DE69918946T2 - Rezeptoren für il-18 - Google Patents
Rezeptoren für il-18 Download PDFInfo
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- DE69918946T2 DE69918946T2 DE69918946T DE69918946T DE69918946T2 DE 69918946 T2 DE69918946 T2 DE 69918946T2 DE 69918946 T DE69918946 T DE 69918946T DE 69918946 T DE69918946 T DE 69918946T DE 69918946 T2 DE69918946 T2 DE 69918946T2
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- polypeptide
- 1rrp1
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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Applications Claiming Priority (7)
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| US7230198P | 1998-01-23 | 1998-01-23 | |
| US72301P | 1998-01-23 | ||
| US7883598P | 1998-03-20 | 1998-03-20 | |
| US78835P | 1998-03-20 | ||
| US9446998P | 1998-07-28 | 1998-07-28 | |
| US94469P | 1998-07-28 | ||
| PCT/US1999/001419 WO1999037772A1 (en) | 1998-01-23 | 1999-01-22 | Il-18 receptors |
Publications (2)
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| DE69918946D1 DE69918946D1 (de) | 2004-09-02 |
| DE69918946T2 true DE69918946T2 (de) | 2005-07-28 |
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| DE69918946T Expired - Lifetime DE69918946T2 (de) | 1998-01-23 | 1999-01-22 | Rezeptoren für il-18 |
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| NZ (1) | NZ505880A (enExample) |
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| US6472179B2 (en) * | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| US7083949B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US20020155526A1 (en) | 1998-09-30 | 2002-10-24 | Busfield Samantha J. | Novel secreted immunomodulatory proteins and uses thereof |
| US6610286B2 (en) | 1999-12-23 | 2003-08-26 | Zymogenetics, Inc. | Method for treating inflammation using soluble receptors to interleukin-20 |
| US7122632B2 (en) | 1999-12-23 | 2006-10-17 | Zymogenetics, Inc. | Soluble Interleukin-20 receptor |
| RU2279441C2 (ru) * | 1999-12-23 | 2006-07-10 | Займодженетикс, Инк. | Выделенный растворимый il-20 рецептор (варианты) |
| SK12942002A3 (sk) | 2000-02-10 | 2003-05-02 | Abbott Laboratories | Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia |
| US20020052475A1 (en) * | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
| US20020025317A1 (en) * | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
| AU2001290524A1 (en) | 2000-08-08 | 2002-02-18 | Zymogenetics Inc. | Soluble zcytor 11 cytokine receptors |
| ATE333888T1 (de) | 2000-09-15 | 2006-08-15 | Zymogenetics Inc | Verwendung eines polypeptids, welches die extrazelluläre domäne von il-20ra und il-20rb enthält, zur behandlung von entzündungen |
| AU2002211744B8 (en) | 2000-10-11 | 2008-03-20 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
| US7718368B2 (en) * | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| GB2375604A (en) * | 2001-05-18 | 2002-11-20 | Warner Lambert Co | Methods for screening using interleukin soluble trimolecular complex |
| TR201809678T4 (tr) | 2001-06-26 | 2018-07-23 | Amgen Fremont Inc | Opgl ye karşi antikorlar. |
| EP1293566A1 (en) * | 2001-09-17 | 2003-03-19 | Societe Des Produits Nestle S.A. | A soluble toll-like receptor |
| WO2003051384A1 (en) | 2001-12-17 | 2003-06-26 | Zymogenetics, Inc. | Method for treating cervical cancer |
| WO2004019866A2 (en) | 2002-08-28 | 2004-03-11 | Immunex Corporation | Compositions and methods for treating cardiovascular disease |
| BR0315155A (pt) * | 2002-10-08 | 2005-08-16 | Ares Trading Sa | Uso de citocina capaz de ligar il-18bp e de inibir a atividade de uma segunda citocina |
| DE602004028347D1 (de) | 2003-03-24 | 2010-09-09 | Zymogenetics Inc | Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| EP1697418A2 (en) | 2003-11-21 | 2006-09-06 | ZymoGenetics, Inc. | Anti-il-20 receptor antibodies and binding partners and methods of using in inflammation |
| US7141382B1 (en) | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
| EA015706B1 (ru) | 2004-10-22 | 2011-10-31 | Займоджинетикс, Инк. | Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела |
| CA2597584A1 (en) * | 2005-02-15 | 2006-08-24 | Apollo Life Sciences Limited | Molecules and chimeric molecules thereof |
| WO2007096398A1 (en) * | 2006-02-22 | 2007-08-30 | University Of Zurich | Soluble receptors and methods for treating autoimmune or demyelinating diseases |
| US7932055B2 (en) | 2006-06-22 | 2011-04-26 | Novo Nordisk A/S | Soluble heterodimeric CD94/NKG2 receptors fusion proteins |
| MX2009012343A (es) * | 2007-05-14 | 2010-02-10 | Biogen Idec Inc | Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello. |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| SI3409289T1 (sl) | 2010-02-26 | 2020-12-31 | Novo Nordisk A/S | Stabilni sestavki, ki vsebujejo protitelo |
| RU2012153786A (ru) | 2010-05-28 | 2014-07-10 | Ново Нордиск А/С | Стабильные многодозовые композиции, содержащие антитело и консервант |
| PT2591006T (pt) * | 2010-07-09 | 2019-07-29 | Bioverativ Therapeutics Inc | Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas |
| KR101603001B1 (ko) | 2010-08-25 | 2016-03-11 | 에프. 호프만-라 로슈 아게 | Il-18r1에 대한 항체 및 그의 용도 |
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| WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| EP0533006A1 (en) * | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| WO1996013593A2 (en) * | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
| US5853721A (en) | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
| ES2305024T3 (es) * | 1995-08-01 | 2008-11-01 | F. Hoffmann-La Roche Ag | Receptores para interleuquina-12 humana. |
| US5776731A (en) | 1996-02-21 | 1998-07-07 | Immunex Corporation | DNA encoding type-I interleukin-I receptor-like protein designated 2F1 |
| US7141393B2 (en) | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
| US6087116A (en) | 1997-03-12 | 2000-07-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18 (IL-18) receptor polypeptides and their uses |
| US6326472B1 (en) | 1997-10-15 | 2001-12-04 | Schering Corporation | Human receptor proteins; related reagents and methods |
| US6280955B1 (en) * | 1997-12-16 | 2001-08-28 | Tularik Inc. | Interleukin-1 receptor accessory proteins, nucleic acids and methods |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US20020052475A1 (en) | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
-
1999
- 1999-01-22 EP EP99904222A patent/EP1047781B1/en not_active Expired - Lifetime
- 1999-01-22 WO PCT/US1999/001419 patent/WO1999037772A1/en not_active Ceased
- 1999-01-22 IL IL13717899A patent/IL137178A0/xx active IP Right Grant
- 1999-01-22 NZ NZ505880A patent/NZ505880A/xx not_active IP Right Cessation
- 1999-01-22 ES ES99904222T patent/ES2226335T3/es not_active Expired - Lifetime
- 1999-01-22 AU AU24668/99A patent/AU737592B2/en not_active Ceased
- 1999-01-22 DK DK99904222T patent/DK1047781T3/da active
- 1999-01-22 JP JP2000528679A patent/JP4271850B2/ja not_active Expired - Fee Related
- 1999-01-22 PT PT99904222T patent/PT1047781E/pt unknown
- 1999-01-22 DE DE69918946T patent/DE69918946T2/de not_active Expired - Lifetime
- 1999-01-22 AT AT99904222T patent/ATE272114T1/de active
- 1999-01-22 CA CA2318482A patent/CA2318482C/en not_active Expired - Fee Related
-
2000
- 2000-07-05 IL IL137178A patent/IL137178A/en not_active IP Right Cessation
- 2000-07-21 US US09/621,502 patent/US6589764B1/en not_active Expired - Fee Related
-
2003
- 2003-05-15 US US10/439,458 patent/US7169581B2/en not_active Expired - Fee Related
-
2007
- 2007-01-29 US US11/699,676 patent/US7704945B2/en not_active Expired - Fee Related
-
2010
- 2010-03-03 US US12/716,993 patent/US8053233B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030199040A1 (en) | 2003-10-23 |
| US7704945B2 (en) | 2010-04-27 |
| JP2002500886A (ja) | 2002-01-15 |
| US8053233B2 (en) | 2011-11-08 |
| US20070135625A1 (en) | 2007-06-14 |
| PT1047781E (pt) | 2004-11-30 |
| AU2466899A (en) | 1999-08-09 |
| EP1047781A1 (en) | 2000-11-02 |
| CA2318482A1 (en) | 1999-07-29 |
| JP4271850B2 (ja) | 2009-06-03 |
| US7169581B2 (en) | 2007-01-30 |
| NZ505880A (en) | 2003-06-30 |
| US20100190211A1 (en) | 2010-07-29 |
| DK1047781T3 (da) | 2004-12-06 |
| IL137178A (en) | 2007-06-17 |
| ES2226335T3 (es) | 2005-03-16 |
| WO1999037772A1 (en) | 1999-07-29 |
| ATE272114T1 (de) | 2004-08-15 |
| AU737592B2 (en) | 2001-08-23 |
| IL137178A0 (en) | 2001-07-24 |
| DE69918946D1 (de) | 2004-09-02 |
| US6589764B1 (en) | 2003-07-08 |
| EP1047781B1 (en) | 2004-07-28 |
| CA2318482C (en) | 2010-04-13 |
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