DK0465358T3 - 2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt - Google Patents

2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt

Info

Publication number
DK0465358T3
DK0465358T3 DK91401833.8T DK91401833T DK0465358T3 DK 0465358 T3 DK0465358 T3 DK 0465358T3 DK 91401833 T DK91401833 T DK 91401833T DK 0465358 T3 DK0465358 T3 DK 0465358T3
Authority
DK
Denmark
Prior art keywords
preparation
derivatives
acid derivative
synthetic intermediate
thienylglycolic acid
Prior art date
Application number
DK91401833.8T
Other languages
English (en)
Inventor
Alain Heymes
Andre Bousquet
Serge Calet
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK0465358T3 publication Critical patent/DK0465358T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DK91401833.8T 1990-07-04 1991-07-03 2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt DK0465358T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008482A FR2664276B1 (fr) 1990-07-04 1990-07-04 Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

Publications (1)

Publication Number Publication Date
DK0465358T3 true DK0465358T3 (da) 1996-05-28

Family

ID=9398353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91401833.8T DK0465358T3 (da) 1990-07-04 1991-07-03 2-thienylglycidsyre-derivat, fremgangsmåde til fremstilling heraf samt anvendelse af derivater som s yntesemellemprodukt

Country Status (13)

Country Link
US (1) US5132435A (da)
EP (1) EP0465358B1 (da)
JP (1) JP3055819B2 (da)
AT (1) ATE133950T1 (da)
CA (1) CA2046126C (da)
DE (1) DE69116943T2 (da)
DK (1) DK0465358T3 (da)
ES (1) ES2083542T3 (da)
FR (1) FR2664276B1 (da)
GR (1) GR3018947T3 (da)
HU (1) HU213397B (da)
IE (1) IE73223B1 (da)
PT (1) PT98181B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013666A (en) * 1996-07-02 2000-01-11 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
US6043368A (en) * 1996-09-04 2000-03-28 Poli Industria Chimica, S.P.A. Method of making thieno-pyridine derivatives
FR2760456B1 (fr) * 1997-03-05 2000-05-12 Sanofi Sa Procede de preparation de derives de 2-thienyl-ethylamine
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
DK1353928T3 (da) * 2001-01-24 2007-03-26 Cadila Healthcare Ltd Fremgangsmåde til fremstilling af clopidogrel
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
EP1467735B1 (en) * 2001-12-18 2008-12-10 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
WO2004098593A1 (en) * 2003-05-05 2004-11-18 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate composition
ES2339944T3 (es) 2003-11-03 2010-05-27 Cadila Healthcare Limited Procedimientos para preparar la forma i de bisulfato de (s)-(+)-clopidogrel.
EP1723141A4 (en) 2004-03-05 2007-10-10 Ipca Lab Ltd MOST TECHNICAL PROCESS FOR THE PREPARATION OF CLOPIDOGRAPHYDROGENSULFATE
EP1704152A2 (en) * 2004-09-21 2006-09-27 Teva Pharmaceutical Industries Ltd Crystalline clopidogrel hydrobromide and processes for preparation thereof
TW200640932A (en) * 2005-02-24 2006-12-01 Teva Pharma Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
WO2007032023A2 (en) * 2005-07-12 2007-03-22 Rpg Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
CN101253271A (zh) * 2005-09-02 2008-08-27 第一精密化学株式会社 光学活性α-羟基羧酸的制造方法
JP2009543759A (ja) * 2006-04-27 2009-12-10 アイエヌディー−スイフト ラボラトリーズ リミテッド クロピドグレル硫酸水素塩の多形相を調製するプロセス
DK2064217T3 (da) 2006-09-04 2011-05-09 Ranbaxy Lab Ltd Forbedret fremgangsmåde til fremstilling af clopidogrel og dets farmaceutisk acceptable salte
KR100978498B1 (ko) * 2006-10-17 2010-08-30 최중헌 클로피도그렐 황산수소염의 제조방법
KR101365689B1 (ko) * 2006-10-27 2014-02-24 (주)유케이케미팜 (r)-2-히드록시-2-(클로로페닐)초산 메틸 에스테르황산염의 제조방법
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
EP2084164A2 (en) * 2007-04-18 2009-08-05 Teva Pharmaceutical Industries Ltd. Improved process for preparing clopidogrel
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel
CN101585842B (zh) * 2009-07-13 2011-07-20 北京赛科药业有限责任公司 氯吡格雷中杂质b的研究及控制方法
CN101987854A (zh) * 2009-08-04 2011-03-23 北京万全阳光医学技术有限公司 一种氯吡格雷及其盐的制备方法
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102250114B (zh) * 2011-04-27 2014-02-26 青岛黄海制药有限责任公司 一种氯吡格雷及其硫酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6047274B2 (ja) * 1976-07-07 1985-10-21 株式会社三和化学研究所 新規のチエノ〔3,2−f〕モルファン誘導体及びその塩並びにこれ等の製法
FR2508456A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de (thienyl-2)-2 ethylamines et (thienyl-3)-2 ethylamines
JPS62103087A (ja) * 1985-10-28 1987-05-13 Toyo Pharma- Kk 5−(2−クロロベンジル)−4,5,6,7−テトラヒドロチエノ〔3,2−c〕ピリジン又はその塩の製造方法

Also Published As

Publication number Publication date
PT98181A (pt) 1993-08-31
HU213397B (en) 1997-06-30
DE69116943T2 (de) 1996-09-19
HU912250D0 (en) 1991-12-30
GR3018947T3 (en) 1996-05-31
IE73223B1 (en) 1997-05-07
HUT61754A (en) 1993-03-01
FR2664276A1 (fr) 1992-01-10
EP0465358A1 (fr) 1992-01-08
FR2664276B1 (fr) 1992-10-23
US5132435A (en) 1992-07-21
CA2046126C (en) 2001-11-20
DE69116943D1 (de) 1996-03-21
ES2083542T3 (es) 1996-04-16
IE912328A1 (en) 1992-01-15
JPH04261174A (ja) 1992-09-17
ATE133950T1 (de) 1996-02-15
CA2046126A1 (en) 1992-01-05
EP0465358B1 (fr) 1996-02-07
PT98181B (pt) 1998-12-31
JP3055819B2 (ja) 2000-06-26

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