DE918567C - Verfahren zur Herstellung eines p-Alkylbenzhydryl-dialkylaminoalkylaethers bzw. von Salzen dieses AEthers - Google Patents
Verfahren zur Herstellung eines p-Alkylbenzhydryl-dialkylaminoalkylaethers bzw. von Salzen dieses AEthersInfo
- Publication number
- DE918567C DE918567C DEN408A DEN0000408A DE918567C DE 918567 C DE918567 C DE 918567C DE N408 A DEN408 A DE N408A DE N0000408 A DEN0000408 A DE N0000408A DE 918567 C DE918567 C DE 918567C
- Authority
- DE
- Germany
- Prior art keywords
- ether
- diphenylcarbinol
- dimethylaminoethanol
- salts
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title claims description 12
- 238000000034 method Methods 0.000 title claims description 8
- 150000002170 ethers Chemical class 0.000 title claims description 7
- 150000003839 salts Chemical class 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title claims description 4
- QILSFLSDHQAZET-UHFFFAOYSA-N diphenylmethanol Chemical class C=1C=CC=CC=1C(O)C1=CC=CC=C1 QILSFLSDHQAZET-UHFFFAOYSA-N 0.000 claims description 9
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 claims description 7
- 229960002887 deanol Drugs 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 2
- 229910000039 hydrogen halide Inorganic materials 0.000 claims description 2
- 239000012433 hydrogen halide Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- -1 dialkylamino alcohol Chemical compound 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL683483X | 1949-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE918567C true DE918567C (de) | 1954-09-30 |
Family
ID=19805584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEN408A Expired DE918567C (de) | 1949-01-19 | 1950-01-18 | Verfahren zur Herstellung eines p-Alkylbenzhydryl-dialkylaminoalkylaethers bzw. von Salzen dieses AEthers |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE493331A (enrdf_load_stackoverflow) |
| DE (1) | DE918567C (enrdf_load_stackoverflow) |
| GB (1) | GB683483A (enrdf_load_stackoverflow) |
| NL (1) | NL77120C (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1143827B (de) * | 1955-07-07 | 1963-02-21 | Koninklijke Pharma Fab Nv | Verfahren zur Herstellung von neuen atropinwirksamen, in o-Stellung substituierten Benzhydryl-ª‰-dialkylaminoaethylaethern |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR898245A (fr) * | 1942-09-23 | 1945-04-13 | Geigy Ag J R | Procédé de préparation d'éther-oxydes amino-alcoyliques dérivant d'alcools de la série aromatique-aliphatique |
| GB585994A (en) * | 1943-09-22 | 1947-03-04 | Geigy Ag J R | Manufacture of aminoalkyl ethers and of quaternary ammonium compounds formed therefrom |
-
0
- NL NL77120D patent/NL77120C/xx active
- BE BE493331D patent/BE493331A/xx unknown
-
1950
- 1950-01-17 GB GB1209/50A patent/GB683483A/en not_active Expired
- 1950-01-18 DE DEN408A patent/DE918567C/de not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR898245A (fr) * | 1942-09-23 | 1945-04-13 | Geigy Ag J R | Procédé de préparation d'éther-oxydes amino-alcoyliques dérivant d'alcools de la série aromatique-aliphatique |
| GB585994A (en) * | 1943-09-22 | 1947-03-04 | Geigy Ag J R | Manufacture of aminoalkyl ethers and of quaternary ammonium compounds formed therefrom |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1143827B (de) * | 1955-07-07 | 1963-02-21 | Koninklijke Pharma Fab Nv | Verfahren zur Herstellung von neuen atropinwirksamen, in o-Stellung substituierten Benzhydryl-ª‰-dialkylaminoaethylaethern |
Also Published As
| Publication number | Publication date |
|---|---|
| GB683483A (en) | 1952-11-26 |
| NL77120C (enrdf_load_stackoverflow) | |
| BE493331A (enrdf_load_stackoverflow) |
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