DE69821796D1 - Sterilisation von glucocorticosteroiden - Google Patents

Sterilisation von glucocorticosteroiden

Info

Publication number
DE69821796D1
DE69821796D1 DE69821796T DE69821796T DE69821796D1 DE 69821796 D1 DE69821796 D1 DE 69821796D1 DE 69821796 T DE69821796 T DE 69821796T DE 69821796 T DE69821796 T DE 69821796T DE 69821796 D1 DE69821796 D1 DE 69821796D1
Authority
DE
Germany
Prior art keywords
glucocorticosteroids
sterilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69821796T
Other languages
English (en)
Other versions
DE69821796T2 (de
Inventor
Ann-Kristin Karlsson
Cheryl Larrivee-Elkins
Ove Molin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20408992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69821796(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69821796D1 publication Critical patent/DE69821796D1/de
Publication of DE69821796T2 publication Critical patent/DE69821796T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023Heat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DE1998621796 1997-11-14 1998-11-11 Sterilisation von glucocorticosteroiden Expired - Lifetime DE69821796T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9704186A SE9704186D0 (sv) 1997-11-14 1997-11-14 New composition of matter
SE9704186 1997-11-14
PCT/SE1998/002039 WO1999025359A1 (en) 1997-11-14 1998-11-11 New composition of matter

Publications (2)

Publication Number Publication Date
DE69821796D1 true DE69821796D1 (de) 2004-03-25
DE69821796T2 DE69821796T2 (de) 2005-01-13

Family

ID=20408992

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998621796 Expired - Lifetime DE69821796T2 (de) 1997-11-14 1998-11-11 Sterilisation von glucocorticosteroiden

Country Status (24)

Country Link
US (3) US6392036B1 (de)
EP (1) EP1032396B1 (de)
JP (2) JP4598268B2 (de)
KR (1) KR100571075B1 (de)
CN (1) CN1173702C (de)
AR (1) AR013765A1 (de)
AT (1) ATE259642T1 (de)
AU (1) AU744992B2 (de)
BR (1) BR9814118A (de)
CA (1) CA2310222C (de)
DE (1) DE69821796T2 (de)
DK (1) DK1032396T3 (de)
ES (1) ES2214749T3 (de)
HK (1) HK1030549A1 (de)
IL (1) IL136086A (de)
MY (1) MY118856A (de)
NO (1) NO327391B1 (de)
NZ (1) NZ504273A (de)
PT (1) PT1032396E (de)
SA (1) SA99190966B1 (de)
SE (1) SE9704186D0 (de)
TW (1) TWI242436B (de)
WO (1) WO1999025359A1 (de)
ZA (1) ZA9810217B (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2213638C (en) * 1995-02-24 2004-05-04 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
SE9704186D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New composition of matter
US20090297602A1 (en) * 1998-11-02 2009-12-03 Devane John G Modified Release Loxoprofen Compositions
IT1303692B1 (it) * 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
AR026072A1 (es) * 1999-10-20 2002-12-26 Nycomed Gmbh Composicion farmaceutica que contiene ciclesonida para aplicacion a la mucosa
AR026073A1 (es) * 1999-10-20 2002-12-26 Nycomed Gmbh Composicion farmaceutica acuosa que contiene ciclesonida
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB2374013C (en) * 2000-11-24 2009-07-01 Breath Ltd Sterilisation of pharmaceuticals
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
GB0130055D0 (en) * 2001-12-14 2002-02-06 Technology Innovation Ltd Medicament packaging
US20030129242A1 (en) * 2002-01-04 2003-07-10 Bosch H. William Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer
ATE464880T1 (de) * 2002-02-04 2010-05-15 Elan Pharma Int Ltd Arzneistoffnanopartikel mit lysozym- oberflächenstabilisator
DE60325459D1 (de) 2002-02-19 2009-02-05 Resolution Chemicals Ltd Auf lösungsmitteln basierende sterilisation von steroiden
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
KR101020687B1 (ko) 2002-07-02 2011-03-11 니코메드 게엠베하 사이클레소나이드 함유 멸균 수성 현탁액
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
EP1556091A1 (de) * 2002-10-04 2005-07-27 Elan Pharma International Limited Gamma-bestrahlung von festen aktivmaterialien in nanopartikularer form
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
DE60323138D1 (de) 2002-12-12 2008-10-02 Nycomed Gmbh Kombinationsarzneimittel aus r,r-formoterol und ciclesonide
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
EP1454636A1 (de) * 2003-03-04 2004-09-08 Dompé S.P.A. Sterilisierung von Glucocorticoid-Arzneimittelteilchen zur Anwendung in der Lunge
ATE477193T1 (de) * 2003-03-15 2010-08-15 Brin Tech Internat Ltd Verpackung für arzneimittel
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
JP2007501683A (ja) * 2003-05-22 2007-02-01 エラン ファーマ インターナショナル リミテッド γ線照射によるナノ粒子活性物質分散体の滅菌法
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
GB0319500D0 (en) 2003-08-19 2003-09-17 Resolution Chemicals Ltd Particle-size reduction apparatus,and use thereof
EP1670482B2 (de) 2003-09-16 2022-06-29 Covis Pharma B.V. Verwendung von ciclesonid zur behandlung von atemwegserkrankungen
PE20050941A1 (es) * 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
DE602005026225D1 (de) * 2004-03-12 2011-03-24 Cipla Ltd Sterilisationsprozess für Steroide
EP1730751B1 (de) * 2004-03-12 2009-10-21 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Magnetoresistives medium
US20070134165A1 (en) * 2004-04-20 2007-06-14 Altana Pharma Ag Use of Ciclesonide for the Treatment of Respiratory Disease in a Smoking Patient
ITMI20040795A1 (it) * 2004-04-23 2004-07-23 Eratech S R L Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa
GB0410995D0 (en) * 2004-05-17 2004-06-23 Norton Healthcare Ltd Heat sterilization of glucocorticosteroids
ITSA20040012A1 (it) * 2004-09-07 2004-12-07 Genetec S P A Processo di sterilizzazione di un glucocorticosteroide.
GB0425266D0 (en) * 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
GB0427568D0 (en) 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
EP1782839A1 (de) 2005-11-03 2007-05-09 Genetic S.p.A. Verfahren zur Sterilisation von Glucocorticosteroiden mit überkritischem CO2
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
EP1968547A1 (de) 2005-11-29 2008-09-17 Farmabios S.p.A. Verfahren zur herstellung von mikronisierten sterilen steroiden
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070178049A1 (en) * 2005-12-20 2007-08-02 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070166184A1 (en) * 2006-01-13 2007-07-19 Zimmer Technology, Inc. Methods for cleaning and sterilizing devices
US20070178051A1 (en) * 2006-01-27 2007-08-02 Elan Pharma International, Ltd. Sterilized nanoparticulate glucocorticosteroid formulations
JP2009526858A (ja) * 2006-02-15 2009-07-23 ティカ レーケメデル アーベー コルチコステロイド溶液を製造する方法
FR2898273B1 (fr) * 2006-03-07 2013-11-08 Merck Generiques Procede de sterilisation par chauffage par voie seche d'une poudre comprenant un glucocorticosteroide
BRPI0714391A2 (pt) * 2006-07-20 2013-04-24 Sicor Inc processo para preparaÇço de um ingrediente farmacÊutico ativo sàlido estÉril
CN102226026B (zh) * 2007-03-12 2013-12-18 广东炜林纳功能材料有限公司 一种聚丙烯的复合β晶型成核剂
CN101265342B (zh) * 2007-03-12 2014-04-02 广东炜林纳功能材料有限公司 一种聚丙烯的复合β晶型成核剂
CA2705159A1 (en) * 2007-11-09 2009-05-14 Map Pharmaceuticals, Inc. Methods for administering corticosteroid formulations
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
HUE038452T2 (hu) 2007-11-13 2018-10-29 Meritage Pharma Inc Gyomor és bélrendszeri gyulladások kezelésére szolgáló kompozíciók
CA2721927C (en) 2008-04-21 2014-01-28 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
AU2009246870B2 (en) 2008-05-14 2013-08-01 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders
US8648119B2 (en) * 2008-05-23 2014-02-11 Otonomy, Inc. Controlled release immunomodulator compositions and methods for the treatment of otic disorders
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
US8846770B2 (en) * 2008-06-18 2014-09-30 Otonomy, Inc. Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders
WO2010011466A2 (en) 2008-06-27 2010-01-28 Otonomy, Inc. Controlled-release cns modulating compositions and methods for the treatment of otic disorders
US8349353B2 (en) * 2008-06-27 2013-01-08 Otonomy, Inc. Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders
US20100016218A1 (en) * 2008-07-14 2010-01-21 Otonomy, Inc. Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders
US8399018B2 (en) * 2008-07-21 2013-03-19 Otonomy, Inc. Controlled release ion channel modulator compositions and methods for the treatment of otic disorders
US8318817B2 (en) 2008-07-21 2012-11-27 Otonomy, Inc. Controlled release antimicrobial compositions and methods for the treatment of otic disorders
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
CA2731769C (en) * 2008-07-21 2013-09-10 Otonomy, Inc. Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders
US20100016450A1 (en) * 2008-07-21 2010-01-21 Otonomy, Inc. Controlled release delivery devices for the treatment of otic disorders
WO2010048095A2 (en) 2008-10-22 2010-04-29 House Ear Institute Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
KR20100079830A (ko) * 2008-12-31 2010-07-08 삼성정밀화학 주식회사 입도 분포가 좁은 토너의 제조방법
LT3222617T (lt) 2009-03-19 2022-10-25 The Johns Hopkins University Psma nukreipti junginiai ir jų naudojimas
US20180009767A9 (en) 2009-03-19 2018-01-11 The Johns Hopkins University Psma targeted fluorescent agents for image guided surgery
US8273725B2 (en) * 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
WO2011135585A2 (en) * 2010-04-28 2011-11-03 Cadila Healthcare Limited Aqueous pharmaceutical solution of ciclesonide
RU2611665C2 (ru) 2011-05-03 2017-02-28 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Улучшенный состав суспензии кортикостероида для ингаляционного введения
CN105705141B (zh) * 2013-03-15 2018-12-28 奥克伍德实验室有限责任公司 缓释微球及其制备方法
EA201690323A1 (ru) 2013-08-27 2016-07-29 Отономи, Инк. Способы лечения заболеваний уха у детей
EP3332767B1 (de) 2014-09-15 2019-03-20 Verona Pharma PLC Flüssige inhalationsformulierung mit rpl554
EP3512513A4 (de) 2016-09-16 2020-04-15 Otonomy, Inc. Gelformulierungen für das ohr zur behandlung von otitis externa
US11814365B2 (en) 2017-06-15 2023-11-14 The Johns Hopkins University PSMA targeted fluorescent agents for image guided surgery
CA3073195A1 (en) 2017-08-15 2019-02-21 Nephron Pharmaceuticals Corporation Aqueous nebulization composition
CN107510687B (zh) * 2017-08-18 2020-07-03 南京海纳医药科技股份有限公司 一种供雾化用含有福莫特罗和布地奈德的吸入混悬液及其制备方法
CN108175763B (zh) * 2017-12-19 2020-09-11 亿腾医药(苏州)有限公司 一种布地奈德无菌原料及其吸入用混悬液的制备方法
GB202202297D0 (en) * 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US396430A (en) * 1889-01-22 Helm reichel
US3337400A (en) * 1965-10-08 1967-08-22 Joel P Smith Aqueous post-surgical injection by infiltration with a local anesthetic, a substantially water-insoluble, local anti-inflammatory gluco corticoid, and an antibiotic
US3692430A (en) * 1971-06-18 1972-09-19 John W Timmons Liquid pumping system
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
US3962430A (en) * 1974-08-07 1976-06-08 Merck & Co., Inc. Sterilization of solid non-electrolyte medicinal agents employing sodium chloride
DE2837115A1 (de) * 1978-08-25 1980-03-06 Bayer Ag Neues verfahren zur herstellung von sterilen feststoffen
PT69652A (fr) 1979-05-22 1979-06-01 Quatrum Empresa Nacional De Qu Procede pour la sterilization de produits non stables a hautes temperatures nommement steroides sous la forme de poudre contenus dans une emballage fermee
JPS5732212A (en) 1980-08-07 1982-02-20 Mitsui Toatsu Chem Inc Sterilizing method of acetylsalicylate salt
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
JPH0660106B2 (ja) 1985-11-14 1994-08-10 徳男 斎藤 生薬類を主剤とする滅菌丸剤の製造法
US5407926A (en) * 1987-12-29 1995-04-18 Alcon Laboratories, Inc. Ophthalmic composition
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5380645A (en) * 1989-03-16 1995-01-10 The Johns Hopkins University Generalized method for assessment of colorectal carcinoma
SE8903219D0 (sv) * 1989-10-02 1989-10-02 Astra Ab Process for the manufacture of budesonide
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
PL164294B1 (pl) 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
US5491062A (en) * 1993-11-23 1996-02-13 Stratagene Polynucleotide amplification mycoplasma assay, primers, and kits therefore
US5837699A (en) * 1994-01-27 1998-11-17 Schering Corporation Use of mometasone furoate for treating upper airway passage diseases
US5843644A (en) * 1994-03-01 1998-12-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Isolation of cellular material under microscopic visualization using an adhesive/extraction reagent tipped probe
GB9410222D0 (en) * 1994-05-21 1994-07-06 Glaxo Wellcome Australia Ltd Medicaments
US5580728A (en) * 1994-06-17 1996-12-03 Perlin; Mark W. Method and system for genotyping
JPH10506280A (ja) * 1994-09-23 1998-06-23 ディー. フィンケルスタイン,シドニー 形態的遺伝子型識別法
KR970705979A (ko) 1994-09-29 1997-11-03 디 히스 치료용 매개체로서의 분무-건조 미소입자 (Spray-dried microparticles as therapeutic vehicles)
US5521168A (en) * 1994-10-13 1996-05-28 Alcon Laboratories, Inc. Estrogen metabolites for lowering intraocular pressure
US5700794A (en) * 1994-10-13 1997-12-23 Alcon Laboratories Inc. Treatment of ocular hypotony
US6255483B1 (en) * 1995-03-15 2001-07-03 Ciba Specialty Chemicals Corporation Biphenyl-substituted triazines
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
WO1997001341A1 (en) * 1995-06-29 1997-01-16 Mcneil-Ppc, Inc. The combination of topical nasal mast cell stabilizers and topical nasal steroids
JPH0930988A (ja) * 1995-07-21 1997-02-04 Sumitomo Osaka Cement Co Ltd 薬剤徐放性多孔質セラミックス成形体及びその製造方法
US5824668A (en) * 1996-11-07 1998-10-20 Supergen, Inc. Formulation for administration of steroid compounds
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
SE9604486D0 (sv) * 1996-12-05 1996-12-05 Astra Ab Novel formulation
DE29717252U1 (de) * 1997-09-26 1998-02-19 Dr. Falk Pharma GmbH, 79108 Freiburg Arzneimittelkit aus einem Budesonid-haltigen und einem Ursodesoxycholsäure-haltigen Arzneimittel zur Behandlung von cholestatischen Lebererkrankungen
DE69804998T2 (de) 1997-10-09 2002-12-12 Schering Corp., Kenilworth Mometasonfuroat-suspensionen zum zerstäuben
US6187765B1 (en) * 1997-10-09 2001-02-13 Schering Corporation Mometasone furoate suspensions for nebulization
SE9704186D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New composition of matter
US6066292A (en) * 1997-12-19 2000-05-23 Bayer Corporation Sterilization process for pharmaceutical suspensions
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
GB2374013C (en) * 2000-11-24 2009-07-01 Breath Ltd Sterilisation of pharmaceuticals
DE60325459D1 (de) 2002-02-19 2009-02-05 Resolution Chemicals Ltd Auf lösungsmitteln basierende sterilisation von steroiden
ITMI20022674A1 (it) 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
ITMI20032054A1 (it) * 2003-10-22 2005-04-23 Monteres S R L Processo per la preparazione di sospensioni farmaceutiche da inalare.
DE602005026225D1 (de) * 2004-03-12 2011-03-24 Cipla Ltd Sterilisationsprozess für Steroide

Also Published As

Publication number Publication date
DK1032396T3 (da) 2004-05-24
WO1999025359A1 (en) 1999-05-27
IL136086A0 (en) 2001-05-20
AU1266699A (en) 1999-06-07
JP2001523638A (ja) 2001-11-27
NO327391B1 (no) 2009-06-22
CA2310222A1 (en) 1999-05-27
ES2214749T3 (es) 2004-09-16
JP2010070567A (ja) 2010-04-02
EP1032396A1 (de) 2000-09-06
ATE259642T1 (de) 2004-03-15
TWI242436B (en) 2005-11-01
CN1285750A (zh) 2001-02-28
JP4598268B2 (ja) 2010-12-15
HK1030549A1 (en) 2001-05-11
PT1032396E (pt) 2004-06-30
DE69821796T2 (de) 2005-01-13
NO20002470L (no) 2000-07-05
NO20002470D0 (no) 2000-05-12
KR20010032088A (ko) 2001-04-16
IL136086A (en) 2005-05-17
NZ504273A (en) 2002-10-25
AU744992B2 (en) 2002-03-07
US20020065256A1 (en) 2002-05-30
ZA9810217B (en) 1999-05-14
SA99190966B1 (ar) 2006-03-07
US7524834B2 (en) 2009-04-28
EP1032396B1 (de) 2004-02-18
CA2310222C (en) 2008-05-13
MY118856A (en) 2005-01-31
AR013765A1 (es) 2001-01-10
US6392036B1 (en) 2002-05-21
SE9704186D0 (sv) 1997-11-14
US20070197489A1 (en) 2007-08-23
CN1173702C (zh) 2004-11-03
KR100571075B1 (ko) 2006-04-14
BR9814118A (pt) 2000-10-03

Similar Documents

Publication Publication Date Title
DE69821796D1 (de) Sterilisation von glucocorticosteroiden
DE69428978D1 (de) Parfümierungsverfahren von geweben
DE69814070D1 (de) Sterilisationsverfahren
BR9500861A (pt) Secador desodorizante e esterilizante
DE69513855D1 (de) Radiochemische Sterilisation
DE69835011D1 (de) Unterschiedliche behandlung von prothesenteilen
DE59804367D1 (de) Sterilisierbehälter
DE69729817D1 (de) Behandlung von Aldehyd-fixierten Geweben
DE69624058D1 (de) Desinfektionsgerät
DE69632258D1 (de) Verminderung von schlechten geruchen
DE69524487D1 (de) Sterilisiervorrichtung
DE69522685D1 (de) Behandlung von blut-plasma
DE69802300D1 (de) Behandlung von schädlichen flüssigkeiten
BR9605714A (pt) Aparelho esterilizador de aplicaç o múltipla
DK0974275T3 (da) Fremgangsmåde til sterilisation
FR2726766B1 (fr) Sterilisateur
KR960030492U (ko) 의료용 멸균기
KR960033519U (ko) 살균 소독고
KR960007075U (ko) 살균 소독고
KR970004296U (ko) 살균 소독기
KR950029556U (ko) 치솔 살균기
KR960004068U (ko) 치솔살균기
KR970020882U (ko) 오존 살균 가구
KR960020183U (ko) 의료용 멸균기
UA26006C2 (uk) Дезіhфекційhий та стерилізуючий препарат

Legal Events

Date Code Title Description
8364 No opposition during term of opposition