DE69940601D1 - Verfahren zur markierung von rns - Google Patents

Verfahren zur markierung von rns

Info

Publication number
DE69940601D1
DE69940601D1 DE69940601T DE69940601T DE69940601D1 DE 69940601 D1 DE69940601 D1 DE 69940601D1 DE 69940601 T DE69940601 T DE 69940601T DE 69940601 T DE69940601 T DE 69940601T DE 69940601 D1 DE69940601 D1 DE 69940601D1
Authority
DE
Germany
Prior art keywords
rna
nucleotide
labeled
fragmentation
labeling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940601T
Other languages
English (en)
Inventor
Ali Laayoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Original Assignee
Biomerieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux SA filed Critical Biomerieux SA
Application granted granted Critical
Publication of DE69940601D1 publication Critical patent/DE69940601D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
DE69940601T 1998-06-17 1999-06-17 Verfahren zur markierung von rns Expired - Lifetime DE69940601D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9807870A FR2780059B1 (fr) 1998-06-17 1998-06-17 Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
PCT/FR1999/001469 WO1999065926A1 (fr) 1998-06-17 1999-06-17 Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus

Publications (1)

Publication Number Publication Date
DE69940601D1 true DE69940601D1 (de) 2009-04-30

Family

ID=9527692

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69940482T Expired - Lifetime DE69940482D1 (de) 1998-06-17 1999-06-17 Verfahren zur Markierung einer Ribonukleinsäure, mit Reinigung
DE69940601T Expired - Lifetime DE69940601D1 (de) 1998-06-17 1999-06-17 Verfahren zur markierung von rns

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69940482T Expired - Lifetime DE69940482D1 (de) 1998-06-17 1999-06-17 Verfahren zur Markierung einer Ribonukleinsäure, mit Reinigung

Country Status (12)

Country Link
US (2) US6376179B1 (de)
EP (3) EP1260596A3 (de)
JP (1) JP4439735B2 (de)
CN (1) CN1330662C (de)
AT (2) ATE425985T1 (de)
AU (1) AU750475B2 (de)
CA (1) CA2335730C (de)
DE (2) DE69940482D1 (de)
ES (2) ES2322215T3 (de)
FR (1) FR2780059B1 (de)
HK (2) HK1051877A1 (de)
WO (1) WO1999065926A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780059B1 (fr) 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
JP2003516762A (ja) * 1999-12-17 2003-05-20 ベーイーオー・メリュー リボ核酸を標識する方法、及びそれにより得られた標識化ｒｎａ断片
WO2001044507A1 (en) * 1999-12-17 2001-06-21 Bio Merieux Process for labeling a nucleic acid
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
CA2731495C (en) 2000-09-01 2015-02-03 Gen-Probe Incorporated Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
FR2824323B1 (fr) * 2001-05-04 2008-04-25 Bio Merieux Reactif de marquage et procede de detection de molecules biologiques
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
FR2824335A1 (fr) * 2001-05-04 2002-11-08 Bio Merieux Procede de marquage et de fragmentation d'adn
US7727722B2 (en) * 2001-08-29 2010-06-01 General Electric Company Ligation amplification
FR2829580B1 (fr) 2001-09-07 2004-02-13 Bio Merieux Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
WO2003064621A2 (en) * 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
CA2475003A1 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Double-stranded oligonucleotides
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
EP1532271A4 (de) * 2002-06-12 2006-10-18 Ambion Inc Verfahren und zusammensetzungen im zusammenhang mit polypeptiden mit rnase-iii-domänen, die rna-interferenz vermitteln
US20100075423A1 (en) * 2002-06-12 2010-03-25 Life Technologies Corporation Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
FR2855832B1 (fr) 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
FR2857375B1 (fr) 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
US20050065599A1 (en) * 2003-09-19 2005-03-24 Mhatre Harischandra K. Heart valve prosthesis
FR2864550B1 (fr) 2003-12-29 2006-02-24 Commissariat Energie Atomique Puce d'analyse avec gamme etalon, trousses et procedes d'analyse.
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2868433B1 (fr) 2004-04-06 2008-01-18 Biomerieux Sa Procede pour le pronostic et/ou le diagnostic d'un cancer
EP2281889B1 (de) 2004-11-12 2014-07-30 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNA-inhibitorischen Molekülen verbunden sind
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
EP2576815B1 (de) 2010-06-04 2018-02-14 Biomérieux Verfahren zur prognose von kolorektalkarzinom
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
CN102643792B (zh) * 2011-02-17 2015-04-22 深圳华大基因科技服务有限公司 Rna断裂试剂及其应用
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
US10072300B2 (en) 2013-05-21 2018-09-11 Biomerieux Kit for the prognosis of colorectal cancer

Family Cites Families (35)

* Cited by examiner, † Cited by third party
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CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
ATE48140T1 (de) 1981-04-17 1989-12-15 Univ Yale Modifizierte nukleotide und verfahren zu ihrer herstellung und anwendung.
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US5348855A (en) * 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
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US4779142A (en) 1987-02-27 1988-10-18 Polaroid Corporation System and method for electronically recording and playing back video images with improved chrominance characteristics using alternate even and odd chrominance signal line matrix encoding
DE3910151A1 (de) * 1989-03-29 1990-10-04 Toni Dr Lindl 5'-bromo-2'-desoxyuridinmarkierte dna- oder rna- sonden
US5582829A (en) * 1990-04-05 1996-12-10 Rx Technologies, Inc. Sonicated borrelia burgdorferi vaccine
US5171853A (en) 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
CA2129105A1 (en) * 1992-02-12 1993-08-19 Michael J. Conrad Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
US5858650A (en) 1992-04-03 1999-01-12 Abbott Laboratories Methods for inactivating nucleotide sequences and metal chelates for use therein
DE4213703A1 (de) * 1992-04-25 1993-10-28 Merck Patent Gmbh Fluoreszenzmarkierte Verbindungen, ihre Herstellung und Verwendung
US5684149A (en) * 1993-01-22 1997-11-04 Research Foundation Of State University Of New York Metal complexes for promoting catalytic cleavage of RNA by transesterification
FR2706618B1 (fr) 1993-06-11 1995-09-01 Bio Merieux Dispositif pour le dosage d'haptènes et son utilisation.
DE4324433C1 (de) * 1993-07-21 1994-08-25 Dmt Gmbh Verfahren zur Sanierung von Industriellen Absetzanlagen
IL110463A0 (en) * 1993-08-13 1994-10-21 Du Pont In situ extraction of microbial DNA
FR2710075B1 (fr) 1993-09-15 1995-10-27 Bio Merieux Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal.
DE4406524A1 (de) * 1994-02-28 1995-08-31 Boehringer Mannheim Gmbh 3'-RNA-Markierung mit Terminaler Transferase
US5484149A (en) * 1994-06-10 1996-01-16 Yuh Jou Co., Ltd. Adjustable roller skate structure
US5688670A (en) * 1994-09-01 1997-11-18 The General Hospital Corporation Self-modifying RNA molecules and methods of making
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
JPH11510361A (ja) * 1994-10-11 1999-09-14 ユニバーシティ・オブ・カリフォルニア 内部開始ｒｎａ翻訳の選択的阻止
DE19509038A1 (de) * 1995-03-14 1996-09-19 Boehringer Mannheim Gmbh C-Nukleosid-Derivate und deren Verwendung in der Detektion von Nukleinsäuren
US5834198A (en) 1996-03-21 1998-11-10 Boehringer Mamnnheim Gmbh Selective photoinducted flavin-dependent cleavage of RNA at G-U base pairs and kits therefor
CA2262019C (fr) * 1996-08-02 2011-11-15 Bio Merieux Procede d'amplification d'une sequence d'un acide nucleique cible
DE19637042A1 (de) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren
US5905024A (en) 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
US5981734A (en) * 1997-07-17 1999-11-09 University Of Chicago Methods for immobilizing nucleic acids on a gel substrate
FR2768743B1 (fr) 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
DE19815864A1 (de) 1998-04-08 1999-10-14 Europ Lab Molekularbiolog 5'-modifizierte Nukleotide und ihre Anwendung in der Molekularbiologie und Medizin
FR2780059B1 (fr) 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
FR2781500B1 (fr) 1998-07-23 2000-09-08 Bio Merieux Dispositif perfectionne et procede de lyse de micro-organismes

Also Published As

Publication number Publication date
EP1260597A2 (de) 2002-11-27
FR2780059A1 (fr) 1999-12-24
EP1260596A2 (de) 2002-11-27
ES2322034T3 (es) 2009-06-16
FR2780059B1 (fr) 2002-10-11
CA2335730A1 (fr) 1999-12-23
US6376179B1 (en) 2002-04-23
HK1051877A1 (en) 2003-08-22
US20020187500A1 (en) 2002-12-12
EP1260596A3 (de) 2003-10-29
ATE423854T1 (de) 2009-03-15
US6921640B2 (en) 2005-07-26
ES2322215T3 (es) 2009-06-17
JP2002517994A (ja) 2002-06-25
ATE425985T1 (de) 2009-04-15
CN1310722A (zh) 2001-08-29
EP1260597B1 (de) 2009-02-25
EP1087983A1 (de) 2001-04-04
WO1999065926A1 (fr) 1999-12-23
EP1260597A3 (de) 2003-01-08
DE69940482D1 (de) 2009-04-09
JP4439735B2 (ja) 2010-03-24
AU750475B2 (en) 2002-07-18
HK1036627A1 (en) 2002-01-11
CA2335730C (fr) 2011-02-22
EP1087983B1 (de) 2009-03-18
AU4269299A (en) 2000-01-05
CN1330662C (zh) 2007-08-08

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