DE69736814D1 - Adipogenische differenzierung von humanen mesenchymalen stammzellen - Google Patents

Adipogenische differenzierung von humanen mesenchymalen stammzellen

Info

Publication number
DE69736814D1
DE69736814D1 DE69736814T DE69736814T DE69736814D1 DE 69736814 D1 DE69736814 D1 DE 69736814D1 DE 69736814 T DE69736814 T DE 69736814T DE 69736814 T DE69736814 T DE 69736814T DE 69736814 D1 DE69736814 D1 DE 69736814D1
Authority
DE
Germany
Prior art keywords
mesenchymal stem
stem cells
differentiate
cells
human mesenchymal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69736814T
Other languages
English (en)
Other versions
DE69736814T2 (de
Inventor
F Pittenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osiris Therapeutics Inc
Original Assignee
Osiris Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osiris Therapeutics Inc filed Critical Osiris Therapeutics Inc
Application granted granted Critical
Publication of DE69736814D1 publication Critical patent/DE69736814D1/de
Publication of DE69736814T2 publication Critical patent/DE69736814T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
DE69736814T 1996-07-30 1997-07-21 Adipogenische differenzierung von humanen mesenchymalen stammzellen Expired - Lifetime DE69736814T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US700753 1996-07-30
US08/700,753 US5827740A (en) 1996-07-30 1996-07-30 Adipogenic differentiation of human mesenchymal stem cells
PCT/US1997/012356 WO1998004682A1 (en) 1996-07-30 1997-07-21 Adipogenic differentiation of human mesenchymal stem cells

Publications (2)

Publication Number Publication Date
DE69736814D1 true DE69736814D1 (de) 2006-11-23
DE69736814T2 DE69736814T2 (de) 2007-08-16

Family

ID=24814738

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736814T Expired - Lifetime DE69736814T2 (de) 1996-07-30 1997-07-21 Adipogenische differenzierung von humanen mesenchymalen stammzellen

Country Status (11)

Country Link
US (3) US5827740A (de)
EP (2) EP0954565B1 (de)
JP (1) JP2001523084A (de)
AT (1) ATE342349T1 (de)
AU (1) AU3729097A (de)
CA (1) CA2262014C (de)
DE (1) DE69736814T2 (de)
DK (1) DK0954565T3 (de)
ES (1) ES2274547T3 (de)
PT (1) PT954565E (de)
WO (1) WO1998004682A1 (de)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
KR20000076007A (ko) * 1997-03-07 2000-12-26 나가야마 오사무 신규 세포주 및 이 세포주를 사용한 스크리닝 방법
US6153432A (en) * 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
US6777231B1 (en) * 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20050076396A1 (en) * 1999-03-10 2005-04-07 Katz Adam J. Adipose-derived stem cells and lattices
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
AUPQ147799A0 (en) * 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
US20050158289A1 (en) * 1999-07-07 2005-07-21 Simmons Paul J. Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US8062675B2 (en) 1999-07-07 2011-11-22 Angioblast Systems, Inc. Mesenchymal precursor cell
EP1226233B1 (de) 1999-08-05 2011-06-29 ABT Holding Company Multipotente erwachsene stammzellen und verfahren zu deren isolierung
AU1472501A (en) * 1999-11-05 2001-05-14 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
AU3081801A (en) * 1999-11-15 2001-05-30 Chemclean Corporation Bio-burden visualization system
AU2001268449A1 (en) 2000-06-14 2001-12-24 Vistagen, Inc. Toxicity typing using liver stem cells
ATE373082T1 (de) * 2000-07-18 2007-09-15 Nestle Sa Pre-adipose zelllinien
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
IL156303A0 (en) * 2000-12-06 2004-01-04 Robert J Hariri Method of collecting placental stem cells
US6869766B2 (en) * 2000-12-22 2005-03-22 The Regents Of The University Of California Gene associated with regulation of adiposity and insulin response
ES2548591T3 (es) 2001-02-14 2015-10-19 Anthrogenesis Corporation Placenta post-parto de mamífero, su uso y células madre placentarias de la misma
EP2336300B1 (de) 2001-02-14 2015-07-08 Anthrogenesis Corporation Post-partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
DK1921133T3 (en) * 2001-12-07 2015-08-24 Cytori Therapeutics Inc System for processing lipoaspiratceller
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US7514075B2 (en) * 2001-12-07 2009-04-07 Cytori Therapeutics, Inc. Systems and methods for separating and concentrating adipose derived stem cells from tissue
US20060204556A1 (en) * 2001-12-07 2006-09-14 Cytori Therapeutics, Inc. Cell-loaded prostheses for regenerative intraluminal applications
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US20050008626A1 (en) * 2001-12-07 2005-01-13 Fraser John K. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20050048036A1 (en) * 2001-12-07 2005-03-03 Hedrick Marc H. Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues
US7651684B2 (en) * 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US8404229B2 (en) 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
US20050095228A1 (en) * 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
JP2005518828A (ja) * 2001-12-20 2005-06-30 マクロポア インコーポレイテッド 脂肪組織から抽出したコラーゲンに富む物質を用いた患者を治療するためのシステム及び方法
CA2471147C (en) * 2002-01-04 2010-08-10 Henry Ford Health System Nitric oxide donors for treatment of disease and injury
KR20040101220A (ko) * 2002-02-07 2004-12-02 더 유니버시티 오브 마이애미 중추신경계 신경 재생을 촉진하는 슈반 세포 브리지임플란트 및 포스포디에스테라제 저해제
US20040076622A1 (en) * 2002-03-02 2004-04-22 Board Of Regents, The University Of Texas System Local production and/or delivery of anti-cancer agents by stromal cell precursors
WO2003080801A2 (en) * 2002-03-19 2003-10-02 Advanced Research & Technology Transfer Adipose stromal stem cells for tissue and vascular modification
TWI288779B (en) * 2002-03-28 2007-10-21 Blasticon Biotech Forschung Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
AU2003230792A1 (en) * 2002-04-03 2003-10-20 Artecel Sciences, Inc. Improvements of adipocytic differentiated adipose derived adult stem cells and uses thereof
US7060494B2 (en) * 2002-04-09 2006-06-13 Reliance Life Sciences Pvt. Ltd. Growth of human Mesenchymal Stem Cells (hMSC) using umbilical cord blood serum and the method for the preparation thereof
US20050118715A1 (en) * 2002-04-12 2005-06-02 Hariri Robert J. Modulation of stem and progenitor cell differentiation, assays, and uses thereof
EP1525308A4 (de) * 2002-05-30 2006-11-02 Celgene Corp Verfahren zur verwendung von jnk- oder mkk-inhibitoren zur modulation der zelldifferenzierung und zur behandlung von myeloproliferativen störungen und myelodysplastischen syndromen
US20040171147A1 (en) 2002-11-26 2004-09-02 Hariri Robert J. Cytotherapeutics, cytotherapeutic units and methods for treatments using them
EP1601248A4 (de) * 2003-02-13 2010-01-27 Anthrogenesis Corp Verwendung von nabelschnurblut zur behandlung von subjekten, die an einer krankheit, einem leiden oder einer störung leiden
KR100865884B1 (ko) 2003-03-18 2008-10-31 (주)안트로젠 동종 이식에 사용하기 위한 분화된 지방 세포
WO2004090112A2 (en) * 2003-04-01 2004-10-21 United States Of America Department Of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
EP1702062A2 (de) * 2003-06-11 2006-09-20 Jan Remmereit Kern-umprogrammierung von zellen für die therapeutische verwendung
WO2005017117A2 (en) * 2003-08-14 2005-02-24 Martin Haas Multipotent amniotic fetal stem cells (mafsc) and banking of same
US7012273B2 (en) * 2003-08-14 2006-03-14 Silicon Storage Technology, Inc. Phase change memory device employing thermal-electrical contacts with narrowing electrical current paths
GB0321337D0 (en) * 2003-09-11 2003-10-15 Massone Mobile Advertising Sys Method and system for distributing advertisements
WO2005033297A1 (en) * 2003-09-19 2005-04-14 The Rockefeller University Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells
NZ597965A (en) 2003-10-08 2013-09-27 Vet Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
WO2005079250A2 (en) * 2004-02-13 2005-09-01 Cornell Research Foundation, Inc. Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
EP1747265B1 (de) 2004-04-23 2011-04-20 BioE LLC Mehrfachlinien-vorläuferzellen
US20090029912A1 (en) * 2004-09-24 2009-01-29 Stan Gronthos Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)
WO2006052991A2 (en) 2004-11-11 2006-05-18 The General Hosptial Corporation Parathyroid hormone receptor activation and stem and progenitor cell expansion
WO2006062989A1 (en) * 2004-12-07 2006-06-15 Bacterin International, Inc. Three-dimensional cell culsture system
CA2512667A1 (en) * 2005-01-07 2006-07-07 Takahiro Ochiya Human hepatocyte-like cells and uses thereof
EP1844434A4 (de) * 2005-01-10 2013-11-13 Cytori Therapeutics Inc Einrichtungen und verfahren zum überwachen, verwalten und warten medizinischer einrichtungen
BRPI0520280A2 (pt) * 2005-05-10 2009-04-28 Us Of America Dept Of Veteran terapia de disfunÇÕes renais e falÊncia méltipla de àrgços com cÉlulas-tronco mesenquimais e meio condicionado por exposiÇço a cÉlulas-tronco mesenquimais
EP2662439A1 (de) 2005-05-27 2013-11-13 Viacord, LLC Behandlung von Ischämie mit Stammzellen
US8568761B2 (en) * 2005-07-15 2013-10-29 Cormatrix Cardiovascular, Inc. Compositions for regenerating defective or absent myocardium
US7531355B2 (en) 2005-07-29 2009-05-12 The Regents Of The University Of California Methods and compositions for smooth muscle reconstruction
WO2007016566A2 (en) * 2005-08-01 2007-02-08 Nupotential, Llc Production of reprogrammed cells with restored potential
EP1940423B1 (de) 2005-09-09 2014-04-16 Duke University Gewebe-engineering-verfahren und zusammensetzungen
CA2974249C (en) 2005-10-13 2021-10-12 Anthrogenesis Corporation Immunomodulation using placental stem cells
US20080070303A1 (en) * 2005-11-21 2008-03-20 West Michael D Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
DK2471903T3 (en) 2005-12-29 2018-05-28 Anthrogenesis Corp Placenta stem cell populations
CN101389754A (zh) 2005-12-29 2009-03-18 人类起源公司 胎盘干细胞和第二来源干细胞的联合培养
WO2007089798A2 (en) * 2006-01-30 2007-08-09 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
WO2007121443A2 (en) 2006-04-17 2007-10-25 Bioe, Inc. Differentiation of multi-lineage progenitor cells to respiratory epithelial cells
US20090304644A1 (en) * 2006-05-30 2009-12-10 Cytori Therapeutics, Inc. Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue
MX2008015645A (es) * 2006-06-09 2009-02-06 Anthrogenesis Corp Nicho placentario y uso de este para cultivar celulas primordiales.
US20100015104A1 (en) * 2006-07-26 2010-01-21 Cytori Therapeutics, Inc Generation of adipose tissue and adipocytes
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
CA2665475A1 (en) * 2006-10-06 2008-05-22 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
ES2709205T3 (es) 2006-10-23 2019-04-15 Celularity Inc Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias
TW200822930A (en) * 2006-11-22 2008-06-01 Chao-Song Hsue Composition for reducing weight and curing hypertriglyceridemia, the effective ingredients thereof containing cyclic AMP, nicotinic acid, prostaglandin, gamma linolenic acid, and xanthine derivates
NZ597779A (en) 2007-02-12 2013-07-26 Anthrogenesis Corp Treatment of inflammatory diseases using placental stem cells
MX2009008559A (es) 2007-02-12 2009-08-21 Anthrogenesis Corp Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-.
US7632340B2 (en) * 2007-03-07 2009-12-15 Hamilton Beach Brands, Inc. Air purifier for removing particles or contaminants from air
WO2008137115A1 (en) * 2007-05-03 2008-11-13 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) * 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
TWM322542U (en) * 2007-05-23 2007-11-21 Universal Scient Ind Co Ltd Testing machine
WO2009015343A2 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
RU2010116271A (ru) * 2007-09-26 2011-11-10 Селджин Селльюлар Терапьютикс (Us) Ангиогенные клетки из плацентарного перфузата человека
PT2203176E (pt) 2007-09-28 2015-03-02 Anthrogenesis Corp Supressão de tumor utilizando perfusato placentário humano e células assassinas naturais intermédias derivadas de placenta humanas
KR20170116221A (ko) * 2007-11-07 2017-10-18 안트로제네시스 코포레이션 조산 합병증의 치료에 있어서의 제대혈의 용도
US20100278788A1 (en) * 2008-01-11 2010-11-04 Bone Therapeutics, S.A. Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors
US20100189338A1 (en) * 2008-04-09 2010-07-29 Nexcelom Bioscience Systems and methods for counting cells and biomolecules
CN102083969A (zh) * 2008-05-06 2011-06-01 乔斯林糖尿病中心股份有限公司 诱导褐色脂肪形成的方法和组合物
KR20110013450A (ko) 2008-05-07 2011-02-09 본 테라퓨틱스 소시에테아노님 간엽 줄기 세포 및 골-형성 세포
EP2294187A2 (de) * 2008-05-21 2011-03-16 BioE LLC Differenzierung von mehrlinien-vorläuferzellen zu pankreaszellen
BRPI0917993B8 (pt) * 2008-08-14 2021-05-25 Mesoblast Int Sarl composições de célula-tronco mesenquimal purificada
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
KR20180049231A (ko) 2008-08-20 2018-05-10 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
NZ591294A (en) 2008-08-20 2012-10-26 Anthrogenesis Corp Treatment of stroke using isolated placental cells
MX339068B (es) 2008-08-22 2016-05-10 Anthrogenesis Corp Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias.
EP2182055A1 (de) 2008-10-14 2010-05-05 Heinrich-Heine-Universität Düsseldorf Aus der menschlichen Nabelschnur gewonnene unrestringierte somatische Stammzellen (USSC)
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
NZ592726A (en) 2008-11-19 2012-12-21 Anthrogenesis Corp Amnion derived adherent cells
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
DK2375907T3 (da) * 2008-11-21 2019-06-11 Celularity Inc Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller
WO2010127310A1 (en) 2009-05-01 2010-11-04 Cytori Therapeutics, Inc. Systems, methods and compositions for optimizing tissue and cell enriched grafts
US9301975B2 (en) 2009-05-01 2016-04-05 Biocardia, Inc. Method of preparing autologous cells and method of use for therapy
NZ619359A (en) 2009-07-02 2015-07-31 Anthrogenesis Corp Method of producing erythrocytes without feeder cells
KR101962477B1 (ko) 2009-07-21 2019-03-26 에이비티 홀딩 컴퍼니 백혈구 혈관외유출을 감소시키기 위한 줄기 세포의 용도
EP2456860B1 (de) 2009-07-21 2018-09-05 ABT Holding Company Verwendung von stammzellen für reduzierte leukozyten-extravasation
WO2011043524A1 (ko) * 2009-10-08 2011-04-14 주식회사 알앤엘바이오 인간 유래 성체 줄기세포를 함유하는 항암용 조성물
EP2489727A4 (de) * 2009-10-08 2013-05-08 Seoul Nat Univ Hospital Verfahren zur herbeiführung einer hohen aktivität menschlicher adipositas-stammzellen und medium dafür
US20140286911A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
AU2011209819A1 (en) 2010-01-26 2012-08-16 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
AU2011220721B2 (en) 2010-02-25 2015-02-05 Abt Holding Company Modulation of macrophage activation
TW202011974A (zh) 2010-04-07 2020-04-01 美商安瑟吉納西斯公司 利用胎盤幹細胞之血管新生
KR20130092394A (ko) 2010-04-08 2013-08-20 안트로제네시스 코포레이션 태반 줄기 세포를 사용한 사르코이드증의 치료
WO2011130402A2 (en) 2010-04-13 2011-10-20 Cellular Dynamics International, Inc. Hepatocyte production by forward programming
CA2802087A1 (en) 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. A compendium of ready-built stem cell models for interrogation of biological response
JP5897002B2 (ja) 2010-07-07 2016-04-13 セルラー ダイナミクス インターナショナル， インコーポレイテッド プログラミングによる内皮細胞の産生
US9296984B2 (en) 2010-07-09 2016-03-29 The Gid Group, Inc. Tissue processing apparatus and method for processing adipose tissue
US9206387B2 (en) 2010-07-09 2015-12-08 The Gid Group, Inc. Method and apparatus for processing adipose tissue
EP2590695A4 (de) 2010-07-09 2017-09-06 The Gid Group, Inc. Vorrichtung und verfahren zur erhebung und verarbeitung von menschlichem biologischem material mit fettgewebe
WO2013106655A1 (en) 2012-01-11 2013-07-18 The Gid Group, Inc. Method for processing adipose tissue and processing apparatus
CN107828727A (zh) 2010-07-13 2018-03-23 人类起源公司 产生自然杀伤细胞的方法、由此获得的细胞群体及其用途
EP2611908A4 (de) * 2010-09-01 2014-04-02 Univ California Zellkultursieb für mittel zur steuerung von adipogenese und myofibroblastendifferenzierung
EP2625263B1 (de) 2010-10-08 2020-03-11 Terumo BCT, Inc. Konfigurierbare verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
US9381219B2 (en) 2010-12-29 2016-07-05 Ethicon Endo-Surgery, Inc. Brown adipocyte modification
AU2011352036A1 (en) 2010-12-31 2013-07-18 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
DK2667878T3 (en) 2011-01-25 2016-06-27 Univ Catholique Louvain Configurations and methods for cell transplantation
WO2013110354A1 (en) 2012-01-25 2013-08-01 Université Catholique de Louvain Compositions and methods for cell transplantation
CA2826386C (en) 2011-02-08 2020-04-28 Cellular Dynamics International, Inc. Hematopoietic precursor cell production by programming
WO2012166844A2 (en) 2011-06-01 2012-12-06 Anthrogenesis Corporation Treatment of pain using placental stem cells
WO2012168295A1 (en) 2011-06-06 2012-12-13 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
JP2014530065A (ja) 2011-10-11 2014-11-17 ボーン セラピューティクスソシエテ アノニム 増殖分化因子８（ｇｄｆ‐８）の使用
WO2013082106A1 (en) 2011-12-02 2013-06-06 The General Hospital Corporation Differentiation into brown adipocytes
WO2013146992A1 (ja) 2012-03-29 2013-10-03 日本ケミカルリサーチ株式会社 歯髄由来の多能性幹細胞の製造方法
EP2834344B1 (de) 2012-09-06 2016-07-20 The GID Group, Inc. Gewebeverarbeitungsvorrichtung und verfahren zur verarbeitung von fettgewebe
DK2900247T3 (en) 2012-09-26 2018-03-05 Bone Therapeutics Sa COMPOSITIONS OF SOLVENT / DETERGENT-TREATED PLASMA AND HYALURONIC ACID FOR USE IN TREATMENT OF MUSCULOSKELETAL DISORDERS
CN105008396A (zh) 2012-11-25 2015-10-28 加利福尼亚大学董事会 刺激皮下脂肪形成的肽
EP3622960A1 (de) 2013-02-05 2020-03-18 Celularity, Inc. Natürliche killerzellen aus plazenta
US20140242595A1 (en) 2013-02-22 2014-08-28 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
WO2014165663A1 (en) 2013-04-03 2014-10-09 Cellular Dynamics International, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
CN115192612A (zh) 2013-04-12 2022-10-18 休斯顿卫理公会医院 改进用于移植的器官
US20140322135A1 (en) 2013-04-30 2014-10-30 Katholieke Universiteit Leuven Cell therapy for myelodysplastic syndromes
US10336980B2 (en) 2013-09-05 2019-07-02 The Gid Group, Inc. Tissue processing apparatus and method for processing adipose tissue
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
EP3613841B1 (de) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passives ersetzen von medien
US20170107486A1 (en) 2014-04-21 2017-04-20 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US10844102B2 (en) 2014-05-28 2020-11-24 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
WO2016044030A1 (en) 2014-09-19 2016-03-24 Osiris Therapeutics, Inc. Bone repair product and methods of use thereof
US20170296589A1 (en) 2014-09-23 2017-10-19 Case Western Reserve University Compositions and methods for treating lung remodeling diseases
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
RU2750695C2 (ru) 2014-11-07 2021-07-01 Экзостемтех Ко., Лтд. Композиция, включающая экзосому, полученную из стволовых клеток, для индукции адипогенной дифференцировки, регенерации жировой ткани, отбеливания кожи или коррекции морщин
KR101629151B1 (ko) * 2014-11-07 2016-06-10 한양대학교 에리카산학협력단 줄기세포 유래 엑소좀을 포함하는 지방세포 분화유도 및 지방조직 재생용 조성물
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
US10080884B2 (en) 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
AU2016251313B2 (en) 2015-04-23 2018-05-17 Bone Therapeutics S.A. In vitro preservation of therapeutic cells
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017210537A1 (en) 2016-06-02 2017-12-07 The Cleveland Clinic Foundation Complement inhibition for improving cell viability
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US10472603B2 (en) 2016-08-30 2019-11-12 Lifecell Corporation Systems and methods for medical device control
USD851777S1 (en) 2017-01-30 2019-06-18 Lifecell Corporation Canister-type device for tissue processing
EP3601521A2 (de) 2017-03-31 2020-02-05 Terumo BCT, Inc. Zellexpansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11732233B2 (en) 2017-07-18 2023-08-22 Gid Bio, Inc. Adipose tissue digestion system and tissue processing method
RU2020113411A (ru) 2017-10-20 2021-11-22 Боун Терапьютикс Са Способы дифференцировки мезенхимальных стволовых клеток
WO2019098310A1 (ja) * 2017-11-16 2019-05-23 日産化学株式会社 ベージュおよび白色脂肪細胞への分化誘導および生産法
CA3103769A1 (en) 2018-07-31 2020-02-06 Jcr Pharmaceuticals Co., Ltd. Method for producing dental pulp-derived cells
SG11202102874UA (en) 2018-09-25 2021-04-29 Bone Therapeutics Sa Methods and uses for determining osteogenic potential of in vitro differentiated cells
SG11202102689UA (en) 2018-09-25 2021-04-29 Bone Therapeutics Sa Methods for differentiating mesenchymal stem cells
AR118008A1 (es) 2019-02-07 2021-09-08 Vitricell Sa Composiciones para criopreservación de un material biológico
CN113825498A (zh) 2019-05-13 2021-12-21 骨治疗公司 包括透明质酸和血浆蛋白的改进冻干制剂及其用途
EP3994245A1 (de) 2019-07-05 2022-05-11 Case Western Reserve University Priming-medium und verfahren für stammzellenkultur und -therapie
TW202146033A (zh) 2020-01-30 2021-12-16 日商Ｊｃｒ製藥股份有限公司 包含源自牙髓的細胞之醫藥組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5827740A (en) * 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells

Also Published As

Publication number Publication date
US6322784B1 (en) 2001-11-27
CA2262014A1 (en) 1998-02-05
EP0954565A4 (de) 2002-09-18
CA2262014C (en) 2010-09-14
JP2001523084A (ja) 2001-11-20
EP1659172A1 (de) 2006-05-24
DE69736814T2 (de) 2007-08-16
PT954565E (pt) 2007-01-31
ES2274547T3 (es) 2007-05-16
AU3729097A (en) 1998-02-20
ATE342349T1 (de) 2006-11-15
WO1998004682A1 (en) 1998-02-05
US6709864B1 (en) 2004-03-23
US5827740A (en) 1998-10-27
EP0954565A1 (de) 1999-11-10
DK0954565T3 (da) 2007-02-05
EP0954565B1 (de) 2006-10-11

Similar Documents

Publication Publication Date Title
ATE342349T1 (de) Adipogenische differenzierung von humanen mesenchymalen stammzellen
DE60120151D1 (de) Isolierung von mesenchymalen stammzellen und deren verwendung
UA37191C2 (uk) Водна структурована композиція поверхнево-активної речовини
BG104780A (en) Inhibitors of phospholipase enzymes
DE69636979D1 (de) Zellinien-gerichtete induktion der menschlichen mesenchymalen stammzelldifferenzierung
ATE255632T1 (de) Immortalisierung bzw. desimmortalisierung von zellen
FI962154A (fi) Koostumus terapeuttisten tuotteiden in vivo valmistusta varten
EP1100870A4 (de) Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
TR199801319T2 (xx) Dezenfekte edici bile�imler ve y�zeyleri dezenfekte etmek i�in i�lemler.
DE69905906T2 (de) Kombination von zwei oder mehreren wirkstoffen unter verwendung von mikrokapsel-formulierungen
MX9710479A (es) Extracto de iridaceas y composiciones que la contienen.
BG101966A (en) Application of 1l-agonist for the treatment of lack of urine retention
AR006160A1 (es) Composicion detergente que comprende alfa-amilasa de actividad especifica y su aplicacion para limpieza
AP1424A (en) 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens.
DE69333931D1 (de) Verwendung von Krillenzymen zur Behandlung von Zahnbelag
DE69717101D1 (de) VERWENDUNG VON alpha-ALKYLGLUCOSIDEN UND DEREN ESTERN ALS ANTIMIKROBIELLE EMULGATOREN
WO2002051986A3 (en) Educated nk t cells and their uses in the treatment of immune-related disorders
DE69637242D1 (de) Methode und zusammensetzungen zur identifizierung von morphogen-analogen
BR9814284A (pt) Composições e métodos para regulação de fagocitose e expressão de icam-1
IL143516A0 (en) COMPOUNDS AND METHODS FOR MODULATING ACTIVATION OF NF-k-B
AU4751797A (en) Defined systems for epithelial cell culture and use thereof
ES2057638T3 (es) Composiciones insecticidas a base de bacillus thuringiensis.
DK0613368T3 (da) Hudregenererende kosmetisk sammensætning
ATE302264T1 (de) Freigabe von intrazellulärem material
WO1997000671A3 (de) Zusammensetzung zur herstellung feindisperser systeme und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: DR. VOLKER VOSSIUS, CORINNA VOSSIUS, TILMAN VOSSIU