JPS5732212A - Sterilizing method of acetylsalicylate salt - Google Patents
Sterilizing method of acetylsalicylate saltInfo
- Publication number
- JPS5732212A JPS5732212A JP10766680A JP10766680A JPS5732212A JP S5732212 A JPS5732212 A JP S5732212A JP 10766680 A JP10766680 A JP 10766680A JP 10766680 A JP10766680 A JP 10766680A JP S5732212 A JPS5732212 A JP S5732212A
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- concentration
- salt
- acid salt
- lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain a sterile product suitable for a medicine readily, by immersing an amino acid salt of acetylsalicylic acid which is unsuitable in the sterility test in ethanol or propanol of a specific concentration at a specified temperature, and separating the amino acid salt.
CONSTITUTION: An amino acid salt of acethylsalicylic acid, e.g. a salt of dl-lysine, l-lysine, dl-arginine or dl-histidine, is immersed in ethyl alcohol, n- or iso-propyl alcohol in a concentration of 70W95wt% at 10W30°C, and if necessary stirred for 1W5hr. The formed crystals are then filtered, washed with the alcohol of the concentration and dried to give the aimed sterile product. The drying operation is preferably carried out at a temperature as low as possible under reduced pressure.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10766680A JPS5732212A (en) | 1980-08-07 | 1980-08-07 | Sterilizing method of acetylsalicylate salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10766680A JPS5732212A (en) | 1980-08-07 | 1980-08-07 | Sterilizing method of acetylsalicylate salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5732212A true JPS5732212A (en) | 1982-02-20 |
Family
ID=14464920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10766680A Pending JPS5732212A (en) | 1980-08-07 | 1980-08-07 | Sterilizing method of acetylsalicylate salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5732212A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002503211A (en) * | 1996-06-27 | 2002-01-29 | ザ、プロクター、エンド、ギャンブル、カンパニー | Cosmetic composition |
WO2003070285A1 (en) * | 2002-02-19 | 2003-08-28 | Resolution Chemicals Limited | Solvent-based sterilisation of pharmaceuticals |
DE10306761B3 (en) * | 2003-02-17 | 2004-08-26 | Völkl, Klaus Peter, Dr. | Process for the production of sterile active pharmaceutical ingredients |
US7524834B2 (en) | 1997-11-14 | 2009-04-28 | Astrazeneca Ab | Sterile powders, formulations, and methods for producing the same |
CN102993036A (en) * | 2011-09-10 | 2013-03-27 | 海南中化联合制药工业股份有限公司 | Preparation method of aspirin-DL-lysine sterile raw material |
-
1980
- 1980-08-07 JP JP10766680A patent/JPS5732212A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002503211A (en) * | 1996-06-27 | 2002-01-29 | ザ、プロクター、エンド、ギャンブル、カンパニー | Cosmetic composition |
US7524834B2 (en) | 1997-11-14 | 2009-04-28 | Astrazeneca Ab | Sterile powders, formulations, and methods for producing the same |
WO2003070285A1 (en) * | 2002-02-19 | 2003-08-28 | Resolution Chemicals Limited | Solvent-based sterilisation of pharmaceuticals |
US8541399B2 (en) | 2002-02-19 | 2013-09-24 | Resolution Chemicals Limited | Solvent-based sterilisation of pharmaceuticals |
DE10306761B3 (en) * | 2003-02-17 | 2004-08-26 | Völkl, Klaus Peter, Dr. | Process for the production of sterile active pharmaceutical ingredients |
DE10306761B9 (en) * | 2003-02-17 | 2004-12-23 | Völkl, Klaus Peter, Dr. | Process for the production of sterile active pharmaceutical ingredients |
CN102993036A (en) * | 2011-09-10 | 2013-03-27 | 海南中化联合制药工业股份有限公司 | Preparation method of aspirin-DL-lysine sterile raw material |
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