DE69737126T2 - Hbv mutanten und methoden für deren nachweis - Google Patents
Hbv mutanten und methoden für deren nachweis Download PDFInfo
- Publication number
- DE69737126T2 DE69737126T2 DE69737126T DE69737126T DE69737126T2 DE 69737126 T2 DE69737126 T2 DE 69737126T2 DE 69737126 T DE69737126 T DE 69737126T DE 69737126 T DE69737126 T DE 69737126T DE 69737126 T2 DE69737126 T2 DE 69737126T2
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- Prior art keywords
- hbv
- mutation
- polymerase
- amino acid
- dna
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- 229940104230 thymidine Drugs 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO351996 | 1996-11-08 | ||
| AUPO3519A AUPO351996A0 (en) | 1996-11-08 | 1996-11-08 | Viral variants and methods for detecting same |
| PCT/AU1997/000520 WO1998021317A1 (en) | 1996-11-08 | 1997-08-15 | Viral variants and methods for detecting same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69737126D1 DE69737126D1 (de) | 2007-02-01 |
| DE69737126T2 true DE69737126T2 (de) | 2007-10-04 |
Family
ID=3797830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737126T Expired - Lifetime DE69737126T2 (de) | 1996-11-08 | 1997-08-15 | Hbv mutanten und methoden für deren nachweis |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6555311B1 (https=) |
| EP (1) | EP0964916B1 (https=) |
| JP (4) | JP2001503277A (https=) |
| AT (1) | ATE348880T1 (https=) |
| AU (1) | AUPO351996A0 (https=) |
| CA (1) | CA2270178C (https=) |
| DE (1) | DE69737126T2 (https=) |
| ES (1) | ES2279542T3 (https=) |
| WO (1) | WO1998021317A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA973367B (en) * | 1996-04-19 | 1997-11-18 | Innogenetics Nv | Method for typing and detecting HBV. |
| USRE40233E1 (en) | 1996-11-08 | 2008-04-08 | Melbourne Health | Viral variants and methods for detecting same |
| AUPO351996A0 (en) * | 1996-11-08 | 1996-12-05 | Western Health Care Network | Viral variants and methods for detecting same |
| AUPP706098A0 (en) * | 1998-11-11 | 1998-12-03 | North Western Health Care Network | Biological compositions, components thereof and uses therefor |
| AUPP967999A0 (en) | 1999-04-09 | 1999-05-06 | North Western Health Care Network | Viral variants |
| AR028149A1 (es) * | 1999-07-08 | 2003-04-30 | Innogenetics Nv | Deteccion de la resistencia a los farmacos contra la hepatitis b |
| AUPQ810900A0 (en) | 2000-06-09 | 2000-07-06 | Austin and Repatriation Medical Centre, The | Viral variants and methods of using same |
| SG90149A1 (en) * | 2000-07-18 | 2002-07-23 | Government Of The Republic Of | Diagnostic assay |
| US6697858B1 (en) * | 2000-08-14 | 2004-02-24 | Telephony@Work | Call center |
| JP4502642B2 (ja) * | 2002-02-07 | 2010-07-14 | メルボルン ヘルス | ヌクレオシドアナログに対する感受性の変化を有するウイルス変種およびその使用 |
| US7405039B2 (en) | 2002-02-07 | 2008-07-29 | Austin Health | Viral variants with altered susceptibility to nucleoside analogs and uses thereof |
| TR200402517T1 (tr) * | 2002-03-29 | 2007-12-24 | Innogenetics N.V. | HBV ilaç direnci tespit metotları |
| EP2033967A1 (en) | 2002-04-12 | 2009-03-11 | Melbourne Health | Hepatitis B viral variants with reduced susceptibility to nucleoside analogs and uses thereof |
| AU2003213874B2 (en) * | 2002-04-12 | 2008-12-04 | Austin Health | Hepatitis B viral variants with redused susceptibility to nucleoside analogs and uses thereof |
| EP1513958B1 (en) | 2002-06-14 | 2011-08-10 | Gen-Probe Incorporated | Compositions for detecting hepatitis b virus |
| WO2004031729A2 (en) * | 2002-10-01 | 2004-04-15 | Georgetown University | Diagnostic for long term response of hbv carrier to 3tc therapy |
| WO2006097284A1 (en) | 2005-03-15 | 2006-09-21 | Rheinische Friedrich-Wilhelms-Universität Bonn | Variants of hepatitis b virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof |
| PL1858916T4 (pl) | 2005-03-15 | 2015-04-30 | Fujirebio Europe N V | Warianty wirusa zapalenia wątroby typu b z obniżoną wrażliwością na analogi nukleozydów i ich zastosowanie |
| JP2008534020A (ja) | 2005-04-08 | 2008-08-28 | メルボルン ヘルス | 抗ウイルス性のヌクレオシド剤に耐性を示すｂ型肝炎ウイルスのバリアントおよびその応用法 |
| AU2006230802A1 (en) | 2005-04-08 | 2006-10-12 | Austin Health | Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof |
| KR100790226B1 (ko) | 2005-11-03 | 2008-01-02 | 연세대학교 산학협력단 | 독성 간염 유발 감수성을 검출하는 방법 |
| CN102317473A (zh) * | 2008-12-11 | 2012-01-11 | 加利福尼亚太平洋生物科学股份有限公司 | 核酸模板的分类 |
| US12527665B2 (en) | 2008-12-11 | 2026-01-20 | Pacific Biosciences Of California, Inc. | Methods for identifying modified bases in nucleic acid templates |
| US9175338B2 (en) | 2008-12-11 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Methods for identifying nucleic acid modifications |
| EP2694686B2 (en) | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
| US9175348B2 (en) | 2012-04-24 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Identification of 5-methyl-C in nucleic acid templates |
| US20230242590A1 (en) * | 2019-12-07 | 2023-08-03 | Isa Pharmaceuticals B.V. | Treatment of diseases related to hepatitis b virus |
| TWI867312B (zh) * | 2021-07-01 | 2024-12-21 | 國立成功大學 | 體外定量b肝病毒大表面蛋白的套組，用於分析hbv感染階段及肝癌預後的生物指標組，以及用於預測、診斷或治療慢性肝病的單株抗體組 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595739A (en) * | 1993-05-07 | 1997-01-21 | Abbott Laboratories | Hepatitis B virus mutants, reagents and methods for detection |
| ZA973367B (en) * | 1996-04-19 | 1997-11-18 | Innogenetics Nv | Method for typing and detecting HBV. |
| AUPO351996A0 (en) * | 1996-11-08 | 1996-12-05 | Western Health Care Network | Viral variants and methods for detecting same |
| USRE40233E1 (en) * | 1996-11-08 | 2008-04-08 | Melbourne Health | Viral variants and methods for detecting same |
| AUPP967999A0 (en) * | 1999-04-09 | 1999-05-06 | North Western Health Care Network | Viral variants |
| AUPQ810900A0 (en) * | 2000-06-09 | 2000-07-06 | Austin and Repatriation Medical Centre, The | Viral variants and methods of using same |
| US7405039B2 (en) * | 2002-02-07 | 2008-07-29 | Austin Health | Viral variants with altered susceptibility to nucleoside analogs and uses thereof |
| TR200402517T1 (tr) * | 2002-03-29 | 2007-12-24 | Innogenetics N.V. | HBV ilaç direnci tespit metotları |
| EP2033967A1 (en) * | 2002-04-12 | 2009-03-11 | Melbourne Health | Hepatitis B viral variants with reduced susceptibility to nucleoside analogs and uses thereof |
| EP1692278B1 (en) * | 2003-10-21 | 2013-07-03 | Melbourne Health | Hbv variants detection and application |
| PL1858916T4 (pl) * | 2005-03-15 | 2015-04-30 | Fujirebio Europe N V | Warianty wirusa zapalenia wątroby typu b z obniżoną wrażliwością na analogi nukleozydów i ich zastosowanie |
| WO2006097284A1 (en) * | 2005-03-15 | 2006-09-21 | Rheinische Friedrich-Wilhelms-Universität Bonn | Variants of hepatitis b virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof |
| AU2006230802A1 (en) * | 2005-04-08 | 2006-10-12 | Austin Health | Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof |
| JP2008534020A (ja) * | 2005-04-08 | 2008-08-28 | メルボルン ヘルス | 抗ウイルス性のヌクレオシド剤に耐性を示すｂ型肝炎ウイルスのバリアントおよびその応用法 |
| CN101548014B (zh) * | 2006-06-06 | 2012-07-04 | 墨尔本保健公司 | 抗病毒抗性突变的检测和应用 |
-
1996
- 1996-11-08 AU AUPO3519A patent/AUPO351996A0/en not_active Abandoned
-
1997
- 1997-08-15 AT AT97934385T patent/ATE348880T1/de active
- 1997-08-15 JP JP52194498A patent/JP2001503277A/ja not_active Withdrawn
- 1997-08-15 ES ES97934385T patent/ES2279542T3/es not_active Expired - Lifetime
- 1997-08-15 CA CA2270178A patent/CA2270178C/en not_active Expired - Lifetime
- 1997-08-15 WO PCT/AU1997/000520 patent/WO1998021317A1/en not_active Ceased
- 1997-08-15 EP EP97934385A patent/EP0964916B1/en not_active Expired - Lifetime
- 1997-08-15 DE DE69737126T patent/DE69737126T2/de not_active Expired - Lifetime
-
1999
- 1999-05-06 US US09/306,420 patent/US6555311B1/en not_active Ceased
-
2002
- 2002-10-01 US US10/260,451 patent/US20030124096A1/en not_active Abandoned
-
2008
- 2008-01-24 JP JP2008014075A patent/JP2008154590A/ja active Pending
- 2008-05-09 US US12/117,869 patent/US20100203506A1/en not_active Abandoned
-
2011
- 2011-12-16 JP JP2011276121A patent/JP2012055322A/ja active Pending
-
2012
- 2012-07-12 US US13/547,392 patent/US20130171620A1/en not_active Abandoned
-
2015
- 2015-02-02 JP JP2015018686A patent/JP2015107127A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008154590A (ja) | 2008-07-10 |
| AUPO351996A0 (en) | 1996-12-05 |
| ES2279542T3 (es) | 2007-08-16 |
| JP2015107127A (ja) | 2015-06-11 |
| HK1027374A1 (en) | 2001-01-12 |
| US6555311B1 (en) | 2003-04-29 |
| JP2012055322A (ja) | 2012-03-22 |
| DE69737126D1 (de) | 2007-02-01 |
| CA2270178C (en) | 2012-06-12 |
| EP0964916A4 (en) | 2001-09-26 |
| JP2001503277A (ja) | 2001-03-13 |
| US20130171620A1 (en) | 2013-07-04 |
| ATE348880T1 (de) | 2007-01-15 |
| US20100203506A1 (en) | 2010-08-12 |
| WO1998021317A1 (en) | 1998-05-22 |
| EP0964916A1 (en) | 1999-12-22 |
| EP0964916B1 (en) | 2006-12-20 |
| US20030124096A1 (en) | 2003-07-03 |
| CA2270178A1 (en) | 1998-05-22 |
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| 8364 | No opposition during term of opposition |