ATE133950T1 - 2-thienylglycidsäurederivat, verfahren zu seiner herstellung und seine verwendung als synthesezwischenprodukt - Google Patents

2-thienylglycidsäurederivat, verfahren zu seiner herstellung und seine verwendung als synthesezwischenprodukt

Info

Publication number
ATE133950T1
ATE133950T1 AT91401833T AT91401833T ATE133950T1 AT E133950 T1 ATE133950 T1 AT E133950T1 AT 91401833 T AT91401833 T AT 91401833T AT 91401833 T AT91401833 T AT 91401833T AT E133950 T1 ATE133950 T1 AT E133950T1
Authority
AT
Austria
Prior art keywords
thienylglycidic
production
acid derivative
intermediate product
synthesis intermediate
Prior art date
Application number
AT91401833T
Other languages
English (en)
Inventor
Andre Bousquet
Serge Calet
Alain Heymes
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of ATE133950T1 publication Critical patent/ATE133950T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)
AT91401833T 1990-07-04 1991-07-03 2-thienylglycidsäurederivat, verfahren zu seiner herstellung und seine verwendung als synthesezwischenprodukt ATE133950T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9008482A FR2664276B1 (fr) 1990-07-04 1990-07-04 Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

Publications (1)

Publication Number Publication Date
ATE133950T1 true ATE133950T1 (de) 1996-02-15

Family

ID=9398353

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91401833T ATE133950T1 (de) 1990-07-04 1991-07-03 2-thienylglycidsäurederivat, verfahren zu seiner herstellung und seine verwendung als synthesezwischenprodukt

Country Status (13)

Country Link
US (1) US5132435A (de)
EP (1) EP0465358B1 (de)
JP (1) JP3055819B2 (de)
AT (1) ATE133950T1 (de)
CA (1) CA2046126C (de)
DE (1) DE69116943T2 (de)
DK (1) DK0465358T3 (de)
ES (1) ES2083542T3 (de)
FR (1) FR2664276B1 (de)
GR (1) GR3018947T3 (de)
HU (1) HU213397B (de)
IE (1) IE73223B1 (de)
PT (1) PT98181B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3464397A (en) * 1996-07-02 1998-01-21 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
US6043368A (en) * 1996-09-04 2000-03-28 Poli Industria Chimica, S.P.A. Method of making thieno-pyridine derivatives
FR2760456B1 (fr) * 1997-03-05 2000-05-12 Sanofi Sa Procede de preparation de derives de 2-thienyl-ethylamine
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
MXPA03006133A (es) * 2001-01-24 2004-05-04 Cadila Healthcare Ltd Proceso para preparar clopidogrel.
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
MXPA04006088A (es) * 2001-12-18 2004-09-27 Teva Pharma Polimorfo de sulfato de hidrogeno de clopidogrel.
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) * 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
WO2004081015A1 (en) * 2003-03-10 2004-09-23 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate
WO2004098593A1 (en) * 2003-05-05 2004-11-18 Hetero Drugs Limited Amorphous clopidogrel hydrogen sulfate composition
US8907090B2 (en) 2003-11-03 2014-12-09 Cadila Healthcare Limited Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate
US7629465B2 (en) * 2004-03-05 2009-12-08 Ipca Laboratories Ltd. Industrial process for preparation of Clopidogrel hydrogen sulphate
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
EP1851231A2 (de) * 2005-02-24 2007-11-07 Teva Pharmaceutical Industries Ltd Zur pharmazeutischen formulierung geeignete clopidogrel-basis und deren herstellung
WO2007032023A2 (en) * 2005-07-12 2007-03-22 Rpg Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
US20080311636A1 (en) * 2005-09-02 2008-12-18 Daiichi Fine Chemical Co., Ltd. Method for Producing Optically Active Alpha-Hydroxycarboxylic Acid
RU2008146758A (ru) * 2006-04-27 2010-06-10 Инд-Свифт Лэборетриз Лимитед (In) Способ получения полиморфных форм клопидогрела гидросульфата
EP2064217B1 (de) 2006-09-04 2011-01-19 Ranbaxy Laboratories Limited Verbessertes verfahren zur herstellung von clopidogrel und pharmazeutisch unbedenklichen salzen davon
KR100978498B1 (ko) * 2006-10-17 2010-08-30 최중헌 클로피도그렐 황산수소염의 제조방법
KR101365689B1 (ko) * 2006-10-27 2014-02-24 (주)유케이케미팜 (ｒ)-2-히드록시-2-(클로로페닐)초산 메틸 에스테르황산염의 제조방법
EP1980563A1 (de) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Verfahren zur Herstellung von Methyl (+)-(S)-Alpha-(O-Chlorophenyl)-6,7-Dihydrothieno-[3,2-C]pyridine-5(4H) Acetat
KR20090086903A (ko) * 2007-04-18 2009-08-14 테바 파마슈티컬 인더스트리즈 리미티드 개선된 클로피도그렐의 제조 방법
WO2010046476A1 (en) * 2008-10-24 2010-04-29 Sandoz Ag A process for the preparation of s-clopidogrel
CN101585842B (zh) * 2009-07-13 2011-07-20 北京赛科药业有限责任公司 氯吡格雷中杂质b的研究及控制方法
CN101987854A (zh) * 2009-08-04 2011-03-23 北京万全阳光医学技术有限公司 一种氯吡格雷及其盐的制备方法
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102250114B (zh) * 2011-04-27 2014-02-26 青岛黄海制药有限责任公司 一种氯吡格雷及其硫酸盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6047274B2 (ja) * 1976-07-07 1985-10-21 株式会社三和化学研究所 新規のチエノ〔３，２−ｆ〕モルファン誘導体及びその塩並びにこれ等の製法
FR2508456A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de (thienyl-2)-2 ethylamines et (thienyl-3)-2 ethylamines
JPS62103087A (ja) * 1985-10-28 1987-05-13 Toyo Pharma- Kk ５−（２−クロロベンジル）−４，５，６，７−テトラヒドロチエノ〔３，２−ｃ〕ピリジン又はその塩の製造方法

Also Published As

Publication number Publication date
EP0465358B1 (de) 1996-02-07
IE912328A1 (en) 1992-01-15
HU912250D0 (en) 1991-12-30
HU213397B (en) 1997-06-30
PT98181B (pt) 1998-12-31
FR2664276B1 (fr) 1992-10-23
JP3055819B2 (ja) 2000-06-26
CA2046126C (en) 2001-11-20
HUT61754A (en) 1993-03-01
CA2046126A1 (en) 1992-01-05
GR3018947T3 (en) 1996-05-31
EP0465358A1 (de) 1992-01-08
DE69116943T2 (de) 1996-09-19
ES2083542T3 (es) 1996-04-16
FR2664276A1 (fr) 1992-01-10
DK0465358T3 (da) 1996-05-28
IE73223B1 (en) 1997-05-07
JPH04261174A (ja) 1992-09-17
DE69116943D1 (de) 1996-03-21
US5132435A (en) 1992-07-21
PT98181A (pt) 1993-08-31

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Legal Events

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UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time