DE69836131T3 - Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen - Google Patents
Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen Download PDFInfo
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- DE69836131T3 DE69836131T3 DE69836131.8T DE69836131T DE69836131T3 DE 69836131 T3 DE69836131 T3 DE 69836131T3 DE 69836131 T DE69836131 T DE 69836131T DE 69836131 T3 DE69836131 T3 DE 69836131T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83263397A | 1997-04-04 | 1997-04-04 | |
| US832633 | 1997-04-04 | ||
| US08/872,855 US6121045A (en) | 1997-04-04 | 1997-06-11 | Human Delta3 nucleic acid molecules |
| US872855 | 1997-06-11 | ||
| EP98915305.1A EP0972041B2 (en) | 1997-04-04 | 1998-04-06 | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
| PCT/US1998/006775 WO1998045434A1 (en) | 1997-04-04 | 1998-04-06 | Novel human delta3 compositions and therapeutic and diagnostic uses therefor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69836131D1 DE69836131D1 (de) | 2006-11-23 |
| DE69836131T2 DE69836131T2 (de) | 2007-08-30 |
| DE69836131T3 true DE69836131T3 (de) | 2017-06-14 |
Family
ID=27125549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69836131.8T Expired - Lifetime DE69836131T3 (de) | 1997-04-04 | 1998-04-06 | Neue menschliche delta3-zusammensetzung und deren therapeutische und diagnostische verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0972041B2 (https=) |
| JP (1) | JP2001521382A (https=) |
| AT (1) | ATE342358T1 (https=) |
| AU (1) | AU6952498A (https=) |
| CA (1) | CA2285020A1 (https=) |
| DE (1) | DE69836131T3 (https=) |
| ES (1) | ES2275304T3 (https=) |
| WO (1) | WO1998045434A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69638023D1 (de) | 1995-06-28 | 2009-10-22 | Univ Yale | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
| US5780300A (en) * | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
| US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
| US6664098B1 (en) * | 1997-05-14 | 2003-12-16 | Asahi Kasei Kabushiki Kaisha | Differentiation inhibitory agent |
| EP1100899A2 (en) * | 1998-07-27 | 2001-05-23 | Amgen Inc. | Delta-related polypeptides |
| AU6913100A (en) * | 1999-08-19 | 2001-03-13 | Chiron Corporation | Notch receptor ligands and uses thereof |
| US6703221B1 (en) | 1999-08-19 | 2004-03-09 | Chiron Corporation | Notch receptor ligands and uses thereof |
| GB9927328D0 (en) | 1999-11-18 | 2000-01-12 | Lorantis Ltd | Immunotherapy |
| GB9927331D0 (en) | 1999-11-18 | 2000-01-12 | Fluorescience Ltd | Assay for measuring enzyme activity in vivo |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| CA2457879A1 (en) * | 2001-08-22 | 2003-03-06 | Galapagos Genomics N.V. | Modulators of bone homeostasis identified in a high-throughput screen |
| JP2003245084A (ja) | 2001-12-20 | 2003-09-02 | Morinaga Milk Ind Co Ltd | 脳梁又は精子の形成不全の診断及び治療に有用な新規遺伝子、並びにその用途 |
| US8048418B2 (en) | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
| US7906116B2 (en) | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
| CA2628221A1 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Anti-frizzled receptor antibodies for treating cancer |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| NZ572177A (en) | 2006-06-06 | 2012-02-24 | Genentech Inc | Anti-dll4 antibodies and methods using same |
| DK2066694T3 (en) | 2006-09-29 | 2016-02-08 | Oncomed Pharm Inc | Compositions and Methods for Diagnosing and Treating Cancer |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| CA2742969A1 (en) | 2008-11-07 | 2010-05-14 | Fabrus Llc | Anti-dll4 antibodies and uses thereof |
| HUE029661T2 (en) | 2009-10-16 | 2017-03-28 | Oncomed Pharm Inc | A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| DK2530091T3 (en) | 2010-01-29 | 2018-05-28 | Chugai Pharmaceutical Co Ltd | ANTI-DLL3 ANTIBODY |
| CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| LT3485903T (lt) | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
| AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
| US9599620B2 (en) | 2012-10-31 | 2017-03-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| ES2808153T3 (es) | 2014-10-31 | 2021-02-25 | Mereo Biopharma 5 Inc | Terapia de combinación para tratamiento de enfermedad |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| JP7314146B2 (ja) | 2017-12-28 | 2023-07-25 | 中外製薬株式会社 | 細胞傷害誘導治療剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them |
| US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| DE69638023D1 (de) | 1995-06-28 | 2009-10-22 | Univ Yale | Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
-
1998
- 1998-04-06 AU AU69524/98A patent/AU6952498A/en not_active Abandoned
- 1998-04-06 DE DE69836131.8T patent/DE69836131T3/de not_active Expired - Lifetime
- 1998-04-06 EP EP98915305.1A patent/EP0972041B2/en not_active Expired - Lifetime
- 1998-04-06 ES ES98915305T patent/ES2275304T3/es not_active Expired - Lifetime
- 1998-04-06 JP JP54299298A patent/JP2001521382A/ja active Pending
- 1998-04-06 WO PCT/US1998/006775 patent/WO1998045434A1/en not_active Ceased
- 1998-04-06 CA CA002285020A patent/CA2285020A1/en not_active Abandoned
- 1998-04-06 AT AT98915305T patent/ATE342358T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001521382A (ja) | 2001-11-06 |
| WO1998045434A1 (en) | 1998-10-15 |
| DE69836131D1 (de) | 2006-11-23 |
| CA2285020A1 (en) | 1998-10-15 |
| EP0972041B1 (en) | 2006-10-11 |
| DE69836131T2 (de) | 2007-08-30 |
| AU6952498A (en) | 1998-10-30 |
| EP0972041A1 (en) | 2000-01-19 |
| ES2275304T3 (es) | 2007-06-01 |
| EP0972041B2 (en) | 2017-01-18 |
| ATE342358T1 (de) | 2006-11-15 |
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