DE69935229T2 - Neue antidiabetische peptide - Google Patents
Neue antidiabetische peptide Download PDFInfo
- Publication number
- DE69935229T2 DE69935229T2 DE69935229T DE69935229T DE69935229T2 DE 69935229 T2 DE69935229 T2 DE 69935229T2 DE 69935229 T DE69935229 T DE 69935229T DE 69935229 T DE69935229 T DE 69935229T DE 69935229 T2 DE69935229 T2 DE 69935229T2
- Authority
- DE
- Germany
- Prior art keywords
- xaa
- seq
- compound according
- solvent
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 108090000765 processed proteins & peptides Proteins 0.000 title description 248
- 102000004196 processed proteins & peptides Human genes 0.000 title description 64
- 239000003472 antidiabetic agent Substances 0.000 title description 2
- 230000003178 anti-diabetic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 127
- 108010041872 Islet Amyloid Polypeptide Proteins 0.000 claims abstract description 69
- 102000036770 Islet Amyloid Polypeptide Human genes 0.000 claims abstract description 69
- 230000000694 effects Effects 0.000 claims abstract description 29
- 239000000556 agonist Substances 0.000 claims abstract description 28
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
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- JWBLQDDHSDGEGR-DRZSPHRISA-N Phe-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 JWBLQDDHSDGEGR-DRZSPHRISA-N 0.000 claims description 3
- PYOHODCEOHCZBM-RYUDHWBXSA-N Phe-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 PYOHODCEOHCZBM-RYUDHWBXSA-N 0.000 claims description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/138,056 US6087334A (en) | 1998-08-21 | 1998-08-21 | Anti-diabetic peptides |
| PCT/US1999/017918 WO2000011029A2 (en) | 1998-08-21 | 1999-08-09 | Novel anti-diabetic peptides |
| US138056 | 2001-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69935229D1 DE69935229D1 (de) | 2007-04-05 |
| DE69935229T2 true DE69935229T2 (de) | 2007-11-08 |
Family
ID=22480238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69935229T Expired - Lifetime DE69935229T2 (de) | 1998-08-21 | 1999-08-09 | Neue antidiabetische peptide |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6087334A (enExample) |
| EP (1) | EP1104438B1 (enExample) |
| JP (1) | JP2002523424A (enExample) |
| AT (1) | ATE354590T1 (enExample) |
| AU (1) | AU766545B2 (enExample) |
| CA (1) | CA2337971C (enExample) |
| DE (1) | DE69935229T2 (enExample) |
| ES (1) | ES2283127T3 (enExample) |
| WO (1) | WO2000011029A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143718A (en) | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| WO2002024727A2 (en) * | 2000-09-19 | 2002-03-28 | University Of Toronto | New inhibitors of iapp fibril formation and uses thereof |
| DE60324387D1 (de) * | 2002-01-08 | 2008-12-11 | Amylin Pharmaceuticals Inc | Verwendung von amylin, amylinanaloga und amylin derivaten zur behandlung von dyslipidämie und hypertriglyceridämie |
| ATE385193T1 (de) | 2002-03-20 | 2008-02-15 | Mannkind Corp | Inhalationsgerät |
| US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| BRPI0507623A (pt) | 2004-02-11 | 2007-07-03 | Amylin Pharmaceuticals Inc | peptìdeos da famìlia da amilina e métodos para prepará-los e empregá-los |
| US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
| DE602005024413D1 (de) | 2004-08-20 | 2010-12-09 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| CN104436170B (zh) | 2004-08-23 | 2018-02-23 | 曼金德公司 | 用于药物输送的二酮哌嗪盐 |
| CA2584906A1 (en) * | 2004-10-26 | 2006-05-04 | Lonza Ag | S-alkyl-sulphenyl protection groups in solid-phase synthesis |
| WO2006099288A2 (en) * | 2005-03-11 | 2006-09-21 | Indevus Pharmaceuticals, Inc. | Controlled release formulations of octreotide |
| US7759312B2 (en) * | 2005-03-11 | 2010-07-20 | Endo Pharmaceuticals Solutions Inc. | Delivery of dry formulations of octreotide |
| US7671023B2 (en) | 2005-03-31 | 2010-03-02 | Amylin Pharmaceuticals, Inc. | Amylin agonist for treating depression, anxiety disorder and schizophrenia |
| JP5167133B2 (ja) | 2005-09-14 | 2013-03-21 | マンカインド コーポレイション | 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法 |
| MX2008010721A (es) | 2006-02-22 | 2008-09-01 | Mannkind Corp | Un metodo para mejorar las propiedades farmaceuticas de microparticulas que contienen dicetopiperazina y un agente activo. |
| US20090181890A1 (en) * | 2006-03-31 | 2009-07-16 | Amylin Pharmaceuticals , Inc. | Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders |
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| GB8709871D0 (en) * | 1987-04-27 | 1987-06-03 | Turner R C | Peptides |
| GB8720115D0 (en) * | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
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| CA2120131A1 (en) * | 1991-09-27 | 1994-05-11 | Robert A. Murgita | Expression and purification of cloned human alpha-fetoprotein |
| AU669636B2 (en) * | 1993-05-12 | 1996-06-13 | University Of Cincinnati, The | Amylin antagonists and agonists |
| US5625032A (en) * | 1993-07-21 | 1997-04-29 | Amylin Pharmaceuticals, Inc. | Selective amylin antagonist peptides and uses therefor |
| US6143718A (en) * | 1995-06-07 | 2000-11-07 | Amylin Pharmaceuticals, Inc. | Treatment of Type II diabetes mellutis with amylin agonists |
-
1998
- 1998-08-21 US US09/138,056 patent/US6087334A/en not_active Expired - Lifetime
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1999
- 1999-08-09 WO PCT/US1999/017918 patent/WO2000011029A2/en not_active Ceased
- 1999-08-09 CA CA2337971A patent/CA2337971C/en not_active Expired - Fee Related
- 1999-08-09 DE DE69935229T patent/DE69935229T2/de not_active Expired - Lifetime
- 1999-08-09 JP JP2000566301A patent/JP2002523424A/ja active Pending
- 1999-08-09 EP EP99939073A patent/EP1104438B1/en not_active Expired - Lifetime
- 1999-08-09 AT AT99939073T patent/ATE354590T1/de not_active IP Right Cessation
- 1999-08-09 ES ES99939073T patent/ES2283127T3/es not_active Expired - Lifetime
- 1999-08-09 AU AU53430/99A patent/AU766545B2/en not_active Ceased
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| EP1104438B1 (en) | 2007-02-21 |
| CA2337971A1 (en) | 2000-03-02 |
| CA2337971C (en) | 2011-04-26 |
| AU5343099A (en) | 2000-03-14 |
| WO2000011029A2 (en) | 2000-03-02 |
| US6087334A (en) | 2000-07-11 |
| ES2283127T3 (es) | 2007-10-16 |
| JP2002523424A (ja) | 2002-07-30 |
| EP1104438A2 (en) | 2001-06-06 |
| ATE354590T1 (de) | 2007-03-15 |
| HK1038025A1 (en) | 2002-03-01 |
| DE69935229D1 (de) | 2007-04-05 |
| AU766545B2 (en) | 2003-10-16 |
| WO2000011029A3 (en) | 2000-06-22 |
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