DE69915144D1 - Aerosoldruckdosiergeräte und Aerosolarzneizusammensetzungen - Google Patents

Aerosoldruckdosiergeräte und Aerosolarzneizusammensetzungen

Info

Publication number
DE69915144D1
DE69915144D1 DE69915144T DE69915144T DE69915144D1 DE 69915144 D1 DE69915144 D1 DE 69915144D1 DE 69915144 T DE69915144 T DE 69915144T DE 69915144 T DE69915144 T DE 69915144T DE 69915144 D1 DE69915144 D1 DE 69915144D1
Authority
DE
Germany
Prior art keywords
aerosol
pharmaceutical compositions
dosing devices
pressure dosing
aerosol pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69915144T
Other languages
English (en)
Other versions
DE69915144T2 (de
Inventor
Frank E Blondino
Michael Brucato
Maria W Buenafe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Research Holdings Inc
Original Assignee
Ivax Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Research Inc filed Critical Ivax Research Inc
Publication of DE69915144D1 publication Critical patent/DE69915144D1/de
Application granted granted Critical
Publication of DE69915144T2 publication Critical patent/DE69915144T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69915144T 1998-06-19 1999-06-18 Aerosoldruckdosiergeräte und Aerosolarzneizusammensetzungen Expired - Fee Related DE69915144T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99779 1998-06-19
US09/099,779 US6451285B2 (en) 1998-06-19 1998-06-19 Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant

Publications (2)

Publication Number Publication Date
DE69915144D1 true DE69915144D1 (de) 2004-04-01
DE69915144T2 DE69915144T2 (de) 2004-12-09

Family

ID=22276581

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69915144T Expired - Fee Related DE69915144T2 (de) 1998-06-19 1999-06-18 Aerosoldruckdosiergeräte und Aerosolarzneizusammensetzungen
DE69911602T Expired - Fee Related DE69911602T2 (de) 1998-06-19 1999-06-18 Druckdosierinhalator und pharmazeutische aerosol formulierungen enthaltend einen beta-agonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69911602T Expired - Fee Related DE69911602T2 (de) 1998-06-19 1999-06-18 Druckdosierinhalator und pharmazeutische aerosol formulierungen enthaltend einen beta-agonisten

Country Status (23)

Country Link
US (2) US6451285B2 (de)
EP (2) EP1085856B1 (de)
JP (1) JP2002518100A (de)
KR (1) KR20010053025A (de)
CN (2) CN1154477C (de)
AR (1) AR018891A1 (de)
AT (2) ATE260093T1 (de)
AU (1) AU762927B2 (de)
BR (1) BR9912170A (de)
CA (1) CA2335303A1 (de)
CO (1) CO5031245A1 (de)
DE (2) DE69915144T2 (de)
DK (2) DK1085856T3 (de)
ES (2) ES2205848T3 (de)
HU (1) HUP0102468A3 (de)
IL (1) IL140340A0 (de)
NO (1) NO20006466L (de)
PL (1) PL345399A1 (de)
PT (2) PT1306082E (de)
RU (1) RU2214230C2 (de)
SK (1) SK19442000A3 (de)
WO (1) WO1999065460A2 (de)
ZA (1) ZA200007455B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
US20010031244A1 (en) * 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
US6451285B2 (en) * 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6315985B1 (en) * 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
IT1317720B1 (it) * 2000-01-07 2003-07-15 Chiesi Farma Spa Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1317846B1 (it) * 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
IT1318514B1 (it) * 2000-05-12 2003-08-27 Chiesi Farma Spa Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari.
US20060257324A1 (en) 2000-05-22 2006-11-16 Chiesi Farmaceutici S.P.A. Pharmaceutical solution formulations for pressurised metered dose inhalers
JP5392880B2 (ja) 2000-05-22 2014-01-22 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
US20030072717A1 (en) * 2001-02-23 2003-04-17 Vapotronics, Inc. Inhalation device having an optimized air flow path
PL207377B1 (pl) * 2001-03-30 2010-12-31 Jagotec Ag Medyczny preparat aerozolowy, sposób wytwarzania medycznego preparatu aerozolowego oraz zastosowanie soli kwasów karboksylowych jako środków pomocniczych w tym preparacie
TR200401980T4 (tr) * 2001-07-02 2004-09-21 Chiesi Farmaceutici S.P.A. Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu
US20030178022A1 (en) * 2001-12-21 2003-09-25 Chiesi Farmaceutici S.P.A. Pressurized metered dose inhaler (PMDI) actuators and medicinal aerosol solution formulation products comprising therse actuators
DE10205087A1 (de) * 2002-02-07 2003-08-21 Pharmatech Gmbh Cyclodextrine als Suspensionsstabilisatoren in druckverflüssigten Treibmitteln
KR100947409B1 (ko) 2002-03-01 2010-03-12 키에시 파르마슈티시 엣스. 피. 에이. 포모테롤 초미세 조성물
GB0207899D0 (en) * 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and cielesonide aerosol formulations
GB0219511D0 (en) * 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
US20050158248A1 (en) * 2002-08-21 2005-07-21 Xian-Ming Zeng Method of preparing dry powder inhalation compositions
US8273331B2 (en) * 2002-08-21 2012-09-25 Norton Healthcare Ltd. Inhalation compositions
GB0323685D0 (en) * 2003-10-09 2003-11-12 Jagotec Ag Improvements in or relating to organic compounds
GB0323684D0 (en) * 2003-10-09 2003-11-12 Jagotec Ag Improvements in or relating to organic compounds
EP1595531A1 (de) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stabile Arzneimittellösung für Druckdosierinhalatoren
WO2007008427A2 (en) * 2005-07-08 2007-01-18 Xemplar Pharmaceuticals, Llc Aerosol compositions and methods
US8367734B1 (en) 2005-08-11 2013-02-05 Amphastar Pharmaceuticals Inc. Stable epinephrine suspension formulation with high inhalation delivery efficiency
ES2774391T3 (es) * 2009-05-29 2020-07-20 Pearl Therapeutics Inc Composiciones, métodos y sistemas para la administración respiratoria de dos o más agentes activos
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
GB0918149D0 (en) 2009-10-16 2009-12-02 Jagotec Ag Improved medicinal aerosol formulation
US20120272951A1 (en) 2009-12-16 2012-11-01 3M Innovative Properties Company Formulations and methods for controlling mdi particle size delivery
GB201108039D0 (en) 2011-05-13 2011-06-29 Mexichem Amanco Holding Sa Compositions
GB201117621D0 (en) 2011-10-12 2011-11-23 Mexichem Amanco Holding Sa Compositions
GB201117619D0 (en) 2011-10-12 2011-11-23 Mexichem Amanco Holding Sa Compositions
RU2696582C2 (ru) 2013-03-15 2019-08-05 Перл Терапьютикс, Инк. Способы и системы кондиционирования дисперсных кристаллических материалов
GB201306984D0 (en) 2013-04-17 2013-05-29 Mexichem Amanco Holding Sa Composition
BR112018011266B1 (pt) 2015-12-04 2023-11-21 Mexichem Fluor S.A. De C.V. Composição farmacêutica, recipiente vedado, e, métodos para tratar um paciente que sofre ou é propenso a sofrer de um distúrbio respiratório e para estabilizar uma composição farmacêutica
US10792256B2 (en) 2016-09-19 2020-10-06 Mexichem Fluor S.A. De C.V. Pharmaceutical composition
EP3515432B1 (de) 2016-09-19 2021-08-25 Mexichem Fluor S.A. de C.V. Pharmazeutische zusammensetzung enthaltend glycopyrrolate
CA3037080C (en) 2016-09-19 2021-05-18 Mexichem Fluor S.A. De C.V. Stable pharmaceutical compositions comprising indacaterol and 1,1-difluoroethane (hfa-152a) suitable for use in metered dose inhalers (mdis)
CN109464429B (zh) * 2018-12-13 2021-04-27 上海方予健康医药科技有限公司 一种吸入压力定量气雾剂药物组合物及其制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE556587A (de) 1957-01-31 1957-04-11
NL7708731A (nl) 1976-08-13 1978-02-15 Montedison Spa Werkwijze voor de bereiding van nieuwe drijf- middelsamenstellingen voor aerosolen.
US5225183A (en) 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
US5776434A (en) * 1988-12-06 1998-07-07 Riker Laboratories, Inc. Medicinal aerosol formulations
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
HUT63554A (en) 1990-06-29 1993-09-28 Fisons Plc Aerosol preparations under pressure
ES2064160T3 (es) 1990-10-18 1995-01-16 Minnesota Mining & Mfg Formulacion de aerosol que comprende 17,21-dipropionato de beclometasona.
MX9203481A (es) 1990-10-18 1992-07-01 Minnesota Mining & Mfg Formulaciones.
US5190029A (en) 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
EP0504112A3 (en) 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
AU2178392A (en) 1991-06-12 1993-01-12 Minnesota Mining And Manufacturing Company Albuterol sulfate suspension aerosol formulations
DE4123663A1 (de) 1991-07-17 1993-01-21 Schwabe Willmar Gmbh & Co Aerosol-zubereitung und verwendung eines treibmittels dafuer
US5736124A (en) * 1991-12-12 1998-04-07 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicament
EP0616525B1 (de) * 1991-12-12 1995-09-27 Glaxo Group Limited Pharmazeutische Aerosolformulierung
AU673660C (en) 1991-12-18 2002-07-25 Astrazeneca Ab New combination of formoterol and budesonide
DE69233319T2 (de) 1991-12-18 2005-02-17 Minnesota Mining & Manufacturing Company, St. Paul Aerosolzusammensetzungen für Arzneimittelsuspensionen
DE59206234D1 (de) 1991-12-31 1996-06-13 Hoechst Ag Medizinische Aerosolformulierung
US5492688A (en) 1993-04-28 1996-02-20 The Center For Innovative Technology Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
US5508023A (en) 1994-04-11 1996-04-16 The Center For Innovative Technology Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant
PL320856A1 (en) 1994-12-22 1997-11-10 Astra Ab Aerosol drug preparations
DE4446891A1 (de) * 1994-12-27 1996-07-04 Falk Pharma Gmbh Stabile wäßrige Budesonid-Lösung
GB9612297D0 (en) 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
GB9616237D0 (en) * 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
US6039932A (en) * 1996-09-27 2000-03-21 3M Innovative Properties Company Medicinal inhalation aerosol formulations containing budesonide
SE9603669D0 (sv) 1996-10-08 1996-10-08 Astra Ab New combination
KR20000069275A (ko) 1996-12-04 2000-11-25 새들러 테리 아이언 약학 조성물과 그 투여를 위한 장치
US6451285B2 (en) * 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
US6004537A (en) * 1998-12-18 1999-12-21 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol

Also Published As

Publication number Publication date
PT1306082E (pt) 2004-05-31
US20020018753A1 (en) 2002-02-14
WO1999065460A3 (en) 2000-04-27
EP1085856B1 (de) 2003-09-24
KR20010053025A (ko) 2001-06-25
AR018891A1 (es) 2001-12-12
EP1306082B1 (de) 2004-02-25
CN1154477C (zh) 2004-06-23
SK19442000A3 (sk) 2001-09-11
IL140340A0 (en) 2002-02-10
DK1085856T3 (da) 2003-12-08
ATE260093T1 (de) 2004-03-15
BR9912170A (pt) 2001-10-23
PT1085856E (pt) 2004-01-30
HUP0102468A3 (en) 2002-12-28
ATE250409T1 (de) 2003-10-15
HUP0102468A2 (hu) 2002-03-28
EP1085856A2 (de) 2001-03-28
DK1306082T3 (da) 2004-06-01
DE69911602D1 (de) 2003-10-30
NO20006466D0 (no) 2000-12-18
RU2214230C2 (ru) 2003-10-20
CA2335303A1 (en) 1999-12-23
US20030077230A1 (en) 2003-04-24
EP1306082A1 (de) 2003-05-02
DE69911602T2 (de) 2004-07-01
DE69915144T2 (de) 2004-12-09
US6451285B2 (en) 2002-09-17
NO20006466L (no) 2001-02-16
AU762927B2 (en) 2003-07-10
CO5031245A1 (es) 2001-04-27
PL345399A1 (en) 2001-12-17
AU4825999A (en) 2000-01-05
ES2205848T3 (es) 2004-05-01
CN1522692A (zh) 2004-08-25
ES2215153T3 (es) 2004-10-01
ZA200007455B (en) 2002-06-13
CN1310611A (zh) 2001-08-29
WO1999065460A2 (en) 1999-12-23
JP2002518100A (ja) 2002-06-25

Similar Documents

Publication Publication Date Title
DE69915144D1 (de) Aerosoldruckdosiergeräte und Aerosolarzneizusammensetzungen
DK1073417T3 (da) Farmaceutisk aerosolformulering
IL155196A0 (en) Benzamide derivatives and pharmaceutical compositions containing the same
EE03664B1 (et) Farmatseutilised aerosoolkompositsioonid
ATE263558T1 (de) Lipasehemmer und chitosan enthaltende pharmazeutische zusammensetzungen
IL151829A0 (en) Carbamate derivatives and pharmaceutical compositions containing the same
IL152451A0 (en) 2-chloro-2-nitrophenylcarboxamide derivatives and pharmaceutical compositions containing the same
HUP0301178A3 (en) Glucopyranosyloxybenzylbenzene derivatives and pharmaceutical compositions containing the same
IL153123A0 (en) N-ureidoheterocycloalkyl-piperidine derivatives and pharmaceutical compositions containing the same
NO20020464D0 (no) Flerkomponent-farmasöytisk doseringsform
IL161616A0 (en) Indazolypyrrolotriazine derivatives and pharmaceutical compositions containing the same
IL158044A0 (en) Cyclopropylindole derivatives and pharmaceutical compositions containing the same
IL158300A0 (en) Bisarylimidazol derivatives and pharmaceutical compositions containing the same
PT102291A (pt) Metanossulfonato de paroxetina processos para a sua preparacao composicao farmaceutica contendo o mesmo e sua utilizacao
IL156812A0 (en) Phthalazinone-piperidino derivatives and pharmaceutical compositions containing the same
EE200000652A (et) Farmatseutiline kompositsioon ja produkt
IL150905A0 (en) Andrographolide derivatives and pharmaceutical compositions containing the same
DE60024476D1 (de) Pedikulizide und veterinärmedizinische zusammensetzungen
ID30032A (id) Formulasi farmasi
PT1216021E (pt) Composicoes farmaceuticas e/ou cosmeticas
DE69900336D1 (de) Pentoxifyllin und antizytokin enthaltende pharmazeutische zusammensetzungen
IL156032A0 (en) Spiroindene derivatives and pharmaceutical compositions containing the same
GB0014849D0 (en) Pharmaceutical aerosol formulation
IL157909A0 (en) Indolopyrrolocarbazole derivatives and pharmaceutical compositions containing the same
SE9803771D0 (sv) Pharmaceutical composition and use

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee