DE69910568T2 - Furopyridinderivate und ihre therapeutische verwendung - Google Patents
Furopyridinderivate und ihre therapeutische verwendung Download PDFInfo
- Publication number
- DE69910568T2 DE69910568T2 DE69910568T DE69910568T DE69910568T2 DE 69910568 T2 DE69910568 T2 DE 69910568T2 DE 69910568 T DE69910568 T DE 69910568T DE 69910568 T DE69910568 T DE 69910568T DE 69910568 T2 DE69910568 T2 DE 69910568T2
- Authority
- DE
- Germany
- Prior art keywords
- pyridine
- carboxylic acid
- amide
- alkyl
- methoxyfuro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 7
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- 229910002091 carbon monoxide Inorganic materials 0.000 claims abstract description 10
- 150000001204 N-oxides Chemical class 0.000 claims abstract description 7
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
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- MXZUIDYEQFPNEH-UHFFFAOYSA-N 2-ethyl-7-methoxy-n-(3-methylpyridin-4-yl)furo[2,3-c]pyridine-4-carboxamide Chemical compound C1=NC(OC)=C2OC(CC)=CC2=C1C(=O)NC1=CC=NC=C1C MXZUIDYEQFPNEH-UHFFFAOYSA-N 0.000 claims description 3
- JBHMSHKWKKUOBI-UHFFFAOYSA-N 7-methoxy-2-(methoxymethyl)furo[2,3-c]pyridine-4-carboxylic acid Chemical compound C1=NC(OC)=C2OC(COC)=CC2=C1C(O)=O JBHMSHKWKKUOBI-UHFFFAOYSA-N 0.000 claims description 3
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- CCAJLYNVQAPNDK-UHFFFAOYSA-N furo[2,3-c]pyridine-4-carboxylic acid Chemical compound OC(=O)C1=CN=CC2=C1C=CO2 CCAJLYNVQAPNDK-UHFFFAOYSA-N 0.000 claims description 3
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- JESCGEWQDVNBSE-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxamide Chemical compound C1=NC(OC)=C2OC(CC)=CC2=C1C(=O)NC1=C(Cl)C=NC=C1Cl JESCGEWQDVNBSE-UHFFFAOYSA-N 0.000 claims description 3
- MWWJOVIPSZWFRA-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-7-methoxy-2-(oxan-4-yl)furo[2,3-c]pyridine-4-carboxamide Chemical compound C1=2C=C(C3CCOCC3)OC=2C(OC)=NC=C1C(=O)NC1=C(Cl)C=NC=C1Cl MWWJOVIPSZWFRA-UHFFFAOYSA-N 0.000 claims description 3
- CLOSCVOTKUSWOJ-UHFFFAOYSA-N n-(3-chloropyridin-4-yl)-2-ethyl-7-methoxyfuro[2,3-c]pyridine-4-carboxamide Chemical compound C1=NC(OC)=C2OC(CC)=CC2=C1C(=O)NC1=CC=NC=C1Cl CLOSCVOTKUSWOJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
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- AHYNSZBGYURKIP-UHFFFAOYSA-N 7-(difluoromethoxy)-n-(3,5-dimethyl-1,2-oxazol-4-yl)-2-ethylfuro[2,3-c]pyridine-4-carboxamide Chemical compound C1=NC(OC(F)F)=C2OC(CC)=CC2=C1C(=O)NC=1C(C)=NOC=1C AHYNSZBGYURKIP-UHFFFAOYSA-N 0.000 claims description 2
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- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812322.7A GB9812322D0 (en) | 1998-06-08 | 1998-06-08 | Benzofurans and their therapeutic use |
| GB9812322 | 1998-06-08 | ||
| GBGB9820768.1A GB9820768D0 (en) | 1998-09-23 | 1998-09-23 | Heterocyclic compounds and their therapeutic use |
| GB9820768 | 1998-09-23 | ||
| PCT/GB1999/001791 WO1999064423A1 (en) | 1998-06-08 | 1999-06-07 | Furopyridine derivatives and their therapeutical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69910568D1 DE69910568D1 (de) | 2003-09-25 |
| DE69910568T2 true DE69910568T2 (de) | 2004-06-17 |
Family
ID=26313823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69910568T Expired - Fee Related DE69910568T2 (de) | 1998-06-08 | 1999-06-07 | Furopyridinderivate und ihre therapeutische verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6169090B1 (https=) |
| EP (1) | EP1086106B1 (https=) |
| JP (1) | JP2003526601A (https=) |
| AT (1) | ATE247660T1 (https=) |
| AU (1) | AU753897B2 (https=) |
| CA (1) | CA2333629A1 (https=) |
| CO (1) | CO5080802A1 (https=) |
| DE (1) | DE69910568T2 (https=) |
| ES (1) | ES2204171T3 (https=) |
| PE (1) | PE20000734A1 (https=) |
| TW (1) | TW555759B (https=) |
| WO (1) | WO1999064423A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000038683A1 (en) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| GB0003256D0 (en) * | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| WO2002012189A1 (en) * | 2000-08-09 | 2002-02-14 | Mitsubishi Pharma Corporation | Fused bicyclic amide compounds and medicinal use thereof |
| US8176296B2 (en) | 2000-10-26 | 2012-05-08 | Cypress Semiconductor Corporation | Programmable microcontroller architecture |
| US6724220B1 (en) | 2000-10-26 | 2004-04-20 | Cyress Semiconductor Corporation | Programmable microcontroller architecture (mixed analog/digital) |
| US6479493B1 (en) | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
| MXPA05009921A (es) * | 2003-03-17 | 2005-11-04 | Kyowa Hakko Kogyo Kk | Agentes terapeuticos y/o preventivos para enfermedades cutaneas cronicas. |
| DE10318610A1 (de) * | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-Azaindole und deren Verwendung als Therapeutika |
| US8069436B2 (en) | 2004-08-13 | 2011-11-29 | Cypress Semiconductor Corporation | Providing hardware independence to automate code generation of processing device firmware |
| JP5878327B2 (ja) * | 2011-10-12 | 2016-03-08 | 花王株式会社 | 手洗い用食器洗浄剤組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910193A (en) | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
| US5559127A (en) | 1992-10-14 | 1996-09-24 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| AU673569B2 (en) | 1992-12-02 | 1996-11-14 | Pfizer Inc. | Catechol diethers as selective PDE-IV inhibitors |
| ATE180780T1 (de) | 1993-08-05 | 1999-06-15 | Hoechst Marion Roussel Inc | 2-(piperidin-4-yl, pyridin-4-yl und tetrahydropyridin-4-yl)-benzofuran-7-carbamat derivate, ihre herstellung und verwendung als acetylcholinesterase inhibitoren |
| JPH07267961A (ja) * | 1994-03-30 | 1995-10-17 | Taisho Pharmaceut Co Ltd | ベンゾフロ［３，２−ｄピリミジン−４−オン誘導体 |
| WO1996036638A1 (en) | 1995-05-19 | 1996-11-21 | Chiroscience Limited | Xanthines and their therapeutic use |
| JPH09108832A (ja) | 1995-10-19 | 1997-04-28 | Mitsubishi Electric Corp | 溶接構造体およびその溶接方法 |
| KR19990071894A (ko) * | 1995-12-05 | 1999-09-27 | 마르크 젠너 | 벤조퓨란 카르복사미드 및 술폰아미드 |
| ES2187775T3 (es) * | 1996-05-15 | 2003-06-16 | Altana Pharma Ag | Imidazopiridinas. |
| CN1219171A (zh) * | 1996-05-20 | 1999-06-09 | 达尔文发现有限公司 | 苯并呋喃甲酰胺及其治疗用途 |
| WO1998007715A1 (en) * | 1996-08-19 | 1998-02-26 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel benzofuran-4-carboxamides |
| JP4166296B2 (ja) | 1997-04-25 | 2008-10-15 | 塩野義製薬株式会社 | ドーパミン受容体拮抗作用を有する化合物 |
-
1999
- 1999-06-03 TW TW088109174A patent/TW555759B/zh active
- 1999-06-07 DE DE69910568T patent/DE69910568T2/de not_active Expired - Fee Related
- 1999-06-07 ES ES99955472T patent/ES2204171T3/es not_active Expired - Lifetime
- 1999-06-07 EP EP99955472A patent/EP1086106B1/en not_active Expired - Lifetime
- 1999-06-07 CA CA002333629A patent/CA2333629A1/en not_active Abandoned
- 1999-06-07 AU AU42776/99A patent/AU753897B2/en not_active Ceased
- 1999-06-07 JP JP2000553432A patent/JP2003526601A/ja active Pending
- 1999-06-07 WO PCT/GB1999/001791 patent/WO1999064423A1/en not_active Ceased
- 1999-06-07 AT AT99955472T patent/ATE247660T1/de not_active IP Right Cessation
- 1999-06-08 US US09/328,182 patent/US6169090B1/en not_active Expired - Fee Related
- 1999-06-08 PE PE1999000510A patent/PE20000734A1/es not_active Application Discontinuation
- 1999-06-08 CO CO99035782A patent/CO5080802A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PE20000734A1 (es) | 2000-08-18 |
| AU753897B2 (en) | 2002-10-31 |
| CO5080802A1 (es) | 2001-09-25 |
| DE69910568D1 (de) | 2003-09-25 |
| EP1086106B1 (en) | 2003-08-20 |
| ES2204171T3 (es) | 2004-04-16 |
| ATE247660T1 (de) | 2003-09-15 |
| CA2333629A1 (en) | 1999-12-16 |
| WO1999064423A1 (en) | 1999-12-16 |
| EP1086106A1 (en) | 2001-03-28 |
| AU4277699A (en) | 1999-12-30 |
| TW555759B (en) | 2003-10-01 |
| JP2003526601A (ja) | 2003-09-09 |
| US6169090B1 (en) | 2001-01-02 |
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| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |