DK0461630T3 - Fremgangsmåde til fremstilling af mikrokugler - Google Patents

Fremgangsmåde til fremstilling af mikrokugler

Info

Publication number
DK0461630T3
DK0461630T3 DK91109610.5T DK91109610T DK0461630T3 DK 0461630 T3 DK0461630 T3 DK 0461630T3 DK 91109610 T DK91109610 T DK 91109610T DK 0461630 T3 DK0461630 T3 DK 0461630T3
Authority
DK
Denmark
Prior art keywords
fatty acid
solvent
acid ester
mixed solvent
oil phase
Prior art date
Application number
DK91109610.5T
Other languages
English (en)
Inventor
Ichiro Yamakawa
Ryoichi Machida
Sumio Watanabe
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15284990A external-priority patent/JPH0446115A/ja
Priority claimed from JP15285090A external-priority patent/JPH0446116A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DK0461630T3 publication Critical patent/DK0461630T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK91109610.5T 1990-06-13 1991-06-12 Fremgangsmåde til fremstilling af mikrokugler DK0461630T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15284990A JPH0446115A (ja) 1990-06-13 1990-06-13 マイクロスフィアの製造法
JP15285090A JPH0446116A (ja) 1990-06-13 1990-06-13 マイクロスフィアの製造方法
JP4857991 1991-02-22

Publications (1)

Publication Number Publication Date
DK0461630T3 true DK0461630T3 (da) 1995-11-13

Family

ID=27293336

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91109610.5T DK0461630T3 (da) 1990-06-13 1991-06-12 Fremgangsmåde til fremstilling af mikrokugler

Country Status (9)

Country Link
US (1) US5980947A (da)
EP (1) EP0461630B1 (da)
JP (1) JP3116311B2 (da)
AT (1) ATE127686T1 (da)
CA (1) CA2044353A1 (da)
DE (1) DE69112914T2 (da)
DK (1) DK0461630T3 (da)
ES (1) ES2076412T3 (da)
GR (1) GR3017411T3 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
DE69316101T2 (de) * 1992-08-07 1998-10-22 Takeda Chemical Industries Ltd Herstellung von Mikrokapseln, die wasserlösliche Arzneimittel enthalten
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
EP0835101B1 (en) 1995-06-27 2004-06-09 Takeda Chemical Industries, Ltd. Method of producing sustained-release preparation
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2241322C (en) 1996-03-28 2009-01-13 Takeda Chemical Industries, Ltd. Sustained-release preparation and its production
KR19990065921A (ko) * 1998-01-19 1999-08-16 김충섭 항생제의서방성제제
KR20020093059A (ko) * 2000-04-24 2002-12-12 다나베 세이야꾸 가부시키가이샤 마이크로스피어 제조 방법
JP2002129057A (ja) * 2000-10-27 2002-05-09 Riken Vitamin Co Ltd 多芯型カロテノイドビーズ
ATE309788T1 (de) * 2000-12-13 2005-12-15 Merckle Gmbh Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung
CA2432904C (en) 2000-12-21 2007-09-11 Nektar Therapeutics Induced phase transition method for the production of microparticles containing hydrophobic active agents
EP1369130A1 (en) * 2001-03-16 2003-12-10 Takeda Chemical Industries, Ltd. Process for producing sustained release preparation
CA2497973C (en) * 2002-09-05 2012-11-06 Catherine G. Ambrose Antibiotic microspheres for treatment of infections and osteomyelitis
US8986737B2 (en) * 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
AU2003262048A1 (en) * 2002-09-11 2004-04-30 Tanabe Seiyaku Co., Ltd. Process for the production of microspheres and unit therefor
CN100571682C (zh) 2003-06-03 2009-12-23 参天制药株式会社 微粒的制造方法
CA2615939A1 (en) * 2005-08-02 2007-02-08 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
JP2007222807A (ja) * 2006-02-24 2007-09-06 Nisso Engineering Co Ltd 修復型マイクロカプセルの製造方法
ES2791698T3 (es) 2006-12-18 2020-11-05 Takeda Pharmaceuticals Co Composición de liberación sostenida y método para producir la misma
KR101105292B1 (ko) * 2009-06-05 2012-01-17 주식회사 리젠 바이오텍 생분해성 고분자 미세입자와 그의 제조방법
KR102009698B1 (ko) 2011-12-20 2019-08-13 바이옴 테라퓨틱스 리미티드 진균 감염의 치료를 위한 국소 오일 조성물
JP2014028764A (ja) * 2012-07-31 2014-02-13 Pure Green Kk 水溶性生理活生物質のマイクロスフィアを含有する油脂及びその製造方法
CA2914583C (en) * 2013-06-04 2019-06-18 Vyome Biosciences Pvt. Ltd. Coated particles and compositions comprising same
JP6944033B1 (ja) * 2020-10-05 2021-10-06 ミヨシ油脂株式会社 生分解性樹脂水系分散体とその製造方法、および生分解性樹脂水系分散体を用いた食品包装用紙
CN114656677B (zh) * 2022-02-11 2022-12-16 华南理工大学 一种基于w/o/w型复乳溶剂挥发的木质素多孔微球及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4542025A (en) * 1982-07-29 1985-09-17 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4671954A (en) * 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JPS6341416A (ja) * 1986-08-08 1988-02-22 Takeda Chem Ind Ltd 鎮痛性ペプチド含有マイクロカプセルの製造法
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
US4954338A (en) * 1987-08-05 1990-09-04 Rohm And Haas Company Microbicidal microemulsion

Also Published As

Publication number Publication date
EP0461630A2 (en) 1991-12-18
EP0461630A3 (en) 1992-04-01
JP3116311B2 (ja) 2000-12-11
EP0461630B1 (en) 1995-09-13
US5980947A (en) 1999-11-09
CA2044353A1 (en) 1991-12-14
ATE127686T1 (de) 1995-09-15
GR3017411T3 (en) 1995-12-31
JPH0665063A (ja) 1994-03-08
DE69112914D1 (de) 1995-10-19
ES2076412T3 (es) 1995-11-01
DE69112914T2 (de) 1996-04-04

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