WO1997010366A3 - High throughput screening method for sequences or genetic alterations in nucleic acids - Google Patents

High throughput screening method for sequences or genetic alterations in nucleic acids Download PDF

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Publication number
WO1997010366A3
WO1997010366A3 PCT/US1996/014842 US9614842W WO9710366A3 WO 1997010366 A3 WO1997010366 A3 WO 1997010366A3 US 9614842 W US9614842 W US 9614842W WO 9710366 A3 WO9710366 A3 WO 9710366A3
Authority
WO
WIPO (PCT)
Prior art keywords
sequences
high throughput
genetic alterations
nucleic acids
nucleic acid
Prior art date
Application number
PCT/US1996/014842
Other languages
French (fr)
Other versions
WO1997010366A2 (en
Inventor
Anthony P Shuber
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Priority to AU70736/96A priority Critical patent/AU7073696A/en
Priority to EP96931600A priority patent/EP0789781A1/en
Priority to JP09512176A priority patent/JP2000513202A/en
Priority to PCT/US1996/014842 priority patent/WO1997010366A2/en
Publication of WO1997010366A2 publication Critical patent/WO1997010366A2/en
Publication of WO1997010366A3 publication Critical patent/WO1997010366A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A high throughput method for screening nucleic acid samples to identify target sequences or one or more genetic alterations in target sequences present in the nucleic acid samples is provided. Methods of identifying target nucleic acid sequences in patient samples, and of identifying randomly permuted alterations in nucleic acid sequences of interest are also disclosed.
PCT/US1996/014842 1995-09-15 1996-09-13 High throughput screening method for sequences or genetic alterations in nucleic acids WO1997010366A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU70736/96A AU7073696A (en) 1996-09-13 1996-09-13 High throughput screening method for sequences or genetic alterations in nucleic acids
EP96931600A EP0789781A1 (en) 1995-09-15 1996-09-13 High throughput screening method for sequences or genetic alterations in nucleic acids
JP09512176A JP2000513202A (en) 1995-09-15 1996-09-13 Large-scale screening of nucleic acid sequencing or genetic replacement
PCT/US1996/014842 WO1997010366A2 (en) 1995-09-15 1996-09-13 High throughput screening method for sequences or genetic alterations in nucleic acids

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US378895P 1995-09-15 1995-09-15
US60/003,788 1995-09-15
PCT/US1996/014842 WO1997010366A2 (en) 1995-09-15 1996-09-13 High throughput screening method for sequences or genetic alterations in nucleic acids

Publications (2)

Publication Number Publication Date
WO1997010366A2 WO1997010366A2 (en) 1997-03-20
WO1997010366A3 true WO1997010366A3 (en) 1997-07-17

Family

ID=26672194

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/014842 WO1997010366A2 (en) 1995-09-15 1996-09-13 High throughput screening method for sequences or genetic alterations in nucleic acids

Country Status (3)

Country Link
EP (1) EP0789781A1 (en)
JP (1) JP2000513202A (en)
WO (1) WO1997010366A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds
AU9586598A (en) * 1997-09-23 1999-04-12 Oncormed, Inc. Genetic panel assay for susceptibility mutations in breast and ovarian cancer
AU766544B2 (en) * 1998-06-06 2003-10-16 Genostic Pharma Limited Probes used for genetic profiling
JP2008011829A (en) * 2006-07-10 2008-01-24 Olympus Corp Method for detecting nucleic acid
EP2576823A1 (en) 2010-06-04 2013-04-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Constitutively active prolactin receptor variants as prognostic markers and therapeutic targets to prevent progression of hormone-dependent cancers towards hormone-independence
JP2014533506A (en) * 2011-11-16 2014-12-15 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． Detection of mutations in highly homologous genomic regions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408918A1 (en) * 1989-06-23 1991-01-23 Canon Kabushiki Kaisha Method for detecting nucleic acid
WO1992010587A1 (en) * 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microfluorescence detection
WO1993025563A1 (en) * 1992-06-17 1993-12-23 City Of Hope A method of detecting and discriminating between nucleic acid sequences
WO1995014107A1 (en) * 1993-11-19 1995-05-26 Smithkline Beecham Biologicals (S.A.) Analytical method of detecting mutations in virus mixtures or attenuated live virus vaccines
WO1996003529A1 (en) * 1994-07-28 1996-02-08 Genzyme Corporation High throughput screening method for sequences or genetic alterations in nucleic acids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0408918A1 (en) * 1989-06-23 1991-01-23 Canon Kabushiki Kaisha Method for detecting nucleic acid
WO1992010587A1 (en) * 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microfluorescence detection
WO1993025563A1 (en) * 1992-06-17 1993-12-23 City Of Hope A method of detecting and discriminating between nucleic acid sequences
WO1995014107A1 (en) * 1993-11-19 1995-05-26 Smithkline Beecham Biologicals (S.A.) Analytical method of detecting mutations in virus mixtures or attenuated live virus vaccines
WO1996003529A1 (en) * 1994-07-28 1996-02-08 Genzyme Corporation High throughput screening method for sequences or genetic alterations in nucleic acids

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
SHUBER A P ET AL: "EFFICIENT 12-MUTATION TESTING IN THE CFTR GENE: A GENERAL MODEL FOR COMPLEX MUTATION ANALYSIS", HUMAN MOLECULAR GENETICS, vol. 2, no. 2, 1 February 1993 (1993-02-01), pages 153 - 158, XP000335860 *
SHUBER, A. ET AL.: "High throughput parallel analysis of hundreds of patient samples for more than 100 mutations in multiple disease genes", HUMAN MOLECULAR GENETICS, vol. 6, no. 3, March 1997 (1997-03-01), pages 337 - 47, XP000673446 *
SOCRANSKY S S ET AL: ""CHECKERBOARD" DNA-DNA HYBRIDIZATION", BIOTECHNIQUES, vol. 17, no. 4, 1 October 1994 (1994-10-01), pages 788 - 792, XP000474865 *
SYVANEN A -C ET AL: "DETECTION OF POINT MUTATIONS BY SOLID-PHASE METHODS", HUMAN MUTATION, vol. 3, no. 3, 1 January 1994 (1994-01-01), pages 172 - 179, XP000600258 *

Also Published As

Publication number Publication date
WO1997010366A2 (en) 1997-03-20
EP0789781A1 (en) 1997-08-20
JP2000513202A (en) 2000-10-10

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