DK0594772T3 - - Google Patents

Info

Publication number
DK0594772T3
DK0594772T3 DK92916161.0T DK92916161T DK0594772T3 DK 0594772 T3 DK0594772 T3 DK 0594772T3 DK 92916161 T DK92916161 T DK 92916161T DK 0594772 T3 DK0594772 T3 DK 0594772T3
Authority
DK
Denmark
Prior art keywords
carrier molecule
attached
group
reagents
divinyl sulfone
Prior art date
Application number
DK92916161.0T
Other languages
Danish (da)
English (en)
Inventor
Allan Otto Fog Lihme
Thomas Boenisch
Original Assignee
Immunodex K S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26065568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0594772(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK911309A external-priority patent/DK130991D0/da
Application filed by Immunodex K S filed Critical Immunodex K S
Application granted granted Critical
Publication of DK0594772T3 publication Critical patent/DK0594772T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Graft Or Block Polymers (AREA)
  • Saccharide Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DK92916161.0T 1991-07-04 1992-06-29 DK0594772T3 (OSRAM)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK911309A DK130991D0 (da) 1991-07-04 1991-07-04 Polymere konjugater
US07/789,757 US5543332A (en) 1991-07-04 1991-11-08 Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone

Publications (1)

Publication Number Publication Date
DK0594772T3 true DK0594772T3 (OSRAM) 1997-02-24

Family

ID=26065568

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92916161.0T DK0594772T3 (OSRAM) 1991-07-04 1992-06-29

Country Status (12)

Country Link
EP (1) EP0594772B1 (OSRAM)
JP (1) JP3340434B2 (OSRAM)
AT (1) ATE142021T1 (OSRAM)
AU (1) AU667051B2 (OSRAM)
CA (1) CA2112992C (OSRAM)
DE (1) DE69213240T2 (OSRAM)
DK (1) DK0594772T3 (OSRAM)
ES (1) ES2094920T3 (OSRAM)
FI (1) FI115413B (OSRAM)
GR (1) GR3021806T3 (OSRAM)
NO (1) NO315443B1 (OSRAM)
WO (1) WO1993001498A1 (OSRAM)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5773227A (en) * 1993-06-23 1998-06-30 Molecular Probes, Inc. Bifunctional chelating polysaccharides
US5446090A (en) * 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
WO1995032305A1 (en) 1994-05-19 1995-11-30 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
US5747639A (en) * 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
GB9624165D0 (en) * 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
EP0942740B1 (en) 1996-12-06 2003-08-27 Amgen Inc., Combination therapy using a tnf binding protein for treating tnf-mediated diseases
US6709873B1 (en) * 1997-04-09 2004-03-23 Isodiagnostika Inc. Method for production of antibodies to specific sites of rapamycin
US5994089A (en) * 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
US6066446A (en) * 1997-12-19 2000-05-23 Nen Life Science Products, Inc. Assay member and method for its manufacture
WO1999040438A1 (en) * 1998-02-03 1999-08-12 Synbiotics Corporation Device and method to detect immunoprotective antibody titers
DK1101115T3 (da) * 1998-07-30 2004-10-25 Oakville Trading Hong Kong Ltd Fremgangsmåde til fremstilling af vandoplöselige tværbundne konjugater
US6686454B1 (en) * 1998-10-09 2004-02-03 Isotechnika, Inc. Antibodies to specific regions of cyclosporine related compounds
WO2000022000A1 (en) * 1998-10-09 2000-04-20 Isotechnika, Inc. Methods for the production of antibodies to specific regions of cyclosporine and cyclosporine metabolites
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
JP3781934B2 (ja) 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
DE10039112A1 (de) * 2000-08-07 2002-03-07 Pe Diagnostik Gmbh Verfahren zum Herstellen von Antikörper aus einer verunreinigten Antigenlösung
GB0029617D0 (en) * 2000-12-05 2001-01-17 Norchip As Ligand detection method
ES2747357T3 (es) 2001-03-14 2020-03-10 Dako Denmark As Construcciones de moléculas MHC y sus usos para el diagnóstico y terapia
US7034127B2 (en) * 2002-07-02 2006-04-25 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
EP1405907A3 (en) * 2002-07-22 2004-10-13 Roche Diagnostics GmbH Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof
CA2433479A1 (en) 2002-07-22 2004-01-22 F. Hoffmann-La Roche Ag Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof
WO2005062048A1 (de) 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogenes nachweisverfahren
WO2005054860A1 (en) 2003-12-01 2005-06-16 Dako Denmark A/S Methods and compositions for immuno-histochemical detection
CA2547353A1 (en) * 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Conjugates, and use thereof in detection methods
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
GB0426822D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
KR101354114B1 (ko) 2005-06-14 2014-01-24 타이젠 바이오테크놀러지 컴퍼니 리미티드 피리미딘 화합물
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
JP2009530639A (ja) 2006-03-20 2009-08-27 インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 電気化学的検出のための水溶性コンジュゲート
EP2155782A2 (en) * 2007-03-26 2010-02-24 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP3620465B1 (en) 2007-07-03 2025-02-19 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
SI2268635T1 (sl) 2008-04-21 2015-10-30 Taigen Biotechnology Co., Ltd. Heterociklične spojine
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
WO2010031749A1 (en) 2008-09-17 2010-03-25 Innate Pharma Compositions and methods for detecting tlr3
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
US9023834B2 (en) 2008-11-13 2015-05-05 Taigen Biotechnology Co., Ltd. Lyophilization formulation
EP2270506A3 (en) * 2009-07-02 2011-03-09 Amic AB Amplified labeled conjugate for use in immunoassays
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
CN111748607B (zh) 2012-08-14 2024-04-30 10X基因组学有限公司 微胶囊组合物及方法
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014124338A1 (en) 2013-02-08 2014-08-14 10X Technologies, Inc. Polynucleotide barcode generation
WO2014208776A1 (ja) 2013-06-28 2014-12-31 国立大学法人九州大学 タンパク質-ポリマ複合体、TGase基質含有ポリマ、TGase基質含有モノマ、タンパク質-ポリマ複合体の製造方法、および固液の界面あるいは界面近傍でタンパク質機能を高める方法
CN114534806B (zh) 2014-04-10 2024-03-29 10X基因组学有限公司 用于封装和分割试剂的流体装置、系统和方法及其应用
EP3155426B1 (en) 2014-06-13 2023-07-19 Immudex ApS General detection and isolation of specific cells by binding of labeled molecules
CN113249435B (zh) 2014-06-26 2024-09-03 10X基因组学有限公司 分析来自单个细胞或细胞群体的核酸的方法
CN106536756A (zh) 2014-06-26 2017-03-22 10X基因组学有限公司 核酸序列的分析
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
WO2016137973A1 (en) 2015-02-24 2016-09-01 10X Genomics Inc Partition processing methods and systems
SG11201804086VA (en) 2015-12-04 2018-06-28 10X Genomics Inc Methods and compositions for nucleic acid analysis
WO2017157980A1 (en) 2016-03-15 2017-09-21 Mipsalus Aps Detection method and means therefor
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3545089B1 (en) 2017-01-30 2022-03-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
WO2019200326A1 (en) 2018-04-13 2019-10-17 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
EP3898666A2 (en) 2018-12-17 2021-10-27 Immudex ApS Panel comprising borrelia mhc multimers
AU2021213439B2 (en) 2020-01-31 2023-01-05 Cell.Copedia GmbH Methods of isolating a biological entity
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
CN111965341B (zh) * 2020-08-10 2023-04-11 武汉菲恩生物科技有限公司 一种基于葡聚糖的HRP-羊抗鼠IgG标记抗体及其制备方法
WO2022033975A1 (en) 2020-08-10 2022-02-17 Innate Pharma Cell surface mica and micb detection using antibodies
CN117242093A (zh) 2021-04-05 2023-12-15 先天制药公司 免疫组织化学方法和kir3dl2特异性试剂
CN115537410A (zh) * 2022-09-27 2022-12-30 凯莱英医药化学(阜新)技术有限公司 酶固定化载体及其制备方法、固定化酶及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2712344C2 (de) * 1977-03-21 1982-09-23 Hans Dr. 4803 Steinhagen Bünemann Löslicher Komplexbildner für die affinitätsspezifische Trennung von Nukleinsäuren
SE7812237L (sv) * 1978-11-28 1980-05-29 Pharmacia Diagnostics Ab Koncentrationsbestemning av substanser med formaga att biospecifikt binda molekyler med biologiskt ursprung
FR2453847B1 (fr) * 1979-04-13 1985-08-16 Anvar Procede pour l'obtention d'ampholytes porteurs utilisables dans les diverses techniques d'electrofocalisation
US4752339A (en) * 1983-10-31 1988-06-21 Hi-Tek Polymers, Inc. Thixotropic aqueous solutions containing a divinylsulfone-crosslinked polygalactomannan gum
US4780409A (en) * 1985-05-02 1988-10-25 Genetic Systems Corporation Thermally induced phase separation immunoassay
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
CA1304682C (en) * 1986-11-19 1992-07-07 Nobuo Monji Membrane affinity concentration immunoassay
AU609241B2 (en) * 1988-01-29 1991-04-26 Abbott Laboratories Ion-capture assays and devices
CA1341592C (en) * 1989-07-07 2009-04-14 Abbott Laboratories Ion capture reagents and methods for performing binding assays

Also Published As

Publication number Publication date
NO940030L (no) 1994-03-03
CA2112992C (en) 2002-06-11
CA2112992A1 (en) 1993-01-21
NO315443B1 (no) 2003-09-01
FI115413B (fi) 2005-04-29
JPH06509167A (ja) 1994-10-13
GR3021806T3 (en) 1997-02-28
DE69213240T2 (de) 1997-04-24
WO1993001498A1 (en) 1993-01-21
NO940030D0 (no) 1994-01-04
FI940023A7 (fi) 1994-02-25
EP0594772B1 (en) 1996-08-28
EP0594772A1 (en) 1994-05-04
ES2094920T3 (es) 1997-02-01
DE69213240D1 (de) 1996-10-02
AU2348992A (en) 1993-02-11
FI940023A0 (fi) 1994-01-04
JP3340434B2 (ja) 2002-11-05
AU667051B2 (en) 1996-03-07
ATE142021T1 (de) 1996-09-15

Similar Documents

Publication Publication Date Title
DK0594772T3 (OSRAM)
US9134302B2 (en) Analyte detection utilizing polynucleotide sequences, composition, process and kit
US5109124A (en) Nucleic acid probe linked to a label having a terminal cysteine
EP0154884A2 (en) Nucleic acid-protein conjugate
US5650334A (en) Fluorescent labelling compositions and methods for their use
US5728588A (en) Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
Nakamura et al. Detection and removal of Escherichia coli using fluorescein isothiocyanate conjugated monoclonal antibody immobilized on bacterial magnetic particles
US4824775A (en) Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
CA1341592C (en) Ion capture reagents and methods for performing binding assays
JP3124018B2 (ja) 結合アッセイ用固相の調製方法
CA2336564A1 (en) Method for preparing water-soluble cross-linked conjugates
US4670380A (en) Assays utilizing labeled nucleic acid probes
EP0397113A3 (de) Verfahren zum Nachweis spezifisch bindefähiger Substanzen in Körperflüssigkeiten
WO2007137418A1 (en) Polymer backbone element tags
Ngo Facile activation of Sepharose hydroxyl groups by 2-fluoro-1 methylpyridinium toluene-4-sulfonate: preparation of affinity and covalent chromatographic matrices
KR920015133A (ko) 숙신이미드함유 중합체로 생물학적 활성 시약을 제조하는 방법, 분석 요소 및 이것의 사용방법
JPH05504481A (ja) 改良された抗体―酵素直接接合体及びその製造方法
CA1256024A (en) Method of immunological dosage of monoamines
EP0256117A1 (en) Latex agglutination using avidin/biotin system
CN1268142A (zh) 氨基烷基三烷基甲硅烷基纤维素及其表面涂敷的方法
US5225516A (en) Polymers
WO1996024688A1 (en) Diagnostics based on dna duplex repair
WO1995025282A1 (en) Ion-capture reagents and methods for performing binding assays
Bayer et al. Avidin–Biotin Technology: Preparation of Biotinylated Probes
Mahoney et al. [2] Ganglioside-based neoglycoproteins