DK0609606T3 - - Google Patents
Info
- Publication number
- DK0609606T3 DK0609606T3 DK93307373.6T DK93307373T DK0609606T3 DK 0609606 T3 DK0609606 T3 DK 0609606T3 DK 93307373 T DK93307373 T DK 93307373T DK 0609606 T3 DK0609606 T3 DK 0609606T3
- Authority
- DK
- Denmark
- Prior art keywords
- combinations
- compound
- immunopotentiatory
- hydroxyphenoxymethyl
- tumours
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- XEDONBRPTABQFB-UHFFFAOYSA-N 4-[(2-formyl-3-hydroxyphenoxy)methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1COC1=CC=CC(O)=C1C=O XEDONBRPTABQFB-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002924 anti-infective effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Securing Globes, Refractors, Reflectors Or The Like (AREA)
- Planar Illumination Modules (AREA)
- Illuminated Signs And Luminous Advertising (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929220715A GB9220715D0 (en) | 1992-10-01 | 1992-10-01 | Immunopotentiatory agent and physiologically acceptable salts thereof |
| GB929226874A GB9226874D0 (en) | 1992-12-23 | 1992-12-23 | Immunopotentiatory agents and physiologically acceptable salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0609606T3 true DK0609606T3 (cg-RX-API-DMAC10.html) | 1997-03-17 |
Family
ID=26301715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93307373.6T DK0609606T3 (cg-RX-API-DMAC10.html) | 1992-10-01 | 1993-09-17 |
Country Status (24)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996005836A2 (en) * | 1994-08-25 | 1996-02-29 | Medical University Of South Carolina | Methods of treating cold symptoms using pentoxifylline |
| GB9601544D0 (en) | 1996-01-26 | 1996-03-27 | Smithkline Beecham Plc | Pharmaceuticals |
| US6080725A (en) * | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| WO1998052573A1 (en) * | 1997-05-20 | 1998-11-26 | Galenica Pharmaceuticals, Inc. | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
| MXPA00003108A (es) * | 1997-10-03 | 2001-07-01 | Polisacaridos formadores de iminas, preparacion de los mismos y el uso como adyuvantes e inmunoestimulan | |
| WO2000009075A2 (en) | 1998-08-14 | 2000-02-24 | Galenica Pharmaceuticals, Inc. | Chemically modified saponins and the use thereof as adjuvants |
| GB9818627D0 (en) * | 1998-08-26 | 1998-10-21 | Glaxo Group Ltd | Improvements in dva vaccination |
| US6939896B2 (en) * | 1999-12-21 | 2005-09-06 | Astrazeneca Ab | Cd45 inhibitors |
| JP2003518085A (ja) * | 1999-12-21 | 2003-06-03 | アストラゼネカ アクチボラグ | Ｃｄ４５阻害剤 |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| WO2001070663A2 (en) * | 2000-03-17 | 2001-09-27 | Corixa Corporation | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
| KR100863632B1 (ko) | 2000-03-31 | 2008-10-15 | 퍼듀 리서치 파운데이션 | 리간드-면역원 접합체를 사용한 치료 방법 |
| WO2001076626A2 (en) * | 2000-04-11 | 2001-10-18 | Galenica Pharmaceuticals, Inc. | Lipophilic aromatic aldehyde and ketone derivatives and the use thereof as immunostimulants and adjuvants |
| WO2002087424A2 (en) * | 2001-05-02 | 2002-11-07 | Purdue Research Foundation | Treatment and diagnosis of macrophage mediated disease |
| KR20040053136A (ko) * | 2001-09-28 | 2004-06-23 | 펄듀 리서치 파운데이션 | 리간드-면역원 공액체를 이용한 치료 방법 |
| US8246969B2 (en) * | 2001-11-16 | 2012-08-21 | Skinmedica, Inc. | Compositions containing aromatic aldehydes and their use in treatments |
| US20030157154A1 (en) * | 2002-01-04 | 2003-08-21 | Bryan Fuller | Compositions containing hydroxy aromatic aldehydes and their use in treatments |
| US6911434B2 (en) * | 2002-02-04 | 2005-06-28 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds |
| EP2283838A3 (en) * | 2002-09-27 | 2011-04-20 | Martek Biosciences Corporation | Docosahexaenoic acid for treating subclinical inflammation |
| EP1622554A4 (en) * | 2003-05-15 | 2008-01-02 | Bioform Medical Inc | COMPOSITIONS CONTAINING A COMBINATION OF A PHARMACEUTICAL AGENT OR A COSMETIC AGENT AND AN OXY-GROUP-WEARING AROMATIC ALDEHYDE |
| KR20050118057A (ko) * | 2004-04-24 | 2005-12-15 | 김상희 | 아세틸디아실글리세롤류의 화합물을 유효성분으로함유하는 항암제 및 건강식품 |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| US8168164B2 (en) * | 2006-02-03 | 2012-05-01 | Purdue Research Foundation | Targeted conjugates and radiation |
| WO2009065002A1 (en) * | 2007-11-15 | 2009-05-22 | Endocyte, Inc. | Method of administering conjugates |
| CA3043905A1 (en) | 2011-01-07 | 2012-07-12 | Allergan, Inc. | Compositions comprising substituted benzaldehydes and use thereof for lightening skin or treating hyperpigmenation and hypermelanosis disorders |
| HK1249052A1 (zh) | 2015-03-06 | 2018-10-26 | BeyondSpring Pharmaceuticals Inc. | 治疗与ras突变相关的癌症的方法 |
| JP6969848B2 (ja) | 2015-07-13 | 2021-11-24 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | プリナブリン組成物 |
| BR112018016054A2 (pt) * | 2016-02-08 | 2019-02-12 | Beyondspring Pharmaceuticals, Inc. | composições farmacêuticas e/ou métodos para tratar câncer e/ou para romper vasculatura de tumor associada ao câncer em indivíduo |
| RU2760348C2 (ru) | 2016-06-06 | 2021-11-24 | Бейондспринг Фармасьютикалс, Инк. | Способ уменьшения нейтропении |
| EP3565812B1 (en) | 2017-01-06 | 2023-12-27 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| WO2018144764A1 (en) | 2017-02-01 | 2018-08-09 | Beyondspring Pharmaceuticals, Inc. | Method of reducing neutropenia |
| CN112135614A (zh) | 2018-01-24 | 2020-12-25 | 大连万春布林医药有限公司 | 通过施用普那布林减少血小板减少症的组合物和方法 |
| CA3215047A1 (en) | 2021-04-09 | 2022-10-13 | Lan Huang | Therapeutic compositions and methods for treating tumors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54126731A (en) * | 1978-03-20 | 1979-10-02 | Rikagaku Kenkyusho | Carcinostatic agent |
| JPS5545658A (en) * | 1978-09-28 | 1980-03-31 | Rikagaku Kenkyusho | Carcinostatic agent |
| JPS5569510A (en) * | 1978-11-16 | 1980-05-26 | Mitsubishi Chem Ind Ltd | Carcinostatic agent |
| GB2090830B (en) * | 1980-12-18 | 1984-09-26 | Wellcome Found | Formyl ether derivatives |
| LU85365A1 (de) * | 1984-05-16 | 1986-01-29 | Chimicasa Gmbh | Verfahren und praeparat zur stimulierung des immunsystems |
| DE3431236A1 (de) * | 1984-08-24 | 1986-02-27 | Carnivora-Deutschland GmbH, 7109 Jagsthausen | Verwendung von 1,4-naphthochinon-derivaten in niedrigen konzentrationen zur immunstimulation |
| DE3528709A1 (de) * | 1985-08-09 | 1987-02-19 | Schleicher Peter | Mundpflegemittel |
| JPS63264409A (ja) * | 1988-01-13 | 1988-11-01 | Rikagaku Kenkyusho | 制癌剤 |
| JPH03254007A (ja) * | 1990-03-01 | 1991-11-13 | Tir Syst Ltd | 非吸収性で且つ透過率が可変のカバーを有した照明装置 |
| GB9018061D0 (en) * | 1990-08-17 | 1990-10-03 | Wellcome Found | Compositions for vaccines |
| EP0499015A1 (en) * | 1991-02-15 | 1992-08-19 | Fockerman, Jasmine | Benzopyran phenol derivates for use as antibacterial, antiviral or immunostimulating agents |
-
1993
- 1993-09-17 DE DE69306545T patent/DE69306545T2/de not_active Expired - Lifetime
- 1993-09-17 DK DK93307373.6T patent/DK0609606T3/da active
- 1993-09-17 SG SG1996004981A patent/SG48993A1/en unknown
- 1993-09-17 EP EP95110267A patent/EP0678298A3/en not_active Withdrawn
- 1993-09-17 AT AT93307373T patent/ATE146075T1/de not_active IP Right Cessation
- 1993-09-17 EP EP93307373A patent/EP0609606B1/en not_active Expired - Lifetime
- 1993-09-17 ES ES93307373T patent/ES2096215T3/es not_active Expired - Lifetime
- 1993-09-29 IL IL107157A patent/IL107157A0/xx unknown
- 1993-09-30 EP EP93921034A patent/EP0614357A1/en not_active Withdrawn
- 1993-09-30 KR KR1019940701840A patent/KR100348775B1/ko not_active Expired - Fee Related
- 1993-09-30 MX MX9306079A patent/MX9306079A/es unknown
- 1993-09-30 NZ NZ256110A patent/NZ256110A/en unknown
- 1993-09-30 JP JP6508846A patent/JPH07504204A/ja not_active Withdrawn
- 1993-09-30 JP JP27730093A patent/JP3717950B2/ja not_active Expired - Fee Related
- 1993-09-30 WO PCT/GB1993/002039 patent/WO1994007479A2/en not_active Ceased
- 1993-09-30 HR HR931243A patent/HRP931243A2/hr not_active Application Discontinuation
- 1993-09-30 CN CNB931144442A patent/CN1213746C/zh not_active Expired - Fee Related
- 1993-09-30 SK SK652-94A patent/SK65294A3/sk unknown
- 1993-09-30 YU YU62793A patent/YU62793A/sh unknown
- 1993-09-30 AU AU48311/93A patent/AU676491B2/en not_active Ceased
- 1993-09-30 RU RU94028670/14A patent/RU94028670A/ru unknown
- 1993-09-30 CA CA002124677A patent/CA2124677C/en not_active Expired - Fee Related
- 1993-09-30 SI SI9300514A patent/SI9300514A/sl unknown
- 1993-09-30 CZ CZ941327A patent/CZ132794A3/cs unknown
- 1993-09-30 HU HU9401631A patent/HUT70482A/hu unknown
-
1995
- 1995-05-19 US US08/446,080 patent/US5508310A/en not_active Expired - Fee Related
-
1997
- 1997-02-12 GR GR970400229T patent/GR3022541T3/el unknown
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