DE69213240D1 - Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten - Google Patents

Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten

Info

Publication number
DE69213240D1
DE69213240D1 DE69213240T DE69213240T DE69213240D1 DE 69213240 D1 DE69213240 D1 DE 69213240D1 DE 69213240 T DE69213240 T DE 69213240T DE 69213240 T DE69213240 T DE 69213240T DE 69213240 D1 DE69213240 D1 DE 69213240D1
Authority
DE
Germany
Prior art keywords
carrier molecule
attached
reagents
group
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69213240T
Other languages
English (en)
Other versions
DE69213240T2 (de
Inventor
Allan Lihme
Thomas Boenisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dako Denmark ApS
Original Assignee
IMMUNODEX K/S GLOSTRUP DK
Immunodex K S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26065568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69213240(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK911309A external-priority patent/DK130991D0/da
Application filed by IMMUNODEX K/S GLOSTRUP DK, Immunodex K S filed Critical IMMUNODEX K/S GLOSTRUP DK
Application granted granted Critical
Publication of DE69213240D1 publication Critical patent/DE69213240D1/de
Publication of DE69213240T2 publication Critical patent/DE69213240T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
DE69213240T 1991-07-04 1992-06-29 Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten Expired - Lifetime DE69213240T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK911309A DK130991D0 (da) 1991-07-04 1991-07-04 Polymere konjugater
US07/789,757 US5543332A (en) 1991-07-04 1991-11-08 Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone
PCT/DK1992/000206 WO1993001498A1 (en) 1991-07-04 1992-06-29 Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone

Publications (2)

Publication Number Publication Date
DE69213240D1 true DE69213240D1 (de) 1996-10-02
DE69213240T2 DE69213240T2 (de) 1997-04-24

Family

ID=26065568

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69213240T Expired - Lifetime DE69213240T2 (de) 1991-07-04 1992-06-29 Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten

Country Status (12)

Country Link
EP (1) EP0594772B1 (de)
JP (1) JP3340434B2 (de)
AT (1) ATE142021T1 (de)
AU (1) AU667051B2 (de)
CA (1) CA2112992C (de)
DE (1) DE69213240T2 (de)
DK (1) DK0594772T3 (de)
ES (1) ES2094920T3 (de)
FI (1) FI115413B (de)
GR (1) GR3021806T3 (de)
NO (1) NO315443B1 (de)
WO (1) WO1993001498A1 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US5773227A (en) * 1993-06-23 1998-06-30 Molecular Probes, Inc. Bifunctional chelating polysaccharides
US5446090A (en) * 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
AU2522095A (en) 1994-05-19 1995-12-18 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
US5747639A (en) * 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
US6309646B1 (en) * 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
GB9624165D0 (en) * 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
DE69724451T2 (de) 1996-12-06 2004-03-18 Amgen Inc., Thousand Oaks Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen
US6709873B1 (en) * 1997-04-09 2004-03-23 Isodiagnostika Inc. Method for production of antibodies to specific sites of rapamycin
US5994089A (en) * 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
US6066446A (en) * 1997-12-19 2000-05-23 Nen Life Science Products, Inc. Assay member and method for its manufacture
WO1999040438A1 (en) * 1998-02-03 1999-08-12 Synbiotics Corporation Device and method to detect immunoprotective antibody titers
PT1101115E (pt) 1998-07-30 2004-09-30 Oakville Trading Hong Kong Ltd Metodo para preparar conjugados reticulados soluveis em agua
JP3595506B2 (ja) * 1998-10-09 2004-12-02 アイソテクニカ インコーポレイテッド シクロスポリンおよびシクロスポリン代謝産物の、特定領域に対する抗体の生産方法
US6686454B1 (en) * 1998-10-09 2004-02-03 Isotechnika, Inc. Antibodies to specific regions of cyclosporine related compounds
JP3781934B2 (ja) 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
DE10039112A1 (de) * 2000-08-07 2002-03-07 Pe Diagnostik Gmbh Verfahren zum Herstellen von Antikörper aus einer verunreinigten Antigenlösung
GB0029617D0 (en) * 2000-12-05 2001-01-17 Norchip As Ligand detection method
AU2002240818C1 (en) 2001-03-14 2008-11-06 Agilent Technologies, Inc. MHC molecule constructs and their uses for diagnosis and therapy
US7034127B2 (en) * 2002-07-02 2006-04-25 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
CA2433479A1 (en) 2002-07-22 2004-01-22 F. Hoffmann-La Roche Ag Conjugate of a tissue non-specific alkaline phosphatase and dextran, process for its production and use thereof
EP1405907A3 (de) * 2002-07-22 2004-10-13 Roche Diagnostics GmbH Konjugat aus einer gewebsunspezifischen alkalischen Phosphatase und Dextran, Verfahren zur Herstellung und Verwendung
EP1697750B1 (de) 2003-12-01 2013-03-20 Dako Denmark A/S Verfahren und zusammensetzungen für den immunhistochemischen nachweis
JP2007512542A (ja) * 2003-12-01 2007-05-17 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 複合体、及び検出方法におけるそれらの使用
WO2005062048A1 (de) 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogenes nachweisverfahren
GB0426822D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
NZ564222A (en) 2005-06-14 2011-10-28 Taigen Biotechnology Co Ltd Pyrimidine compounds
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
CN101395473B (zh) 2006-03-20 2012-09-19 阿莱瑞士股份有限公司 利用水溶性轭合物的电化学检测方法
EP2155782A2 (de) * 2007-03-26 2010-02-24 Dako Denmark A/S Mhc-peptid-komplexe und anwendungen davon bei infektionskrankheiten
EP2167537A2 (de) 2007-07-03 2010-03-31 Dako Denmark A/S Zusammengestellte verfahren für die analyse und sortierung von proben
EP2197908A2 (de) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc-multimere in tuberkulose-diagnostika, -impfstoff und therapeutika
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
EP2268635B1 (de) 2008-04-21 2015-06-10 Taigen Biotechnology Co., Ltd. Heterocyclische verbindungen
US10722562B2 (en) 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
EP2334703B1 (de) 2008-09-17 2015-07-08 Innate Pharma Zusammensetzungen und verfahren zum nachweis von tlr3
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
WO2010056847A2 (en) 2008-11-13 2010-05-20 Taigen Biotechnology Co., Ltd. Lyophilization formulation
EP2270506A3 (de) * 2009-07-02 2011-03-09 Amic AB Verstärkt markiertes Konjugat zur Verwendung bei Immuntests
US9315860B2 (en) 2009-10-26 2016-04-19 Genovoxx Gmbh Conjugates of nucleotides and method for the application thereof
MX364957B (es) 2012-08-14 2019-05-15 10X Genomics Inc Composiciones y metodos para microcapsulas.
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2900481A1 (en) 2013-02-08 2014-08-14 10X Genomics, Inc. Polynucleotide barcode generation
JP6353446B2 (ja) 2013-06-28 2018-07-04 国立大学法人九州大学 タンパク質−ポリマ複合体、ＴＧａｓｅ基質含有ポリマ、ＴＧａｓｅ基質含有モノマ、タンパク質−ポリマ複合体の製造方法、および固液の界面あるいは界面近傍でタンパク質機能を高める方法
AU2015243445B2 (en) 2014-04-10 2020-05-28 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
US11585806B2 (en) 2014-06-13 2023-02-21 Immudex Aps General detection and isolation of specific cells by binding of labeled molecules
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
EP3262407B1 (de) 2015-02-24 2023-08-30 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
SG11201804086VA (en) 2015-12-04 2018-06-28 10X Genomics Inc Methods and compositions for nucleic acid analysis
EP3430402A1 (de) 2016-03-15 2019-01-23 Mipsalus Aps Detektionsverfahren und mittel dafür
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019157529A1 (en) 2018-02-12 2019-08-15 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
US10871485B2 (en) 2018-04-13 2020-12-22 Rarecyte, Inc. Kits for labeling of biomarkers and methods of using the same
AU2021213439B2 (en) 2020-01-31 2023-01-05 Cell.Copedia GmbH Methods of isolating a biological entity
CN111965341B (zh) * 2020-08-10 2023-04-11 武汉菲恩生物科技有限公司 一种基于葡聚糖的HRP-羊抗鼠IgG标记抗体及其制备方法
CN116547301A (zh) 2020-08-10 2023-08-04 先天制药公司 使用抗体进行的细胞表面mica和micb检测
AU2022255908A1 (en) 2021-04-05 2023-10-05 Innate Pharma Immunohistochemistry methods and kir3dl2-specific reagents
CN115537410A (zh) * 2022-09-27 2022-12-30 凯莱英医药化学（阜新）技术有限公司 酶固定化载体及其制备方法、固定化酶及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2712344C2 (de) * 1977-03-21 1982-09-23 Hans Dr. 4803 Steinhagen Bünemann Löslicher Komplexbildner für die affinitätsspezifische Trennung von Nukleinsäuren
SE7812237L (sv) * 1978-11-28 1980-05-29 Pharmacia Diagnostics Ab Koncentrationsbestemning av substanser med formaga att biospecifikt binda molekyler med biologiskt ursprung
FR2453847B1 (fr) * 1979-04-13 1985-08-16 Anvar Procede pour l'obtention d'ampholytes porteurs utilisables dans les diverses techniques d'electrofocalisation
US4752339A (en) * 1983-10-31 1988-06-21 Hi-Tek Polymers, Inc. Thixotropic aqueous solutions containing a divinylsulfone-crosslinked polygalactomannan gum
US4780409A (en) * 1985-05-02 1988-10-25 Genetic Systems Corporation Thermally induced phase separation immunoassay
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
CA1304682C (en) * 1986-11-19 1992-07-07 Nobuo Monji Membrane affinity concentration immunoassay
AU609241B2 (en) * 1988-01-29 1991-04-26 Abbott Laboratories Ion-capture assays and devices
CA1341592C (en) * 1989-07-07 2009-04-14 Abbott Laboratories Ion capture reagents and methods for performing binding assays

Also Published As

Publication number Publication date
NO940030L (no) 1994-03-03
FI940023A (fi) 1994-02-25
ES2094920T3 (es) 1997-02-01
NO940030D0 (no) 1994-01-04
NO315443B1 (no) 2003-09-01
CA2112992C (en) 2002-06-11
JP3340434B2 (ja) 2002-11-05
JPH06509167A (ja) 1994-10-13
EP0594772A1 (de) 1994-05-04
ATE142021T1 (de) 1996-09-15
EP0594772B1 (de) 1996-08-28
CA2112992A1 (en) 1993-01-21
WO1993001498A1 (en) 1993-01-21
FI115413B (fi) 2005-04-29
AU2348992A (en) 1993-02-11
FI940023A0 (fi) 1994-01-04
DE69213240T2 (de) 1997-04-24
DK0594772T3 (de) 1997-02-24
AU667051B2 (en) 1996-03-07
GR3021806T3 (en) 1997-02-28

Similar Documents

Publication Publication Date Title
DE69213240D1 (de) Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten
US5109124A (en) Nucleic acid probe linked to a label having a terminal cysteine
EP0128332A1 (de) Bestimmungsmethode unter Verwendung von Polynucleotidsequenzen
US5728588A (en) Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
US4824775A (en) Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
KR100209072B1 (ko) 숙신이미드함유 중합체로 생물학적 활성 시약을 제조하는 방법, 분석 요소 및 이것의 사용방법
US4670380A (en) Assays utilizing labeled nucleic acid probes
EP0856155A1 (de) Fluoreszent- und lumineszentmarkierungszusammensetzungen und verfahren zu ihrer verwendung
CA2336564A1 (en) Method for preparing water-soluble cross-linked conjugates
US20010004527A1 (en) Use of nucleic acids bound to carrier macromolecules
CA2046130A1 (en) Biologically active reagent, analytical element and methods for use of the reagent
EP1409728A2 (de) Nicht-enzymatischer liposomen-gebundener, aus einer dichtgepackten elektrodenanordnung bestehender test (nel-ela) zur detektion und qantifizierung von nukleinsäuren
ES2554766T3 (es) Resina cromatográfica mejorada y métodos y dispositivos relacionados con la misma
EP0256117A1 (de) Latexagglutinierung mittels avidin-biotin-system
JPH09508199A (ja) 標識付け
Howell et al. An ammoniacal-silver stain technique specific for satellite III DNA regions on human chromosomes
GB2238384A (en) Oligomer/polymer label
Liabeuf et al. The detection of the Epstein‐Barr virus (EBV) nuclear antigen (EBNA) by anti‐complement immunofluorescence. Immunoglobulin class of antibodies and role of complement
DE102007056875B4 (de) Affinitätsstrukturen zur spezifischen Bindung von Substanzen durch nicht-kovalente Interaktionsformen
Bayer et al. Avidin–Biotin Technology: Preparation of Biotinylated Probes
CN116953222A (zh) 一种纳米聚合酶标记抗体及其制备方法和应用
WO1999004042A1 (en) Synthetic oligonucleotide-peptide conjugates and methods of use
Anderson Covalent labeling of a protein: An experiment in protein technology
Wilchek et al. [36] Affinity cytochemistry
Sorensen Detection and assay of viruses using latex particles

Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: DAKO A/S, GLOSTRUP, DK

8327 Change in the person/name/address of the patent owner

Owner name: DAKOCYTOMATION DENMARK A/S, GLOSTRUP, DK

8327 Change in the person/name/address of the patent owner

Owner name: DAKO DENMARK A/S, GLOSTRUP, DK

R071 Expiry of right

Ref document number: 594772

Country of ref document: EP