DK0496306T3 - Fremgangsmåde til fremstilling af 3-amino-9,13b-dihydro-1-H-dibenz(c,f)imidazo(1,5)azepin- hydrochlorid - Google Patents

Fremgangsmåde til fremstilling af 3-amino-9,13b-dihydro-1-H-dibenz(c,f)imidazo(1,5)azepin- hydrochlorid

Info

Publication number
DK0496306T3
DK0496306T3 DK92100798.5T DK92100798T DK0496306T3 DK 0496306 T3 DK0496306 T3 DK 0496306T3 DK 92100798 T DK92100798 T DK 92100798T DK 0496306 T3 DK0496306 T3 DK 0496306T3
Authority
DK
Denmark
Prior art keywords
dibenz
dihydro
azepine
imidazo
amino
Prior art date
Application number
DK92100798.5T
Other languages
English (en)
Inventor
Heinrich Dr Schneider
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK0496306T3 publication Critical patent/DK0496306T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK92100798.5T 1991-01-25 1992-01-18 Fremgangsmåde til fremstilling af 3-amino-9,13b-dihydro-1-H-dibenz(c,f)imidazo(1,5)azepin- hydrochlorid DK0496306T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4102148A DE4102148A1 (de) 1991-01-25 1991-01-25 Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid

Publications (1)

Publication Number Publication Date
DK0496306T3 true DK0496306T3 (da) 1996-01-22

Family

ID=6423672

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92100798.5T DK0496306T3 (da) 1991-01-25 1992-01-18 Fremgangsmåde til fremstilling af 3-amino-9,13b-dihydro-1-H-dibenz(c,f)imidazo(1,5)azepin- hydrochlorid

Country Status (9)

Country Link
US (1) US5312916A (da)
EP (1) EP0496306B1 (da)
JP (1) JP3133448B2 (da)
KR (1) KR100196965B1 (da)
AT (1) ATE127802T1 (da)
DE (2) DE4102148A1 (da)
DK (1) DK0496306T3 (da)
ES (1) ES2078559T3 (da)
GR (1) GR3017693T3 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131177A (ja) * 1999-11-08 2001-05-15 Ohara Yakuhin Kogyo Kk ジベンズ［ｃ，ｆ］イミダゾ［１，５−ａ］アゼピンの製造方法及びその製造中間体
DE19954516A1 (de) * 1999-11-12 2001-05-17 Boehringer Ingelheim Int Epinastin-haltige Lösungen
DE19958460A1 (de) * 1999-12-03 2001-06-07 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation
KR100392692B1 (ko) * 2001-05-31 2003-07-28 바이오네스트 주식회사 에피나스틴 및 그 약제학적으로 허용되는 염의 새로운제조방법
JP4298212B2 (ja) * 2002-03-29 2009-07-15 大日本印刷株式会社 塩酸エピナスチン高融点型結晶の製造法
US7196193B2 (en) * 2002-04-11 2007-03-27 Konica Minolta Chemical Co., Ltd. Method for preparing 6-aminomethyl-6, 11-dihydro-5h-dibenz[b,e]azepine
JP4514017B2 (ja) * 2003-03-27 2010-07-28 大日本印刷株式会社 塩酸エピナスチンの製造方法
KR101386530B1 (ko) 2006-12-29 2014-04-18 케이피엑스 라이프사이언스 주식회사 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법
CN101130544B (zh) * 2007-09-26 2010-09-08 杭州龙山化工有限公司 依匹斯汀的化学合成方法
KR100909295B1 (ko) * 2007-11-15 2009-07-24 주식회사 참조아 6-아미노메틸- 6,11-디하이드로-5Ｈ-디벤즈[ｂ,ｅ]아제핀의 제조방법
JP2009102434A (ja) * 2009-02-09 2009-05-14 Dainippon Printing Co Ltd ６−アミノメチル−６，１１−ジヒドロ−５Ｈ−ジベンズ［ｂ，ｅ］アゼピンの製造方法
JP2010120960A (ja) * 2010-02-17 2010-06-03 Dainippon Printing Co Ltd 塩酸エピナスチンの製造方法
CN104098575B (zh) * 2013-04-15 2016-06-01 四川科瑞德凯华制药有限公司 一种盐酸依匹斯汀晶型及其制备方法和用途
CN104447757B (zh) * 2014-11-17 2017-03-22 合肥华方医药科技有限公司 依匹斯汀的合成方法
CN105153169B (zh) * 2014-11-27 2018-11-30 兆科药业（广州）有限公司 一种盐酸依匹斯汀的合成方法
CN107118216B (zh) * 2017-05-08 2019-03-08 宏冠生物药业有限公司 一种盐酸依匹斯汀杂质b的合成方法
CN107141297B (zh) * 2017-06-23 2019-07-02 合肥华方医药科技有限公司 一种盐酸依匹斯汀的合成方法
KR102080239B1 (ko) 2019-08-06 2020-02-21 한양대학교 에리카산학협력단 에피나스틴의 신규 제조방법
CN112028897A (zh) * 2020-11-06 2020-12-04 南京远淑医药科技有限公司 一种盐酸依匹斯汀的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3008944A1 (de) * 1980-03-08 1981-09-24 C.H. Boehringer Sohn, 6507 Ingelheim Dibenzimidazoazepine, ihre herstellung und verwendung

Also Published As

Publication number Publication date
US5312916A (en) 1994-05-17
DE59203611D1 (de) 1995-10-19
KR920014814A (ko) 1992-08-25
KR100196965B1 (ko) 1999-06-15
GR3017693T3 (en) 1996-01-31
JP3133448B2 (ja) 2001-02-05
ES2078559T3 (es) 1995-12-16
ATE127802T1 (de) 1995-09-15
DE4102148A1 (de) 1992-07-30
JPH04346988A (ja) 1992-12-02
EP0496306B1 (de) 1995-09-13
EP0496306A1 (de) 1992-07-29

Similar Documents

Publication Publication Date Title
DK0496306T3 (da) Fremgangsmåde til fremstilling af 3-amino-9,13b-dihydro-1-H-dibenz(c,f)imidazo(1,5)azepin- hydrochlorid
EP0125607A3 (en) Dibenzo(1,4)diazepinone, pyrido(1,4)benzodiazepinone, pyrido(1,5)benzodiazepinone derivatives and pharmacological activities thereof
HUP0202494A3 (en) Imidazo[1,2-a]pyridine and pyrazolo[2,3-a]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
DE69406907D1 (de) 9H-INDENO[1,2-b]PYRAZIN-3(4H)-ONE UND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONE UND IHRE HERSTELLUNG UND VERWENDUNG
HUP0400743A3 (en) Imidazo[1,5-a]pyrimido[5,4-d]benzazepine derivatives, process for their preparation and pharmaceutical conpositions containing them
FI92401B (fi) Menetelmä valmistaa farmakologisesti arvokasta pyrrolo/3,2,1-jk//1,4/bentsodiatsepiinijohdannaista
DK0837860T3 (da) Tricykliske 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo-[4,3-alfa]pyridiner
DE3475619D1 (en) Quaternary salts of dibenzo(1,4)diazepinone, pyrido-(1,4)benzodiazepinone, pyrido(1,5)benzodiazepinone derivatives and pharmacological activity thereof
CA2257222A1 (en) Amide derivatives
IL124453A0 (en) 2,7-substituted octahydro-pyrrolo [1,2-A]pyrazine derivatives
HUP0301399A3 (en) Process for the preparation of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidine
ES8604589A1 (es) Procedimiento para preparar nuevos derivados de imidazo (1,5-a) pirimidina
CA2150805A1 (en) Antiallergic imidazo[1,2-a](pyrrolo, thieno or furano)[2,3-d]azepine derivatives
JO2259B1 (en) Method for the manufacture of diazapine derivatives
HU913296D0 (en) Process for the production of 5,11-dihydro-6h-dipirido(3,2-b:2',3'-e)(1,4)diazepines
PL349912A1 (en) Process to prepare (5r)-(methylamino)-5,6-dihydro-4h-imidazo[4,5,1-ij]-quinolin-2(1h)-one
ZA928096B (en) Heterocyclic compounds and their preparation and use
OA09487A (fr) "Procédé de préparation de nouvelles pyrrolo (1,2-a)thiéno (3,2-f) diazépines(1,4)".
MX9700716A (es) 2-aril-5,11-dihidro-6h-dipirido[3,2-b:2',3'-e][1,4] diazepinas y su uso en el tratamiento de la infeccion por vih.
EE200100700A (et) Asendatud [1,4]diasepino[6,7,1-hi]indool-4-oonidevalmistamismeetod
FI93837C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4-okso-4,5-dihydro-imidatso/1,5-a/pyrido/2,3-e/pyratsiinijohdannaisten valmistamiseksi
HU910067D0 (en) Process for the production of 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo (1.5-a)pyrimidines
FI921091A0 (fi) Menetelmä terapeuttisesti aktiivisen 2-fenyylisubstituoidun imidatso[1,5-a]kinoksaliini-1,3(2H,5H)-dionijohdannaisen valmistamiseksi
ES2004298A6 (es) Metodo para la fabricacion de 7h-1,3,4 tiadiazolo(3,2-a)pirimidonas sustituidas en doble posicion con frupos que contienen amina
HU911708D0 (en) Process for producing 6,7-dichlorine-1,5-dihydro-imidazo(2,1-b) quinazoline-2(3h)-one