GR3018947T3 - 2-Thienylglycidic acid derivative, process for its preparation and its use as synthetic intermediate - Google Patents

2-Thienylglycidic acid derivative, process for its preparation and its use as synthetic intermediate

Info

Publication number
GR3018947T3
GR3018947T3 GR960400346T GR960400346T GR3018947T3 GR 3018947 T3 GR3018947 T3 GR 3018947T3 GR 960400346 T GR960400346 T GR 960400346T GR 960400346 T GR960400346 T GR 960400346T GR 3018947 T3 GR3018947 T3 GR 3018947T3
Authority
GR
Greece
Prior art keywords
preparation
thienylglycidic
acid derivative
synthetic intermediate
isopropyl
Prior art date
Application number
GR960400346T
Other languages
English (en)
Inventor
Andre Bousquet
Serge Calet
Alain Heymes
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of GR3018947T3 publication Critical patent/GR3018947T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
GR960400346T 1990-07-04 1996-02-14 2-Thienylglycidic acid derivative, process for its preparation and its use as synthetic intermediate GR3018947T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008482A FR2664276B1 (fr) 1990-07-04 1990-07-04 Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

Publications (1)

Publication Number Publication Date
GR3018947T3 true GR3018947T3 (en) 1996-05-31

Family

ID=9398353

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960400346T GR3018947T3 (en) 1990-07-04 1996-02-14 2-Thienylglycidic acid derivative, process for its preparation and its use as synthetic intermediate

Country Status (13)

Country Link
US (1) US5132435A (el)
EP (1) EP0465358B1 (el)
JP (1) JP3055819B2 (el)
AT (1) ATE133950T1 (el)
CA (1) CA2046126C (el)
DE (1) DE69116943T2 (el)
DK (1) DK0465358T3 (el)
ES (1) ES2083542T3 (el)
FR (1) FR2664276B1 (el)
GR (1) GR3018947T3 (el)
HU (1) HU213397B (el)
IE (1) IE73223B1 (el)
PT (1) PT98181B (el)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR980009260A (ko) * 1996-07-02 1998-04-30 주상섭 오시란카르복실산 유도체 및 그의 제조방법
US6043368A (en) * 1996-09-04 2000-03-28 Poli Industria Chimica, S.P.A. Method of making thieno-pyridine derivatives
FR2760456B1 (fr) * 1997-03-05 2000-05-12 Sanofi Sa Procede de preparation de derives de 2-thienyl-ethylamine
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
EA006198B2 (ru) * 2001-01-24 2007-10-26 Кадила Хелзкэр Лтд. Способ получения клопидогрела
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
MXPA04006088A (es) * 2001-12-18 2004-09-27 Teva Pharma Polimorfo de sulfato de hidrogeno de clopidogrel.
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
AU2003241149A1 (en) * 2003-05-05 2004-11-26 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate composition
US8907090B2 (en) 2003-11-03 2014-12-09 Cadila Healthcare Limited Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate
WO2005104663A2 (en) 2004-03-05 2005-11-10 Ipca Laboratories Limited Industrial process for preparation of clopidogrel hydrogen sulphate
KR20070052780A (ko) * 2004-09-21 2007-05-22 테바 파마슈티컬 인더스트리즈 리미티드 결정질 클로피도그렐 브롬산염 및 이의 제조 방법
JP2008526896A (ja) * 2005-02-24 2008-07-24 テバ ファーマシューティカル インダストリーズ リミティド 医薬製剤に適したグロピドグレル塩基及びその調製
EP1902058A2 (en) * 2005-07-12 2008-03-26 RPG Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
WO2007026860A1 (ja) * 2005-09-02 2007-03-08 Daiichi Fine Chemical Co., Ltd. 光学活性α－ヒドロキシカルボン酸の製造方法
WO2007125544A2 (en) * 2006-04-27 2007-11-08 Ind-Swift Laboratories Limited Process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate
ES2359851T3 (es) 2006-09-04 2011-05-27 Ranbaxy Laboratories Limited Proceso mejorado para la preparación de clopidogrel y sus sales farmaceuticamente aceptables.
KR100978498B1 (ko) * 2006-10-17 2010-08-30 최중헌 클로피도그렐 황산수소염의 제조방법
KR101365689B1 (ko) * 2006-10-27 2014-02-24 (주)유케이케미팜 (ｒ)-2-히드록시-2-(클로로페닐)초산 메틸 에스테르황산염의 제조방법
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법
EP2346879A1 (en) * 2008-10-24 2011-07-27 Sandoz AG A process for the preparation of s-clopidogrel
CN101585842B (zh) * 2009-07-13 2011-07-20 北京赛科药业有限责任公司 氯吡格雷中杂质b的研究及控制方法
CN101987854A (zh) * 2009-08-04 2011-03-23 北京万全阳光医学技术有限公司 一种氯吡格雷及其盐的制备方法
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102250114B (zh) * 2011-04-27 2014-02-26 青岛黄海制药有限责任公司 一种氯吡格雷及其硫酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6047274B2 (ja) * 1976-07-07 1985-10-21 株式会社三和化学研究所 新規のチエノ〔３，２−ｆ〕モルファン誘導体及びその塩並びにこれ等の製法
FR2508456A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de (thienyl-2)-2 ethylamines et (thienyl-3)-2 ethylamines
JPS62103087A (ja) * 1985-10-28 1987-05-13 Toyo Pharma- Kk ５−（２−クロロベンジル）−４，５，６，７−テトラヒドロチエノ〔３，２−ｃ〕ピリジン又はその塩の製造方法

Also Published As

Publication number Publication date
DK0465358T3 (da) 1996-05-28
ATE133950T1 (de) 1996-02-15
DE69116943D1 (de) 1996-03-21
CA2046126C (en) 2001-11-20
CA2046126A1 (en) 1992-01-05
PT98181A (pt) 1993-08-31
HU912250D0 (en) 1991-12-30
HUT61754A (en) 1993-03-01
ES2083542T3 (es) 1996-04-16
FR2664276B1 (fr) 1992-10-23
IE73223B1 (en) 1997-05-07
EP0465358A1 (fr) 1992-01-08
JPH04261174A (ja) 1992-09-17
EP0465358B1 (fr) 1996-02-07
DE69116943T2 (de) 1996-09-19
PT98181B (pt) 1998-12-31
US5132435A (en) 1992-07-21
IE912328A1 (en) 1992-01-15
FR2664276A1 (fr) 1992-01-10
HU213397B (en) 1997-06-30
JP3055819B2 (ja) 2000-06-26

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