DK0602126T3 - Immunoglobulinvarianter til specifikke FC epsilon-receptorer - Google Patents

Immunoglobulinvarianter til specifikke FC epsilon-receptorer

Info

Publication number
DK0602126T3
DK0602126T3 DK92918713T DK92918713T DK0602126T3 DK 0602126 T3 DK0602126 T3 DK 0602126T3 DK 92918713 T DK92918713 T DK 92918713T DK 92918713 T DK92918713 T DK 92918713T DK 0602126 T3 DK0602126 T3 DK 0602126T3
Authority
DK
Denmark
Prior art keywords
ige
receptor
specific
binding
useful
Prior art date
Application number
DK92918713T
Other languages
Danish (da)
English (en)
Inventor
Paula M Jardieu
Leonard G Presta
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27114350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0602126(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DK0602126T3 publication Critical patent/DK0602126T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92918713T 1991-08-14 1992-08-14 Immunoglobulinvarianter til specifikke FC epsilon-receptorer DK0602126T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74476891A 1991-08-14 1991-08-14
US87949592A 1992-05-07 1992-05-07
PCT/US1992/006860 WO1993004173A1 (fr) 1991-08-14 1992-08-14 Variantes d'immunoglobulines pour des recepteurs specifiques fc epsilon

Publications (1)

Publication Number Publication Date
DK0602126T3 true DK0602126T3 (da) 2003-06-16

Family

ID=27114350

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92918713T DK0602126T3 (da) 1991-08-14 1992-08-14 Immunoglobulinvarianter til specifikke FC epsilon-receptorer
DK02009009T DK1260521T3 (da) 1991-08-14 1992-08-14 Immunoglobulinvarianter af specifikke Fc-epsilonreceptorer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02009009T DK1260521T3 (da) 1991-08-14 1992-08-14 Immunoglobulinvarianter af specifikke Fc-epsilonreceptorer

Country Status (12)

Country Link
EP (2) EP1260521B1 (fr)
JP (1) JP3457962B2 (fr)
AT (1) ATE233813T1 (fr)
AU (2) AU2498192A (fr)
CA (1) CA2113813C (fr)
DE (3) DE122006000006I2 (fr)
DK (2) DK0602126T3 (fr)
ES (2) ES2296839T3 (fr)
HK (2) HK1014542A1 (fr)
LU (1) LU91219I2 (fr)
NL (1) NL300220I2 (fr)
WO (1) WO1993004173A1 (fr)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770396A (en) * 1992-04-16 1998-06-23 The United States Of America As Represented By The Department Of Health And Human Services Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E
DE69333484T2 (de) * 1992-09-24 2005-03-24 Novartis Ag Umgestaltete monoklonale Antikörper gegen ein Immunglobulinisotyp
US5958708A (en) * 1992-09-25 1999-09-28 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US6066718A (en) * 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
GB9324013D0 (en) * 1993-11-22 1994-01-12 3I Res Expl Ltd Polypeptides
EP0739214B1 (fr) * 1994-01-18 1998-03-18 Genentech, Inc. PROCEDE DE TRAITEMENT DE LA PARASITOSE A L'AIDE D'ANTAGONISTES DE L'IgE
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US20040197326A1 (en) * 1995-07-27 2004-10-07 Genentech, Inc. Method for treatment of allergic asthma
DK0885244T4 (da) * 1996-03-01 2008-06-16 Novartis Ag Peptidimmunogener til vaccination imod og til behandling af allergi
US5958880A (en) * 1996-12-19 1999-09-28 Heska Corporation Feline Fc epsilon receptor alpha chain proteins and therapeutic uses thereof
US7122636B1 (en) 1997-02-21 2006-10-17 Genentech, Inc. Antibody fragment-polymer conjugates and uses of same
US5994511A (en) 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6172213B1 (en) 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
US6057127A (en) * 1998-01-29 2000-05-02 Heska Corporation Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof
US7393529B2 (en) * 1998-04-09 2008-07-01 Idexx Laboratories, Inc. Methods and compositions for inhibiting binding of IgE to a high affinity receptor
US6504013B1 (en) * 2000-02-01 2003-01-07 Idexx Laboratories, Inc. Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6299875B1 (en) 1998-06-04 2001-10-09 Panacea Pharmaceuticals, Llc Methods to block IGE binding to cell surface receptors of mast cells
TWI227241B (en) 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
CN1520423A (zh) * 1999-02-25 2004-08-11 ʷ��˿�������ȳ�ķ���޹�˾ 来源于IgE的Cε3或Cε4区的抗原决定基或拟表位,其拮抗物,及其治疗用途
US6889145B1 (en) 2000-03-15 2005-05-03 Northwestern University Three-dimensional model of a Fc region of an IgE antibody and uses thereof
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
AU2002213441B2 (en) 2000-10-12 2006-10-26 Genentech, Inc. Reduced-viscosity concentrated protein formulations
JP4460302B2 (ja) 2002-02-05 2010-05-12 ジェネンテック インコーポレイテッド タンパク質精製法
DK1501369T3 (en) 2002-04-26 2015-09-28 Genentech Inc Non-affinity purification of proteins
US7365168B2 (en) 2002-10-15 2008-04-29 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US20060034845A1 (en) 2002-11-08 2006-02-16 Karen Silence Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
US9320792B2 (en) 2002-11-08 2016-04-26 Ablynx N.V. Pulmonary administration of immunoglobulin single variable domains and constructs thereof
EP1558650A2 (fr) 2002-11-08 2005-08-03 Ablynx N.V. Procede d'administration de polypeptides therapeutiques et polypeptides associes
JP2006519763A (ja) 2002-11-08 2006-08-31 アブリンクス エン.ヴェー. 治療用ポリペプチドの投与法およびそのためのポリペプチド
ZA200507757B (en) 2003-04-04 2007-01-31 Genentech Inc High concentration antibody and protein formulations
WO2005016968A2 (fr) 2003-07-28 2005-02-24 Genentech, Inc. Reduction de la lixiviation de la proteine a lors de la chromatographie d'affinite sur la proteine a
EP1673395A1 (fr) 2003-10-15 2006-06-28 PDL BioPharma, Inc. Modification de demi-vies seriques de proteines de fusion fc par mutagenese de positions 250, 314 et/ou 428 de la region constante de la chaine lourde des immunoglobulines
US7655229B2 (en) 2004-09-02 2010-02-02 Chan Andrew C Anti-FC-gamma RIIB receptor antibody and uses therefor
US7662926B2 (en) 2004-09-02 2010-02-16 Genentech, Inc. Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
US8080249B2 (en) * 2005-06-30 2011-12-20 Risk Glifford G Methods to treating chronic obstructive pulmonary disease
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008079302A2 (fr) 2006-12-21 2008-07-03 Millipore Corporation Purification de protéines
EP2120915B1 (fr) 2007-01-22 2011-09-28 Genentech, Inc. Précipitation de polyélectrolyte et purification de protéines
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
LT3327026T (lt) 2007-07-09 2019-11-11 Genentech Inc Disulfidinio ryšio redukcijos prevencija rekombinantinių polipeptidų gaminimo metu
PE20120259A1 (es) 2007-08-09 2012-04-04 Boehringer Ingelheim Int Anticuerpos anti-cd37
JP5189098B2 (ja) 2007-08-23 2013-04-24 三菱化学メディエンス株式会社 非特異反応抑制剤
ES2666170T3 (es) 2007-10-30 2018-05-03 Genentech, Inc. Purificación de anticuerpos mediante cromatografía de intercambio catiónico
WO2009151514A1 (fr) 2008-06-11 2009-12-17 Millipore Corporation Bioréacteur à cuve agitée
LT2848625T (lt) 2008-08-14 2019-10-10 Genentech, Inc. Priemaišų pašalinimo būdai, panaudojant reziduojančio baltymo pakeitimą jonų mainų membraninės chromatografijos pagalba
CN102209554A (zh) 2008-09-10 2011-10-05 弗·哈夫曼-拉罗切有限公司 用于防止蛋白质氧化降解的组合物和方法
CN102256993A (zh) 2008-12-16 2011-11-23 米利波尔公司 蛋白的纯化
US20100190963A1 (en) 2008-12-16 2010-07-29 Millipore Corporation Stirred Tank Reactor And Method
CN102333548B (zh) 2009-02-27 2013-01-30 健泰科生物技术公司 用于蛋白质标记的方法和组合物
RU2011140498A (ru) 2009-03-06 2013-04-20 Дженентек, Инк. Препарат антител
EP3431588A1 (fr) 2009-08-11 2019-01-23 F. Hoffmann-La Roche AG Production de protéines dans des milieux de culture cellulaire sans glutamine
WO2011028753A1 (fr) 2009-09-01 2011-03-10 Genentech, Inc. Purification améliorée d'une protéine grâce à une élution modifiée de la protéine a
KR101878369B1 (ko) 2010-03-22 2018-07-16 제넨테크, 인크. 단백질-함유 제제의 안정화에 유용한 조성물 및 방법
JP2013525484A (ja) 2010-05-03 2013-06-20 ジェネンテック, インコーポレイテッド タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法
WO2011146394A1 (fr) 2010-05-17 2011-11-24 Millipore Corporation Polymères répondant à des stimuli pour la purification de biomolécules
WO2011150241A2 (fr) 2010-05-28 2011-12-01 Genentech, Inc. Réduction du niveau de lactate et augmentation de la production de polypeptides par régulation négative de l'expression de la lactate déshydrogénase et de la pyruvate déshydrogénase kinase
MY161390A (en) 2010-06-24 2017-04-14 Genentech Inc Compositions and methods containing alkylglycosides for stabilizing protein-containing formulations
EP2603525A1 (fr) 2010-08-13 2013-06-19 F.Hoffmann-La Roche Ag Anticorps anti-il-1 et il-18, pour le traitement de maladies
WO2012030512A1 (fr) 2010-09-03 2012-03-08 Percivia Llc. Procédé de purification de protéine en flux
UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
SG194763A1 (en) 2011-07-08 2013-12-30 Emd Millipore Corp Improved depth filters for disposable biotechnological processes
EP2791172B1 (fr) 2011-12-16 2017-07-19 Synthon Biopharmaceuticals B.V. Composés et méthodes de traitement de maladies inflammatoires
EP2794635B8 (fr) 2011-12-22 2018-11-14 H. Hoffnabb-La Roche Ag Chromatographie par échange d'ions sur membrane
CN104350156B (zh) 2012-03-27 2019-04-02 弗·哈夫曼-拉罗切有限公司 用于重组蛋白质的改进的收获操作
US20130309226A1 (en) 2012-05-18 2013-11-21 Genentech, Inc. High-concentration monoclonal antibody formulations
GB2503883A (en) * 2012-07-09 2014-01-15 King S College London Variant IgE with reduced affinity to CD23
US9393327B2 (en) 2012-12-19 2016-07-19 Genentech, Inc. Methods and compositions for radiohalogen protein labeling
EP3777535A1 (fr) 2014-07-09 2021-02-17 F. Hoffmann-La Roche AG Réglage de ph pour améliorer la récupération par décongélation de banques de cellules
CA3019373A1 (fr) 2016-03-29 2017-10-05 Geltor, Inc. Expression de proteines dans des bacteries gram negatif, avec un rapport du volume periplasmique au volume cytoplasmique compris entre 0,5:1 et 10:1
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
CN110049778A (zh) 2016-12-22 2019-07-23 豪夫迈·罗氏有限公司 减少冻干多肽重构时间的方法和制剂
JP7128191B2 (ja) * 2017-01-06 2022-08-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 治療抗IgE抗体並びにその方法及び組成物
WO2018224673A1 (fr) 2017-06-08 2018-12-13 Zaklady Farmaceutyczne Polpharma S.A. Méthodes améliorées de culture cellulaire
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CN111315413A (zh) 2017-11-07 2020-06-19 秀比特生物技术公司 通过IgE类特异性免疫反应的抑制效果阻止婴儿期变态反应素质获得的方法
US20210253996A1 (en) 2018-07-03 2021-08-19 Bristol-Myers Squibb Company Methods of producing recombinant proteins
CN113166695A (zh) 2018-10-10 2021-07-23 勃林格殷格翰国际公司 用于高密度生物反应器培养中的膜气体转移的方法
TW202102266A (zh) 2019-04-01 2021-01-16 美商建南德克公司 用於穩定含有蛋白質之配方之組合物及方法
CN113993885A (zh) 2019-04-12 2022-01-28 格尔托公司 重组弹性蛋白及其生产
JP2022543781A (ja) 2019-08-01 2022-10-14 ブリストル-マイヤーズ スクイブ カンパニー フェッドバッチ細胞培養におけるタンパク質産生性の改良方法
KR20230042030A (ko) 2020-07-10 2023-03-27 상하이 제민케어 파마슈티칼 컴퍼니 리미티드 항-IgE 조작된 항체 및 이의 적용
KR20230073270A (ko) 2020-09-22 2023-05-25 브리스톨-마이어스 스큅 컴퍼니 치료 단백질의 생산 방법
WO2023015234A1 (fr) 2021-08-05 2023-02-09 Bristol-Myers Squibb Company Procédés de culture cellulaire pour la production de protéines thérapeutiques
WO2023049687A1 (fr) 2021-09-21 2023-03-30 Bristol-Myers Squibb Company Procédés de régulation du taux d'oxygène dissous (do) dans une solution comprenant une protéine recombinante dans un récipient de stockage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
JPS63225397A (ja) * 1986-10-03 1988-09-20 Dainippon Pharmaceut Co Ltd 抗アレルギー作用を有する新規ペプチド
US4940782A (en) * 1987-06-08 1990-07-10 G. D. Searle & Co. Monoclonal antibodies against IgE-associated determinants, hybrid cell lines producing these antibodies, and use therefore
GB8727045D0 (en) * 1987-11-19 1987-12-23 Research Corp Ltd Immunoglobulin e competitor
ATE121299T1 (de) * 1987-12-31 1995-05-15 Tanox Biosystems Inc Antigene epitope, die sich ausschliesslich auf ige-tragenden b-lymphocyten befinden.

Also Published As

Publication number Publication date
WO1993004173A1 (fr) 1993-03-04
HK1050696A1 (en) 2003-07-04
AU706584C (en) 2003-07-10
DE69232944D1 (de) 2003-04-10
DE69232944T2 (de) 2003-12-24
AU7038096A (en) 1997-01-16
AU706584B2 (en) 1999-06-17
NL300220I1 (nl) 2006-04-03
AU2498192A (en) 1993-03-16
DE69233716D1 (de) 2008-01-03
ATE233813T1 (de) 2003-03-15
EP0602126A1 (fr) 1994-06-22
NL300220I2 (nl) 2006-08-01
EP0602126B1 (fr) 2003-03-05
LU91219I2 (fr) 2006-04-03
EP1260521A2 (fr) 2002-11-27
DE122006000006I1 (de) 2006-04-27
EP1260521B1 (fr) 2007-11-21
CA2113813A1 (fr) 1993-03-04
ES2296839T3 (es) 2008-05-01
DK1260521T3 (da) 2008-03-25
DE69233716T2 (de) 2008-10-30
CA2113813C (fr) 2005-04-12
JP3457962B2 (ja) 2003-10-20
JPH06509944A (ja) 1994-11-10
HK1014542A1 (en) 1999-09-30
EP1260521A3 (fr) 2004-01-02
ES2193136T3 (es) 2003-11-01
DE122006000006I2 (de) 2011-06-16

Similar Documents

Publication Publication Date Title
DK0602126T3 (da) Immunoglobulinvarianter til specifikke FC epsilon-receptorer
ATE197053T1 (de) Humaner rezeptor fc(gamma)riii
DE69841170D1 (de) Menschliche Toll-ähliche Rezeptorproteine, zugehörige Reagenzien und Verfahren
CA2345024A1 (fr) Proteines modifiees de la superfamille du tgf-.beta.
ES2187946T3 (es) Uso de interleucina-15.
DE68929545D1 (de) Pollen Allergene
CA2185112A1 (fr) Anticorps monoclonaux humanises contre l'interleukine-4 chez l'homme
DE69233673D1 (de) Protein S polypeptide und deren Verwendungen
PT524421E (pt) Herpesvirus humano tipo 6 proteina p 100, sequencias de adn correspondentes, preparacao e utilizacao