DK0626954T3 - Benzocycloheptener, benzoxepiner og benzothiepiner - Google Patents
Benzocycloheptener, benzoxepiner og benzothiepinerInfo
- Publication number
- DK0626954T3 DK0626954T3 DK94902708T DK94902708T DK0626954T3 DK 0626954 T3 DK0626954 T3 DK 0626954T3 DK 94902708 T DK94902708 T DK 94902708T DK 94902708 T DK94902708 T DK 94902708T DK 0626954 T3 DK0626954 T3 DK 0626954T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- group
- sec
- bond
- compounds
- Prior art date
Links
- NIGNBCLEMMGDQP-UHFFFAOYSA-N 1-benzothiepine Chemical class S1C=CC=CC2=CC=CC=C12 NIGNBCLEMMGDQP-UHFFFAOYSA-N 0.000 title 1
- ZVCPCZRXWGOICC-UHFFFAOYSA-N 1h-benzo[7]annulene Chemical class C1=CC=CC=C2CC=CC=C21 ZVCPCZRXWGOICC-UHFFFAOYSA-N 0.000 title 1
- 150000005119 benzoxepines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9214720A FR2698873B1 (fr) | 1992-12-07 | 1992-12-07 | Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant. |
| PCT/EP1993/003445 WO1994013658A2 (en) | 1992-12-07 | 1993-12-07 | Benzocycloheptenes, benzoxepines and benzothiepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0626954T3 true DK0626954T3 (da) | 1999-10-11 |
Family
ID=9436308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94902708T DK0626954T3 (da) | 1992-12-07 | 1993-12-07 | Benzocycloheptener, benzoxepiner og benzothiepiner |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5602152A (cs) |
| EP (1) | EP0626954B1 (cs) |
| JP (1) | JPH07503977A (cs) |
| KR (1) | KR100236810B1 (cs) |
| CN (1) | CN1050127C (cs) |
| AT (1) | ATE177742T1 (cs) |
| AU (1) | AU680856B2 (cs) |
| CA (1) | CA2129642A1 (cs) |
| CZ (1) | CZ184894A3 (cs) |
| DE (1) | DE69324001T2 (cs) |
| DK (1) | DK0626954T3 (cs) |
| ES (1) | ES2132373T3 (cs) |
| FI (1) | FI943646A7 (cs) |
| FR (1) | FR2698873B1 (cs) |
| GR (1) | GR3030514T3 (cs) |
| HU (1) | HUT67852A (cs) |
| IL (1) | IL107891A0 (cs) |
| LT (1) | LT3167B (cs) |
| LV (1) | LV10451B (cs) |
| NO (1) | NO942914L (cs) |
| NZ (1) | NZ258896A (cs) |
| PL (1) | PL174246B1 (cs) |
| RO (1) | RO113040B1 (cs) |
| RU (1) | RU2127268C1 (cs) |
| SI (1) | SI9300632A (cs) |
| SK (1) | SK93994A3 (cs) |
| TW (1) | TW276255B (cs) |
| WO (1) | WO1994013658A2 (cs) |
| ZA (1) | ZA939127B (cs) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| CA2199944A1 (en) * | 1994-09-13 | 1996-03-21 | Len Fang Lee | Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US5952326A (en) * | 1997-12-10 | 1999-09-14 | Pfizer Inc. | Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases |
| AU1890299A (en) * | 1998-01-14 | 1999-08-02 | Nippon Shinyaku Co. Ltd. | Potassium channel activators |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| PT1140185E (pt) | 1998-12-23 | 2003-10-31 | Searle Llc | Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com agentes sequestrantes de acido biliar para indicacoes cardiovasculares |
| DE69908645T2 (de) | 1998-12-23 | 2004-05-13 | G.D. Searle Llc, Chicago | Kombinationen von cholesteryl ester transfer protein inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| DE69908414T2 (de) | 1998-12-23 | 2004-04-01 | G.D. Searle Llc, Chicago | Kombinationen von ileumgallensäuretransports inhibitoren und cholesteryl ester transfer protein inhibitoren |
| JP2002533408A (ja) * | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびニコチン酸誘導体の組み合わせ |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| JP2002533414A (ja) * | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
| CN1342090A (zh) | 1998-12-23 | 2002-03-27 | G·D·瑟尔有限公司 | 适用于心血管疾病的回肠胆汁酸转运抑制剂和贝酸衍生物的组合 |
| BR9916564A (pt) * | 1998-12-23 | 2002-01-29 | Searle Llc | Combinações para indicações cardiovasculares |
| US20020061888A1 (en) * | 2000-03-10 | 2002-05-23 | Keller Bradley T. | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| HK1052183A1 (zh) | 2000-03-10 | 2003-09-05 | Pharmacia Corporation | 制造tetrahydrobenzothiepines的方法 |
| US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
| BR0213501A (pt) * | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| CA2471639A1 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| RU2387648C1 (ru) * | 2008-12-15 | 2010-04-27 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | Способ получения алкиловых эфиров 3-оксо-1,3-дигидробензо[с]оксепин-4-карбоновой кислоты |
| EP3278796A1 (en) | 2011-10-28 | 2018-02-07 | Lumena Pharmaceuticals LLC | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| EP3266457A1 (en) | 2011-10-28 | 2018-01-10 | Lumena Pharmaceuticals LLC | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| EP2834216A1 (en) | 2012-04-04 | 2015-02-11 | Catylix Inc. | Selective androgen receptor modulators |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1593760A1 (de) * | 1967-02-01 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Benz-epinderivate |
| US3444176A (en) * | 1967-04-28 | 1969-05-13 | Mcneilab Inc | Certain 4-diloweralkylamino-lower alkyl - 5 - pyridyl (or phenyl)-2,3-dihydro - 1 - benzothiepins and derivatives thereof |
| AU8402275A (en) * | 1974-08-26 | 1977-02-17 | Takeda Chemical Industries Ltd | Benzocycloheptene derivatives |
| US4066663A (en) * | 1976-07-01 | 1978-01-03 | Syntex (U.S.A.) Inc. | 6,11-Dihydrodibenzo-[b. e.]-thiepin-11-one-3-aldehyde and 3-acetal derivatives |
| DE3274350D1 (en) | 1981-09-25 | 1987-01-08 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
| US4416687A (en) * | 1982-02-01 | 1983-11-22 | Monsanto Company | 3,5-Bis (trifluoromethyl)phenoxy carboxylic acids and derivatives thereof |
| NZ207110A (en) * | 1983-02-15 | 1986-05-09 | Merrell Dow Pharma | (4a,11b)-3,4,4a,5,6,11b-hexahydro-2h-(1)benzoxepino(5,4,b)-1,4-oxazine derivatives and pharmaceutical compositions |
| NZ219311A (en) * | 1986-02-27 | 1989-04-26 | Janssen Pharmaceutica Nv | Imidazoles and herbicidal compositions |
| AU597671B2 (en) * | 1986-06-20 | 1990-06-07 | Suntory Limited | 2-Phenylbenzoxepin derivative |
| DE3726261A1 (de) | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
| US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
| GB8812765D0 (en) * | 1988-05-28 | 1988-06-29 | Beecham Group Plc | Novel compounds |
| DE3831697A1 (de) * | 1988-09-17 | 1990-03-22 | Hoechst Ag | 2,3,4,5-tetrahydro-1-benzoxepine, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
| DE3922392A1 (de) * | 1989-07-07 | 1991-01-17 | Merck Patent Gmbh | Chromanderivate |
| JP3018386B2 (ja) * | 1990-01-24 | 2000-03-13 | 吉富製薬株式会社 | 光学活性なベンゾチエピノピリダジン化合物の製造法 |
-
1992
- 1992-12-07 FR FR9214720A patent/FR2698873B1/fr not_active Expired - Fee Related
-
1993
- 1993-12-03 LT LTIP1525A patent/LT3167B/lt not_active IP Right Cessation
- 1993-12-03 SI SI9300632A patent/SI9300632A/sl unknown
- 1993-12-06 IL IL10789193A patent/IL107891A0/xx unknown
- 1993-12-06 CN CN93120135A patent/CN1050127C/zh not_active Expired - Fee Related
- 1993-12-06 ZA ZA939127A patent/ZA939127B/xx unknown
- 1993-12-07 RU RU94040853A patent/RU2127268C1/ru active
- 1993-12-07 NZ NZ258896A patent/NZ258896A/en unknown
- 1993-12-07 HU HU9402302A patent/HUT67852A/hu unknown
- 1993-12-07 SK SK939-94A patent/SK93994A3/sk unknown
- 1993-12-07 KR KR1019940702708A patent/KR100236810B1/ko not_active Expired - Fee Related
- 1993-12-07 EP EP94902708A patent/EP0626954B1/en not_active Expired - Lifetime
- 1993-12-07 ES ES94902708T patent/ES2132373T3/es not_active Expired - Lifetime
- 1993-12-07 TW TW082110417A patent/TW276255B/zh active
- 1993-12-07 DE DE69324001T patent/DE69324001T2/de not_active Expired - Fee Related
- 1993-12-07 AU AU56975/94A patent/AU680856B2/en not_active Ceased
- 1993-12-07 DK DK94902708T patent/DK0626954T3/da active
- 1993-12-07 US US08/284,454 patent/US5602152A/en not_active Expired - Fee Related
- 1993-12-07 PL PL93304719A patent/PL174246B1/pl unknown
- 1993-12-07 JP JP6513771A patent/JPH07503977A/ja active Pending
- 1993-12-07 CA CA002129642A patent/CA2129642A1/en not_active Abandoned
- 1993-12-07 AT AT94902708T patent/ATE177742T1/de not_active IP Right Cessation
- 1993-12-07 WO PCT/EP1993/003445 patent/WO1994013658A2/en not_active Ceased
- 1993-12-07 CZ CZ941848A patent/CZ184894A3/cs unknown
- 1993-12-07 FI FI943646A patent/FI943646A7/fi unknown
- 1993-12-07 RO RO94-01321A patent/RO113040B1/ro unknown
-
1994
- 1994-08-05 NO NO942914A patent/NO942914L/no unknown
- 1994-08-05 LV LVP-94-154A patent/LV10451B/en unknown
-
1995
- 1995-06-05 US US08/460,866 patent/US5652252A/en not_active Expired - Fee Related
-
1999
- 1999-06-15 GR GR990401589T patent/GR3030514T3/el unknown
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| HU9500710D0 (en) | Ureido-acetamide derivatives, preparation thereof and drugs containing same | |
| DE69116680D1 (de) | Imidazol-2-yl-derivate von bicyclischen verbindungen und verfahren zu deren herstellung | |
| NO921482D0 (no) | 20-metyl-5,7-pregnadien 3beta,21-diolderivater | |
| JO1755B1 (en) | Therapeutic agents |