETILCROMANO, COMPOSICION FARMACEUTICA Y USO EN LA PREPARACIoN DE MEDICAMENTOS. | |
BR0212077A (pt) | Compostos de aminopirróis como agentes antiinflamatórios | |
ES2141134T3 (es) | Derivados de carbamoil pirrolidona para el tratamiento de la depresion y de los trastornos cerebrovasculares. | |
DE59103080D1 (de) | 9-Amino-2-phenylbicyclo[3.3.1]nonane und 9-Amino-2-phenylbicyclo[3.3.1]-non-2-ene und diese enthaltende therapeutische Mittel. |