DE99585T1 - Verfahren zur herstellung von additionsverbindung von dipeptiden-ester und aminosaeure-ester. - Google Patents

Verfahren zur herstellung von additionsverbindung von dipeptiden-ester und aminosaeure-ester.

Info

Publication number
DE99585T1
DE99585T1 DE198383107165T DE83107165T DE99585T1 DE 99585 T1 DE99585 T1 DE 99585T1 DE 198383107165 T DE198383107165 T DE 198383107165T DE 83107165 T DE83107165 T DE 83107165T DE 99585 T1 DE99585 T1 DE 99585T1
Authority
DE
Germany
Prior art keywords
methyl ester
acid
phenylalanine methyl
aqueous solution
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198383107165T
Other languages
German (de)
English (en)
Inventor
Tsuneo Shinnanyo-Shi Yamaguchi-Ken Harada
Shigeaki Kumage-Gun Yamaguchi-Ken Irino
Masao Yokohama-Shi Kanagawa-Ken Nakamura
Kiyotaka Hikari-Shi Yamaguchi-Ken Oyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Ajinomoto Co Inc
Sagami Chemical Research Institute
Toyo Soda Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Sagami Chemical Research Institute, Toyo Soda Manufacturing Co Ltd filed Critical Ajinomoto Co Inc
Publication of DE99585T1 publication Critical patent/DE99585T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE198383107165T 1982-07-23 1983-07-21 Verfahren zur herstellung von additionsverbindung von dipeptiden-ester und aminosaeure-ester. Pending DE99585T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57128420A JPS5917997A (ja) 1982-07-23 1982-07-23 ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法

Publications (1)

Publication Number Publication Date
DE99585T1 true DE99585T1 (de) 1984-06-20

Family

ID=14984317

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198383107165T Pending DE99585T1 (de) 1982-07-23 1983-07-21 Verfahren zur herstellung von additionsverbindung von dipeptiden-ester und aminosaeure-ester.
DE8383107165T Expired DE3374318D1 (en) 1982-07-23 1983-07-21 Process for producing an addition compound of a dipeptide ester and an amino acid ester

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8383107165T Expired DE3374318D1 (en) 1982-07-23 1983-07-21 Process for producing an addition compound of a dipeptide ester and an amino acid ester

Country Status (6)

Country Link
US (1) US4521514A (en:Method)
EP (1) EP0099585B1 (en:Method)
JP (1) JPS5917997A (en:Method)
AU (1) AU562486B2 (en:Method)
CA (1) CA1209942A (en:Method)
DE (2) DE99585T1 (en:Method)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3532027A1 (de) * 1985-09-09 1987-03-19 Hoechst Ag Verfahren zur herstellung von aspartam und mittel zu seiner durchfuehrung
FR2589480B1 (fr) * 1985-11-05 1988-09-16 Hoechst France Procede biologique de preparation de n-(n-benzyloxycarbonyl l-aspartyl-1) l-phenylalaninate de methyle
FR2609376B1 (fr) * 1987-01-14 1990-12-07 Hoechst France Procede de preparation de l'aspartame par voie enzymatique
DK72587D0 (da) * 1987-02-13 1987-02-13 Carlsberg Biotechnology Ltd Fremgangsmaade til enzymatisk fremstilling af dipeptider
DK15888D0 (da) * 1988-01-14 1988-01-14 Carlsberg Biotechnology Ltd Enzymatisk fremgangsmaade til fremstilling af immunmodulerende pentapeptider samt mellemprodukter til brug ved fremgangsmaaden
EP0344803B1 (en) * 1988-06-03 1995-09-13 Sharp Kabushiki Kaisha Electronic device with calendar function
US5002872A (en) * 1989-05-10 1991-03-26 W. R. Grace & Co.-Conn. Enzyme mediated coupling reactions
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
KR930002966B1 (ko) * 1990-11-24 1993-04-16 주식회사 미 원 디펩티드의 제조방법
TW306932B (en:Method) * 1993-08-27 1997-06-01 Holland Sweetener Co
DE69613305T2 (de) * 1995-10-11 2002-05-02 Holland Sweetener Co. V.O.F., Maastricht Verbesserte enzymatische Kupplungsreaktion von N-geschützte L-Asparaginsäure und Phenylalaninmethylester

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH508590A (fr) * 1970-10-29 1971-06-15 Ajinomoto Kk Procédé de préparation des esters d'alcoyle inférieurs de l'a-L-aspartyl-L-phénylalanine
US4119493A (en) * 1975-10-23 1978-10-10 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide
DE2801238C2 (de) * 1977-01-27 1986-06-05 (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo Verfahren zur Herstellung von Salzen aus L,L-Dipeptiden und Phenylalaninestern
JPS5411293A (en) * 1977-05-23 1979-01-27 Toyo Soda Mfg Co Ltd Recovery of protease
JPS5411294A (en) * 1977-05-23 1979-01-27 Toyo Soda Mfg Co Ltd Recovery of protease
JPS55135595A (en) * 1979-04-03 1980-10-22 Toyo Soda Mfg Co Ltd Preparation of dipeptide
IE52242B1 (en) * 1981-02-02 1987-08-19 Searle & Co Preparation of amino protected-l-aspartyl-l-phenylalanine alkyl ester
DE3274985D1 (en) * 1981-09-21 1987-02-12 Toyo Soda Mfg Co Ltd Process for recovering a dipeptide derivative

Also Published As

Publication number Publication date
CA1209942A (en) 1986-08-19
DE3374318D1 (en) 1987-12-10
JPH052317B2 (en:Method) 1993-01-12
US4521514A (en) 1985-06-04
AU562486B2 (en) 1987-06-11
EP0099585A1 (en) 1984-02-01
JPS5917997A (ja) 1984-01-30
EP0099585B1 (en) 1987-11-04
AU1716983A (en) 1984-01-26

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